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81. Anterior segment optical coherence tomography for evaluation of cornea and ocular surface (Full text)

Anterior segment optical coherence tomography for evaluation of cornea and ocular surface Current corneal assessment technologies make the process of corneal evaluation extremely fast and simple. Several devices and technologies allow to explore and manage patients better. Optical coherence tomography (OCT) technology has evolved over the years, and hence a detailed evaluation of anterior segment (AS) structures such as cornea, conjunctiva, tear meniscus, anterior chamber, iris, and crystalline (...) lens has been possible in a noncontact and safe procedure. The purpose of this special issue is to present and update in the evaluation of cornea and ocular surface, and this paper reviews a description of the AS-OCT, presenting the technology and common clinical uses of OCT in the management of diseases involving cornea and ocular surface to provide an updated information of the clinical recommendations of this technique in eye care practice.

2018 Indian journal of ophthalmology

82. Morphometric analysis of cornea in the Slc39a13/Zip13-knockout mice (Full text)

Morphometric analysis of cornea in the Slc39a13/Zip13-knockout mice Ehlers-Danlos syndrome (EDS) is a group of hereditary diseases caused by mutation of extracellular matrix-related genes. Recently, spondylodysplastic EDS-Zip13 (spEDS-Zip13: OMIM 612350) was recognized as a new EDS type. This current study could reveal various morphometric differences of collagenous population in the proper substance of cornea between the wild type and spEDS-Zip13-knockout (Zip13-KO) mice. Blockade of Smad

2018 The Journal of Veterinary Medical Science

83. Clinical outcomes after Descemet’s stripping endothelial keratoplasty using donor corneas from children younger than 3 years (Full text)

Clinical outcomes after Descemet’s stripping endothelial keratoplasty using donor corneas from children younger than 3 years There is limited literature on paediatric donors in endothelial keratoplasty.This study investigated the efficacy of and appropriate paediatric donor age for Descemet's stripping endothelial keratoplasty (DSEK).Retrospective and observational case series.Thirty-eight consecutive patients underwent DSEK with paediatric donor corneas.The age of the donors ranged from 32 (...)  weeks gestation (premature neonate) to 3 years old. All donor consents were obtained from the parents. The causes of donor death included traffic accident, congenital heart disease and neonatal respiratory distress syndrome.The outcome measures included best-corrected visual acuity, endothelial cell loss and complications.Best-corrected visual acuity at last follow-up was >20/40 in 28 of 38 eyes (73.7%). The mean preoperative endothelial cell density of donor corneas was 4682 ± 520 cells/mm2

2018 Clinical & experimental ophthalmology

84. Melanopsin expression in the cornea (Full text)

Melanopsin expression in the cornea A unique class of intrinsically photosensitive retinal ganglion cells in mammalian retinae has been recently discovered and characterized. These neurons can generate visual signals in the absence of inputs from rods and cones, the conventional photoreceptors in the visual system. These light sensitive ganglion cells (mRGCs) express the non-rod, non-cone photopigment melanopsin and play well documented roles in modulating pupil responses to light (...) localization of this photopigment in nerve fibers within the cornea. Surprisingly, we were unable to detect light responses in the melanopsin-expressing corneal fibers in spite of our histological evidence based on genetically driven markers and antibody staining. We tested further for melanopsin localization in cell bodies of the trigeminal ganglia (TG), the principal nuclei of the peripheral nervous system that project sensory fibers to the cornea, and found expression of melanopsin mRNA in a subset

2018 Visual neuroscience

85. A Cloudy Conical Cornea (Full text)

A Cloudy Conical Cornea 29849311 2019 02 26 2474-252X 2 1 2018 Feb Clinical practice and cases in emergency medicine Clin Pract Cases Emerg Med A Cloudy Conical Cornea. 89-90 10.5811/cpcem.2017.9.35314 Biggs Katherine K Naval Medical Center Portsmouth, Department of Emergency Medicine, Portsmouth, Virginia. Stuart Sean S Naval Medical Center Portsmouth, Department of Emergency Medicine, Portsmouth, Virginia. eng Case Reports 2018 01 09 United States Clin Pract Cases Emerg Med 101718968 2474

2018 Clinical Practice and Cases in Emergency Medicine

86. Improved High-Frequency Ultrasound Corneal Biometric Accuracy by Micrometer-Resolution Acoustic-Property Maps of the Cornea (Full text)

Improved High-Frequency Ultrasound Corneal Biometric Accuracy by Micrometer-Resolution Acoustic-Property Maps of the Cornea Mapping of epithelial thickness (ET) is useful for detection of keratoconus, a disease characterized by corneal thinning and bulging in which epithelial thinning occurs over the apex. In prior clinical studies, optical coherence tomography (OCT) measurements of ET were systematically thinner than those obtained by 40-MHz high-frequency ultrasound (HFU) where a constant (...) speed of sound (c) of 1636 m/s was used for all corneal layers. The purpose of this work was to study the acoustic properties, that is, c, acoustic impedance (Z), and attenuation (α) of the corneal epithelium and stroma independently using a scanning acoustic microscope (SAM) to investigate the discrepancy between OCT and HFU estimates of ET.Twelve unfixed pig corneas were snap-frozen and 6-μm sections were scanned using a custom-built SAM with an F-1.08, 500-MHz transducer and a 264-MHz bandwidth

2018 Translational vision science & technology

87. New intraocular pressure measurement method using reflected pneumatic pressure from cornea deformed by air puff of ring-type nozzle. (Full text)

New intraocular pressure measurement method using reflected pneumatic pressure from cornea deformed by air puff of ring-type nozzle. In this study, a non-contact type intraocular pressure (IOP) measuring system using reflected pneumatic pressure is proposed to overcome the disadvantages of existing measurement systems. A ring-type nozzle, a key component in the proposed system, is designed via computational fluid analysis. It predicts the reflected pneumatic pressure based on the nozzle exit (...) the measurement distance is short and eye pressure is low. The cornea of an artificial eye is significantly deformed at a low IOP, and the applied pneumatic pressure is more concentrated in front of the ring-type nozzle because of the deformed cornea. Thus, the reflected pneumatic pressure at a low IOP has more inflows into the pressure sensor inserted inside the nozzle. The sensitivity of the output based on the IOP at measurement distances between 3-5 mm is -0.0027, -0.0022, -0.0018, -0.0015, and -0.0012

2017 PLoS ONE

88. Corneal Tear Film Imaging of the Cornea Before and After Restasis Therapy

Corneal Tear Film Imaging of the Cornea Before and After Restasis Therapy Corneal Tear Film Imaging of the Cornea Before and After Restasis Therapy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Corneal (...) Tear Film Imaging of the Cornea Before and After Restasis Therapy The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03403023 Recruitment Status : Not yet recruiting First Posted : January 18, 2018 Last Update Posted

2018 Clinical Trials

89. OCT in Diagnosis of Irregular Corneas

OCT in Diagnosis of Irregular Corneas OCT in Diagnosis of Irregular Corneas - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. OCT in Diagnosis of Irregular Corneas The safety and scientific validity (...) , Oregon Health and Science University Study Details Study Description Go to Brief Summary: This main goal of this study is to improve the detection, classification, monitoring, and treatment of irregular corneas due to keratoconus, warpage, dry eye, scar, stromal dystrophies, and other corneal conditions. The primary goal will be achieved by using optical coherence tomography (OCT) to: Develop an OCT-based system to classify and evaluate corneal-shape irregularities. Develop OCT metrics for more

2018 Clinical Trials

90. Application of Real-time PCR Platform for Detection of Vittaforma Corneae Among Patients With Microsporidia Keratitis

Application of Real-time PCR Platform for Detection of Vittaforma Corneae Among Patients With Microsporidia Keratitis Application of Real-time PCR Platform for Detection of Vittaforma Corneae Among Patients With Microsporidia Keratitis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number (...) of saved studies (100). Please remove one or more studies before adding more. Application of Real-time PCR Platform for Detection of Vittaforma Corneae Among Patients With Microsporidia Keratitis (MK) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details

2018 Clinical Trials

91. Statistical analysis of physiological aberrations of the cornea. (PubMed)

Statistical analysis of physiological aberrations of the cornea. To determine corneal aberrometric values in a normal population.Corneal topography from a group of 4340 patients was retrospectively evaluated. Exclusion criteria were applied in order to select a population with good visual acuity, no previous ocular surgery, no contact lens influence, and no corneal disease. Aberrometric analysis of the corneal wavefront derived from the topographical data of the selected population

2017 Journal of Refractive Surgery

92. Theoretical elastic response of the cornea to refractive surgery: risk factors for keratectasia. (PubMed)

Theoretical elastic response of the cornea to refractive surgery: risk factors for keratectasia. To explore the role that mechanical elastic factors may have in post-refractive surgery corneal phenomena, from mild curvature changes to keratectasia.The central cornea near the apex was modeled as an elastic spherical thin shell loaded by the intraocular pressure (IOP). Equations for myopic laser in situ keratomileusis (LASIK) were obtained to estimate shifts and curvature changes of the posterior (...) experimental findings. These changes rise non-linearly with the attempted correction, and are greater for thinner preoperative corneas, higher IOP smaller Young's modulus, and thicker flaps. Corneas with Young's modulus half the average or less, or thickness <500 microm, may present high risk of ectasia, especially for high IOP and thick flaps.Some postoperative effects may be explained in part by elasticity. Research efforts are needed to explain other biomechanical behaviors. The accepted criterion

2017 Journal of Refractive Surgery

93. Ultrastructural features of posterior crocodile shagreen of the cornea. (PubMed)

Ultrastructural features of posterior crocodile shagreen of the cornea. Three elderly patients with a clinical diagnosis of posterior crocodile shagreen of the cornea underwent penetrating keratoplasty. Each of the patients had the characteristic symmetrical, polygonal opacities with indistinct edges and intervening clear spaces in the central posterior corneal stroma. Electron microscopic examination of the keratoplasty specimens disclosed the presence of vacuoles throughout the corneal stroma (...) , many of which contained electron-dense material. The vacuoles were observed with increasing density posteriorly and were most concentrated adjacent to the anterior banded portion of Descemet's membrane. A sawtooth-like configuration of the stromal collagenous lamellae was noted in the posterior cornea in one case. We reviewed the three cases of central corneal clouding reported with histopathological findings as well as the clinical descriptions of this entity. Although a sawtooth-like lamellar

2017 Survey of Ophthalmology

94. Fitting Tips and Visual Rehabilitation of Irregular Cornea with a New Design of Corneoscleral Contact Lens: Objective and Subjective Evaluation (Full text)

Fitting Tips and Visual Rehabilitation of Irregular Cornea with a New Design of Corneoscleral Contact Lens: Objective and Subjective Evaluation To study the fitting and the visual rehabilitation obtained with a corneoscleral contact lens, namely, Rose K2 XL in patients with irregular cornea.This prospective study included 36 eyes of 36 patients with irregular cornea fitted with Rose K2 XL. Refractive and visual outcomes and mesopic and aberrometric parameters of fitted eyes were assessed at 2 (...) of the lens by most of them. At the end of follow-up, the mean wearing time was 9.9 ± 2.9 hours per day. The most common cause of wearing discontinuation was persistent discomfort (16.7%) and high lens expenses(16.7%). Self-assessed questionnaire showed statistically significant improvement in nearly all measured subjective parameters.Rose K2 XL lenses provide patients with irregular cornea with both quantitative and qualitative optimal visual function with high degree of patient comfort and satisfaction.

2018 Journal of ophthalmology

95. Anatomy of cornea and ocular surface (Full text)

Anatomy of cornea and ocular surface Important functions of cornea in the eye include protecting the structures inside the eye, contributing to the refractive power of the eye, and focusing light rays on the retina with minimum scatter and optical degradation. Considerable advances have taken place in understanding the organization of collagen in the corneal stroma and its clinical significance. In this review, the structure and function of various components of cornea and ocular surface

2018 Indian journal of ophthalmology

96. Cornea and anterior eye assessment with slit lamp biomicroscopy, specular microscopy, confocal microscopy, and ultrasound biomicroscopy (Full text)

Cornea and anterior eye assessment with slit lamp biomicroscopy, specular microscopy, confocal microscopy, and ultrasound biomicroscopy Current corneal assessment technologies make the process of corneal evaluation extremely fast and simple, and several devices and technologies show signs that help in identification of different diseases thereby, helping in diagnosis, management, and follow-up of patients. The purpose of this review is to present and update readers on the evaluation of cornea

2018 Indian journal of ophthalmology

97. Clinical signs in cornea and ocular surface (Full text)

Clinical signs in cornea and ocular surface A careful examination of cornea and ocular surface eliciting the basic signs will help a clinician toward an accurate diagnosis. Flipping the upper lid or pulling the lower lid to look at the inferior fornix may help to pick up any subtle clinical sign. Meticulous documentation by diffuse and slit view will help in following up the disease. Eyelids and ocular surface are evaluated externally and by slit lamp. Slit-lamp examination with the use (...) of the stains such as fluorescein, rose bengal, or lissamine green provides extensive knowledge about the ocular surface. Tests of tear production are also detailed herein. This review is intended to help the eye practitioners in eliciting common clinical signs seen in cornea and ocular surface diseases.

2018 Indian journal of ophthalmology

98. Endothelial parameters in central and peripheral cornea in patients wearing contact lenses (Full text)

Endothelial parameters in central and peripheral cornea in patients wearing contact lenses To measure the parameters of endothelium in the central and peripheral parts of the cornea and evaluate the influence of wearing the hard and soft contact lenses on the mentioned parameters.A specular microscope was used to measure the corneal endothelium parameters in both eyes of 139 Caucasians (a total of 278). All participants were divided into three groups: soft lens wearers, hard lens wearers

2018 International journal of ophthalmology

99. The use of WaveLight Contoura to create a uniform cornea: 6-month results with subjective patient surveys (Full text)

The use of WaveLight Contoura to create a uniform cornea: 6-month results with subjective patient surveys The aim of this study was to report on the 6-month visual results of Contoura with Layer Yolked Reduction of Astigmatism (LYRA) protocol, as well as the subjective patient-reported outcomes (PRO) by standardized survey.A retrospective analysis was conducted in 50 consecutive eyes with 6-month results that had bilateral Contoura laser-assisted in situ keratomileusis (LASIK) correction (...) error changes due to epithelial masking of higher order aberrations (HOAs) over the follow-up period, a number that was also likely artificially high due to study bias.Contoura measured axis and astigmatism-eliminated HOA, resulting in a more uniform cornea with an accurate removal of astigmatism, excellent 20/15 and 20/20 visual outcomes, and favorable patient-reported subjective outcomes.

2018 Clinical ophthalmology (Auckland, N.Z.)

100. An Investigation of the Effects of Riboflavin Concentration on the Efficacy of Corneal Cross-Linking Using an Enzymatic Resistance Model in Porcine Corneas. (Full text)

An Investigation of the Effects of Riboflavin Concentration on the Efficacy of Corneal Cross-Linking Using an Enzymatic Resistance Model in Porcine Corneas. To investigate riboflavin concentration on enzymatic resistance following corneal cross-linking (CXL).Ninety-six porcine eyes were divided into five groups in two treatment runs. Group 1 remained untreated. Group 2 received riboflavin 0.05%, group 3 riboflavin 0.1%, group 4 riboflavin 0.2%, and group 5 riboflavin 0.3%. Treated eyes (...) underwent CXL with ultraviolet A at 9 mW/cm2 for 10 minutes. Eight-millimeter discs from each cornea were submerged in pepsin digest solution. In the first run, disc diameters were measured daily. After 10 days, dry weights were recorded from five samples in each group. In the second run, dry weights were recorded in five samples in each group at 10 and 20 days.CXL-treated corneas took longer to digest than untreated (P < 0.001). Although eyes treated with higher riboflavin concentrations generally took

2018 Investigative Ophthalmology & Visual Science

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