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21. [Clinical comparison analysis in surgically induced astigmatism of the total, anterior and posterior cornea after 2.2-mm versus 3.0-mm clear corneal incision cataract surgery]. (Abstract)

[Clinical comparison analysis in surgically induced astigmatism of the total, anterior and posterior cornea after 2.2-mm versus 3.0-mm clear corneal incision cataract surgery]. Objective: To compare the surgical induced astigmatism(SIA) of the total, anterior and posterior cornea between eyes with 2.2-mm and 3.0-mm clear corneal incisions in phacoemulsification. Methods: A prospective double-blind randomized controlled study was conducted on 131 patients (131 eyes) with age-related cataract (...) ±0.42) D, P<0.01] and 3.0-mm group [(-0.58±0.66) vs. (-0.37±0.42) D, P<0.01]. Conclusions: Compared with the 3.0-mm incision, the 2.2-mm coaxial micro-incision cataract surgery has a lower and more stable SIA. The effect of a clear corneal incision in cataract surgery on the total cornea is more obvious than that on the anterior surface of the cornea. The difference is significant in the early stage and gradually decrease with time. (Chin J Ophthalmol, 2019, 55: 495-501).

2019 [Zhonghua yan ke za zhi] Chinese journal of ophthalmology Controlled trial quality: uncertain

22. Influence of peripheral corneal relaxing incisions during cataract surgery for corneal astigmatism up to 2.5 dioptres on corneal densitometry. (Abstract)

Influence of peripheral corneal relaxing incisions during cataract surgery for corneal astigmatism up to 2.5 dioptres on corneal densitometry. To assess the effect of peripheral corneal relaxing incisions (PCRI) for astigmatism between 0.75 and 2.5 dioptres during cataract surgery on corneal densitometry (CD).In this prospective, randomised study, 80 eyes (80 patients), received either tIOL or PCRI. Assessment at pre-operative and 1, 3, 6, 12 months post-operative visit included uncorrected (...) thereafter. For zones 1, 2 and 3, CD significantly reduced after 3 months with tIOLs whereas with PCRIs, it reduced 1 month onwards. For zone 4, CD reduced only at 12 months with tIOLs compared to 3 months onwards with PCRIs. In both groups CD was higher in the zone 4 and anterior layer. Significant reduction in CD was found in all three layers of cornea after 3 months in tIOL and after first month in PCRI groups, respectively.Cataract surgery alone reduces the CD. Reducing keratometric astigmatism

2019 Eye (London, England) Controlled trial quality: uncertain

23. CCR2+ migratory macrophages with M1 status are the early-responders in the cornea of HSV-1 infected mice. Full Text available with Trip Pro

CCR2+ migratory macrophages with M1 status are the early-responders in the cornea of HSV-1 infected mice. Complex interactions between HSV-1 and infiltrating immune cells play important roles in establishing localized, acute virus replication as well as chronic latent infection. The extent and duration of initial virus replication are the key determinants of subsequent pathologic inflammatory responses and therefore, the accumulation of immune cell populations at this time point is a key target (...) for prevention. Therefore, we evaluated the role of various immune cell infiltrates between 1 h and 28 days post-infection (PI) using mice infected with virulent HSV-1 strain McKrae without corneal scarification. The effect of corneal scarification on immune cell infiltrates was also determined. We first determined the activation status and origin of macrophage infiltrates as early as 1 h PI. We found a sharp increase in the total macrophage population after 12 h PI, that was primarily due to infiltration

2019 PLoS ONE

24. Comprehensive evaluation of total corneal refractive power by ray tracing in predicting corneal power in eyes after small incision lenticule extraction. Full Text available with Trip Pro

Comprehensive evaluation of total corneal refractive power by ray tracing in predicting corneal power in eyes after small incision lenticule extraction. To assess the prediction accuracy of four variations of total corneal refractive power (TCRP) by the ray tracing method in determining corneal power in eyes after myopic small incision lenticule extraction (SMILE).Forty eyes of forty patients who had undergone myopic SMILE were enrolled in this prospective study. Manifest refraction (...) to 0.96 D), respectively, while the modified 4.0 mm TCRPpupil,zone (TCRPpuil,zone + 0.70 D) and TCRPapex,zone (TCRPapex,zone+0.70 D) yielded the narrowest 95% LOA of (-0.96 to 0.95 D) and (-0.96D, 1.05 D).Total corneal refractive power using the ray tracing method could predict corrected corneal power derived from the CHM in eyes following SMILE surgery after simple modification.

2019 PLoS ONE

25. Correction: Paradox response of cornea to different color intensities of visible light: An experimental study. Full Text available with Trip Pro

Correction: Paradox response of cornea to different color intensities of visible light: An experimental study. [This corrects the article DOI: 10.1371/journal.pone.0196827.].

2019 PLoS ONE

26. Microvesicle delivery of a lysosomal transport protein to ex vivo rabbit cornea Full Text available with Trip Pro

Microvesicle delivery of a lysosomal transport protein to ex vivo rabbit cornea Therapeutic use of transmembrane proteins is limited because of irreversible denaturation when away from their native lipid membrane. Mutations in lysosomal membrane transport proteins cause many lethal disorders including cystinosis which results from mutations in CTNS, which codes for the lysosomal cystine transport protein, cystinosin. Cystinosin-deficient fibroblasts, including keratocytes (corneal fibroblasts (...) ) accumulate lysosomal cystine. Cystinosis patients develop highly painful corneal cystine crystals, resulting in severe visually debilitating photophobia. The only available therapy is daily treatment with cysteamine eye drops. We have previously shown that microvesicles containing functional cystinosin are spontaneously produced by infecting Spodoptera frugiperda cells (Sf9) with baculovirus containing human wt CTNS. Infecting Sf9 cells for 3 days at a MOI of 1 yields 1011microvesicles /ml with a modal

2020 Molecular genetics and metabolism reports

27. Reticular Corneal Edema or Corneal Honeycombing in Eyes Treated With Netarsudil: A Case Series. (Abstract)

Reticular Corneal Edema or Corneal Honeycombing in Eyes Treated With Netarsudil: A Case Series. This is a descriptive case series of 3 patients with uncontrolled intraocular pressure that developed reticular corneal changes after initiating netarsudil (0.02%). In all cases, upon observing reticular corneal edema, netarsudil (0.02%) was stopped followed by disappearance of corneal honeycombing. With the increasing use of this novel glaucoma medication, potentially more rare side effects (...) will be observed. Reticular corneal edema or corneal honeycombing is an ocular examination finding that can rarely occur after initiating netarsudil (0.02%) regardless of prior corneal edema status. In our experience, the reticular changes resolve upon cessation of netarsudil.

2020 Journal of Glaucoma

28. Cystadrops - cysteamine - Corneal cystine crystal deposits

Cystadrops - cysteamine - Corneal cystine crystal deposits cysteamine | CADTH.ca Find the information you need cysteamine cysteamine Last Updated: July 3, 2019 Result type: Reports Project Number: SR0595-000 Product Line: Generic Name: cysteamine Brand Name: Cystadrops Manufacturer: Recordati Rare Diseases Canada Inc. Indications: Corneal cystine crystal deposits Manufacturer Requested Reimbursement Criteria 1 : For the treatment of corneal cystine crystal deposits in adults and children from 2

2018 Canadian Agency for Drugs and Technologies in Health - Common Drug Review

34. Corneal endothelial keratoplasty for the treatment of corneal endothelial dysfunction

consider endothelial keratoplasty only in the presence of pure corneal endothelial dysfunction, and at centers with adequate technological training. The coverage policies found consider endothelial keratoplasty for the treatment of endothelial dysfunction when there is no other condition at corneal level. Final publication URL www.iecs.org.ar Indexing Status Subject indexing assigned by CRD MeSH Cornea; Corneal Transplantation; Humans; Vascular Diseases Language Published Spanish Country (...) Corneal endothelial keratoplasty for the treatment of corneal endothelial dysfunction Corneal endothelial keratoplasty for the treatment of corneal endothelial dysfunction Corneal endothelial keratoplasty for the treatment of corneal endothelial dysfunction Brito V, Ciapponi A, Pichon-Riviere A, Augustovski F, García Martí S, Alcaraz A, Bardach A, López A, Rey-Ares L Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation

2015 Health Technology Assessment (HTA) Database.

35. Intrastromal corneal implants for ectatic corneal disorders. Decision Support Document 85.

Intrastromal corneal implants for ectatic corneal disorders. Decision Support Document 85. Intrastromal corneal implants for ectatic corneal disorders - Repository of AIHTA GmbH English | Browse - - - Intrastromal corneal implants for ectatic corneal disorders Fischer, S. and Zechmeister-Koss, I. (2015): Intrastromal corneal implants for ectatic corneal disorders. Decision Support Document 85. Preview - Sie müssen einen PDF-Viewer auf Ihrem PC installiert haben wie z. B. , oder 541kB Abstract (...) Keratoconus and corneal ectasia after LASIK are rare diseases. In contrast to corneal transplantation that is the most frequently used treatment for ectatic corneal disorders in later stages, corneal implantation is a less invasive and reversible intervention. Therefore, we assessed the effectiveness and safety of these corneal implants. Since we exclusively found uncontrolled trials, the level of evidence was very low to low. However, the studies predict an improvement in visual acuity with moderate re

2015 Austrian Institute of Health Technology Assessment

36. Biomechanical changes in the cornea following cataract surgery: A prospective assessment with the Corneal Visualisation Scheimpflug Technology. (Abstract)

Biomechanical changes in the cornea following cataract surgery: A prospective assessment with the Corneal Visualisation Scheimpflug Technology. Intraocular pressure (IOP) is often reduced following cataract surgery. Postoperative changes in corneal stiffness are likely to be at least partly responsible for any reduction in IOP measured with applanation tonometry.To determine the effect of cataract surgery and corneal incision size on corneal biomechanics.Prospective randomized trial.One hundred (...) prospectively enrolled patients qualifying for cataract surgery.Participants were randomized to clear corneal incisions with a 2.20 or 2.85 mm keratome. Corneal Visualisation Scheimpflug Technology (Corvis-ST) tonometry and dynamic corneal response measurements were obtained preoperatively, and 3 mo postoperatively. Multiple regression analysis was completed using R software.Corvis-ST biomechanical parameters.Ninety-three eyes of 93 patients were included in the final analysis. Mean Corvis-ST

2018 Clinical & experimental ophthalmology Controlled trial quality: uncertain

37. Differences in Posterior Corneal Features Between Normal Corneas and Subclinical Keratoconus. (Abstract)

Differences in Posterior Corneal Features Between Normal Corneas and Subclinical Keratoconus. To compare posterior corneal features and their discriminating power for differentiating normal corneas from subclinical keratoconus using the Placido dual-Scheimpflug analyzer.Patients were retrospectively included in the study. The preoperative normal right eyes of 79 patients imaged with a Placido dual-Scheimpflug system and with a stable postoperative LASIK follow-up of a minimum of 36 months were (...) included in the normal group and were compared to 39 contralateral topographically normal eyes with clinically evident keratoconus in the fellow eye. The posterior surface variables measured were categorized according to the feature of the corneal shape they were characterizing (curvature, elevation, asymmetry, and eccentricity) and compared between the two groups using the Student's two-sample t test. The discriminating ability of the posterior surface variables was compared by receiver operator

2018 Journal of Refractive Surgery

38. Repeatability and Reproducibility of Corneal Epithelial Thickness Mapping with Spectral Domain Optical Coherence Tomography in Normal and Diseased Cornea Eyes. (Abstract)

Repeatability and Reproducibility of Corneal Epithelial Thickness Mapping with Spectral Domain Optical Coherence Tomography in Normal and Diseased Cornea Eyes. To evaluate the performance of the epithelial thickness mapping (ETM) of the iVue spectral-domain optical coherence tomography (SD-OCT) device (Optovue Inc, Fremont, California, USA) in normal and diseased cornea eyes.Reliability and validity analysis.Sixty eyes of 60 subjects were recruited for the study, which included normal subjects (...) variability for both groups. Repeatability and reproducibility were similar in all subgroups of cornea patients, excluding the DES group, for which reproducibility was significantly lower (range 3.2%-5.5% for DES patients and 1.1%-2.9% for normal subjects).The iVue SD-OCT provides good corneal ETM repeatability and reproducibility in normal and diseased cornea eyes through all map zones.Copyright © 2018 Elsevier Inc. All rights reserved.

2018 American Journal of Ophthalmology

39. Improved High-Frequency Ultrasound Corneal Biometric Accuracy by Micrometer-Resolution Acoustic-Property Maps of the Cornea Full Text available with Trip Pro

Improved High-Frequency Ultrasound Corneal Biometric Accuracy by Micrometer-Resolution Acoustic-Property Maps of the Cornea Mapping of epithelial thickness (ET) is useful for detection of keratoconus, a disease characterized by corneal thinning and bulging in which epithelial thinning occurs over the apex. In prior clinical studies, optical coherence tomography (OCT) measurements of ET were systematically thinner than those obtained by 40-MHz high-frequency ultrasound (HFU) where a constant (...) speed of sound (c) of 1636 m/s was used for all corneal layers. The purpose of this work was to study the acoustic properties, that is, c, acoustic impedance (Z), and attenuation (α) of the corneal epithelium and stroma independently using a scanning acoustic microscope (SAM) to investigate the discrepancy between OCT and HFU estimates of ET.Twelve unfixed pig corneas were snap-frozen and 6-μm sections were scanned using a custom-built SAM with an F-1.08, 500-MHz transducer and a 264-MHz bandwidth

2018 Translational vision science & technology

40. Early Changes in Visual Quality and Corneal Structure after DMEK: Does DMEK Approach Optical Quality of a Healthy Cornea? Full Text available with Trip Pro

Early Changes in Visual Quality and Corneal Structure after DMEK: Does DMEK Approach Optical Quality of a Healthy Cornea? To evaluate early changes in visual function and visual quality parameters after Descemet membrane endothelial keratoplasty (DMEK) and to compare the outcomes with healthy controls.Thirteen patients who underwent DMEK and 14 controls were evaluated. All subjects underwent visual function evaluation, including visual acuity under photopic and mesopic lighting conditions (...) and contrast sensitivity (CSV) tests CSV 1000 and Pelli-Robson. Corneal parameters were assessed with Oculus Pentacam. Corneal mean keratometry (Km), corneal densitometry values, and low and high order aberrations (LOA and HOA) were recorded. In DMEK patients, all tests were performed before surgery and 1 and 6 months after surgery.In patients who underwent DMEK, photopic visual acuity improved from 0.59 to 0.31 at 1 month (p=0.013) and 0.13 at 6 months (p=0.008); mesopic visual acuity and all contrast

2018 Journal of ophthalmology

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