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Contusion

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9461. Delayed Nogo receptor therapy improves recovery from spinal cord contusion. Full Text available with Trip Pro

Delayed Nogo receptor therapy improves recovery from spinal cord contusion. Myelin-associated inhibitors play a role in limiting axonal growth in the adult central nervous system. Blocking these inhibitors may promote neurological recovery from spinal cord contusion.The soluble Nogo-66 receptor (NgR(310)ecto-Fc) protein, which can neutralize three myelin inhibitors, was infused into rats after spinal cord contusion for 28 days. Treatment was initiated intrathecally at the time of injury or 3

2006 Annals of Neurology

9462. Three exercise paradigms differentially improve sensory recovery after spinal cord contusion in rats. Full Text available with Trip Pro

Three exercise paradigms differentially improve sensory recovery after spinal cord contusion in rats. Spinal cord injury (SCI) induces incapacitating neuropathic pain in the form of allodynia-a painful response to normally non-noxious stimuli. Unfortunately, the underlying mechanisms of these sensory changes are not well understood, and effective treatments for allodynia have proven elusive. We examined whether physical exercise can improve sensory function after experimental SCI by promoting (...) neurotrophin expression in the spinal cord and periphery, which modulates synaptic transmission and function. Female rats with moderate spinal cord contusion participated in treadmill training, swim training, stand training or were untrained. Exercise training began 4 days post surgery, lasted 20-25 min per day, 5 days a week for 7 weeks. Allodynia, as measured using von Frey hairs of different bending forces to the plantar hind paw, developed in the untrained group 3 weeks after SCI. Treadmill training

2004 Brain

9463. A validation of the post concussion symptom scale in the assessment of complex concussion using cognitive testing and functional MRI. Full Text available with Trip Pro

A validation of the post concussion symptom scale in the assessment of complex concussion using cognitive testing and functional MRI. Clinical assessment of cerebral concussion relies on the presence and duration of post concussive symptoms (PCS). Given that these PCS are subjective reports and not always specific to concussion, their usefulness remains to be validated.To evaluate the usefulness of self-reported PCS by means of cognitive tests and functional MRI (fMRI).28 male athletes (...) with and without concussion were grouped according to their PCS score. They were then administered a computerised cognitive test battery and submitted to an fMRI session where cerebral activations associated with verbal and non-verbal working memory tasks were analysed.Behaviourally, response accuracy and speed on the cognitive test battery were comparable for the control and low PCS group. The moderate PCS group showed significantly slower response times than the control group on the matching (p<0.05) and one

2007 Neurosurgery and Psychiatry

9464. Mechanical allodynia following contusion injury of the rat spinal cord is associated with loss of GABAergic inhibition in the dorsal horn. (Abstract)

Mechanical allodynia following contusion injury of the rat spinal cord is associated with loss of GABAergic inhibition in the dorsal horn. The present study investigated whether mechanical allodynia following contusive spinal cord injury (SCI) of the thoracic segments 12 and 13 of the rat was associated with a reduction in gamma-aminobutyric acid (GABA)ergic inhibition adjacent to the site of injury. Five to 7 days following SCI, extracellular recordings were obtained from dorsal horn neurones

2004 Pain

9465. A rat model for isolated bilateral lung contusion from blunt chest trauma. (Abstract)

A rat model for isolated bilateral lung contusion from blunt chest trauma. Lung contusion affects 17%-25% of adult blunt trauma patients, and is the leading cause of death from blunt thoracic injury. A small animal model for isolated bilateral lung contusion has not been developed. We induced lung contusion in anesthetized rats by dropping a 0.3-kg weight onto a precordial protective shield to direct the impact force away from the heart and toward the lungs. Lung injury was characterized (...) as a function of chest impact energy (1.8-2.7 J) by measurements of arterial oxygenation, bronchoalveolar lavage (BAL) albumin and cytology, pressure-volume mechanics, and histopathology. Histology confirmed bilateral lung contusion without substantial cardiac muscle trauma. Rats receiving 2.7 J of chest impact energy had 33% mortality that exceeded prospectively defined limits for sublethal injury. Hypoxemia in rats with maximal sublethal injury (2.45 J) met criteria for acute lung injury at < or =24 h

2005 Anesthesia and Analgesia

9466. Nitric oxide inhalation is useful in the management of right ventricular failure caused by myocardial contusion. (Abstract)

Nitric oxide inhalation is useful in the management of right ventricular failure caused by myocardial contusion. We report a severe head injury and blunt chest trauma with sternal and multiple rib fractures with high-energy impact in a 22-year-old man. Twelve hours after the accident, haemodynamic status of the patient rapidly worsened because of right ventricular (RV) failure due to myocardial contusion, requiring increasing doses of catecholamine. Nitric oxide inhalation was used to decrease

2005 Acta Anaesthesiologica Scandinavica

9467. Cumulative effects associated with recurrent concussion in collegiate football players: the NCAA Concussion Study. Full Text available with Trip Pro

Cumulative effects associated with recurrent concussion in collegiate football players: the NCAA Concussion Study. Approximately 300 000 sport-related concussions occur annually in the United States, and the likelihood of serious sequelae may increase with repeated head injury.To estimate the incidence of concussion and time to recovery after concussion in collegiate football players.Prospective cohort study of 2905 football players from 25 US colleges were tested at preseason baseline in 1999 (...) , 2000, and 2001 on a variety of measures and followed up prospectively to ascertain concussion occurrence. Players injured with a concussion were monitored until their concussion symptoms resolved and were followed up for repeat concussions until completion of their collegiate football career or until the end of the 2001 football season.Incidence of concussion and repeat concussion; type and duration of symptoms and course of recovery among players who were injured with a concussion during

2003 JAMA

9468. Acute effects and recovery time following concussion in collegiate football players: the NCAA Concussion Study. Full Text available with Trip Pro

Acute effects and recovery time following concussion in collegiate football players: the NCAA Concussion Study. Lack of empirical data on recovery time following sport-related concussion hampers clinical decision making about return to play after injury.To prospectively measure immediate effects and natural recovery course relating to symptoms, cognitive functioning, and postural stability following sport-related concussion.Prospective cohort study of 1631 football players from 15 US colleges (...) . All players underwent preseason baseline testing on concussion assessment measures in 1999, 2000, and 2001. Ninety-four players with concussion (based on American Academy of Neurology criteria) and 56 noninjured controls underwent assessment of symptoms, cognitive functioning, and postural stability immediately, 3 hours, and 1, 2, 3, 5, 7, and 90 days after injury.Scores on the Graded Symptom Checklist (GSC), Standardized Assessment of Concussion (SAC), Balance Error Scoring System (BESS

2003 JAMA

9469. The eighth wonder of the world: the mythology of concussion management Full Text available with Trip Pro

The eighth wonder of the world: the mythology of concussion management 10205701 1999 06 09 2018 11 13 0306-3674 33 2 1999 Apr British journal of sports medicine Br J Sports Med The eighth wonder of the world: the mythology of concussion management. 136-7 McCrory P P Olympic Park Sports Medicine Centre, Melbourne, Australia. eng Journal Article England Br J Sports Med 0432520 0306-3674 IM Athletic Injuries complications diagnosis prevention & control therapy Brain Concussion complications

1999 British Journal of Sports Medicine

9470. The nature of concussion: a speculative hypothesis Full Text available with Trip Pro

The nature of concussion: a speculative hypothesis 11375871 2001 08 02 2018 11 13 0306-3674 35 3 2001 Jun British journal of sports medicine Br J Sports Med The nature of concussion: a speculative hypothesis. 146-7 McCrory P P Centre for Sports Medicine Research and Education and the Brain, Research Institute University of Melbourne, Parkville, Victoria, Australia. pmccrory@compuserve.com eng Journal Article England Br J Sports Med 0432520 0306-3674 IM Biomechanical Phenomena Brain Concussion

2001 British Journal of Sports Medicine

9471. Do mouthguards prevent concussion? Full Text available with Trip Pro

Do mouthguards prevent concussion? 11273965 2001 06 28 2018 11 13 0306-3674 35 2 2001 Apr British journal of sports medicine Br J Sports Med Do mouthguards prevent concussion? 81-2 McCrory P P Centre for Sports Medicine Research and Education, University of Melbourne, Parkville, Victoria, Australia 3052. pmccrory@compuserve.com eng Journal Article England Br J Sports Med 0432520 0306-3674 IM Athletic Injuries prevention & control Brain Concussion prevention & control Facial Injuries prevention

2001 British Journal of Sports Medicine

9472. INTERNATIONAL SYMPOSIUM ON CONCUSSION IN SPORT Full Text available with Trip Pro

INTERNATIONAL SYMPOSIUM ON CONCUSSION IN SPORT 11579081 2001 12 04 2018 11 30 0306-3674 35 5 2001 Oct British journal of sports medicine Br J Sports Med International Symposium on Concussion in Sport. Abstracts. 367-77 eng Congress Overall England Br J Sports Med 0432520 0306-3674 IM Br J Sports Med 2002 Jun;36(3):217 Athletic Injuries Brain Concussion Humans 2001 10 2 10 0 2002 1 5 10 1 2001 10 2 10 0 ppublish 11579081 PMC1724376

2001 British Journal of Sports Medicine

9473. Computerised cognitive assessment of concussed Australian Rules footballers Full Text available with Trip Pro

Computerised cognitive assessment of concussed Australian Rules footballers "Paper and pencil" neuropsychological tests play an important role in the management of sports related concussions. They provide objective information on the athlete's cognitive function and thus facilitate decisions on safe return to sport. It has been proposed that computerised cognitive tests have many advantages over such conventional tests, but their role in this domain is yet to be established.To measure cognitive (...) impairment after concussion in a case series of concussed Australian Rules footballers, using both computerised and paper and pencil neuropsychological tests. To investigate the role of computerised cognitive tests in the assessment and follow up of sports related concussions.Baseline measures on the Digit Symbol Substitution Test (DSST), Trail Making Test-Part B (TMT), and a simple reaction time (SRT) test from a computerised cognitive test battery (CogState) were obtained in 240 players. Tests were

2001 British Journal of Sports Medicine

9474. Concussion among Swedish elite ice hockey players. Full Text available with Trip Pro

Concussion among Swedish elite ice hockey players. To evaluate the frequency of concussion in Swedish ice hockey and to establish a uniform grading and treatment model for concussions of different severity.Frequency of concussion was investigated in two studies, one retrospective and one prospective. In the retrospective study, all Swedish elite ice hockey players (n = 265) were asked to answer a questionnaire on the number and treatment of previous concussions. Only concussions diagnosed (...) by a doctor were recorded. The questionnaire was completed by 227 players (86%). In the prospective study, all injuries including concussions occurring during game and practice in the Swedish Elite League (n = 12 teams) were recorded during four years. The causes of injury, referees judgements, diagnosis, treatment, and time absent from ice hockey were registered on special cards.In the retrospective study, 51 out of 227 players (22%) in the Swedish Elite League reported at least one concussion

1996 British Journal of Sports Medicine

9475. Does rugby headgear prevent concussion? Attitudes of Canadian players and coaches Full Text available with Trip Pro

Does rugby headgear prevent concussion? Attitudes of Canadian players and coaches To examine the attitudes of players and coaches to the use of protective headgear, particularly with respect to the prevention of concussion.A questionnaire designed to assess attitudes to headgear was administered to 63 players from four different Canadian teams, each representing a different level of play (high school, university, community club, national). In addition, coaches from all four levels were (...) questioned about team policies and their personal opinions about the use of headgear to prevent concussion.Although the players tended to believe that the headgear could prevent concussion (62%), the coaches were less convinced (33%). Despite the players' belief that headgear offers protection against concussion, only a minority reported wearing headgear (27%) and few (24%) felt that its use should be made mandatory. Common reasons for not wearing headgear were "its use is not mandatory

2002 British Journal of Sports Medicine

9476. Summary and agreement statement of the first International Conference on Concussion in Sport, Vienna 2001* Full Text available with Trip Pro

Summary and agreement statement of the first International Conference on Concussion in Sport, Vienna 2001* 11867482 2002 03 28 2008 11 20 0306-3674 36 1 2002 Feb British journal of sports medicine Br J Sports Med Summary and agreement statement of the First International Conference on Concussion in Sport, Vienna 2001. Recommendations for the improvement of safety and health of athletes who may suffer concussive injuries. 6-10 Aubry M M Division of Neurosurgery, Montreal General Hospital, Quebec (...) , Canada. Cantu R R Dvorak J J Graf-Baumann T T Johnston K K Kelly J J Lovell M M McCrory P P Meeuwisse W W Schamasch P P Concussion in Sport Group eng Consensus Development Conference Journal Article Review England Br J Sports Med 0432520 0306-3674 IM Athletic Injuries diagnosis prevention & control rehabilitation Brain Concussion diagnosis prevention & control rehabilitation Clinical Protocols standards Disability Evaluation Humans Magnetic Resonance Imaging Neuropsychological Tests Protective

2002 British Journal of Sports Medicine

9477. Should we treat concussion pharmacologically? Full Text available with Trip Pro

Should we treat concussion pharmacologically? 11867481 2002 03 28 2014 11 20 0306-3674 36 1 2002 Feb British journal of sports medicine Br J Sports Med Should we treat concussion pharmacologically? The need for evidence based pharmacological treatment for the concussed athlete. 3-5 McCrory P P eng Editorial England Br J Sports Med 0432520 0306-3674 0 Adrenal Cortex Hormones 0 Antioxidants 0 Calcium Channel Blockers 0 Excitatory Amino Acid Antagonists 0 Free Radical Scavengers 0 Monoamine (...) Oxidase Inhibitors 0 Narcotic Antagonists 0 Nerve Growth Factors 27YG812J1I Arachidonic Acid 5Y5F15120W Thyrotropin-Releasing Hormone IM Adrenal Cortex Hormones therapeutic use Antioxidants therapeutic use Arachidonic Acid antagonists & inhibitors Brain Concussion drug therapy physiopathology Calcium Channel Blockers therapeutic use Evidence-Based Medicine Excitatory Amino Acid Antagonists therapeutic use Free Radical Scavengers therapeutic use Humans Hyperbaric Oxygenation Monoamine Oxidase

2002 British Journal of Sports Medicine

9478. The impact of face shield use on concussions in ice hockey: a multivariate analysis Full Text available with Trip Pro

The impact of face shield use on concussions in ice hockey: a multivariate analysis To identify specific risk factors for concussion severity among ice hockey players wearing full face shields compared with half face shields (visors).A prospective cohort study was conducted during one varsity hockey season (1997-1998) with 642 male ice hockey players (median age 22 years) from 22 teams participating in the Canadian Inter-University Athletics Union. Half of the teams wore full face shields (...) practices and games per concussion (2.4 times) than players who wore full face shields (4.07 sessions (95% confidence interval (CI) 3.48 to 4.74) v 1.71 sessions (95% CI 1.32 to 2.18) respectively). Significantly more playing time was lost by players wearing half shields during practices and games, and did not depend on whether the athletes were forwards or defence, rookies or veterans, or whether the concussions were new or recurrent. In addition, players who wore half face shields and no mouthguards

2002 British Journal of Sports Medicine

9479. Are Reliable Change (RC) calculations appropriate for determining the extent of cognitive change in concussed athletes? Full Text available with Trip Pro

Are Reliable Change (RC) calculations appropriate for determining the extent of cognitive change in concussed athletes? 12893731 2003 10 09 2018 11 13 0306-3674 37 4 2003 Aug British journal of sports medicine Br J Sports Med Are Reliable Change (RC) calculations appropriate for determining the extent of cognitive change in concussed athletes? 370-2 Collie A A Maruff P P McStephen M M Darby D D eng Letter England Br J Sports Med 0432520 0306-3674 IM Br J Sports Med. 2005 Aug;39(8):483-7 (...) ; discussion 487-8 16046326 Athletic Injuries psychology Brain Concussion psychology Cognition Disorders diagnosis Data Interpretation, Statistical Humans Neuropsychological Tests Psychometrics 2003 8 2 5 0 2003 10 10 5 0 2003 8 2 5 0 ppublish 12893731 PMC1724689 Circulation. 1982 Mar;65(3):477-84 7055869 Br J Sports Med. 2001 Oct;35(5):297-302 11579059 Orthop Rev. 1986 Sep;15(9):590-5 3453487 J Clin Exp Neuropsychol. 2000 Oct;22(5):622-32 11094397 Br J Sports Med. 2002 Aug;36(4):260-4 12145115 Ann Thorac

2003 British Journal of Sports Medicine

9480. Psychometric issues associated with computerised neuropsychological assessment of concussed athletes Full Text available with Trip Pro

Psychometric issues associated with computerised neuropsychological assessment of concussed athletes Psychometric issues associated with computerised neuropsychological assessment in sports concussion are put forward. Issues critical to ensuring test reliability and sensitivity are discussed, with particular reference to how inappropriate test design can affect clinical decision making.

2003 British Journal of Sports Medicine

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