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Cornea

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1. Artificial corneas versus donor corneas for repeat corneal transplants. (PubMed)

Artificial corneas versus donor corneas for repeat corneal transplants. Individuals who have failed one or more full thickness penetrating keratoplasties (PKs) may be offered repeat corneal surgery using an artificial or donor cornea. An artificial or prosthetic cornea is known as a keratoprosthesis. Both donor and artificial corneal transplantations involve removal of the diseased and opaque recipient cornea (or the previously failed cornea) and replacement with another donor or prosthetic (...) cornea.To assess the effectiveness of artificial versus donor corneas in individuals who have had one or more failed donor corneal transplantations.We searched CENTRAL (which contains the Cochrane Eyes and Vision Group Trials Register) (2013, Issue 10), Ovid MEDLINE, Ovid MEDLINE In-Process and Other Non-Indexed Citations, Ovid MEDLINE Daily, Ovid OLDMEDLINE (January 1946 to November 2013), EMBASE (January 1980 to November 2013), Latin American and Caribbean Health Sciences Literature Database (LILACS

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2014 Cochrane

2. Repeatability of Cornea and Sublayer Thickness Measurements Using Optical Coherence Tomography in Corneas of Anomalous Refractive Status. (PubMed)

Repeatability of Cornea and Sublayer Thickness Measurements Using Optical Coherence Tomography in Corneas of Anomalous Refractive Status. To assess the repeatability of epithelial, stromal, and total corneal thickness measurements with spectral-domain optical coherence tomography (SD-OCT; RTVue-XR; Optovue, Inc., Fremont, CA) in patients with myopia, keratoconus, and corneas after transepithelial photorefractive keratectomy (PRK), small incision lenticule extraction (SMILE), and femtosecond (...) ranged from 0.2% to 2.0% for myopia, 0.7% to 4.2% for post-transepithelial PRK, 0.3% to 2.4% for post-SMILE, 0.3% to 1.9% for post-FS-LASIK, 0.6% to 3.0% for mild keratoconus, and 1.0% to 5.9% for advanced keratoconus.RTVue-XR SD-OCT showed excellent repeatability when generating the pachymetric map in myopic eyes. Measurements, especially for epithelial thickness, were relatively more variable for corneas with keratoconus and those having undergone keratorefractive surgery. [J Refract Surg. 2019;35

2019 Journal of Refractive Surgery

3. Comparison of seropositivity of human immunodeficiency virus, hepatitis B virus, hepatitis C virus, and syphilis among Hospital Cornea Retrieval Programme-Donors versus voluntary cornea donors at a large eye bank in Eastern India (PubMed)

Comparison of seropositivity of human immunodeficiency virus, hepatitis B virus, hepatitis C virus, and syphilis among Hospital Cornea Retrieval Programme-Donors versus voluntary cornea donors at a large eye bank in Eastern India To compare the serology profile of donors from Hospital Cornea Retrieval Programme-donors (HCRP-D) and voluntary cornea donors (VC-D) from a large eye bank in Eastern India.This is a retrospective analysis of donor details from January 2011 to December 2016. Donor

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2017 Indian journal of ophthalmology

4. In situ cornea harvesting through the Red Cross Organization: a new approach to relieving severe cornea donor shortage in Chinese eye banks (PubMed)

In situ cornea harvesting through the Red Cross Organization: a new approach to relieving severe cornea donor shortage in Chinese eye banks Corneal diseases are currently the second main cause of blindness in China. Although most of the corneal blindness could be treated by corneal transplantation, only about 10 000 operations were carried out each year owing to the severe shortage of corneal donors and limited eye bank programs. A feasible cornea donation program was established through (...) the organization of the Red Cross, and in situ corneal removal techniques were developed to avoid conflicts with Chinese traditions of keeping the deceased intact. The number of donated corneas, which had a safe and secure quality, increased significantly year by year.

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2017 International journal of ophthalmology

5. A new worm infiltrating the human cornea: A report of three cases (PubMed)

A new worm infiltrating the human cornea: A report of three cases To characterize a new species of parasitic nematode that triggers uveitis.Three previously healthy, relatively young people each contracted a corneal stromal nematode that, upon surgical removal and examination, did not match any known nematodes. Clinical ocular findings included corneal opacification, visible corneal worms, conjunctival injection, and uveitis.The three cases presented here represent a previously undescribed (...) parasitic infection of the cornea by an unidentified nematode. These findings may represent a previously unrecognized zoonotic infection from wildlife sources and potentially a newly documented nematode requiring description. Future clinical findings regarding this newly described nematode are needed to further develop our understanding of the disease.

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2018 American journal of ophthalmology case reports

6. Delayed-onset Candida parapsilosis cornea tunnel infection and endophthalmitis after cataract surgery: Histopathology and clinical course (PubMed)

Delayed-onset Candida parapsilosis cornea tunnel infection and endophthalmitis after cataract surgery: Histopathology and clinical course To describe a patient with late post-operative endophthalmitis and clear cornea tunnel infection caused by Candida parapsilosis that was masquerading as chronic anterior uveitis.A 62-year old woman with history of uncomplicated cataract surgery 7 months prior and chronic postoperative anterior uveitis, presented with an endothelial plaque, hypopyon

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2018 American journal of ophthalmology case reports

7. Case of progressive hyperopia due to flattening of cornea (PubMed)

Case of progressive hyperopia due to flattening of cornea To report a case that had a progressive decrease in the visual acuity caused by a progressive increase in the hyperopia due to a flattening of the cornea.A 50-year-old woman complained of decreased vision in both eyes. Her decimal best-corrected visual acuity was 1.2 in the right and 0.5 in the left eyes, and the refractive error (spherical equivalent) was +3.75 diopters (D) for the right eye and +6.5 D for the left eye. Slit-lamp (...) examinations showed clear corneas but Descemet's folds and fine pigmentations and opacities were present beneath the corneal epithelium in both eyes. Analysis of the corneal shape by anterior segment optical coherence tomography showed that the corneas were flattened, and the corneal refractive power was decreased in both eyes. The large values of the higher-order aberration in the cornea and total eye displayed bilateral irregular astigmatism. She obtained good vision by wearing hard contact lenses

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2018 American journal of ophthalmology case reports

8. CCR2+ migratory macrophages with M1 status are the early-responders in the cornea of HSV-1 infected mice. (PubMed)

CCR2+ migratory macrophages with M1 status are the early-responders in the cornea of HSV-1 infected mice. Complex interactions between HSV-1 and infiltrating immune cells play important roles in establishing localized, acute virus replication as well as chronic latent infection. The extent and duration of initial virus replication are the key determinants of subsequent pathologic inflammatory responses and therefore, the accumulation of immune cell populations at this time point is a key target

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2019 PLoS ONE

9. Correction: Paradox response of cornea to different color intensities of visible light: An experimental study. (PubMed)

Correction: Paradox response of cornea to different color intensities of visible light: An experimental study. [This corrects the article DOI: 10.1371/journal.pone.0196827.].

2019 PLoS ONE

10. University students' knowledge of corneal donation and willingness to donate corneas in the occupied Palestinian territory: a cross-sectional study. (PubMed)

University students' knowledge of corneal donation and willingness to donate corneas in the occupied Palestinian territory: a cross-sectional study. Access to corneal transplantation is limited worldwide because of poor knowledge. Ethical, religious, and cultural barriers contribute to low rates of corneal donation. In the occupied Palestinian territory, limited information is available on factors affecting corneal donation. The aim of this study was to assess the knowledge and willingness (...) %) respondents were aware of a lack in corneal donation, but 274 (64%; p=0·01) of these respondents did not show willingness towards corneal donation. 429 (68%) respondents were not willing to donate their corneas, the most common reasons being disapproval by family members and poor awareness. We found no association between sociodemographic factors and willingness was determined.Palestinian students are aware of the lack of local cornea donation but are unwilling to donate their corneas. The study results

2018 Lancet

11. A case of hypertrophic herpes simplex virus affecting the eyelid and cornea masquerading as IgG4-related disease (PubMed)

A case of hypertrophic herpes simplex virus affecting the eyelid and cornea masquerading as IgG4-related disease To report a case of hypertrophic herpes simplex virus (HSV) of the eyelid and cornea masquerading as IgG4-related disease.A 37-year old African American female with a past medical history of human immunodeficiency virus (HIV) on highly active antiretroviral therapy (HAART) and a recent history of treated genital herpes, presented with an ulcerative lesion of the left upper and lower

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2017 American journal of ophthalmology case reports

12. Angiostrongylus-a technique for removing a rare parasite from the cornea of a child. (PubMed)

Angiostrongylus-a technique for removing a rare parasite from the cornea of a child. We report a case of an Angiostrongylus parasite in the corneal stroma in an 8-year-old boy and our technique for its removal. The parasite was identified on slit-lamp examination. Its location was confirmed on anterior segment optical coherence topography (AS-OCT). The parasite was found on the superficial corneal stroma in the periphery and was removed after lamellar dissection of the cornea following marking

2019 JAAPOS - Journal of the American Association for Pediatric Ophthalmology and Strabismus

13. Opposing Effects of Neuropilin-1 and -2 on Sensory Nerve Regeneration in Wounded Corneas: Role of Sema3C in Ameliorating Diabetic Neurotrophic Keratopathy. (PubMed)

Opposing Effects of Neuropilin-1 and -2 on Sensory Nerve Regeneration in Wounded Corneas: Role of Sema3C in Ameliorating Diabetic Neurotrophic Keratopathy. The diabetic cornea exhibits pathological alterations such as delayed epithelial wound healing and nerve regeneration. We sought to investigate the role of Semaphorin (SEMA) 3C in corneal wound healing and re-innervation in normal and diabetic B6 mice. Wounding induced the expression of SEMA3A, 3C and their receptor Neuropilin (NRP) 2 (...) , but not NRP1 in normal corneal epithelial cells (CECs); this upregulation was suppressed for SEMA3C and NRP2 in diabetic corneas. Injections of Sema3C-specific siRNA and NRP2 neutralizing antibodies in wounded mice resulted in a decrease in the rate of wound healing and regenerating nerve fibers, while exogenous SEMA3C had opposing effects in diabetic corneas. NRP1 neutralization, on the other hand, decreased epithelial wound closure but increased sensory nerve regeneration in diabetic corneas, suggesting

2019 Diabetes

14. Semaphorin3A induces nerve regeneration in the adult cornea-a switch from its repulsive role in development. (PubMed)

Semaphorin3A induces nerve regeneration in the adult cornea-a switch from its repulsive role in development. The peripheral sensory nerves that innervate the cornea can be easily damaged by trauma, surgery, infection or diabetes. Several growth factors and axon guidance molecules, such as Semaphorin3A (Sema3A) are upregulated upon cornea injury. Nerves can regenerate after injury but do not recover their original density and patterning. Sema3A is a well known axon guidance and growth cone (...) repellent protein during development, however its role in adult cornea nerve regeneration remains undetermined. Here we investigated the neuro-regenerative potential of Sema3A on adult peripheral nervous system neurons such as those that innervate the cornea. First, we examined the gene expression profile of the Semaphorin class 3 family members and found that all are expressed in the cornea. However, upon cornea injury there is a fast increase in Sema3A expression. We then corroborated that Sema3A

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2018 PLoS ONE

15. Paradox response of cornea to different color intensities of visible light: An experimental study. (PubMed)

Paradox response of cornea to different color intensities of visible light: An experimental study. The technological development is associated with human daily life and had an impact on its social life. Due to the difficulty of estimating the daily exposure to light; research is needed to determine how much natural and man-made lights could affect the cornea. Visible light radiation could have damaging effect on the human eye; the type and degree of damage are related to the duration

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2018 PLoS ONE

16. Transformation of the Transcriptomic Profile of Mouse Periocular Mesenchyme During Formation of the Embryonic Cornea. (PubMed)

Transformation of the Transcriptomic Profile of Mouse Periocular Mesenchyme During Formation of the Embryonic Cornea. Defects in neural crest development are a major contributing factor in corneal dysgenesis, but little is known about the genetic landscape during corneal development. The purpose of this study was to provide a detailed transcriptome profile and evaluate changes in gene expression during mouse corneal development.RNA sequencing was used to uncover the transcriptomic profile (...) of periocular mesenchyme (pNC) isolated at embryonic day (E) 10.5 and corneas isolated at E14.5 and E16.5. The spatiotemporal expression of several differentially expressed genes was validated by in situ hybridization.Analysis of the whole-transcriptome profile between pNC and embryonic corneas identified 3815 unique differentially expressed genes. Pathway analysis revealed an enrichment of differentially expressed genes involved in signal transduction (retinoic acid, transforming growth factor-β, and Wnt

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2019 Investigative Ophthalmology & Visual Science

17. Brillouin Spectroscopy of Normal and Keratoconus Corneas. (PubMed)

Brillouin Spectroscopy of Normal and Keratoconus Corneas. To investigate the age-dependence of Brillouin spectroscopy of the cornea and to compare normal and keratoconus corneas.Retrospective case-control study STUDY POPULATION: Healthy patients and patients suffering from keratoconus seen at the Institut für Refraktive und Ophthalmo-Chirurgie (IROC) between December 2016 and March 2017.Brillouin frequency shifts of patients of 2 different groups were examined with Brillouin spectroscopy (...) ) with an increase in Brillouin frequency shift of 4MHz per decade in normal corneas. Keratoconus corneas have a significantly reduced Brillouin frequency shift at the thinnest point compared to normal corneas (5.7072 ± 0.0214 vs. 5.7236 ± 0.0146 GHz, p<0.001). The Brillouin frequency shift at the point of maximum posterior elevation showed best correlation with geometry-derived keratoconus indices. The receiver operating characteristic curve analysis of Brillouin frequency shift showed substantially worse

2019 American Journal of Ophthalmology

18. Enhancing Rose Bengal-Photosensitized Protein Crosslinking in the Cornea. (PubMed)

Enhancing Rose Bengal-Photosensitized Protein Crosslinking in the Cornea. Rose bengal (RB)-photosensitized protein crosslinking has been proposed for several applications in the eye. This study identifies oxygen-dependent and oxygen-independent mechanistic pathways in cornea for RB-photosensitized crosslinking to enhance its efficiency for ocular treatments.Rabbit corneas ex vivo were stained with 1 mM RB and irradiated at 532 nm. RB photobleaching, measured by spectrophotometry and linear (...) an efficient electron transfer pathway. Rapid photobleaching was observed below 80 to 120 μm only when arginine was present.These results indicate that RB photosensitizes crosslinking in cornea by both singlet oxygen and electron transfer mechanisms and that adding enhancers may increase the efficiency of this treatment.

2019 Investigative Ophthalmology & Visual Science

19. Overexpression of MMPs in Corneas Requiring Penetrating and Deep Anterior Lamellar Keratoplasty. (PubMed)

Overexpression of MMPs in Corneas Requiring Penetrating and Deep Anterior Lamellar Keratoplasty. Matrix metalloproteinases (MMPs) comprise a family of zinc-dependent endopeptidases involved in wound healing processes, including neovascularization and fibrosis. We assessed MMP protein expression levels in diseased corneas of patients requiring penetrating and deep anterior lamellar keratoplasty. The purpose of this study was to test the hypothesis that upregulation of MMPs in diseased corneas (...) keratoplasty) and 6 normal control corneas.Luminex-based expression analysis revealed a significant overexpression of four of the nine MMPs tested (MMP2, MMP8, MMP12, and MMP13) in patient samples compared to control. Significant overexpression of MMP1, MMP2, MMP8, MMP12, and MMP13 was observed in diseased corneas with neovascularization compared with diseased corneas without neovascularization. Overexpression of MMP1, MMP2, MMP8, MMP12, and MMP13 also corresponded with the levels of corneal fibrosis

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2019 Investigative Ophthalmology & Visual Science

20. Lassa Virus Targeting of Anterior Uvea and Endothelium of Cornea and Conjunctiva in Eye of Guinea Pig Model. (PubMed)

Lassa Virus Targeting of Anterior Uvea and Endothelium of Cornea and Conjunctiva in Eye of Guinea Pig Model. Lassa virus (LASV), a hemorrhagic fever virus endemic to West Africa, causes conjunctivitis in patients with acute disease. To examine ocular manifestations of LASV, we histologically examined eyes from infected guinea pigs. In fatal disease, LASV immunostaining was most prominent in the anterior uvea, especially in the filtration angle, ciliary body, and iris and in and around vessels (...) in the bulbar conjunctiva and peripheral cornea, where it co-localized with an endothelial marker (platelet endothelial cell adhesion molecule). Antigen was primarily associated with infiltration of T-lymphocytes around vessels in the anterior uvea and with new vessel formation at the peripheral cornea. In animals that exhibited clinical signs but survived infection, eyes had little to no inflammation and no LASV immunostaining 6 weeks after infection. Overall, in this model, LASV antigen was restricted

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2019 Emerging Infectious Diseases

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