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Conversion Disorder

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1. Conversion and somatic symptom disorders

psychiatric conditions benefit overall functioning and recovery. Long-term management involves interrupting perpetuating factors, maintaining the same doctor, and providing strategies for self-efficacy, distress tolerance, coping, and modulating the interaction of anxiety, stress, and physical symptoms. Definition Conversion and somatic symptom disorders are psychiatric conditions that fall under the somatic symptoms and related disorders category of the DSM-5. Somatic symptom and related disorders (...) are those with distressing physical symptoms that are not fully explained by other medical, neurological, or psychiatric disorders (also known as somatisation). Conversion disorder is characterised by voluntary motor or sensory function deficits that suggest neurological or medical conditions but are rather associated with clinical findings that are not compatible with such conditions. Somatic symptom disorder is characterised by one or more somatic symptoms that are distressing or result in significant

2018 BMJ Best Practice

2. Group education, night splinting and home exercises reduce conversion to surgery for carpal tunnel syndrome: a multicentre randomised trial Full Text available with Trip Pro

Group education, night splinting and home exercises reduce conversion to surgery for carpal tunnel syndrome: a multicentre randomised trial Group education, night splinting and home exercises reduce conversion to surgery for carpal tunnel syndrome: a multicentre randomised trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable (...) Your RSS Feed Name of RSS Feed: Number of items displayed: Create RSS Cancel RSS Link Copy Actions Cite Share Permalink Copy Page navigation J Physiother Actions . 2020 Apr;66(2):97-104. doi: 10.1016/j.jphys.2020.03.007. Epub 2020 Apr 11. Group education, night splinting and home exercises reduce conversion to surgery for carpal tunnel syndrome: a multicentre randomised trial , , , , , Affiliations Expand Affiliations 1 Occupational Therapy Department, Gold Coast University Hospital, Gold Coast

2020 EvidenceUpdates

3. Association of Initial Disease-Modifying Therapy With Later Conversion to Secondary Progressive Multiple Sclerosis. Full Text available with Trip Pro

Association of Initial Disease-Modifying Therapy With Later Conversion to Secondary Progressive Multiple Sclerosis. Within 2 decades of onset, 80% of untreated patients with relapsing-remitting multiple sclerosis (MS) convert to a phase of irreversible disability accrual termed secondary progressive MS. The association between disease-modifying treatments (DMTs), and this conversion has rarely been studied and never using a validated definition.To determine the association between the use (...) with fingolimod, alemtuzumab, or natalizumab was associated with a lower risk of conversion than initial treatment with glatiramer acetate or interferon beta (HR, 0.66; 95% CI, 0.44-0.99; P = .046); 5-year absolute risk, 7% [16 of 235] vs 12% [46 of 380]; median follow-up, 5.8 years [IQR, 4.7-8.0]). The probability of conversion was lower when glatiramer acetate or interferon beta was started within 5 years of disease onset vs later (HR, 0.77; 95% CI, 0.61-0.98; P = .03; 5-year absolute risk, 3% [4 of 120] vs

2019 JAMA

4. ThermoMixer-Aided Endpoint Quaking-Induced Conversion (EP-QuIC) Permits Faster Sporadic Creutzfeldt-Jakob Disease (sCJD) Identification than Real-Time Quaking-Induced Conversion (RT-QuIC) Full Text available with Trip Pro

ThermoMixer-Aided Endpoint Quaking-Induced Conversion (EP-QuIC) Permits Faster Sporadic Creutzfeldt-Jakob Disease (sCJD) Identification than Real-Time Quaking-Induced Conversion (RT-QuIC) 29695523 2019 02 27 1098-660X 56 7 2018 07 Journal of clinical microbiology J. Clin. Microbiol. ThermoMixer-Aided Endpoint Quaking-Induced Conversion (EP-QuIC) Permits Faster Sporadic Creutzfeldt-Jakob Disease (sCJD) Identification than Real-Time Quaking-Induced Conversion (RT-QuIC). e00423-18 10.1128/JCM

2018 Journal of clinical microbiology

5. Overcoming barriers to the involvement of deafblind people in conversations about research: recommendations from individuals with Usher syndrome Full Text available with Trip Pro

Overcoming barriers to the involvement of deafblind people in conversations about research: recommendations from individuals with Usher syndrome Usher syndrome is the most common cause of deafblindness worldwide and is estimated to affect between 3 and 6 people in every 100,000. Children are born with hearing loss and develop sight loss in their early years of life. A barrier to the involvement and participation of deafblind people in research is access to information in appropriate formats (...) . The degree of sight and hearing impairment experienced by individuals is variable, so there is not a one size fits all solution. We held a research discussion group, that included five people with Usher syndrome, to consider people's accessibility needs for an upcoming research project involving this condition.We have identified a number of considerations for including deafblind people in conversations about research: i) using appropriately sized meeting rooms which offer control over lighting, layout

2018 Research involvement and engagement

6. Prothrombin conversion is accelerated in the antiphospholipid syndrome and insensitive to thrombomodulin Full Text available with Trip Pro

Prothrombin conversion is accelerated in the antiphospholipid syndrome and insensitive to thrombomodulin Antiphospholipid syndrome (APS) is a condition in which the presence of antibodies against phospholipid-binding proteins is associated with thrombophilia and/or pregnancy morbidity. Although antiphospholipid antibodies have anticoagulant characteristics in vitro, they are associated with thromboembolic complications. Thrombin generation (TG) is a sensitive global test of coagulation (...) , and elevated TG is associated with thrombosis. Increased TG can be caused by increased prothrombin conversion, decreased thrombin inactivation, or a combination of both. In this study, we measured TG in APS patients and healthy controls with and without vitamin K antagonist (VKA) treatment at 1 and 5 pM tissue factor and with thrombomodulin. Prothrombin conversion and thrombin inactivation were determined by thrombin dynamics analysis. The TG peak was increased in nontreated APS patients at 1 pM TF

2018 Blood advances

7. Women and Kidney Disease: A Twitter Conversation for One and All Full Text available with Trip Pro

Women and Kidney Disease: A Twitter Conversation for One and All 29988924 2018 11 14 2468-0249 3 4 2018 Jul Kidney international reports Kidney Int Rep Women and Kidney Disease: A Twitter Conversation for One and All. 767-768 10.1016/j.ekir.2018.05.001 McLean Radha R Department of Medicine, College of Physicians and Surgeons at Columbia University, New York, New York, USA. Shirazian Shayan S Columbia University Medical Center, Division of Nephrology, Department of Medicine, College

2018 Kidney international reports

8. Conversion of sleeve gastrectomy to Roux-en-Y gastric bypass in patients with gastroesophageal reflux disease: results of a multicenter study. (Abstract)

Conversion of sleeve gastrectomy to Roux-en-Y gastric bypass in patients with gastroesophageal reflux disease: results of a multicenter study. The main side effect of long-term laparoscopic sleeve gastrectomy is the onset of severe gastroesophageal reflux disease (GERD).The aim of this study was to evaluate the effectiveness of gastric bypass conversion in controlling postsleeve GERD.University Hospital and Private Hospital, France and Private Hospital, Italy.This retrospective multicenter (...) during conversion to bypass (P = .0004). Six months after surgery, 23 of 80 patients maintained reflux symptomatology with a daily frequency, for which continued proton pump inhibitor treatment was required. The persistence of GERD was significantly more frequent among patients with previous gastric banding (n = 19) compared with patients with no history of gastric banding (n = 4, P = .02). In other words, the likelihood of having poor clinical success from conversion of the sleeve to bypass because

2020 Surgery for Obesity and Related Diseases

9. Predictive value of preoperative DeMeester score on conversion to Roux-en-Y gastric bypass for gastroeosophageal reflux disease after sleeve gastrectomy. (Abstract)

Predictive value of preoperative DeMeester score on conversion to Roux-en-Y gastric bypass for gastroeosophageal reflux disease after sleeve gastrectomy. Obesity is well known to increase the risk of gastroesophageal reflux disease (GERD). The impact of sleeve gastrectomy (SG) on GERD is still discussed but seems to be associated with the development of de novo GERD or the exacerbation of preexisting GERD.The objective of this study was to evaluate the impact of preoperative pH monitoring (...) , using the DeMeester score (DMS), on the risk of conversion to Roux-en-Y gastric bypass (RYGB) after SG.University Hospital in Nantes, France.This monocentric study reported the results of a retrospective chart review of 523 obese individuals treated between 2011 and 2018. All patients underwent primary bariatric surgery; 95% had undergone an SG. GERD diagnosis was established with preoperative DMS based on 24-hour esophageal pH monitoring.Preoperative DMS was identified in 423 patients (86%). Sixty

2020 Surgery for Obesity and Related Diseases

10. Online Module Builds Skills for Internal Medicine Interns in Responding to Emotions During Complex Serious Illness Conversations. (Abstract)

Online Module Builds Skills for Internal Medicine Interns in Responding to Emotions During Complex Serious Illness Conversations. Responding to emotion cues is an essential skill for communicating with patients and families, but many health care trainees have difficulty applying this skill within the context of a complex conversation.We created an original online module to facilitate deliberate practice of a three-skill framework for responding to emotion cues during complex or nonlinear (...) information, eliciting information about patient perspective.) CONCLUSION: Our online emotion cue module is a novel tool for deliberate practice of advanced skills for responding to emotion cues in serious illness conversations. In future studies, we will investigate whether our module's efficacy is enhanced by using it as a part of a flipped classroom curriculum with an in-person simulation session.Copyright © 2020 American Academy of Hospice and Palliative Medicine. Published by Elsevier Inc. All rights

2020 Journal of pain and symptom management

11. Predictive validity of conversion from the clinical high risk syndrome to frank psychosis. (Abstract)

Predictive validity of conversion from the clinical high risk syndrome to frank psychosis. Although the clinical high risk for psychosis (CHR) paradigm has become well-established over the past two decades, one key component has received surprisingly little investigative attention: the predictive validity of the criteria for conversion or transition to frank psychosis. The current study evaluates the predictive validity of the transition to psychosis as measured by the Structured Interview (...) for Psychosis-Risk Syndromes (SIPS) in CHR individuals. Participants included 33 SIPS converters and 399 CHR non-converters both from the North American Prodromal Longitudinal Study (NAPLS-2), as well as a sample of 67 separately ascertained first-episode psychosis (FEP) patients from the STEP program. Comparisons were made at baseline and one-year follow-up on demographic, diagnostic stability (SCID), and available measurement domains relating to severity of illness (psychotropic medication, psychosocial

2020 Schizophrenia Research

12. Chest discomfort at night and risk of acute coronary syndrome: cross-sectional study of telephone conversations. (Abstract)

Chest discomfort at night and risk of acute coronary syndrome: cross-sectional study of telephone conversations. During telephone triage, it is difficult to assign adequate urgency to patients with chest discomfort. Considering the time of calling could be helpful.To assess the risk of acute coronary syndrome (ACS) in certain time periods and whether sex influences this risk.Cross-sectional study of 1655 recordings of telephone conversations of patients who called the out-of-hours services (...) primary care (OHS-PC) for chest discomfort. Call time, patient characteristics, symptoms, medical history and urgency allocation of the triage conversations were collected. The final diagnosis of each call was retrieved at the patient's general practice. Absolute numbers of patients with and without ACS were plotted and risks per hour were calculated. The risk ratio of ACS at night (0 to 9 am) was calculated by comparing to the risk at other hours and was adjusted for gender and age.The mean age

2020 Family Practice

13. Intraindividual Neurofilament Dynamics in Serum Mark the Conversion to Sporadic Parkinson's Disease. Full Text available with Trip Pro

Intraindividual Neurofilament Dynamics in Serum Mark the Conversion to Sporadic Parkinson's Disease. With disease-modifying treatment strategies on the horizon, stratification of individual patients at the earliest stages of Parkinson's disease (PD) is key-ideally already at clinical disease onset. Blood levels of neurofilament light chain (NfL) provide an easily accessible fluid biomarker that might allow capturing the conversion from prodromal to manifest PD.We assessed longitudinal serum NfL (...) manifest PD, providing a potential stratification biomarker for individual disease onset in the advent of precision medicine for PD. © 2020 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.© 2020 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.

2020 Movement Disorders

14. α-Synuclein real-time quaking-induced conversion in the submandibular glands of Parkinson's disease patients. (Abstract)

α-Synuclein real-time quaking-induced conversion in the submandibular glands of Parkinson's disease patients. Identification of a peripheral biomarker is a major roadblock in the diagnosis of PD. Immunohistological identification of p-serine 129 α-synuclein in the submandibular gland tissues of PD patients has been recently reported.We report on a proof-of-principle study for using an ultra-sensitive and specific, real-time quaking-induced conversion assay to detect pathological α-synuclein (...) in the submandibular gland tissues of PD patients.The α-synuclein real-time quaking-induced conversion assay was used to detect and quantify pathological α-synuclein levels in PD, incidental Lewy body disease, and control submandibular gland tissues as well as in formalin-fixed paraffin-embedded sections.We determined the quantitative seeding kinetics of pathological α-synuclein present in submandibular gland tissues from autopsied subjects using the α-synuclein real-time quaking-induced conversion assay. A total

2020 Movement Disorders

15. A multipredictor model to predict the conversion of mild cognitive impairment to Alzheimer's disease by using a predictive nomogram. Full Text available with Trip Pro

A multipredictor model to predict the conversion of mild cognitive impairment to Alzheimer's disease by using a predictive nomogram. Predicting the probability of converting from mild cognitive impairment (MCI) to Alzheimer's disease (AD) is still a challenging task. This study aims at providing a personalized MCI-to-AD conversion estimation by using a multipredictor nomogram that integrates neuroimaging features, cerebrospinal fluid (CSF) biomarker, and clinical assessments. To do so, 290 MCI (...) patients were collected from the Alzheimer's Disease Neuroimaging Initiative (ADNI), of whom 76 has converted to AD and 214 remained with MCI. All subjects were randomly divided into a primary and validation cohort. Radiomics signature (Rad-sig) was obtained based on 17 cerebral cortex features selected by using Least Absolute Shrinkage and Selection Operator (LASSO) algorithm. Clinical factors and amyloid-beta peptide (Aβ) concentration were selected by using Spearman correlation between the converted

2020 Neuropsychopharmacology

16. Serious illness care Programme UK: assessing the 'face validity', applicability and relevance of the serious illness conversation guide for use within the UK health care setting. Full Text available with Trip Pro

Serious illness care Programme UK: assessing the 'face validity', applicability and relevance of the serious illness conversation guide for use within the UK health care setting. When doctors have honest conversations with patients about their illness and involve them in decisions about their care, patients express greater satisfaction with care and lowered anxiety and depression. The Serious Illness Care Programme (the Programme), originally developed in the United States (U.S), promotes (...) meaningful, realistic and focused conversations about patient's wishes, fears and worries for the future with their illness. The Serious Illness Conversation Guide (the guide) provides a framework to structure these conversations. The aim of this paper is to present findings from a study to examine the 'face validity', acceptability and relevance of the Guide for use within the United Kingdom (UK) health care setting.A multi-stage approach was undertaken, using three separate techniques: 1. Nominal Group

2019 BMC health services research

17. What relationship do stressful life events, neglect and abuse have with functional neurological disorder (conversion disorder)?

which is comprised of neurologists, psychiatrists, physiotherapists and basic scientists. As a group they use psychophysical and neurophysiological techniques to study motor control and how it is disrupted in common movement disorders such as Parkinson’s disease, dystonia, functional movement disorders, and Tourette’s syndrome. There is a strong clinical and translational component to the work, using the group’s clinical expertise in the diagnosis and treatment of people with movement disorders (...) What relationship do stressful life events, neglect and abuse have with functional neurological disorder (conversion disorder)? Functional neurological disorder (conversion disorder) Search National Elf Service Search National Elf Service » » » » What relationship do stressful life events, neglect and abuse have with functional neurological disorder (conversion disorder)? Mar 9 2018 Posted by Functional neurological disorder (conversion disorder) is a common cause of disabling neurological

2018 The Mental Elf

18. Correction: Evidence of embodied social competence during conversation in high functioning children with autism spectrum disorder. Full Text available with Trip Pro

Correction: Evidence of embodied social competence during conversation in high functioning children with autism spectrum disorder. [This corrects the article DOI: 10.1371/journal.pone.0193906.].

2018 PLoS ONE

19. Evidence of embodied social competence during conversation in high functioning children with autism spectrum disorder. Full Text available with Trip Pro

Evidence of embodied social competence during conversation in high functioning children with autism spectrum disorder. Even high functioning children with Autism Spectrum Disorder (ASD) exhibit impairments that affect their ability to carry out and maintain effective social interactions in multiple contexts. One aspect of subtle nonverbal communication that might play a role in this impairment is the whole-body motor coordination that naturally arises between people during conversation (...) . The current study aimed to measure the time-dependent, coordinated whole-body movements between children with ASD and a clinician during a conversational exchange using tools of nonlinear dynamics. Given the influence that subtle interpersonal coordination has on social interaction feelings, we expected there to be important associations between the dynamic motor movement measures introduced in the current study and the measures used traditionally to categorize ASD impairment (ADOS-2, joint attention

2018 PLoS ONE

20. Accuracy of Rating Scales and Clinical Measures for Screening of Rapid Eye Movement Sleep Behavior Disorder and for Predicting Conversion to Parkinson’s Disease and Other Synucleinopathies Full Text available with Trip Pro

Accuracy of Rating Scales and Clinical Measures for Screening of Rapid Eye Movement Sleep Behavior Disorder and for Predicting Conversion to Parkinson’s Disease and Other Synucleinopathies Rapid eye movement (REM) sleep behavior disorder (RBD) is characterized by repeated episodes of REM sleep-related vocalizations and/or complex motor behaviors. Definite diagnosis of RBD is based on history and polysomnography, both of which are less accessible due to the lack of trained specialists and high (...) cost. While RBD may be associated with disorders like narcolepsy, focal brain lesions, and encephalitis, idiopathic RBD (iRBD) may convert to Parkinson's disease (PD) and other synucleinopathies in more than 80% of patients and it is to date the most specific clinical prodromal marker of PD. Identification of individuals at high risk for development of PD is becoming one of the most important topics for current PD-related research as well as for future treatment trials targeting prodromal PD

2018 Frontiers in neurology

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