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Cornea

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61. IL-1R and MyD88 Contribute to the Absence of a Bacterial Microbiome on the Healthy Murine Cornea (Full text)

IL-1R and MyD88 Contribute to the Absence of a Bacterial Microbiome on the Healthy Murine Cornea Microbial communities are important for the health of mucosal tissues. Traditional culture and gene sequencing have demonstrated bacterial populations on the conjunctiva. However, it remains unclear if the cornea, a transparent tissue critical for vision, also hosts a microbiome. Corneas of wild-type, IL-1R (-/-) and MyD88 (-/-) C57BL/6 mice were imaged after labeling with alkyne-functionalized D (...) -alanine (alkDala), a probe that only incorporates into the peptidoglycan of metabolically active bacteria. Fluorescence in situ hybridization (FISH) was also used to detect viable bacteria. AlkDala labeling was rarely observed on healthy corneas. In contrast, adjacent conjunctivae harbored filamentous alkDala-positive forms, that also labeled with DMN-Tre, a Corynebacterineae-specific probe. FISH confirmed the absence of viable bacteria on healthy corneas, which also cleared deliberately inoculated

2018 Frontiers in microbiology

62. Production of interleukin-1β related to mammalian target of rapamycin/Toll-like receptor 4 signaling pathway during Aspergillus fumigatus infection of the mouse cornea (Full text)

Production of interleukin-1β related to mammalian target of rapamycin/Toll-like receptor 4 signaling pathway during Aspergillus fumigatus infection of the mouse cornea To elucidate the effect of rapamycin on regulating the production of interleukin (IL)-1β in Aspergillus fumigatus (A. fumigatus)-induced keratitis and to verify whether the expression of IL-1β in A. fumigatus keratitis is associated with the mammalian target of rapamycin (mTOR)/Toll-like receptor 4 (TLR4) signaling

2018 International journal of ophthalmology

63. Early Changes in Visual Quality and Corneal Structure after DMEK: Does DMEK Approach Optical Quality of a Healthy Cornea? (Full text)

Early Changes in Visual Quality and Corneal Structure after DMEK: Does DMEK Approach Optical Quality of a Healthy Cornea? To evaluate early changes in visual function and visual quality parameters after Descemet membrane endothelial keratoplasty (DMEK) and to compare the outcomes with healthy controls.Thirteen patients who underwent DMEK and 14 controls were evaluated. All subjects underwent visual function evaluation, including visual acuity under photopic and mesopic lighting conditions

2018 Journal of ophthalmology

64. Cornea Thermography: Optimal Evaluation of the Outcome and the Resulting Reproducibility (Full text)

Cornea Thermography: Optimal Evaluation of the Outcome and the Resulting Reproducibility The aim of the study was to establish a standardized quantitative evaluation of corneal temperature (CT) that includes anchoring reference points in the topography and minimization of artifacts. We further investigated the distribution and the short- and long-term reproducibility of the CT values, as well as the influence of the core temperatures.The CT values in both eyes of 40 healthy subjects were

2018 Translational vision science & technology

65. Soft transparent graphene contact lens electrodes for conformal full-cornea recording of electroretinogram (Full text)

Soft transparent graphene contact lens electrodes for conformal full-cornea recording of electroretinogram Visual electrophysiology measurements are important for ophthalmic diagnostic testing. Electrodes with combined optical transparency and softness are highly desirable, and sometimes indispensable for many ocular electrophysiology measurements. Here we report the fabrication of soft graphene contact lens electrodes (GRACEs) with broad-spectrum optical transparency, and their application (...) in conformal, full-cornea recording of electroretinography (ERG) from cynomolgus monkeys. The GRACEs give higher signal amplitude than conventional ERG electrodes in recordings of various full-field ERG responses. High-quality topographic mapping of multifocal ERG under simultaneous fundus monitoring is realized. A conformal and tight interface between the GRACEs and cornea is revealed. Neither corneal irritation nor abnormal behavior of the animals is observed after ERG measurements with GRACEs

2018 Nature communications

66. Biomechanical Properties of the Cornea Using a Dynamic Scheimpflug Analyzer in Healthy Eyes (Full text)

Biomechanical Properties of the Cornea Using a Dynamic Scheimpflug Analyzer in Healthy Eyes To investigate biomechanical properties of the cornea using a dynamic Scheimpflug analyzer according to age.In this prospective, cross-sectional, observational study, participants underwent ophthalmic investigations including corneal biomechanical properties, keratometric values, intraocular pressure (IOP), and manifest refraction spherical equivalent (MRSE). We determined the relationship

2018 Yonsei medical journal

67. Wasp sting of the cornea (Full text)

Wasp sting of the cornea Many treatments, such as conservative management or penetrating keratoplasty, exist for corneal wasp sting. Here, we report a case of paper wasp sting of the cornea treated by anterior chamber wash immediately following admission, which soon resolved the inflammation.A healthy 9-year-old boy who had been stung by a paper wasp on his left eye 2 days prior to presentation at Dokkyo Medical University Saitama Medical Center was found to have corneal opacity accompanied (...) by ciliary injection. The boy had difficulty opening his left eye due to pain. His left corneal endothelial cell density was 2,789 cells/mm2, which was relatively lesser than that in the right eye. We diagnosed a paper wasp sting of the cornea based on both the patient's clinical findings and sting history. The anterior chamber was promptly irrigated using a balanced salt solution; the inflammation resolved in a few hours, and the patient could open his left eye easily the following day. One day after

2018 International medical case reports journal

68. Long-term safety of laser in situ keratomileusis in eyes with thin corneas: 5-year follow-up (Full text)

Long-term safety of laser in situ keratomileusis in eyes with thin corneas: 5-year follow-up To investigate the long term (≥5y) efficacy, predictability, and safety of laser in situ keratomileusis (LASIK) in eyes with thin corneas [central corneal thickness (CCT) <500 µm].A total of 339 patients met the criteria of this study. Finally, 175 eyes of 89 patients who had thin corneas and underwent LASIK≥5y ago returned to our clinic and included in this study. Preoperative parameters recorded

2018 International journal of ophthalmology

69. Early expression of PTX3 in Aspergillus fumigatus infected rat cornea (Full text)

Early expression of PTX3 in Aspergillus fumigatus infected rat cornea To investigate the expression of pentraxin 3 (PTX3) in rat corneal epithelium at the early stage of Aspergillus fumigatus (A. fumigatus) infection.A total of 50 Wistar rats were randomly divided into control group, Sham group and experimental group (fungal keratitis group, FK group). The right eye was chosen as the experiment one and infected by A. fumigatus. Rats were executed at 8, 16 and 24h after the experimental models (...) being established. Corneal epithelia were collected to assess the expression of PTX3 by quantitative reverse transcription polymerase chain reaction (qRT-PCR) and Western blot analysis.Corneal inflammation scores increased as infection prolonged (P<0.05, P<0.001). PTX3 mRNA expression was low in normal and Sham group rats' corneas. Level of PTX3 mRNA in infected rat cornea was elevated at 8h and peaked at 16h. The difference was significant compared with control group (P<0.001). Western blot

2018 International journal of ophthalmology

70. Evaluation of artificial tears on cornea epithelium healing (Full text)

Evaluation of artificial tears on cornea epithelium healing To observe the efficacy of different artificial eye drops on corneal epithelium healing in rabbit.Thirty-five rabbits with 6 mm diameter central corneal epithelium removed were randomly assigned to six groups: 0.9% normal saline (NS) group, 0.1% hyaluronate (HA) group, 0.3% HA group, Tears Naturale Free® (TNF) group, 0.4% polyethylene glycol (PEG) group, 0.5% carboxymethyl cellulose (CMC) group and blank control group. Treatments were (...) administered topically four times daily. Corneal epithelium healing was evaluated by the percentage reduction in wound area at 24, 36, 48, 60, and 72h after removal of the corneal epithelium. Cornea re-epithelialization was also assessed by histological analysis and electron microscopy.All corneal wounds completely re-epithelialized in less than 72h. The average re-epithelialization time was 47.61±4.25h in the 0.3% HA group and 49.72±1.05h in the 0.9% NS group, followed by 0.1% HA, TNF, 0.4% PEG, 0.5% CMC

2018 International journal of ophthalmology Controlled trial quality: uncertain

71. Advances in Cornea (Full text)

Advances in Cornea 30123377 2019 01 24 1874-3641 12 2018 The open ophthalmology journal Open Ophthalmol J Advances in Cornea. 130-133 10.2174/1874364101812010130 Vanathi M M Cornea & Ocular Surface, Cataract & Refractive Services, R. P. Centre for Ophthalmic Sciences, All India Institute Of Medical Sciences, New Delhi 110029, India; ; E-mail: mvanathi.rpc@gmail.com. eng Editorial 2018 07 23 United Arab Emirates Open Ophthalmol J 101480505 1874-3641 2018 8 21 6 0 2018 8 21 6 0 2018 8 21 6 1 (...) epublish 30123377 10.2174/1874364101812010130 TOOPHTJ-12-130 PMC6062899 Cornea. 2011 May;30(5):580-7 21598430 Am J Ophthalmol. 2015 Mar;159(3):590-6 25526945 Clin Ophthalmol. 2014 Nov 27;8:2373-81 25473264 Graefes Arch Clin Exp Ophthalmol. 2014 Aug;252(8):1329-35 24862302 Cornea. 2015 Aug;34(8):859-65 26057329 J Refract Surg. 2014 Oct;30(10):702-7 25291754 Sci Rep. 2016 May 18;6:26113 27189516 Ophthalmology. 2015 Sep;122(9):1757-64 26088620 J Refract Surg. 2017 Mar 1;33(3):193-198 28264134 Br J

2018 The open ophthalmology journal

72. Corrigendum: Diabetic cornea wounds produce significantly weaker electric signals that may contribute to impaired healing (Full text)

Corrigendum: Diabetic cornea wounds produce significantly weaker electric signals that may contribute to impaired healing This corrects the article DOI: 10.1038/srep26525.

2018 Scientific reports

73. Novel application of In Vivo Micro-Optical Coherence Tomography to assess Cornea scarring in an Animal Model (Full text)

Novel application of In Vivo Micro-Optical Coherence Tomography to assess Cornea scarring in an Animal Model This pilot study uses a micro-optical coherence tomography (micro-OCT) system with ~1 μm axial resolution specifically to image the cornea and corneal scars in vivo. We used an established murine corneal scar model by irregular phototherapeutic keratectomy in ten C57BL/6 mice, with serial imaging using the micro-OCT and compared to anterior segment (AS-OCT) (RTvue, Optovue, Fremont, CA

2018 Scientific reports

74. Endoilluminator-assisted pediatric cataract surgery with hazy cornea (Full text)

Endoilluminator-assisted pediatric cataract surgery with hazy cornea The purpose of this study was to demonstrate the usefulness of endoilluminator in pediatric cataract with hazy corneas. We describe a series of three cases of pediatric cataract where visualization of intraocular structures was inadequate under the operating microscope. The endoilluminator was held at the limbus with light directed obliquely to visualize the details of intraocular structures against the hazy cornea using (...) oblique illumination. It allowed structures behind the hazy cornea to be seen with ease. A simple modification in surgical procedure of pediatric cataract using an endoilluminator helps in better visualization of intraocular structures in difficult situations.

2018 Indian journal of ophthalmology

75. An Experimental Study of Femto-Laser in Assisting Xenograft Acellular Cornea Matrix Lens Transplantation (Full text)

An Experimental Study of Femto-Laser in Assisting Xenograft Acellular Cornea Matrix Lens Transplantation BACKGROUND The aim of this study was to evaluate the feasibility of using a femto-laser in assisting xenograft cornea matrix lens transplantation in correcting ametropia, along with evaluating the effectiveness and predictability of this procedure. MATERIAL AND METHODS A corneal matrix pouch was prepared on the right eyes on 8 healthy New Zealand rabbits by a femto-laser that was also (...) employed to perform small incision lenticule extraction (SMILE) on 8 bovine cornea matrix lenses (+6D). A lens was treated acellular and implanted into a right rabbit cornea matrix pouch. Surface inflammation was observed at 1, 2, 4, 8, 12, and 24 weeks after surgery. Anterior ocular segment optical coherence tomography (OCT), corneal topography, retinoscopy, and cornea endothelial cell enumeration were performed. RESULTS All the surgeries were successfully performed without any complications

2018 Medical science monitor : international medical journal of experimental and clinical research

76. Role of microRNA 146a on the healing of cornea alkali burn treated with mesenchymal stem cells (Full text)

Role of microRNA 146a on the healing of cornea alkali burn treated with mesenchymal stem cells The aim of the present study was to investigate the effect of microRNA 146a (miR146a) on promoting the repair of corneal alkali burn with bone marrow mesenchymal stem cells (MSCs). A total of 24 Sprague‑Dawley female rats were divided into a normal group (Control), a normal MSC treatment group (Normal MSCs), an miR146a knockout MSC treatment group (miR146a‑low MSCs) and an miR146a high‑expression MSC (...) endothelial growth factor (VEGF), CD45, interferon (IFN)‑γ and interleukin (IL)‑10 by ELISA. The miR146a‑high MSCs improved cell viability of MSCs and inhibited apoptosis of MSCs following alkali burn. miR146a‑high MSCs decreased the expression levels of p65NF‑κB and PCNA, and enhanced the expression level of Fas. Furthermore, miR146a‑high MSCs improved the cornea opacity and enhanced the inhibition of neovascularization in the rats following alkali burn. miR146a‑high MSCs inhibit the expression of VEGF

2018 Molecular medicine reports

77. Connective tissue growth factor is not necessary for haze formation in excimer laser wounded mouse corneas. (Full text)

Connective tissue growth factor is not necessary for haze formation in excimer laser wounded mouse corneas. We sought to determine if connective tissue growth factor (CTGF) is necessary for the formation of corneal haze after corneal injury. Mice with post-natal, tamoxifen-induced, knockout of CTGF were subjected to excimer laser phototherapeutic keratectomy (PTK) and the corneas were allowed to heal. The extent of scaring was observed in non-induced mice, heterozygotes, and full homozygous (...) knockout mice and quantified by macrophotography. The eyes from these mice were collected after euthanization for re-genotyping to control for possible Cre-mosaicism. Primary corneal fibroblasts from CTGF knockout corneas were established in a gel plug assay. The plug was removed, simulating an injury, and the rate of hole closure and the capacity for these cells to form light reflecting cells in response to CTGF and platelet-derived growth factor B (PDGF-B) were tested and compared to wild-type cells

2017 PLoS ONE

78. Role of vasoactive intestinal peptide in Aspergillus fumigatus-infected cornea (Full text)

Role of vasoactive intestinal peptide in Aspergillus fumigatus-infected cornea To investigate the anti-inflammatory role of vasoactive intestinal peptide (VIP) in Aspergillus fumigatus (A. fumigatus) ketatitis.Expression of VIP was tested by polymerase chain reaction (PCR) in C57BL/6 and BALB/c normal and A. fumigatus infected corneas. C57BL/6 mice were pretreated with recombinant (r) VIP, while BALB/c mice were pretreated with VIP antagonist, and then infected with A. fumigatus. Clinical score (...) was recorded. Expression of pro- and anti-inflammatory cytokines, toll-like receptor 4 (TLR4), lectin-like oxidized low-density lipoprotein receptor 1 (LOX-1), and neutrophil infiltration were tested by PCR, enzyme-linked immunosorbent assay (ELISA), and myeloperoxidase (MPO) assay.VIP mRNA expression in BALB/c cornea was higher than C57BL/6 cornea at 1 and 3d post infection (p.i.). rVIP treatment of C57BL/6 mice showed alleviated disease and down-regulated expression of interleukin-1β (IL-1β) and tumor

2018 International journal of ophthalmology

79. Modified ulcer debridement in the treatment of the superficial fungal infection of the cornea (Full text)

Modified ulcer debridement in the treatment of the superficial fungal infection of the cornea To evaluate the efficacy of modified corneal ulcer debridement in superficial fungal keratitis unresponsive to medications.A total of 209 patients (209 eyes) with fungal keratitis, involving no more than 50% of the stromal depth and not responding to antifungal agents for 2wk, were recruited in this retrospective, noncomparative study. The patients were treated with modified corneal ulcer debridement (...) by penetrating keratoplasty (PK) (1 eye), anterior lamellar keratoplasty (LK) (7 eyes), conjunctival flap covering (4 eyes) or amniotic membrane transplantation (2 eyes). The best corrected visual acuity (BCVA) was ≥20/70 in 80.3% of the eyes, ≥20/40 in 56.9% of the eyes, and ≥20/25 in 27.3% of the eyes. The corneas at the lesions became thinner, but all in the safe range. No fungal recurrence or corneal ectasis developed during the follow-up. The risk of treatment failure was higher in patients

2018 International journal of ophthalmology

80. Cornea and anterior eye assessment with placido-disc keratoscopy, slit scanning evaluation topography and scheimpflug imaging tomography (Full text)

Cornea and anterior eye assessment with placido-disc keratoscopy, slit scanning evaluation topography and scheimpflug imaging tomography Current corneal assessment technologies make the process of corneal evaluation extremely fast and simple and several devices and technologies allow to explore and to manage patients. The purpose of this special issue is to present and also to update in the evaluation of cornea and ocular surface and this second part, reviews a description of the corneal (...) topography and tomography techniques, providing updated information of the clinical recommendations of these techniques in eye care practice. Placido-based topographers started an exciting anterior corneal surface analysis that allows the development of current corneal tomographers that provide a full three-dimensional reconstruction of the cornea including elevation, curvature, and pachymetry data of anterior and posterior corneal surfaces. Although, there is not an accepted reference standard

2018 Indian journal of ophthalmology

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