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Contusion

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141. A combination of methylprednisolone and quercetin is effective for the treatment of cardiac contusion following blunt chest trauma in rats (PubMed)

A combination of methylprednisolone and quercetin is effective for the treatment of cardiac contusion following blunt chest trauma in rats Cardiac contusion is a potentially fatal complication of blunt chest trauma. The effects of a combination of quercetin and methylprednisolone against trauma-induced cardiac contusion were studied. Thirty-five female Sprague-Dawley rats were divided into five groups (n=7) as follows: sham, cardiac contusion with no therapy, treated with methylprednisolone (30 (...) mg/kg on the first day, and 3 mg/kg on the following days), treated with quercetin (50 mg·kg(-1)·day(-1)), and treated with a combination of methylprednisolone and quercetin. Serum troponin I (Tn-I) and tumor necrosis factor-alpha (TNF-α) levels and cardiac histopathological findings were evaluated. Tn-I and TNF-α levels were elevated after contusion (P=0.001 and P=0.001). Seven days later, Tn-I and TNF-α levels decreased in the rats treated with methylprednisolone, quercetin, and the combination

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2014 Brazilian Journal of Medical and Biological Research

142. Large-Scale Chondroitin Sulfate Proteoglycan Digestion with Chondroitinase Gene Therapy Leads to Reduced Pathology and Modulates Macrophage Phenotype following Spinal Cord Contusion Injury (PubMed)

Large-Scale Chondroitin Sulfate Proteoglycan Digestion with Chondroitinase Gene Therapy Leads to Reduced Pathology and Modulates Macrophage Phenotype following Spinal Cord Contusion Injury Chondroitin sulfate proteoglycans (CSPGs) inhibit repair following spinal cord injury. Here we use mammalian-compatible engineered chondroitinase ABC (ChABC) delivered via lentiviral vector (LV-ChABC) to explore the consequences of large-scale CSPG digestion for spinal cord repair. We demonstrate (...) significantly reduced secondary injury pathology in adult rats following spinal contusion injury and LV-ChABC treatment, with reduced cavitation and enhanced preservation of spinal neurons and axons at 12 weeks postinjury, compared with control (LV-GFP)-treated animals. To understand these neuroprotective effects, we investigated early inflammatory changes following LV-ChABC treatment. Increased expression of the phagocytic macrophage marker CD68 at 3 d postinjury was followed by increased CD206 expression

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2014 The Journal of Neuroscience

143. Spinal cord contusion (PubMed)

Spinal cord contusion Spinal cord injury is a major cause of disability with devastating neurological outcomes and limited therapeutic opportunities, even though there are thousands of publications on spinal cord injury annually. There are two major types of spinal cord injury, transaction of the spinal cord and spinal cord contusion. Both can theoretically be treated, but there is no well documented treatment in human being. As for spinal cord contusion, we have developed an operation

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2014 Neural Regeneration Research

144. Splenic Laceration and Pulmonary Contusion Injury From Bean Bag Weapon (PubMed)

Splenic Laceration and Pulmonary Contusion Injury From Bean Bag Weapon 24672591 2015 10 30 2018 11 13 1936-900X 15 2 2014 Mar The western journal of emergency medicine West J Emerg Med Splenic laceration and pulmonary contusion injury from bean bag weapon. 118-9 10.5811/westjem.2013.10.19900 Patel Amar A Pennsylvania State University, College of Medicine, Hershey, Pennsylvania. Toohey Shannon S University of California Irvine Medical Center, Department of Emergency Medicine, Orange, California (...) . Boysen-Osborn Megan M University of California Irvine Medical Center, Department of Emergency Medicine, Orange, California. eng Case Reports Journal Article United States West J Emerg Med 101476450 1936-900X IM Contusions diagnosis diagnostic imaging etiology Humans Lacerations diagnosis diagnostic imaging etiology Lung Injury diagnosis diagnostic imaging etiology Male Middle Aged Spleen injuries Tomography, X-Ray Computed Wounds, Gunshot diagnosis diagnostic imaging Original DateCompleted: 20140327

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2014 Western Journal of Emergency Medicine

145. Investigation of myocardial contusion with sternal fracture in the emergency department: Multicentre review (PubMed)

Investigation of myocardial contusion with sternal fracture in the emergency department: Multicentre review To describe the use of initial electrocardiogram (ECG), follow-up ECG or equivalent monitoring, and troponin I in patients presenting with sternal fracture who are assessed in emergency departments or by front-line physicians.Multicentre descriptive retrospective study.Two traumatology teaching centres in Quebec city, Que.Fifty-four trauma patients presenting with sternal (...) fracture.Assessment of the use of initial ECG, ECG or equivalent monitoring 6 hours after trauma, and troponin administration.In terms of ECG use, quality comparison criteria were selected on the basis of expert opinions in 4 studies. An initial ECG and a follow-up ECG 6 hours after trauma or cardiac monitoring 6 hours after trauma were recommended by most authors for diagnosing myocardial contusion in cases of sternal fracture. Serum troponin I administered 4 to 8 hours after chest trauma was also recommended

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2014 Canadian Family Physician

146. Intraspinal transplantation of motoneuron-like cell combined with delivery of polymer-based glial cell line-derived neurotrophic factor for repair of spinal cord contusion injury (PubMed)

Intraspinal transplantation of motoneuron-like cell combined with delivery of polymer-based glial cell line-derived neurotrophic factor for repair of spinal cord contusion injury To evaluate the effects of glial cell line-derived neurotrophic factor transplantation combined with adipose-derived stem cells-transdifferentiated motoneuron delivery on spinal cord contusion injury, we developed rat models of spinal cord contusion injury, 7 days later, injected adipose-derived stem cells

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2014 Neural Regeneration Research

147. Overexpression of the Astrocyte Glutamate Transporter GLT1 Exacerbates Phrenic Motor Neuron Degeneration, Diaphragm Compromise, and Forelimb Motor Dysfunction following Cervical Contusion Spinal Cord Injury (PubMed)

Overexpression of the Astrocyte Glutamate Transporter GLT1 Exacerbates Phrenic Motor Neuron Degeneration, Diaphragm Compromise, and Forelimb Motor Dysfunction following Cervical Contusion Spinal Cord Injury A major portion of spinal cord injury (SCI) cases affect midcervical levels, the location of the phrenic motor neuron (PhMN) pool that innervates the diaphragm. While initial trauma is uncontrollable, a valuable opportunity exists in the hours to days following SCI for preventing PhMN loss (...) midcervical (C4) contusion SCI, numbers of GLT1-expressing astrocytes in ventral horn and total intraspinal GLT1 protein expression were reduced soon after injury and the decrease persisted for ≥6 weeks. We used intraspinal delivery of adeno-associated virus type 8 (AAV8)-Gfa2 vector to rat cervical spinal cord ventral horn for targeting focal astrocyte GLT1 overexpression in areas of PhMN loss. Intraspinal delivery of AAV8-Gfa2-GLT1 resulted in transduction primarily of GFAP(+) astrocytes that persisted

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2014 The Journal of Neuroscience

148. Transplantation of Adult Monkey Neural Stem Cells into A Contusion Spinal Cord Injury Model in Rhesus Macaque Monkeys (PubMed)

Transplantation of Adult Monkey Neural Stem Cells into A Contusion Spinal Cord Injury Model in Rhesus Macaque Monkeys Currently, cellular transplantation for spinal cord injuries (SCI) is the subject of numerous preclinical studies. Among the many cell types in the adult brain, there is a unique subpopulation of neural stem cells (NSC) that can self-renew and differentiate into neurons. The study aims, therefore, to explore the efficacy of adult monkey NSC (mNSC) in a primate SCI model.In (...) established behavioral tests for monkeys.Our findings have indicated that mNSCs can facilitate recovery in contusion SCI models in rhesus macaque monkeys. Additional studies are necessary to determine the im- provement mechanisms after cell transplantation.

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2014 Cell Journal (Yakhteh)

149. Progesterone Reduces Secondary Damage, Preserves White Matter, and Improves Locomotor Outcome after Spinal Cord Contusion (PubMed)

Progesterone Reduces Secondary Damage, Preserves White Matter, and Improves Locomotor Outcome after Spinal Cord Contusion Progesterone is an anti-inflammatory and promyelinating agent after spinal cord injury, but its effectiveness on functional recovery is still controversial. In the current study, we tested the effects of chronic progesterone administration on tissue preservation and functional recovery in a clinically relevant model of spinal cord lesion (thoracic contusion). Using magnetic

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2014 Journal of neurotrauma

150. Contusions (Follow-up)

Contusions (Follow-up) Contusions Follow-up: Return to Play, Complications, Prevention Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvODgxNTMtZm9sbG93dXA= processing > Contusions Follow-up Updated: Jul 25, 2018 (...) Author: Michael A Herbenick, MD; Chief Editor: Sherwin SW Ho, MD Share Email Print Feedback Close Sections Sections Contusions Follow-up Return to Play Contusions, in particular quadriceps contusions, [ ] should be observed closely after injury until the hemorrhage has stopped, which usually occurs 24-48 hours after the injury. It is important to consider compartment syndrome or muscle rupture if the pain or girth of the affected area has not stabilized by 48 hours postinjury. See the images below

2014 eMedicine.com

151. Contusions (Diagnosis)

Contusions (Diagnosis) Contusions: Background, Epidemiology, Functional Anatomy Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvODgxNTMtb3ZlcnZpZXc= processing > Contusions Updated: Jul 25, 2018 Author: Michael (...) A Herbenick, MD; Chief Editor: Sherwin SW Ho, MD Share Email Print Feedback Close Sections Sections Contusions Overview Background Muscle contusion indicates a direct, blunt, compressive force to a muscle. Contusions are one of the most common sports-related injuries. [ , , ] The severity of contusions ranges from simple skin contusions to muscle and bone contusions to internal organ contusions. Although all tissue and organ contusions can result from traumatic sports injury, this article focuses

2014 eMedicine.com

152. Contusions (Treatment)

Contusions (Treatment) Contusions Treatment & Management: Acute Phase, Recovery Phase, Maintenance Phase Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvODgxNTMtdHJlYXRtZW50 processing > Contusions Treatment (...) & Management Updated: Jul 25, 2018 Author: Michael A Herbenick, MD; Chief Editor: Sherwin SW Ho, MD Share Email Print Feedback Close Sections Sections Contusions Treatment Acute Phase Rehabilitation Program Physical Therapy In the acute phase following a muscle contusion, hematoma maturation, inflammation, necrosis of damaged myofibrils, and phagocytosis of the necrotic debris are main features. The goal of therapy is to minimize hemorrhage and inflammation and control pain. Limb immobilization with rest

2014 eMedicine.com

153. Contusions (Overview)

Contusions (Overview) Contusions: Background, Epidemiology, Functional Anatomy Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvODgxNTMtb3ZlcnZpZXc= processing > Contusions Updated: Jul 25, 2018 Author: Michael (...) A Herbenick, MD; Chief Editor: Sherwin SW Ho, MD Share Email Print Feedback Close Sections Sections Contusions Overview Background Muscle contusion indicates a direct, blunt, compressive force to a muscle. Contusions are one of the most common sports-related injuries. [ , , ] The severity of contusions ranges from simple skin contusions to muscle and bone contusions to internal organ contusions. Although all tissue and organ contusions can result from traumatic sports injury, this article focuses

2014 eMedicine.com

154. Brain, Contusion

Brain, Contusion Brain Contusion Imaging: Practice Essentials, Computed Tomography, Magnetic Resonance Imaging Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMzM3NzgyLW92ZXJ2aWV3 processing > Brain Contusion (...) Imaging Updated: Apr 24, 2018 Author: Denise L Morales, MD; Chief Editor: James G Smirniotopoulos, MD Share Email Print Feedback Close Sections Sections Brain Contusion Imaging Practice Essentials Brain injury is often defined differently in published reports. Although many authors use the term brain injury to mean acute traumatic damage to the central nervous system (CNS), others use the term head injury, which allows inclusion of skull injuries, fractures, or soft tissue damage to the face or head

2014 eMedicine Radiology

155. The geometry of brain contusion: relationship between site of contusion and direction of injury. (PubMed)

The geometry of brain contusion: relationship between site of contusion and direction of injury. Up to a fifth of Accident and Emergency admissions are head-injury related. Alcohol is involved in a large proportion of adult head injuries and although the incidence of death due to head injury (HI) is relatively low, long-term sequelae including cognitive disturbance are frequent. Contrecoup contusions (CCs) have been observed commonly in closed head injuries and may be an independent factor (...) in long-term neuro-disability. The mechanisms of their formation are still under debate. The aim of this study was to define the relationship between the direction of the blow to the head and the location of brain contusion after HI. The location of scalp injuries was used as a surrogate for the direction of the blow to the head. Between January 2007 and March 2009, 358 cases of HI were treated at the Newcastle Neurosurgery Unit. Of these, 129 had contusions. Of these, 100 scans were available

2011 British Journal of Neurosurgery

156. Femoral and tibial bone contusions following anterior cruciate ligament rupture: a systematic review and meta-analysis of factors affecting detection on MRI

Femoral and tibial bone contusions following anterior cruciate ligament rupture: a systematic review and meta-analysis of factors affecting detection on MRI Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith

2017 PROSPERO

157. Intracranial biomechanics following cortical contusion in live rats. (PubMed)

Intracranial biomechanics following cortical contusion in live rats. The goal of this study was to examine the mechanical properties of living rat intracranial contents and corresponding brain structural alterations following parietal cerebral cortex contusion.After being anesthetized, young adult rats were subjected to parietal craniotomy followed by cortical contusion using a calibrated weight-drop method. Magnetic resonance imaging was used to visualize the contusion. At the site (...) of contusion, instrumented force-controlled indentation was performed 2 hours to 21 days later on the intact dural surface. The force-deformation (stress-strain) relationship was used to calculate elastic (indentation modulus) and strain changes over time, and constant hold or cyclic stress was used to evaluate viscoelastic deformation. These measurements were followed by histological studies.At contusion sites, the indentation modulus was significantly decreased at 1-3 days and tended to be above control

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2013 Journal of Neurosurgery

158. Soft tissue contusion repairing effects of Hong Yao with different penetration enhancers. (PubMed)

Soft tissue contusion repairing effects of Hong Yao with different penetration enhancers. Hong Yao aerosol (HYA) is a new dosage form developed from Hong Yao, a traditional Chinese medicine preparation, which has the efficacy of promoting soft tissue contusion repair, anti-inflammation, and analgesia.To evaluate the soft tissue contusion repairing, anti-inflammatory and analgesic effects of HYA formulations with different penetration enhancers (PE) and to quantify the transdermal absorption (...) of HYA component.Three preparations of HYA with different PEs were made: DMSO preparation (5% DMSO as additional PE), Azone preparation (3% azone as additional PE), and NAPE preparation (no additional PE). Four in vivo rodent models were employed to evaluate the pharmacodynamic effects of the HYAs: mouse soft tissue contusion model, rat paw edema model, mouse ear swelling model, and mouse analgesia model of electric-stimulated foot. In vitro skin penetration experiment was applied to evaluate

2013 Journal of Ethnopharmacology

159. Microstructural basis of contusion expansion in traumatic brain injury: insights from diffusion tensor imaging. (PubMed)

Microstructural basis of contusion expansion in traumatic brain injury: insights from diffusion tensor imaging. Traumatic brain injury (TBI) is often exacerbated by events that lead to secondary brain injury, and represent potentially modifiable causes of mortality and morbidity. Diffusion tensor imaging was used to characterize tissue at-risk in a group of 35 patients scanned at a median of 50 hours after injury. Injury progression was assessed in a subset of 16 patients with two scans. All (...) contusions within the first few days of injury showed a core of restricted diffusion, surrounded by an area of raised apparent diffusion coefficient (ADC). In addition to these two well-defined regions, a thinner rim of reduced ADC was observed surrounding the region of increased ADC in 91% of patients scanned within the first 3 days after injury. In patients who underwent serial imaging, the rim of ADC hypointensity was subsumed into the high ADC region as the contusion enlarged. Overall contusion

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2013 Journal of Cerebral Blood Flow and Metabolism

160. Persistent phosphorylation of NKCC1 and WNK1 in the epicenter of the spinal cord following contusion injury. (PubMed)

Persistent phosphorylation of NKCC1 and WNK1 in the epicenter of the spinal cord following contusion injury. NKCC1 regulates neuronal homeostasis of chloride ions and mediates GABAergic activities in nociceptive processing. WNK1 is an upstream regulator of NKCC1 and acts via SPAK (STE20/SPS1-related proline/alanine-rich kinase) and oxidative stress-responsive kinase 1. NKCC1 activity has been shown to be important in edema formation and nociception following spinal cord injury (SCI (...) ).To determine the role of NKCC1 and WNK1 in spinal cord tissues in the acute and chronic phases following contusional SCI.An experimental study investigating the phosphorylation profile of an important Cl-regulatory protein Na+-K+-Cl- cotransporter 1 (NKCC1) and its regulatory-kinase WNK1 (kinase with-no-lysine).Sprague-Dawley rats underwent a contusive SCI at T9. The epicenter spinal cord tissues were harvested at Days 1, 3, and 7 for acute phase of injury or Days 35 and 42 in the chronic phase of injury

2013 The Spine Journal

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