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61. Identification of a Primary Stroma and Novel Endothelial Cell Projections in the Developing Human Cornea. Full Text available with Trip Pro

Identification of a Primary Stroma and Novel Endothelial Cell Projections in the Developing Human Cornea. To investigate the initial events in the development of the human cornea, focusing on cell migration, and extracellular matrix synthesis and organization. To determine whether elastic fibers are present in the extracellular matrix during early human corneal development.Human corneas were collected from week 7 to week 17 of development. An elastic fiber-enhancing stain, tannic acid-uranyl (...) acetate, was applied to all tissue. Three-dimensional serial block-face scanning electron microscopy combined with conventional transmission electron microscopy was used to analyze the corneal stroma.An acellular collagenous primary stroma with an orthogonal arrangement of fibrils was identified in the central cornea from week 7 of corneal development. At week 7.5, mesenchymal cells migrated toward the central cornea and associated with the acellular collagenous matrix. Novel cell extensions from

2020 Investigative Ophthalmology & Visual Science

62. Corneal Sensitivity and Tear Function in Recurrent Corneal Erosion Syndrome. Full Text available with Trip Pro

Corneal Sensitivity and Tear Function in Recurrent Corneal Erosion Syndrome. To determine the association of corneal sensitivity and tear functions on the prognosis of eyes after posttraumatic recurrent corneal erosion syndrome (RCES).Patients were enrolled retrospectively and had unilateral RCES and a history of ocular surface trauma. A corneal sensitivity test and tear function test (tear break-up time and Schirmer test) were performed at three time points (month 1 to month 3, month 3 (...) to month 6, and month 6 to month 12). Depending on the number of recurrences during the follow-up, patients were divided into group A (n > 2) or group B (n = 2). A comparison between diseased and normal fellow eyes in each patient was performed.A total of 31 patients were enrolled and divided into group A (n = 14) and group B (n = 17). The mean age was 40.3 ± 12.2 years, whereas the mean follow-up was 28.0 ± 3.6 months. During the study period, corneal sensitivity, tear break-up time, and the Schirmer

2020 Investigative Ophthalmology & Visual Science

63. Microvesicle delivery of a lysosomal transport protein to ex vivo rabbit cornea Full Text available with Trip Pro

Microvesicle delivery of a lysosomal transport protein to ex vivo rabbit cornea Therapeutic use of transmembrane proteins is limited because of irreversible denaturation when away from their native lipid membrane. Mutations in lysosomal membrane transport proteins cause many lethal disorders including cystinosis which results from mutations in CTNS, which codes for the lysosomal cystine transport protein, cystinosin. Cystinosin-deficient fibroblasts, including keratocytes (corneal fibroblasts (...) ) accumulate lysosomal cystine. Cystinosis patients develop highly painful corneal cystine crystals, resulting in severe visually debilitating photophobia. The only available therapy is daily treatment with cysteamine eye drops. We have previously shown that microvesicles containing functional cystinosin are spontaneously produced by infecting Spodoptera frugiperda cells (Sf9) with baculovirus containing human wt CTNS. Infecting Sf9 cells for 3 days at a MOI of 1 yields 1011microvesicles /ml with a modal

2020 Molecular genetics and metabolism reports

64. Cystadrops - cysteamine - Corneal cystine crystal deposits

Cystadrops - cysteamine - Corneal cystine crystal deposits cysteamine | CADTH.ca Find the information you need cysteamine cysteamine Last Updated: July 3, 2019 Result type: Reports Project Number: SR0595-000 Product Line: Generic Name: cysteamine Brand Name: Cystadrops Manufacturer: Recordati Rare Diseases Canada Inc. Indications: Corneal cystine crystal deposits Manufacturer Requested Reimbursement Criteria 1 : For the treatment of corneal cystine crystal deposits in adults and children from 2

2018 Canadian Agency for Drugs and Technologies in Health - Common Drug Review

65. Corneal (Foreign Body)

body can be irrigated away with normal saline Foreign body on conjunctiva can be removed with a sterile cotton bud Assess depth of corneal foreign body (slit lamp optical section) Carry out Seidel test to check for corneal perforation Corneal foreign body may require removal with a hypodermic needle or other disposable instrument. To reduce the risk of corneal penetration, ensure that the needle approaches the cornea tangentially After removal, assess size of remaining epithelial defect so (...) Corneal (Foreign Body) Corneal (or other superficial ocular) foreign body submit The College submit You're here: Corneal (or other superficial ocular) foreign body Corneal (or other superficial ocular) foreign body The CMGs are guidelines on the diagnosis and management of a range of common and rare, but important, eye conditions that present with varying frequency in primary and first contact care. Share options Aetiology Patient often gives history of foreign body entering eye wind blown high

2020 College of Optometrists

66. Corneal hydrops

to keratoconus with intracameral injection of sulfur hexafluoride (SF6). Cornea 2007;26:1067- 9 Rowson NJ, Dart JK, Buckley RJ. Corneal neovascularisation in acute hydrops. Eye 1992;6:404-6 Sharma N, Maharana PK, Jhanji V, Vajpayee RB. Management of acute corneal hydrops in ectatic corneal disorders. Curr Opin Ophthalmol. 2012;23(4):317-23 Lay summary This is a rare occurrence seen occasionally in people in whom the cornea (the clear window of the eye) is thinned and distorted, for example in the condition (...) Corneal hydrops Corneal hydrops submit The College submit You're here: Corneal hydrops Corneal hydrops The CMGs are guidelines on the diagnosis and management of a range of common and rare, but important, eye conditions that present with varying frequency in primary and first contact care. Share options Aetiology Rupture of Descemet’s membraneAcute leakage of aqueous into corneal stroma and epithelium Predisposing factors Keratoconus, keratoglobus, pellucid marginal degeneration or other

2020 College of Optometrists

67. Corneal abrasion

by failure of the normal blink reflex, or when its sensitivity to touch is reduced by damage to its nerves, as in diabetes or following shingles of the eye. Corneal abrasion can be very painful as the cornea is one of the most sensitive areas of the body. The clinician will assess the area involved and prescribe treatment accordingly. The damage to the surface can be seen more easily if fluorescein, an orange dye, is instilled into the eye. Anti-inflammatory or antibiotic eye drops are often recommended (...) Corneal abrasion Corneal abrasion submit The College submit You're here: Corneal abrasion Corneal abrasion The CMGs are guidelines on the diagnosis and management of a range of common and rare, but important, eye conditions that present with varying frequency in primary and first contact care. Share options Aetiology Loss of corneal epithelial tissue due to: sub-tarsal foreign body trauma (e.g. fingernail, twig, edge of paper, mascara brush) contact lens related trauma trichiasis (e.g. lash

2020 College of Optometrists

68. Fuchs Corneal dystrophy

be asymmetrical) Central cornea affected (may extend to periphery in time) excrescences on posterior surface (guttata) produce ‘beaten metal’ appearance and interrupt specular image of endothelium thickened Descemet’s membrane fine pigment dusting on endothelium cystic epithelial oedema, ground glass appearance (bullous keratopathy) stromal oedema and thickening (endothelial decompensation) posterior stromal scarring Loss of contrast sensitivity Reduced corneal sensitivity The stages of Fuchs Dystrophy have (...) been graded by a number of authorities, but none have gained universal acceptance Differential diagnosis Pseudophakic or aphakic bullous keratopathy Posterior polymorphous dystrophy Cornea guttata (often listed as a dystrophy, but not necessarily progressive) Corneal hydrops (in keratoconus) Contact lens overwear Management by optometrist Practitioners should recognise their limitations and where necessary seek further advice or refer the patient elsewhere Non pharmacological Photography

2020 College of Optometrists

69. Intrastromal corneal implants for ectatic corneal disorders. Decision Support Document 85.

Intrastromal corneal implants for ectatic corneal disorders. Decision Support Document 85. Intrastromal corneal implants for ectatic corneal disorders - Repository of AIHTA GmbH English | Browse - - - Intrastromal corneal implants for ectatic corneal disorders Fischer, S. and Zechmeister-Koss, I. (2015): Intrastromal corneal implants for ectatic corneal disorders. Decision Support Document 85. Preview - Sie müssen einen PDF-Viewer auf Ihrem PC installiert haben wie z. B. , oder 541kB Abstract (...) Keratoconus and corneal ectasia after LASIK are rare diseases. In contrast to corneal transplantation that is the most frequently used treatment for ectatic corneal disorders in later stages, corneal implantation is a less invasive and reversible intervention. Therefore, we assessed the effectiveness and safety of these corneal implants. Since we exclusively found uncontrolled trials, the level of evidence was very low to low. However, the studies predict an improvement in visual acuity with moderate re

2015 Austrian Institute of Health Technology Assessment

70. Corneal endothelial keratoplasty for the treatment of corneal endothelial dysfunction

consider endothelial keratoplasty only in the presence of pure corneal endothelial dysfunction, and at centers with adequate technological training. The coverage policies found consider endothelial keratoplasty for the treatment of endothelial dysfunction when there is no other condition at corneal level. Final publication URL www.iecs.org.ar Indexing Status Subject indexing assigned by CRD MeSH Cornea; Corneal Transplantation; Humans; Vascular Diseases Language Published Spanish Country (...) Corneal endothelial keratoplasty for the treatment of corneal endothelial dysfunction Corneal endothelial keratoplasty for the treatment of corneal endothelial dysfunction Corneal endothelial keratoplasty for the treatment of corneal endothelial dysfunction Brito V, Ciapponi A, Pichon-Riviere A, Augustovski F, García Martí S, Alcaraz A, Bardach A, López A, Rey-Ares L Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation

2015 Health Technology Assessment (HTA) Database.

71. Biomechanical changes in the cornea following cataract surgery: A prospective assessment with the Corneal Visualisation Scheimpflug Technology. (Abstract)

Biomechanical changes in the cornea following cataract surgery: A prospective assessment with the Corneal Visualisation Scheimpflug Technology. Intraocular pressure (IOP) is often reduced following cataract surgery. Postoperative changes in corneal stiffness are likely to be at least partly responsible for any reduction in IOP measured with applanation tonometry.To determine the effect of cataract surgery and corneal incision size on corneal biomechanics.Prospective randomized trial.One hundred (...) prospectively enrolled patients qualifying for cataract surgery.Participants were randomized to clear corneal incisions with a 2.20 or 2.85 mm keratome. Corneal Visualisation Scheimpflug Technology (Corvis-ST) tonometry and dynamic corneal response measurements were obtained preoperatively, and 3 mo postoperatively. Multiple regression analysis was completed using R software.Corvis-ST biomechanical parameters.Ninety-three eyes of 93 patients were included in the final analysis. Mean Corvis-ST

2018 Clinical & experimental ophthalmology Controlled trial quality: uncertain

72. Long-term Clinical Outcomes of Phototherapeutic Keratectomy in Corneas With Granular Corneal Dystrophy Type 2 Exacerbated After LASIK. Full Text available with Trip Pro

Long-term Clinical Outcomes of Phototherapeutic Keratectomy in Corneas With Granular Corneal Dystrophy Type 2 Exacerbated After LASIK. To investigate the long-term clinical outcomes and recurrence patterns of phototherapeutic keratectomy (PTK) in patients with granular corneal dystrophy type 2 (GCD2) exacerbated after LASIK.Fifty-one patients (76 eyes) with GCD2 exacerbated after LASIK who underwent PTK between January 2007 and February 2017 were included. Participants underwent ophthalmic (...) of and significant recurrence.PTK improved corneal transparency and visual acuity in patients with GCD2 exacerbated after LASIK, although GCD2 eventually recurred. PTK with flap removal was superior to PTK with flap conservation in terms of visual acuity, recurrence, and complications. [J Refract Surg. 2018;34(2):132-139.].Copyright 2018, SLACK Incorporated.

2018 Journal of Refractive Surgery

73. An Investigation of the Effects of Riboflavin Concentration on the Efficacy of Corneal Cross-Linking Using an Enzymatic Resistance Model in Porcine Corneas. Full Text available with Trip Pro

An Investigation of the Effects of Riboflavin Concentration on the Efficacy of Corneal Cross-Linking Using an Enzymatic Resistance Model in Porcine Corneas. To investigate riboflavin concentration on enzymatic resistance following corneal cross-linking (CXL).Ninety-six porcine eyes were divided into five groups in two treatment runs. Group 1 remained untreated. Group 2 received riboflavin 0.05%, group 3 riboflavin 0.1%, group 4 riboflavin 0.2%, and group 5 riboflavin 0.3%. Treated eyes (...) underwent CXL with ultraviolet A at 9 mW/cm2 for 10 minutes. Eight-millimeter discs from each cornea were submerged in pepsin digest solution. In the first run, disc diameters were measured daily. After 10 days, dry weights were recorded from five samples in each group. In the second run, dry weights were recorded in five samples in each group at 10 and 20 days.CXL-treated corneas took longer to digest than untreated (P < 0.001). Although eyes treated with higher riboflavin concentrations generally took

2018 Investigative Ophthalmology & Visual Science

74. High-intensity corneal collagen crosslinking with riboflavin and UVA in rat cornea. Full Text available with Trip Pro

High-intensity corneal collagen crosslinking with riboflavin and UVA in rat cornea. Corneal collagen cross-linking (CXL) halts human corneal ectasias progression by increasing stromal mechanical stiffness. Although some reports describe that this procedure is effective in dealing with some infectious and immunologic corneal thinning diseases, there is a need for more animal models whose corneal thickness more closely resemble those occurring in these patients. To meet this need, we describe (...) here high-intensity protocols that are safe and effective for obtaining CXL in rat corneas. Initially, a range of potentially effective UVA doses were evaluated based on their effectiveness in increasing tissue enzymatic resistance to dissolution. At UVA doses higher than a threshold level of 0.54 J/cm2, resistance to enzymatic digestion increased relative to that in non-irradiated corneas. Based on the theoretical threshold CXL dose, a CXL regimen was established in which the UVA tissue irradiance

2017 PLoS ONE

75. Trends in corneal transplantation from 2001 to 2016 in Germany: A report of the DOG-Section Cornea and its Keratoplasty Registry. Full Text available with Trip Pro

Trends in corneal transplantation from 2001 to 2016 in Germany: A report of the DOG-Section Cornea and its Keratoplasty Registry. The purpose of this retrospective panel study was to provide an overview of absolute numbers and of trends in the types of and indications for corneal transplantation in Germany from 2001 to 2016.A questionnaire about absolute numbers, types of transplantation, and indications was sent to 111 ophthalmologic departments in Germany, out of which 94 (85%) provided (...) their data.Since the year 2001, the number of corneal transplantations has increased by 1.5-fold, from 4730 penetrating keratoplasties (PKPs) in 2001 to 7325 penetrating and lamellar keratoplasties in 2016. The shift from penetrating to lamellar procedures began in 2006. In 2014, lamellar procedures (231 [4%] anterior and 2883 [49%] posterior lamellar keratoplasties) surpassed PKPs (2721, 47%) for the first time. Main indications for keratoplasty in Germany (2016) are Fuchs endothelial corneal dystrophy (46

2018 American Journal of Ophthalmology

76. Changes in shape and astigmatism of total, anterior, and posterior cornea after long versus short clear corneal incision cataract surgery. (Abstract)

Changes in shape and astigmatism of total, anterior, and posterior cornea after long versus short clear corneal incision cataract surgery. To compare changes in the shape and astigmatism of the total, anterior, and posterior cornea between eyes with long-length clear corneal incisions (CCIs) and eyes with short-length CCIs in cataract surgery.Hayashi Eye Hospital, Fukuoka, Japan.Prospective case series.Both eyes of patients having phacoemulsification with temporal CCIs were randomized to have (...) a long-length (≥1.75 mm) or short-length (<1.75 mm) CCI. Corneal astigmatic changes were decomposed to vertical/horizontal (Jackson cross-cylinder, axes at 180 degrees and 90 degrees [J0]) and oblique changes (Jackson cross-cylinder, axes at 45 degrees and 135 degrees [J45]) using power vector analysis. Corneal shape changes were assessed using the average of the difference map on videokeratography 2 days and 2, 4, and 8 weeks postoperatively.The mean J0 and J45 values of the total cornea in the 120

2018 Journal of cataract and refractive surgery Controlled trial quality: uncertain

77. Modeling Diabetic Corneal Neuropathy in a 3D In Vitro Cornea System Full Text available with Trip Pro

Modeling Diabetic Corneal Neuropathy in a 3D In Vitro Cornea System Diabetes mellitus is a disease caused by innate or acquired insulin deficiency, resulting in altered glucose metabolism and high blood glucose levels. Chronic hyperglycemia is linked to development of several ocular pathologies affecting the anterior segment, including diabetic corneal neuropathy and keratopathy, neovascular glaucoma, edema, and cataracts leading to significant visual defects. Due to increasing disease (...) prevalence, related medical care costs, and visual impairment resulting from diabetes, a need has arisen to devise alternative systems to study molecular mechanisms involved in disease onset and progression. In our current study, we applied a novel 3D in vitro model of the human cornea comprising of epithelial, stromal, and neuronal components cultured in silk scaffolds to study the pathological effects of hyperglycemia on development of diabetic corneal neuropathy. Specifically, exposure to sustained

2018 Scientific reports

78. Corneal Tissue Engineering: An In Vitro Model of the Stromal-nerve Interactions of the Human Cornea Full Text available with Trip Pro

Corneal Tissue Engineering: An In Vitro Model of the Stromal-nerve Interactions of the Human Cornea Tissue engineering has gained substantial recognition due to the high demand for human cornea replacements with an estimated 10 million people worldwide suffering from corneal vision loss1. To address the demand for viable human corneas, significant progress in three-dimensional (3D) tissue engineering has been made2,3,4. These cornea models range from simple monolayer systems to multilayered (...) models, leading to 3D full-thickness corneal equivalents2. However, the use of a 3D tissue-engineered cornea in the context of in vitro disease models studied to date lacks resemblance to the multilayered 3D corneal tissue structure, function, and the networking of different cell types (i.e., nerve, epithelium, stroma, and endothelium)2,3. In addition, the demand for in vitro cornea tissue models has increased in an attempt to reduce animal testing for pharmaceutical products. Thus, more

2018 Journal of visualized experiments : JoVE

79. Early Changes in Visual Quality and Corneal Structure after DMEK: Does DMEK Approach Optical Quality of a Healthy Cornea? Full Text available with Trip Pro

Early Changes in Visual Quality and Corneal Structure after DMEK: Does DMEK Approach Optical Quality of a Healthy Cornea? To evaluate early changes in visual function and visual quality parameters after Descemet membrane endothelial keratoplasty (DMEK) and to compare the outcomes with healthy controls.Thirteen patients who underwent DMEK and 14 controls were evaluated. All subjects underwent visual function evaluation, including visual acuity under photopic and mesopic lighting conditions (...) and contrast sensitivity (CSV) tests CSV 1000 and Pelli-Robson. Corneal parameters were assessed with Oculus Pentacam. Corneal mean keratometry (Km), corneal densitometry values, and low and high order aberrations (LOA and HOA) were recorded. In DMEK patients, all tests were performed before surgery and 1 and 6 months after surgery.In patients who underwent DMEK, photopic visual acuity improved from 0.59 to 0.31 at 1 month (p=0.013) and 0.13 at 6 months (p=0.008); mesopic visual acuity and all contrast

2018 Journal of ophthalmology

80. Cellular therapy of the corneal stroma: a new type of corneal surgery for keratoconus and corneal dystrophies Full Text available with Trip Pro

Cellular therapy of the corneal stroma: a new type of corneal surgery for keratoconus and corneal dystrophies Cellular therapy of the corneal stroma, with either ocular or extraocular stem cells, has been gaining a lot of interest over the last decade. Multiple publications from different research groups are showing its potential benefits in relation to its capacity to improve or alleviate corneal scars, improve corneal transparency in metabolic diseases by enhancing the catabolism (...) to ethical implications, the discovery of the induced pluripotent stem cells (iPSC) has opened a new and very promising field for future research as they are pluripotent cells with the capacity to theoretically differentiate into any cell type, with the special advantage that they are obtained from adult differentiated cells. Cellular delivery into the corneal stroma has been experimentally assayed in vivo in multiple ways: systemic versus local injections with or without a carrier. Encouraging

2018 Eye and Vision

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