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Cornea

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11201. Crystalline stromal dystrophy: histochemistry and ultrastructure of the cornea. (Full text)

Crystalline stromal dystrophy: histochemistry and ultrastructure of the cornea. A report of a woman in her fifties with Schnyder's crystalline stromal dystrophy is presented. There is no personal or family history of hypercholesterolaemia. A full thickness corneal disc was removed before grafting and examined by polarised light, histochemistry, and electron microscopy. Specific lipid histochemical methods showed deposits of cholesterol and cholesterol ester in the superficial stroma

1980 The British journal of ophthalmology

11202. Unilateral lattice dystrophy of the cornea. (Full text)

Unilateral lattice dystrophy of the cornea. Five cases of unilateral and 1 case of bilateral lattice dystrophy of the cornea in 1 family are reported. The diagnosis was made on the basis of the characteristic clinical appearance. The unilateral lesions were generally asymptomatic and required no treatemnt.

1980 The British journal of ophthalmology

11203. Prevalence of map-dot-fingerprint changes in the cornea. (Full text)

Prevalence of map-dot-fingerprint changes in the cornea. Map-dot-fingerprint basement-membrane abnormalities of the cornea are common in the general population, affecting as many as 76% of persons over age 50 and 42% of persons of all ages. The prevalence of this condition in the general population is not significantly different from that found in families of patients with recurrent corneal erosions and map-dot-fingerprint corneal changes. Despite this extremely high prevalence of basement (...) -membrane changes the incidence of recurrent erosive symptoms in total groups of patients with basement-membrane changes is quite rare, suggesting that these 2 entities are possibly not related. Although previous observers have suggested an autosomal dominant mode of inheritance of these basement-membrane changes, our data raise the possibility that map-dot-fingerprint basement-membrane changes represent an age-dependent, degenerative condition of the cornea. We were unable, however, to prove either

1981 The British journal of ophthalmology

11204. Penetrating keratoplasty using MK stored corneas and Na Hyaluronate (Healon). (Full text)

Penetrating keratoplasty using MK stored corneas and Na Hyaluronate (Healon). 6763798 1983 07 08 2018 11 13 0065-9533 80 1982 Transactions of the American Ophthalmological Society Trans Am Ophthalmol Soc Penetrating keratoplasty using MK stored corneas and Na Hyaluronate (Healon). 248-61 Polack F M FM eng Journal Article United States Trans Am Ophthalmol Soc 7506106 0065-9533 9004-61-9 Hyaluronic Acid IM Adult Age Factors Corneal Diseases surgery Corneal Transplantation Graft Rejection Graft

1982 Transactions of the American Ophthalmological Society

11205. Aetiology of spheroidal degeneration of the cornea in Labrador. (Full text)

Aetiology of spheroidal degeneration of the cornea in Labrador. To determine the aetiology of spheroidal degeneration of the cornea (Labrador keratopathy), total population surveys were conducted in 5 communities in coastal Labrador and northern Newfoundland. For 4 years records were also kept on all clinic patients aged 40 or more throughout the region. Both methods gave a peak prevalence at latitudes 55 degrees--56 degrees north. The greatest severity and earliest age of onset occurred around

1981 The British journal of ophthalmology

11206. Comparison of K-Sol and M-K medium for cornea storage: results of penetrating keratoplasty in rabbits. (Full text)

Comparison of K-Sol and M-K medium for cornea storage: results of penetrating keratoplasty in rabbits. Five pairs of rabbit corneas were stored for two weeks at 4 degrees C, one of each pair in K-Sol medium, and one in McCarey-/Kaufman (M-K) medium. After transplantation all penetrating keratoplasty grafts became clear and thin. Endothelial cell loss was significantly less in the K-Sol stored corneas. Another five pairs of corneas were stored for two weeks in K-Sol or three days in M-K medium

1986 The British journal of ophthalmology

11207. Histological study of corneas preserved in two new media. (Full text)

Histological study of corneas preserved in two new media. A new corneal preserving medium (K-Sol), developed by Kaufman and others, contains purified chondroitin sulphate, TC 199, HEPES buffer, and gentamicin. Another new medium (JM) containing bicarbonate-free glucose-phosphate Ringer solution and dextran 70 has been developed in Japan. New Zealand white rabbit corneas with scleral rims were stored in each medium at 4 degrees C for one or two weeks. The condition of the endothelium (...) was evaluated histologically. Corneas preserved in both media were in good condition at the end of one week. Corneas preserved in K-Sol for two weeks showed fewer endothelial changes than similar tissue stored in JM for two weeks. Corneal swelling was also less in corneas preserved in K-Sol, than in corneas preserved in JM.

1987 The British journal of ophthalmology

11208. Cryopreservation of rabbit corneas: assessment by microscopy and transplantation. (Full text)

Cryopreservation of rabbit corneas: assessment by microscopy and transplantation. Rabbit corneas were frozen and thawed by three methods and compared by full thickness transplantation as well as specular microscopy, histology, and transmission electron microscopy. Two of the methods used a recently described technique, in which the excised cornea was immersed in a potassium-rich buffered solution containing the cryoprotectant dimethyl sulphoxide (Me2SO, 2 mol/l). This solution was designed (...) to restrict the loss of intracellular potassium and to prevent cell swelling at low temperatures. In one group the corneas were frozen and thawed surrounded by 5 ml of medium, while in the second group corneas were drained of excess fluid and frozen in air. The third group consisted of corneas cryopreserved by Capella and colleagues' method. All the cryopreserved corneas were damaged, but those that had been frozen in air after exposure to the new medium showed better structure and function than corneas

1986 The British journal of ophthalmology

11209. Scrolls of Descemet's membrane as unusual giant nodules on the posterior cornea: histochemical and ultrastructural findings. (Full text)

Scrolls of Descemet's membrane as unusual giant nodules on the posterior cornea: histochemical and ultrastructural findings. Unusual giant nodules on the posterior surface of Descemet's membrane were observed in two out of over 400 corneae examined during routine histopathological reporting. Both of the patients, a 60-year-old man and a 26-year-old woman, had histories of corneal trauma. Neither was associated with chronic keratitis or corneal dystrophy. Light microscopy showed these nodules

1986 The British journal of ophthalmology

11210. Eosinophils in corneas removed by penetrating keratoplasty. (Full text)

Eosinophils in corneas removed by penetrating keratoplasty. One hundred consecutively submitted corneas removed by penetrating keratoplasty were studied histologically to determine the frequency in which eosinophils are found. In 20 corneas eosinophils occurred in densities ranging from 0.2 to more than 50 per high power field (HPF), and accounted for 1.5% to 100% of the total leucocytes counted. More than half of the corneal specimens containing eosinophils, including six of seven corneas (...) having the highest eosinophil concentrations, were failed grafts. Because the concentration of eosinophils was in many cases beyond that attributable to non-specific vascular permeability, the existence of eosinophil chemotaxic substances in the cornea is postulated.

1986 The British journal of ophthalmology

11211. Changes of MK medium during storage of human cornea. (Full text)

Changes of MK medium during storage of human cornea. By comparing the composition of McCarey-Kaufman (MK) medium before and after corneal storage we attempted to identify specific physiological changes in the medium as predictors of tissue damage. We also tried to determine if hydrocortisone (a lysosomal membrane stabiliser) added to the medium could reduce tissue damage during storage. Corneas (human and rabbit) were stored in the MK medium with and without hydrocortisone for 4 days at 4 (...) degrees C. The water and nitrogen contents of the stored cornea were compared with those of the fresh cornea. The medium was analysed before and after corneal storage to determine the concentrations of glucose, protein, and amino acids as well as pH and osmolarity. Scanning electron microscopy (SEM) was used to estimate the degree of the corneal endothelial cell damage. The nitrogen contents and dry weights of the steroid treated and untreated stored corneas were similar to those of the fresh unstored

1987 The British journal of ophthalmology

11212. Iontophoretic application of tobramycin to uninfected and Pseudomonas aeruginosa-infected rabbit corneas. (Full text)

Iontophoretic application of tobramycin to uninfected and Pseudomonas aeruginosa-infected rabbit corneas. Pseudomonas aeruginosa keratitis was induced in rabbits to study the effects of corneal infection on the delivery of tobramycin by iontophoresis. Some rabbits were treated by use of an eye cup with no current as a control for iontophoresis, and others were treated with fortified drops (1.36%) delivered topically for comparison with results of earlier studies. One hour after treatment (...) with tobramycin, the concentration of drug in the infected corneas was compared with that achieved in mock-infected and uninfected eyes. Iontophoresis of 25 mg of tobramycin per ml at 0.8 mA for 10 min delivered significantly more drug (P = 0.0001) to corneal tissue than did drops or use of an eye cup without current in P. aeruginosa-infected eyes mock-infected eyes, or uninfected eyes. Tobramycin concentrations in the infected corneas (605.9 micrograms/g) were not significantly different (P = 0.815) from

1988 Antimicrobial Agents and Chemotherapy

11213. Effectiveness of a decontamination method for donor corneas. (Full text)

Effectiveness of a decontamination method for donor corneas. A retrospective study was made of the effectiveness of an eye bank decontamination and storage method. A comparison was made between microbial cultures taken from the limbus at enucleation and from scleral remnants recovered after surgery. Organisms were isolated from the limbus of 73% of donor eyes and from 4% of remnants. Standard eye bank procedures were found to eradicate gut and skin organisms, including candida, from donor

1988 The British journal of ophthalmology

11214. Hypothermic preservation of corneas in a hyperkalaemic solution (CPTES): I. Short-term storage in the absence of colloid osmotic agents. (Full text)

Hypothermic preservation of corneas in a hyperkalaemic solution (CPTES): I. Short-term storage in the absence of colloid osmotic agents. Preservation solutions for short-term storage of isolated donor corneas for use in penetrating keratoplasty have all been based on tissue culture medium, on the assumption that media designed to maintain the viability of cells at physiological temperatures will also provide suitable conditions for preservation at reduced temperatures. But for hypothermic (...) preservation of some other tissues and organs, when ionic pumps are inhibited, it is unnecessary to support metabolism, and beneficial control of ion and water distribution between intra- and extracellular compartments is achieved by storage in appropriately formulated 'intracellular-type' solutions. We have therefore designed a solution that will restrict ionic imbalances and minimise endothelial cell swelling in corneas during exposure at reduced temperatures. This potassium-rich solution contains

1989 The British journal of ophthalmology

11215. Hypothermic preservation of corneas in a hyperkalaemic solution (CPTES): II. Extended storage in the presence of chondroitin sulphate. (Full text)

Hypothermic preservation of corneas in a hyperkalaemic solution (CPTES): II. Extended storage in the presence of chondroitin sulphate. Periods of preservation for donor corneas, even for short times, are necessary to facilitate optimum conditions in penetrating keratoplasty. However, current techniques for corneal storage at low temperatures may not provide optimal conditions for maintaining tissue integrity. In particular, the ionic composition of the storage medium has received little (...) that the normal regulatory processes are switched off. The effect of adding the natural polymer chondroitin sulphate (CS) as a colloid osmotic agent to the hyperkalaemic storage medium is now examined. Corneas stored in CPTES containing 2.5% chondroitin sulphate retained a very high level of structural and functional integrity after three, five, and seven days storage at 0 degrees C; furthermore, stromal swelling was restricted to only 21%. All corneas stored in CPTES + 2.5% CS showed active endothelial

1989 The British journal of ophthalmology

11216. Endothelial cell damage in human and rabbit corneas stored in K-Sol without antioxidants. (Full text)

Endothelial cell damage in human and rabbit corneas stored in K-Sol without antioxidants. Human and rabbit corneas were stored at 4 degrees C in K-Sol with and without antioxidants (ascorbic acid, reduced glutathione, alpha-tocopherol, and retinol acetate) for two to three weeks. All the corneas were then examined visually and by scanning electron microscopy. They appeared clear and slightly oedematous. Scanning electron micrographs were used to grade corneal endothelial cell morphology (...) in a masked manner in terms of cell shape, cell borders, cell swelling, and apical holes. Corneas stored in K-Sol without antioxidants showed changes in cell shape, cell borders, and apical holes. Human corneas showed more morphological changes than rabbit corneas. The results suggest that antioxidants in K-Sol have an important role in the preservation of endothelial cell morphology.

1989 The British journal of ophthalmology

11217. Manipulative damage to the endothelium of infant and adult donor corneas. (Full text)

Manipulative damage to the endothelium of infant and adult donor corneas. Six human donor corneas were studied with the scanning electron microscope to quantify the hazards to the endothelium during the excision of corneoscleral buttons. Although the number studied was small, it was found that: (1) striae were more numerous in the flaccid, very young, donor corneas (under 1 year old) than in the more rigid adult corneas: (2) iridocorneal endothelial touch can result in loss of the posterior (...) membrane and death of the touched endothelial cells. This corroborates the findings of other investigators. Both findings are important, because these conditions reduce the quality of the donor cornea for transplantation.

1990 The British journal of ophthalmology

11218. Lectin binding sites in normal, scarred, and lattice dystrophy corneas. (Full text)

Lectin binding sites in normal, scarred, and lattice dystrophy corneas. Normal, scarred, and dystrophic corneas were histochemically probed with a panel of 16 lectins by means of an avidin-biotin revealing system. Normal corneal epithelial cells, keratocytes, and endothelial cells expressed at least two distinct N-linked oligosaccharide subsets, of the non-bisected, biantennary and bisected, bi-/triantennary types. Corneal scars stained variably with the lectin subsets described above (...) , and with Maclura pomifera agglutinin. Lattice dystrophy corneas showed a loss of the oligosaccharide expression observed on the plasma membranes of normal epithelial cells, and there was concurrent deposition of extracellular glycoprotein within the corneal stroma, which was of the same oligosaccharide subsets as were lost from the epithelial cell plasma membranes. This extracellular stromal glycoprotein was far more widely deposited than the amyloid and extended well beyond the stromal scarring. We propose

1991 The British journal of ophthalmology

11219. Evidence for herpes simplex viral latency in the human cornea. (Full text)

Evidence for herpes simplex viral latency in the human cornea. Patients undergoing penetrating keratoplasty for prior herpes simplex keratitis (group A) and corneal disease unrelated to herpes simplex (group B) were investigated to assess whether the cornea is a site for herpes simplex viral latency. All patients were seropositive for herpes simplex viral antibody. Virus was isolated from the tear film postoperatively in one patient and on cocultivation from the cornea of another patient (...) . Herpes simplex viral DNA, however, was detected in the corneas of all patients from group A and half of those from group B by means of the polymerase chain reaction and primers to three well separated regions of the viral genome. Three donor corneas had no evidence of herpes simplex viral DNA. Using RNA polymerase chain reaction, we found evidence of a latency associated transcript and also that of a glycoprotein C coding transcript in two corneas, indicating viral replication. Nine corneas had

1991 The British journal of ophthalmology

11220. Developmental changes in the type I procollagen processing pathway in chick-embryo cornea. (Full text)

Developmental changes in the type I procollagen processing pathway in chick-embryo cornea. Type I procollagen processing in chick-embryo corneas was studied at days 12, 14 and 17 of development. Pulse-chase experiments and electrophoretic analysis of salt-soluble extracts showed developmental changes in the processing pathway. A kinetic model was fitted to the data to determine rate constants for processing of both N- and C-propeptides. Data for pro alpha 1(I)-chain processing and pro alpha 2(I

1991 Biochemical Journal

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