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61. Cenegermin (Oxervate) - Treatment of moderate (persistent epithelial defect) or severe (corneal ulcer) neurotrophic keratitis in adults

Cenegermin (Oxervate) - Treatment of moderate (persistent epithelial defect) or severe (corneal ulcer) neurotrophic keratitis in adults Published 08 October 2018 . Statement of advice SMC2124 cenegermin 20micrograms/ml eye drops, solution (Oxervate®) Dompé UK Ltd In confidence 7 September 2018 ADVICE: in the absence of a submission from the holder of the marketing authorisation cenegermin (Oxervate®) is not recommended for use within NHSScotland. Indication under review: Treatment of moderate (...) (persistent epithelial defect) or severe (corneal ulcer) neurotrophic keratitis in adults. The holder of the marketing authorisation has not made a submission to SMC regarding this product in this indication. As a result we cannot recommend its use within NHSScotland. Advice context: No part of this advice may be used without the whole of the advice being quoted in full. This advice represents the view of the Scottish Medicines Consortium and was arrived at after careful consideration and evaluation

2018 Scottish Medicines Consortium

62. Clinical Commissioning Policy: Keratoprosthesis for corneal blindness

Clinical Commissioning Policy: Keratoprosthesis for corneal blindness NHS England » Clinical Commissioning Policy: Keratoprosthesis for corneal blindness (all ages) Search Search Menu Clinical Commissioning Policy: Keratoprosthesis for corneal blindness (all ages) Document first published: 6 July 2018 Page updated: 6 July 2018 Topic: , Publication type: This policy document outlines the arrangements for funding of treatment for corneal blindness. Document PDF 289 KB 15 pages

2018 NHS England

63. Comparison of seropositivity of human immunodeficiency virus, hepatitis B virus, hepatitis C virus, and syphilis among Hospital Cornea Retrieval Programme-Donors versus voluntary cornea donors at a large eye bank in Eastern India Full Text available with Trip Pro

Comparison of seropositivity of human immunodeficiency virus, hepatitis B virus, hepatitis C virus, and syphilis among Hospital Cornea Retrieval Programme-Donors versus voluntary cornea donors at a large eye bank in Eastern India To compare the serology profile of donors from Hospital Cornea Retrieval Programme-donors (HCRP-D) and voluntary cornea donors (VC-D) from a large eye bank in Eastern India.This is a retrospective analysis of donor details from January 2011 to December 2016. Donor

2017 Indian journal of ophthalmology

64. In situ cornea harvesting through the Red Cross Organization: a new approach to relieving severe cornea donor shortage in Chinese eye banks Full Text available with Trip Pro

In situ cornea harvesting through the Red Cross Organization: a new approach to relieving severe cornea donor shortage in Chinese eye banks Corneal diseases are currently the second main cause of blindness in China. Although most of the corneal blindness could be treated by corneal transplantation, only about 10 000 operations were carried out each year owing to the severe shortage of corneal donors and limited eye bank programs. A feasible cornea donation program was established through (...) the organization of the Red Cross, and in situ corneal removal techniques were developed to avoid conflicts with Chinese traditions of keeping the deceased intact. The number of donated corneas, which had a safe and secure quality, increased significantly year by year.

2017 International journal of ophthalmology

65. Effects of chalazia on corneal astigmatism : Large-sized chalazia in middle upper eyelids compress the cornea and induce the corneal astigmatism. Full Text available with Trip Pro

Effects of chalazia on corneal astigmatism : Large-sized chalazia in middle upper eyelids compress the cornea and induce the corneal astigmatism. A chalazion is a common eyelid disease that causes eye morbidity due to inflammation and cosmetic disfigurement. Corneal topographic changes are important factors in corneal refractive surgery, intraocular lens power calculations for cataract surgery, and visual acuity assessments. However, the effects of chalazia on corneal astigmatism have not been (...) thoroughly investigated. The changes in corneal astigmatism according to chalazion size and location is necessary for better outcome of ocular surgery. The aim of this study is to evaluate changes in corneal astigmatism according to chalazion size and location.In this cross-sectional study, a total of 44 eyes from 33 patients were included in the chalazion group and 70 eyes from 46 patients comprised the control group. Chalazia were classified according to location and size. An autokeratorefractometer

2017 BMC Ophthalmology

66. Corneal crosslinking for keratoconus and corneal crosslinking for other corneal thinning disorders

that CXL stabilizes the cornea. With keratoconus patients, CXL treatment was shown to produce statistically significant improvements in all outcomes considered except pachymetry. The studies reporting mixed disease groups showed less overall improvement in most measures but still demonstrated significant improvement in BCVA, UCVA, and pachymetry. Both of the included RCTs reported that CXL resulted in stabilization of corneal thinning. A budget impact analysis based on Alberta costs and global (...) Corneal crosslinking for keratoconus and corneal crosslinking for other corneal thinning disorders Corneal crosslinking for keratoconus and corneal crosslinking for other corneal thinning disorders Corneal crosslinking for keratoconus and corneal crosslinking for other corneal thinning disorders Leggett L, Hosein S, Lorenzetti D, Rose S, Clement F Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality

2012 Health Technology Assessment (HTA) Database.

67. Association of sensitive skin with sensitive corneas and sensitive eyelids. (Abstract)

Association of sensitive skin with sensitive corneas and sensitive eyelids. Sensitive scalp or irritable bowel syndrome has been previously shown to be associated with sensitive skin. We wondered whether sensitive eyelids and sensitive eyes could also be associated with sensitive skin.A cross-sectional epidemiological study was carried out on a representative sample of French people, according to the quota method, using a questionnaire.A total of 2048 subjects were included in the present study

2019 Journal of the European Academy of Dermatology and Venereology

68. Quantitative evaluation of visual function in patients with cornea verticillata associated with Fabry disease. (Abstract)

Quantitative evaluation of visual function in patients with cornea verticillata associated with Fabry disease. To evaluate the visual function of patients with cornea verticillata associated with Fabry disease through quantitative evaluations of contrast sensitivity function and straylight.We enrolled 28 eyes of 14 patients with Fabry disease (mean age, 37.1 ± 17.2  years) and 20 eyes of 20 age-matched healthy controls. Comprehensive ophthalmological examinations were performed and contrast (...) sensitivity and letter contrast sensitivity were measured for all patients, following which the area under the log contrast sensitivity function (AULCSF) was calculated. Straylight was quantified using a straylight metre. Furthermore, subgroup analysis was performed according to the whorl-like pattern of cornea verticillata (mild and typical groups).All 28 eyes showed cornea verticillata. Visual acuity and letter contrast sensitivity values were the same for normal eyes and those with Fabry disease

2019 Acta ophthalmologica

69. Multiple Linear Regression Analysis of the Impact of Corneal Epithelial Thickness on Refractive Error Post Corneal Refractive Surgery. (Abstract)

Multiple Linear Regression Analysis of the Impact of Corneal Epithelial Thickness on Refractive Error Post Corneal Refractive Surgery. To evaluate the influence of corneal epithelial thickness (CET) on the deviation from the targeted refraction [refractive error (RE)] post corneal refractive surgery.Retrospective, single-center, cross-sectional study.This study involved 211 eyes of 211 patients who previously underwent laser-assisted in situ keratomileusis (LASIK) or epipolis LASIK (...) for the correction of myopia and myopic astigmatism from August 2000 to May 2014 at the Baptist Eye Institute, Kyoto, Japan, and who subsequently underwent examination of CET via optical coherence tomography imaging of 17 zones (central: n=1 zone, paracentral: n=8 zones, and mid-peripheral: n=8 zones) within a 6.0-mm-diameter area of the central cornea from April 2014 to February 2015. The relationship between CET and RE was evaluated using Spearman's coefficient in 5 parameters: CET in the 1) central, 2

2019 American Journal of Ophthalmology

70. Comparison of changes in corneal endothelial cell density and central corneal thickness between conventional and femtosecond laser-assisted cataract surgery: a randomised, controlled clinical trial. (Abstract)

Comparison of changes in corneal endothelial cell density and central corneal thickness between conventional and femtosecond laser-assisted cataract surgery: a randomised, controlled clinical trial. To identify changes in endothelial cell density (ECD) and central corneal thickness (CCT) in eyes undergoing femtosecond laser-assisted cataract surgery (FLACS) compared with conventional phacoemulsification surgery (CPS).This is an intraindividual randomised, controlled clinical trial. One eye (...) was randomised to receive FLACS, while the contralateral eye of the same patient received CPS. The femtosecond laser pretreatment included creating main and side-port corneal incisions, capsulotomy and lens fragmentation. Non-contact endothelial cell microscopy and pachymetry were performed preoperatively and at postoperative day 1, week 1, month 1 and month 3.A total of 134 paired eyes from 67 patients were included in the analysis. ECD was not significantly different between the two groups at either

2019 British Journal of Ophthalmology Controlled trial quality: uncertain

71. Cornea nerve fibre state determines analgesic response to tapentadol in fibromyalgia patients without effective endogenous pain modulation. Full Text available with Trip Pro

Cornea nerve fibre state determines analgesic response to tapentadol in fibromyalgia patients without effective endogenous pain modulation. Tapentadol is a centrally acting analgesic with μ-agonistic activity combined with noradrenaline reuptake inhibition. Its mechanism of action relies on improvement of descending pain inhibition. In the current study, tapentadol's ability to enhance conditioned pain modulation (CPM, an experimental measure of descending pain inhibition) was evaluated (...) in fibromyalgia patients with absent or reduced CPM responses.A total of 34 fibromyalgia patients completed this double-blind trial. Patients were randomized to receive treatment with tapentadol sustained-release or placebo for a 3-month period with 1-month follow-up. At baseline, the cornea nerve fibre state (CNFS) was quantified to determine the presence of nerve fibre pathology and assess its value in the prediction of the analgesic response.Tapentadol significantly increased CPM responses during treatment

2019 European Journal of Pain Controlled trial quality: predicted high

72. Detection of Subclinical Corneal Ectasia Using Corneal Tomographic and Biomechanical Assessments in a Japanese Population. (Abstract)

Detection of Subclinical Corneal Ectasia Using Corneal Tomographic and Biomechanical Assessments in a Japanese Population. To test the detection of subclinical corneal ectasia using integrated Scheimpflug tomography and biomechanical assessment in a Japanese population.This prospective, case-control study included 23 patients with very asymmetric ectasia (VAE) and 70 normal controls. Patients with VAE had defined clinical ectasia in one eye and a fellow eye with normal topography (VAE-NT (...) ). Objective topography for confirming normal topography in VAE-NT cases included having 0% similarity and 0% severity derived from Placido-disk based topography. Scheimpflug-based corneal tomography and corneal biomechanical assessment were performed. The Belin/Ambrósio Enhanced Ectasia Deviation index (BAD-D), Corvis Biomechanical Index (CBI), and Tomographic Biomechanical Index (TBI) were compared and their discriminating ability for detecting ectasia was assessed.For differentiating normal and VAE-NT

2019 Journal of Refractive Surgery

73. Assessment of the Association Between In Vivo Corneal Biomechanical Changes After Corneal Cross-linking and Depth of Demarcation Line. (Abstract)

, there was no significant correlation between the change in 1/R and the demarcation line ratio (R2 = .002 and P = .75). However, there was a significant association between the preoperative values of 1/R and the respective change in 1/R (P < .0001). The change in 1/R was inversely proportional to the patient's preoperative 1/R; stiffer corneas (lower values of 1/R) were less affected than less stiff corneas (R2 = .23, P < .0001).CXL is associated with changes in DCRs, suggesting a change in corneal biomechanics (...) Assessment of the Association Between In Vivo Corneal Biomechanical Changes After Corneal Cross-linking and Depth of Demarcation Line. To test for an association between stiffening following corneal cross-linking (CXL) and demarcation line depth.Sixty-six eyes of 66 patients treated with CXL for progressive keratoconus were included. Dynamic corneal response parameters (DCRs) were measured with the Corvis ST (Oculus Optikgeräte GmbH; Wetzlar, Germany) on the day of CXL and after 1 month

2019 Journal of Refractive Surgery

74. Effect of Graft Attachment Status and Intraocular Pressure on DSAEK Outcomes in the Cornea Preservation Time Study. (Abstract)

Effect of Graft Attachment Status and Intraocular Pressure on DSAEK Outcomes in the Cornea Preservation Time Study. To examine the association of donor, recipient, and operative factors on graft dislocation after Descemet stripping automated endothelial keratoplasty (DSAEK) in the Cornea Preservation Time Study (CPTS) as well as the effects of graft dislocation and elevated IOP on graft success and endothelial cell density (ECD) 3 years postoperatively.Cohort study within a multi-center, double (...) -masked, randomized clinical trial.1,090 individuals (1,330 study eyes), median age 70 years, undergoing DSAEK for Fuchs endothelial corneal dystrophy (94% of eyes) or pseudophakic or aphakic corneal edema (6% of eyes). Recipient eyes receiving donor corneal tissue randomized by preservation time (PT) of 0-7 days (N=675) or 8-14 days (N=655) were monitored for early or late graft failure through 3 years. Donor, recipient, operative, and postoperative parameters were recorded including graft

2019 American Journal of Ophthalmology Controlled trial quality: uncertain

75. Development and validation of a new intraocular pressure estimate for patients with soft corneas. (Abstract)

Development and validation of a new intraocular pressure estimate for patients with soft corneas. To introduce and clinically validate a new method of estimating intraocular pressure (IOP) in patients with keratoconus and soft corneas with the aim of significantly reducing dependence on corneal biomechanics.Vincieye Clinic, Milan, Italy, and Rio de Janeiro Corneal Tomography and Biomechanics Study Group, Brazil.Retrospective case series.This study comprised participants enrolled at two (...) ). Furthermore, the bIOPs predictions were significantly less affected by corneal thickness and patient age than the Scheimpflug analyzer IOP.The bIOPs algorithm was more reliable at estimating the IOP in eyes with a soft cornea and was validated for use in eyes with keratoconus.Copyright © 2019 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved.

2019 Journal of cataract and refractive surgery

76. Comparing the effects of two different contact lenses on corneal re-epithelialization after corneal collagen cross-linking. Full Text available with Trip Pro

Comparing the effects of two different contact lenses on corneal re-epithelialization after corneal collagen cross-linking. To investigate whether keratoconus (KC) patients who applied the corneal collagen cross-linking (CXL) and two different contact lens (CL) showed any differences in complaints and findings following the CXL.This prospective, comparative, double-blind clinical study involved 60 eyes of 60 patients (38 female and 22 male). At the end of the CXL procedure, CL (Balafilcon (...) A) was inserted in 29 patients (Group-1) while CL with different material content (Hioxifilcon A) designed for therapeutic/bandage purposes were inserted in 31 patients (Group-2).On the 1st and 3th day after the CXL, there were no statistically significant differences between the groups in terms of the postoperative symptoms. On the 3th day after the CXL, all cases of both two groups were found to complete the corneal re-epithelialization. There was more PE ratio in the patients who had allergic

2019 Pakistan Journal Of Medical Sciences Controlled trial quality: uncertain

77. Biomechanical Properties of Human Cornea Tested by Two-Dimensional Extensiometry Ex Vivo in Fellow Eyes: PRK Versus SMILE. (Abstract)

Biomechanical Properties of Human Cornea Tested by Two-Dimensional Extensiometry Ex Vivo in Fellow Eyes: PRK Versus SMILE. To investigate the biomechanical properties of the ex vivo human paired corneas after completion of photorefractive keratectomy (PRK) versus small incision lenticule extraction (SMILE) in the same donor.In this experimental study, 13 pairs of human corneas unsuitable for transplantation were equally divided into two groups. Corneal thickness was measured in each eye (...) directly before laser refractive surgery. Corneas from the right eye were treated with PRK and corneas from the left eye with SMILE. All corneas were subjected to a refractive correction of -10.00 diopters (D) sphere and -0.75 D cylinder at 0° with a 7 mm zone, using either surface ablation (PRK) or 130 µm cap (SMILE). For two-dimensional biomechanical measurements, corneoscleral buttons underwent two testing cycles (preconditioning stress-strain curve from 0.03 to 9.0 N and stress-relaxation at 9.0 N

2019 Journal of Refractive Surgery

78. Intrastromal Lenticule Rotation for Treatment of Astigmatism Up to 10.00 Diopters Ex Vivo in Human Corneas. (Abstract)

and precise for management of regular astigmatism up to 10.00 D ex vivo in human donor corneas. A myopic shift was observed in TCRP. The in vivo corneal remodeling after ISLR warrants investigation. [J Refract Surg. 2019;35(7):451-458.].Copyright 2019, SLACK Incorporated. (...) Intrastromal Lenticule Rotation for Treatment of Astigmatism Up to 10.00 Diopters Ex Vivo in Human Corneas. To evaluate the feasibility of intrastromal lenticule rotation (ISLR) as a novel technique for management of astigmatism up to 10.00 diopters (D).Eighteen human donor corneas were mounted on an artificial anterior chamber. After laser application and dissection, the lenticule was rotated 90° in the intrastromal pocket. Scheimpflug tomography (Pentacam HR; Oculus Optikgeräte GmbH, Wetzlar

2019 Journal of Refractive Surgery

79. Relationship between novel intraocular pressure measurement from Corvis ST and central corneal thickness and corneal hysteresis. (Abstract)

Relationship between novel intraocular pressure measurement from Corvis ST and central corneal thickness and corneal hysteresis. Corvis ST (CST) yields biomechanical corrected IOP (bIOP) which is purported to be less dependent on biomechanical properties. In our accompanied paper, it was suggested that the repeatability of bIOP is high. The purpose of the current study was to assess the relationship between intraocular pressure (IOP) measured with CST and central corneal thickness (CCT (...) ) and corneal hysteresis (CH), in comparison with IOP measured with Goldmann applanation tonometry (GAT) and the ocular response analyzer (ORA).A total of 141 eyes from 141 subjects (35 healthy eyes and 106 glaucomatous eyes) underwent IOP measurements with GAT, CST and ORA. The relationships between IOP measurements (ORA-IOPg, ORA-IOPcc, CST-bIOP and GAT IOP) and biomechanical properties (CCT, CH and corneal resistance factor (CRF)) were analysed using the linear regression analysis.IOPg, IOPcc and GAT IOP

2019 British Journal of Ophthalmology

80. Differential effects of primary disease and corneal vascularisation on corneal transplant rejection and survival. (Abstract)

Differential effects of primary disease and corneal vascularisation on corneal transplant rejection and survival. To investigate the relative risk of pretransplant corneal vascularisation on rate of rejection and graft failure within 5 years of surgery when categorised by indication for transplantation.We analysed all adults recorded in the UK transplant registry who had a first cornea transplant for keratoconus (KC), pseudophakic bullous keratopathy (PBK) or previous infection (viral/bacterial (...) /fungal/protozoan) between 1999 and 2017. We analysed the number of quadrants of the recipient cornea vascularised before transplant and type of vascularisation, the interval post-transplant to rejection, if any, and the outcome at 5 years post-transplant. Risk factors for rejection and transplant failure were modelled by multivariable risk-adjusted Cox regression.Corneal vascularisation was recorded in 10%, 25% and 67% of patients with KC, PBK and infection, respectively. Individuals with PBK had

2019 British Journal of Ophthalmology

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