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1. Artificial corneas versus donor corneas for repeat corneal transplants. Full Text available with Trip Pro

Artificial corneas versus donor corneas for repeat corneal transplants. Individuals who have failed one or more full thickness penetrating keratoplasties (PKs) may be offered repeat corneal surgery using an artificial or donor cornea. An artificial or prosthetic cornea is known as a keratoprosthesis. Both donor and artificial corneal transplantations involve removal of the diseased and opaque recipient cornea (or the previously failed cornea) and replacement with another donor or prosthetic (...) cornea.To assess the effectiveness of artificial versus donor corneas in individuals who have had one or more failed donor corneal transplantations.We searched CENTRAL (which contains the Cochrane Eyes and Vision Group Trials Register) (2013, Issue 10), Ovid MEDLINE, Ovid MEDLINE In-Process and Other Non-Indexed Citations, Ovid MEDLINE Daily, Ovid OLDMEDLINE (January 1946 to November 2013), EMBASE (January 1980 to November 2013), Latin American and Caribbean Health Sciences Literature Database (LILACS

2014 Cochrane

2. Implantation of a corneal graft-keratoprosthesis for severe corneal opacity in wet blinking eyes

in specialist centres by surgeons experienced in the technique; long-term follow-up should be carried out by an experienced multidisciplinary team. 2 2 Indications and current treatments Indications and current treatments 2.1 Injury or disease of the cornea can make it opaque, stopping light from entering the eye and resulting in loss of vision. Some severe corneal diseases can also affect the eye's blink and tear mechanisms. Corneal injuries can be caused by direct trauma, including surgery, as well (...) as chemical or thermal burns. Diseases that can cause corneal opacity include autoimmune diseases, bullous keratopathy, keratoconus, keratitis and corneal stromal dystrophies. 2.2 The standard treatment for significant corneal opacity is a corneal transplant (penetrating keratoplasty). Penetrating keratoplasty removes the opaque cornea using a trephine, replacing it with a donor cornea. Some patients cannot have a standard corneal transplant for reasons including: disease severity; severe involvement

2015 National Institute for Health and Clinical Excellence - Interventional Procedures

3. Exploration of alternative test methods to evaluate phototoxicity of ophthalmic agents by using Statens Seruminstitut Rabbit Cornea cell lines and 3D human reconstituted cornea models. Full Text available with Trip Pro

exposure to ultra violet (UV). However, as phototoxicity may occur in ocular cells, it is necessary to develop a more suitable test for cornea-derived cells. In this study, we attempted to establish a new in vitro PT method in rabbit corneal cell lines (SIRC). We evaluated five ophthalmic agents, ciprofloxacin, levofloxacin, lomefloxacin, norfloxacin, and tetracycline, for their cytotoxic potential and in vitro phototoxicity. The results obtained using 3D human corneal models revealed that the UV (...) Exploration of alternative test methods to evaluate phototoxicity of ophthalmic agents by using Statens Seruminstitut Rabbit Cornea cell lines and 3D human reconstituted cornea models. Many chemicals have been reported to induce phototoxicity. The absorbance of light energy within the sunlight range is a common characteristic of phototoxicity. The 3T3 NRU phototoxicity test (PT) in 3T3 mouse skin fibroblasts has been used to identify the phototoxic potential induced by excited chemicals after

2018 PLoS ONE

4. University students' knowledge of corneal donation and willingness to donate corneas in the occupied Palestinian territory: a cross-sectional study. Full Text available with Trip Pro

University students' knowledge of corneal donation and willingness to donate corneas in the occupied Palestinian territory: a cross-sectional study. Access to corneal transplantation is limited worldwide because of poor knowledge. Ethical, religious, and cultural barriers contribute to low rates of corneal donation. In the occupied Palestinian territory, limited information is available on factors affecting corneal donation. The aim of this study was to assess the knowledge and willingness (...) %) respondents were aware of a lack in corneal donation, but 274 (64%; p=0·01) of these respondents did not show willingness towards corneal donation. 429 (68%) respondents were not willing to donate their corneas, the most common reasons being disapproval by family members and poor awareness. We found no association between sociodemographic factors and willingness was determined.Palestinian students are aware of the lack of local cornea donation but are unwilling to donate their corneas. The study results

2018 Lancet

5. ORA G3 to measure corneal hysteresis

by a healthcare professional through an in-built operator display. The patient positions their head in a headrest, which is adjusted to allow for measurements of the left or right eye. The device blows a short puff of air to slightly flatten the cornea, which then returns to its original shape. During this the device takes 2 measurements: the force needed to flatten the cornea and the force needed for it to reshape. The difference between the 2 measurements is defined as the level of corneal hysteresis (...) ORA G3 to measure corneal hysteresis ORA G3 to measure corneal h ORA G3 to measure corneal hysteresis ysteresis Medtech innovation briefing Published: 18 June 2018 nice.org.uk/guidance/mib150 pathways Summary Summary The technology technology described in this briefing is Ocular Response Analyzer (ORA) G3. It can be used to measure corneal hysteresis, a possible risk factor for glaucoma. The inno innovativ vative aspects e aspects are that ORA G3 is currently the only device capable

2018 National Institute for Health and Clinical Excellence - Advice

6. Repeatability of Cornea and Sublayer Thickness Measurements Using Optical Coherence Tomography in Corneas of Anomalous Refractive Status. (Abstract)

Repeatability of Cornea and Sublayer Thickness Measurements Using Optical Coherence Tomography in Corneas of Anomalous Refractive Status. To assess the repeatability of epithelial, stromal, and total corneal thickness measurements with spectral-domain optical coherence tomography (SD-OCT; RTVue-XR; Optovue, Inc., Fremont, CA) in patients with myopia, keratoconus, and corneas after transepithelial photorefractive keratectomy (PRK), small incision lenticule extraction (SMILE), and femtosecond (...) laser-assisted in situ keratomileusis (FS-LASIK).A total of 352 eyes of 352 patients (75 myopic, 68 post-transepithelial PRK, 61 post-SMILE, 75 post-FS-LASIK, 20 mild keratoconus, and 53 advanced keratoconus eyes) were included. The epithelial, stromal, and total corneal thickness were recorded from the pachymetric map in the following four zones: (1) central 2-mm region, (2) eight paracentral regions within 2- to 5-mm diameter, (3) eight midperipheral regions within 5- to 7-mm diameter, and (4

2019 Journal of Refractive Surgery

7. [Corneal collagen cross-linking and intrastromal corneal ring segments in the treatment of corneal ectasia]

: Haute Autorité de Santé (HAS). 2015 Authors' conclusions These two procedures are presented as an alternative to corneal transplant. The expected effects are stabilisation of the disease from corneal collagen cross-linking (CXL), and visual rehabilitation from placement of intrastromal corneal ring segments (ICRS). Final publication URL INAHTA brief and checklist INAHTA brief and checklist Indexing Status Subject indexing assigned by CRD MeSH Collagen; Cornea; Corneal Diseases; Dilatation (...) [Corneal collagen cross-linking and intrastromal corneal ring segments in the treatment of corneal ectasia] Crosslinking du collagène cornéen et anneaux intra-cornéens dans le traitement des ectasies cornéennes [Corneal collagen cross-linking and intrastromal corneal ring segments in the treatment of corneal ectasia] Crosslinking du collagène cornéen et anneaux intra-cornéens dans le traitement des ectasies cornéennes [Corneal collagen cross-linking and intrastromal corneal ring segments

2015 Health Technology Assessment (HTA) Database.

8. Intrastromal corneal ring segments for treating keratoconus. (Abstract)

Intrastromal corneal ring segments for treating keratoconus. Keratoconus is a degenerative condition of the cornea that profoundly affects vision and vision-specific quality of life. The axial cornea thins and protrudes, resulting in irregularity and, eventually, scarring of the cornea. There are multiple options available for treating keratoconus. Intrastromal corneal ring segments are small, crescent-shaped plastic rings that are placed in the deep, peripheral corneal stroma in order (...) to flatten the cornea. They are made of polymethylmethacrylate (PMMA). The procedure does not involve corneal tissue nor does it invade the central optical zone. Intrastromal corneal ring segments are approved for use when contact lenses or spectacles are no longer adequate.To evaluate the effectiveness and safety of intrastromal corneal ring segments as a treatment for keratoconus.We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (which contains the Cochrane Eyes and Vision Trials

2019 Cochrane

9. Corneal collagen cross-linking and intrastromal corneal ring segments in the treatment of corneal ectasia

Corneal collagen cross-linking and intrastromal corneal ring segments in the treatment of corneal ectasia Corneal collagen cross-linking and intrastromal corneal ring segments in the treatment of corneal ectasia - INAHTA Brief

2015 Haute Autorite de sante

10. Cenegermin (Oxervate) - for the treatment of moderate (persistent epithelial defect) or severe (corneal ulcer) neurotrophic keratitis in adults

Cenegermin (Oxervate) - for the treatment of moderate (persistent epithelial defect) or severe (corneal ulcer) neurotrophic keratitis in adults Search Page - Drug and Health Product Register Language selection Search and menus Search Search website Search Topics menu You are here: Summary Basis of Decision - - Health Canada Expand all Summary Basis of Decision (SBD) for Contact: Summary Basis of Decision (SBD) documents provide information related to the original authorization of a product

2019 Health Canada - Drug and Health Product Register

11. Are Topical Nonsteroidal Anti-Inflammatory Drugs Useful for Analgesia in Patients With Traumatic Corneal Abrasions? Full Text available with Trip Pro

Are Topical Nonsteroidal Anti-Inflammatory Drugs Useful for Analgesia in Patients With Traumatic Corneal Abrasions? Are Topical Nonsteroidal Anti-Inflammatory Drugs Useful for Analgesia in Patients With Traumatic Corneal Abrasions? - Annals of Emergency Medicine Email/Username: Password: Remember me Search Terms Search within Search Share this page Access provided by Volume 73, Issue 2, Pages 157–159 Are Topical Nonsteroidal Anti-Inflammatory Drugs Useful for Analgesia in Patients (...) With Traumatic Corneal Abrasions? x Jason R. West , MD (EBEM Commentator) Department of Emergency Medicine, Lincoln Medical and Mental Health Center, Bronx, NY DOI: | Publication History Published online: December 04, 2018 Expand all Collapse all Article Outline Take-Home Message There is no strong evidence to suggest that topical nonsteroidal anti-inflammatory drugs provide adequate analgesia for patients with traumatic corneal abrasions, yet there is low-quality evidence to suggest that the drugs decreased

2019 Annals of Emergency Medicine Systematic Review Snapshots

12. Changes in corneal thickness and corneal endothelial cell density after phacoemulsification cataract surgery: a double-blind randomized trial Full Text available with Trip Pro

Changes in corneal thickness and corneal endothelial cell density after phacoemulsification cataract surgery: a double-blind randomized trial Age-related cataract is a leading cause of visual impairment, considered a global health burden, it is responsible for over 47% of blindness worldwide. Surgical intervention is usually the treatment of choice and phacoemulsification cataract surgery with implantation of an intraocular lens is the most common procedure, which may have several (...) complications.To determine the effects of phacoemulsification surgery on corneal endothelial cell density and corneal thickness in patients undergoing cataract surgery.The present study was conducted on patients diagnosed with immature senile cataract requiring surgical intervention from November 2013 to 2014 in Khatam al Anbia Hospital (a tertiary ophthalmology center). Physical examination included best-corrected visual acuity using the Snellen chart, refraction, slit-lamp bio-microscopy for anterior chamber

2018 Electronic physician Controlled trial quality: uncertain

13. A new worm infiltrating the human cornea: A report of three cases Full Text available with Trip Pro

A new worm infiltrating the human cornea: A report of three cases To characterize a new species of parasitic nematode that triggers uveitis.Three previously healthy, relatively young people each contracted a corneal stromal nematode that, upon surgical removal and examination, did not match any known nematodes. Clinical ocular findings included corneal opacification, visible corneal worms, conjunctival injection, and uveitis.The three cases presented here represent a previously undescribed (...) parasitic infection of the cornea by an unidentified nematode. These findings may represent a previously unrecognized zoonotic infection from wildlife sources and potentially a newly documented nematode requiring description. Future clinical findings regarding this newly described nematode are needed to further develop our understanding of the disease.

2018 American journal of ophthalmology case reports

14. Case of progressive hyperopia due to flattening of cornea Full Text available with Trip Pro

examinations showed clear corneas but Descemet's folds and fine pigmentations and opacities were present beneath the corneal epithelium in both eyes. Analysis of the corneal shape by anterior segment optical coherence tomography showed that the corneas were flattened, and the corneal refractive power was decreased in both eyes. The large values of the higher-order aberration in the cornea and total eye displayed bilateral irregular astigmatism. She obtained good vision by wearing hard contact lenses (...) Case of progressive hyperopia due to flattening of cornea To report a case that had a progressive decrease in the visual acuity caused by a progressive increase in the hyperopia due to a flattening of the cornea.A 50-year-old woman complained of decreased vision in both eyes. Her decimal best-corrected visual acuity was 1.2 in the right and 0.5 in the left eyes, and the refractive error (spherical equivalent) was +3.75 diopters (D) for the right eye and +6.5 D for the left eye. Slit-lamp

2018 American journal of ophthalmology case reports

15. Delayed-onset Candida parapsilosis cornea tunnel infection and endophthalmitis after cataract surgery: Histopathology and clinical course Full Text available with Trip Pro

Delayed-onset Candida parapsilosis cornea tunnel infection and endophthalmitis after cataract surgery: Histopathology and clinical course To describe a patient with late post-operative endophthalmitis and clear cornea tunnel infection caused by Candida parapsilosis that was masquerading as chronic anterior uveitis.A 62-year old woman with history of uncomplicated cataract surgery 7 months prior and chronic postoperative anterior uveitis, presented with an endothelial plaque, hypopyon (...) , and infiltrates in the capsular bag and within the clear corneal tunnel. Anterior chamber cultures identified C. parapsilosis and pathology of the endothelial plaque showed fungus. Anterior chamber washout, scraping of the endothelial plaque, serial intracameral and intravitreal injections with amphotericin B (10 mcg) failed to control the infection. Pars plana vitrectomy, removal of the intraocular lens and capsular bag, a corneal patch graft, and administration of intravitreal antifungal agents were

2018 American journal of ophthalmology case reports

16. Corneal abrasions

Corneal abrasions Corneal abrasions - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Corneal abrasions Last reviewed: February 2019 Last updated: March 2018 Summary Onset is usually sudden, and typical symptoms include a foreign body sensation (even if none present), photophobia, excessive tearing, blepharospasm, and blurry vision. Treatment involves adequate analgesia and topical antibiotics. Contact lens wearers (...) are at increased risk of Pseudomonas infection. Most abrasions heal within 1 or 2 days and have very few sequelae. Larger defects, or those associated with contact lens use, should have ophthalmological follow-up in 1 to 2 days to ensure healing. Complications are rare but include corneal ulceration and keratitis. Definition Corneal abrasions are corneal epithelial defects. They are common and are typically caused by mechanical trauma from external objects such as fingernails and branches, foreign bodies

2018 BMJ Best Practice

17. Boston Keratoprosthesis Type I for corneal blindness

Boston Keratoprosthesis Type I for corneal blindness Boston K Boston Ker eratoprosthesis T atoprosthesis T ype I for corneal ype I for corneal blindness blindness Medtech innovation briefing Published: 18 January 2017 nice.org.uk/guidance/mib91 pathways Summary Summary The technology technology described in this briefing is the Boston Keratoprosthesis Type I (Boston KPro I). It is an artificial cornea used to provide a transparent optical pathway into the eye of people with corneal blindness (...) in the NHS. The technology The technology The Boston Keratoprosthesis Type I (Boston KPro I; Massachusetts Eye and Ear Infirmary) is an artificial cornea that can be used in people with severe corneal opacity, a condition caused by scarring or clouding of the cornea that can lead to blindness. The current model of the Boston KPro I is the 'Snap-on' model of the device (several other versions of the KPro have previously been available). The Boston KPro I consists of 3 sterilised components that have

2017 National Institute for Health and Clinical Excellence - Advice

18. Corneal shape changes of the total and posterior cornea after temporal versus nasal clear corneal incision cataract surgery. Full Text available with Trip Pro

Corneal shape changes of the total and posterior cornea after temporal versus nasal clear corneal incision cataract surgery. To compare changes in the shape and astigmatism of the total and posterior cornea between eyes with a nasal clear corneal incision (CCI) and eyes with a temporal CCI in cataract surgery.The left eyes of 100 patients undergoing phacoemulsification were randomly assigned to undergo a 2.4 mm nasal (nasal CCI group) or temporal CCI (temporal CCI group). Corneal astigmatic (...) changes were compared between groups using power vector analysis, and corneal shape changes were compared using videokeratography maps at 2 days, and at 2, 4 and 8 weeks postoperatively.The mean J0 and J45 values of the total cornea were significantly greater in the nasal CCI group than in the temporal CCI group at 2 and 4 weeks postoperatively (p≤0.0392), but did not differ significantly between groups at 2 days and 8 weeks. The videokeratography maps revealed a wedge-shaped flattening in the total

2018 British Journal of Ophthalmology Controlled trial quality: uncertain

19. Individualized penetrating keratoplasty using edge-trimmed glycerol-preserved donor corneas for perforated corneal ulcers. Full Text available with Trip Pro

Individualized penetrating keratoplasty using edge-trimmed glycerol-preserved donor corneas for perforated corneal ulcers. To report a surgical technique and the surgical outcomes of individualized penetrating keratoplasty (PK) using edge-trimmed glycerol-preserved donor corneas for perforated corneal ulcers.Fourteen perforated eyes from 14 patients who underwent individualized PK using edge-trimmed glycerol-preserved donor corneas, were included in the retrospective study. The perforations (...) were mainly 1-2 mm in size except for one that was 2.5 × 4 mm. Three patients were treated with PK; one patient was treated with PK and a conjunctival flap; ten patients who had large ulcer areas were treated with PK combined with lamellar keratoplasty (LK). Donor corneas were preserved in sterile pure glycerol at - 80 °C. Corneal grafts were specially edge-trimmed to match the perforation, and then sutured onto the recipient bed avoiding the visual axis.All 14 patients recovered anatomical

2019 BMC Ophthalmology

20. Cornea verticillata in Fabry disease: a comparative study between slit-lamp examination and in vivo corneal confocal microscopy. (Abstract)

Cornea verticillata in Fabry disease: a comparative study between slit-lamp examination and in vivo corneal confocal microscopy. To compare the diagnostic power of slit-lamp examination with the in vivo corneal confocal microscopy (IVCM) as the gold standard in assessing the presence of corneal epithelial deposits in patients with Fabry disease (FD).Fourteen patients with FD (4 males, 10 females; mean age, 46.8 years) and eight healthy controls (4 males, 4 females; mean age, 36.75 years) were (...) included. All subjects underwent slit-lamp examination and IVCM of both central and peripheral corneal quadrants with the Heidelberg Retina Tomograph-III in combination with the Rostock Cornea Module.In patients with FD, 9 of 28 eyes (32%) showed the presence of cornea verticillata at the slit-lamp examination and 25 eyes (89%) showed the presence of epithelial hyper-reflective deposits at the IVCM. Of the 19 eyes negative at the slit-lamp examination, 16 eyes showed the presence of epithelial deposits

2019 British Journal of Ophthalmology

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