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9121. A prospective, randomized, double-blind trial of the use of fibrin sealant for face lifts. (Abstract)

, 55). The side treated with fibrin glue had a median drainage of 10 ml and the control side 30 ml. The Wilcoxon signed rank test shows a significant difference in drainage between sides (p = 0.002). The reduction in postoperative drainage could also reduce pain and bruising, increasing patient satisfaction with this procedure. The need for drains may also be obviated.

2001 Plastic and reconstructive surgery Controlled trial quality: uncertain

9122. Multicentre, prospective, randomized trial of 4 vs. 6 French catheters in 410 patients undergoing coronary angiography. (Abstract)

< 0.05). Patients who had 4 Fr angiography mobilized safely at 1 hr and reported significantly less discomfort and bruising than 6 Fr patients. Good-quality diagnostic coronary angiograms can be achieved using 4 Fr catheters with the advantage of earlier postprocedural mobilization and reduced discomfort and bruising for the patient.Copyright 2001 Wiley-Liss, Inc.

2001 Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions Controlled trial quality: uncertain

9123. Improved safety with equivalent asthma control in adults with chronic severe asthma on high-dose fluticasone propionate. (Abstract)

control. Serum osteocalcin and the pyridinoline:creatinine ratio, as well as the deoxypyridinoline:creatinine ratio, were also shown to increase only in the FP group. Subjective assessments such as quality of life score, the incidence and ease of bruising, and reports of hoarseness also favoured the FP group.It is concluded that, at the doses studied and with the delivery devices used clinically, FP is at least as effective as BDP/BUD in the management of severe asthma and may offer clinical

2001 Respirology (Carlton, Vic.) Controlled trial quality: uncertain

9124. Use of Arnica to relieve pain after carpal-tunnel release surgery. (Abstract)

Use of Arnica to relieve pain after carpal-tunnel release surgery. Arnica is commonly used by the public as a treatment for bruising and swelling.To assess whether Arnica administration affects recovery from hand surgery.Double-blind, randomized comparison of Arnica administration versus placebo.Specialist hand surgery unit at the Queen Victoria NHS Trust.Thirty-seven patients undergoing bilateral endoscopic carpal-tunnel release between June 1998 and January 2000.Homeopathic Arnica tablets

2002 Alternative Therapies in Health & Medicine Controlled trial quality: uncertain

9125. Efficacy and safety of topical hirudin (Hirudex): a double-blind, placebo-controlled study. (Abstract)

Efficacy and safety of topical hirudin (Hirudex): a double-blind, placebo-controlled study. Hirudin, a thrombin inhibitor isolated from the leech Hirudo medicinalis, has been long known for its anticoagulant effects. In 1990, the former German BGA has published a monograph on Hirudo medicinalis extract (containing Hirudin and Eglin), stating that its local use is indicated in bruises with or without hematoma. The aim of this double-blind, placebo-controlled clinical trial was to evaluate (...) the efficacy and safety of a Hirudin-containing cream (Hirudex cream; Hirudo medicinalis extract 280 UI/100 g) in patients affected with bruises with or without hematoma. 60 men and women between the ages of 18 and 65 years with a unilateral acute musculoskeletal injury (bruise) with or without hematoma were included. Dosage schedule and application route for both treatments were the following: 3-4 daily applications for 5 days for a total of 15-20 administrations during the whole study period

2002 European review for medical and pharmacological sciences Controlled trial quality: uncertain

9126. A randomised controlled clinical trial of antibiotic impregnation of testosterone pellet implants to reduce extrusion rate. (Abstract)

-group, open-label study design in a single centre. One hundred and eighty-six androgen-deficient men (400 implantation procedures) were randomised into either a group who had their pellets soaked for approximately 2 min in gentamicin solution prior to implantation, or a control group who had the standard implantation procedure.Extrusion, infection and/or bruising were evaluated prospectively by self-report from the participants, and retrospectively at subsequent implantation. Other variables (site (...) , shaving, skin preparation, operator, pellet batch, bruising) were collected at implantation time.The extrusion rate was 20% lower (odds ratio=0.80, 95% confidence interval (CI) 0.40-1.62) but not statistically different between the two groups (extrusion rate 23/205 (11.2%) for the control group vs 18/195 (9.2%) for the antibiotic-soak group, P=0.42). One operator experienced more total (P=0.0002) and infection-related (P=0.0008) extrusions and marginally more bruising (P=0.06) than other operators

2002 European journal of endocrinology / European Federation of Endocrine Societies Controlled trial quality: predicted high

9127. Evaluation of the ThinkFirst Canada, Smart Hockey, brain and spinal cord injury prevention video. Full Text available with Trip Pro

, competitive 11-12 year old male ice hockey players and hockey team coaches.The Smart Hockey video was shown to experimental teams at mid-season. An interview was conducted with coaches to understand reasons to accept or refuse the injury prevention video.A test of concussion knowledge was administered before, immediately after, and three months after exposure to the video. The incidence of aggressive penalties was measured before and after viewing the video.The number of causes and mechanisms (...) of concussion named by players increased from 1.13 to 2.47 and from 0.67 to 1.22 respectively. This effect was maintained at three months. There was no significant change in control teams. There was no significant change in total penalties after video exposure; however, specific body checking related penalties were significantly reduced in the experimental group.This study showed some improvements in knowledge and behaviours after a single viewing of a video; however, these findings require confirmation

2003 Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention Controlled trial quality: uncertain

9128. A prospective, open, randomized clinical study to assess the efficacy and safety of two gonadotropin preparations administered in WHO Group II anovulatory subfertile women. (Abstract)

offered unless conception or severe adverse reaction occurred. The presence of redness, swelling, bruising and pain of the injection sites was noted and compared.Seven patients became pregnant (3 in the Metrodin group and 4 in the Metrodin HP group) and the pregnancy rates per patient and per cycle were 7/20 (35%) and 7/45 (15.6%), respectively. No local reactions were found in the majority of cycles. There was no significant difference in pregnancy rates and the number of cycles complicated by bruise

1998 The journal of obstetrics and gynaecology research Controlled trial quality: uncertain

9129. Postoperative compression after breast augmentation. (Abstract)

Postoperative compression after breast augmentation. In a randomized study of 130 patients undergoing breast augmentation, postoperative compression did not reduce the frequency of postoperative bruising or hematoma formation, and 37.5% of the 64 patients having compression had complaints regarding their use. Postoperative compression is of no value after breast augmentation.

2001 Aesthetic plastic surgery Controlled trial quality: uncertain

9130. Influence of implantation site and track geometry on the extrusion rate and pharmacology of testosterone implants. (Abstract)

of a four-track abdominal site. Additionally, the study aimed to evaluate the effects of site and track geometry on other adverse effects (bruising, infection) and the pharmacology of testosterone release from the implants.A prospective, parallel-group unmasked study design in a single centre. The primary objective was to evaluate sites, with evaluation of track geometry a subordinate objective made necessary by anatomical differences. Accordingly, androgen deficient men requiring testosterone (...) procedure, and secondary end-points (bruising or infection post procedure) were evaluated prospectively by self-report from the participants, and verified when they returned next for implantation. The pharmacology substudy involved monthly blood sampling for hormone (total and free testosterone, LH, FSH) measurements.The extrusion rate was significantly higher [odds ratio (OR) = 2.6, 95% confidence interval (CI) 1.1-7.1] for the hip site (15/125, 12%) compared with the abdominal site (6/121, 5%). Track

2001 Clinical endocrinology Controlled trial quality: uncertain

9131. Surgical stabilization of internal pneumatic stabilization? A prospective randomized study of management of severe flail chest patients. (Abstract)

the groups.Age, sex, Injury Severity Score, chest Abbreviated Injury Score, number of rib fractures, severity of lung contusion, and Pao2/Fio2 ratio at admission were all equivalent in the two groups. The S group showed a shorter ventilatory period (10.8 +/- 3.4 days) than the I group (18.3 +/- 7.4 days) (p < 0.05), shorter intensive care unit stay (S group, 16.5 +/- 7.4 days; I group, 26.8 +/- 13.2 days; p < 0.05), and lower incidence of pneumonia (S group, 24%; I group, 77%; p < 0.05). Percent forced vital

2002 Journal of Trauma Controlled trial quality: uncertain

9132. Dosing in heavy-weight/obese patients with the LMWH, tinzaparin: a pharmacodynamic study. (Abstract)

, indicating that tinzaparin pharmacodynamics are not influenced by body weight or BMI. The range of AUA and Amax values in the study population overlapped that of historical control normal-weight subjects (<100 kg), indicating that weight-adjusted tinzaparin dosing yields a predictable response regardless of body weight or BMI. Tinzaparin was well tolerated, although injection site bruising was commonly reported. SC tinzaparin dosing in heavy or obese patients is appropriate based on body weight alone

2002 Thrombosis and haemostasis Controlled trial quality: uncertain

9133. Does heparin prophylaxis prevent exacerbations of hereditary angioedema? (Abstract)

specifically related to the injection process itself (tenderness, bruising, redness, pain, and itching at the injection site). The injection treatment was also associated with a larger overall number of reported adverse events (70 vs 48 in the placebo treatment). Tenderness and bruising at the injection site were entirely confined to the injected heparin treatment.Injected and inhaled heparin failed to attenuate average flare intensity, the primary endpoint, compared with placebo. Interestingly, after

2002 The Journal of allergy and clinical immunology Controlled trial quality: predicted high

9134. Exposure to pulsed magnetic fields enhances motor recovery in cats after spinal cord injury. (Abstract)

Exposure to pulsed magnetic fields enhances motor recovery in cats after spinal cord injury. Animal model study of eight healthy commercial cats was conducted.To determine whether pulsed electromagnetic field (PMF) stimulation results in improvement of function after contusive spinal cord injury in cats.PMF stimulation has been shown to enhance nerve growth, regeneration, and functional recovery of peripheral nerves. Little research has been performed examining the effects of PMF stimulation (...) on the central nervous system and no studies of PMF effects on in vivo spinal cord injury (SCI) models have been reported.PMF stimulation was noninvasively applied for up to 12 weeks to the midthoracic spine of cats with acute contusive spinal cord injury. The injury was produced using a weight-drop apparatus. Motor functions were evaluated with the modified Tarlov assessment scale. Morphologic analyses of the injury sites and somatosensory-evoked potential measurements were conducted to compare results

2003 Spine

9135. Atlantooccipital distraction: a diagnostic and therapeutic dilemma: report of two cases. (Abstract)

driver. Both patients were found to have severe atlantooccipital distraction on the lateral topogram of the computed tomography. In both cases, the initial MRI of the craniocervical junction failed to show medullary contusion. The diagnosis of severe medullary contusion was made by follow-up MRI performed 48 hours later.Both patients were treated initially with halo vest. Patient 1 survived the injury with tetraplegia and was referred to a spinal center for rehabilitation. At this writing, he

2003 Spine

9136. Cerebral energy metabolism during transient hyperglycemia in patients with severe brain trauma. (Abstract)

pressure. One microdialysis catheter was inserted via a burr hole frontally to that used for the intraventricular catheter ("better" position). In patients with focal lesions one or more catheters were inserted into cerebral cortex surrounding an evacuated focal contusion or underlying an evacuated hematoma ("worse" position). Perfusion rate was 0.3 micro l/min and samples were taken every 30 or 60 min. The levels of glucose, pyruvate, lactate, glutamate, and glycerol were analyzed and displayed

2003 Intensive Care Medicine

9137. Moderate hypothermia may be detrimental after traumatic brain injury in fentanyl-anesthetized rats. (Abstract)

. Secondary outcome variables were physiologic variables monitored during the first 2 hrs after traumatic brain injury and plasma catecholamine and serum fentanyl concentrations measured at the end of both hypothermia and rewarming (1 and 2 hrs after traumatic brain injury). Contusion volume was larger in hypothermic vs. normothermic rats (44.3 +/- 4.2 vs. 28.6 +/- 4.0 mm, p <.05), but hippocampal neuronal survival did not differ between groups. Physiologic variables did not differ between groups. Plasma

2003 Critical Care Medicine

9138. Effects of early and late intravenous norepinephrine infusion on cerebral perfusion, microcirculation, brain-tissue oxygenation, and edema formation in brain-injured rats. (Abstract)

, pericontusional cortical perfusion was measured using the laser Doppler flowmetry scanning technique before injury and before, during, and after the infusion period. In a second series, intracranial and cerebral perfusion pressure and intraparenchymal perfusion and tissue oxygen measured within the contused and pericontusional cortex were recorded continuously before, during, and after norepinephrine infusion. Changes in cortical microcirculation were investigated by orthogonal polarization spectral imaging

2003 Critical Care Medicine

9139. Functional evaluation by quantitative dimercaptosuccinic Acid scintigraphy after kidney trauma in children. (Abstract)

was compared with that of a normal kidney in a control patient (mean 19.1% +/- 4.2% versus 19.5% +/- 3.7%, not significant). Creatinine clearance was normal in each patient. DISCUSSION A renal contusion always induces parenchymal loss. Major kidney trauma has significant consequences on the opposite side. At 6 months the presumably uninjured contralateral kidney may be limited in its ability to compensate through hypertrophy, which worsens the global renal functional prognosis of a traumatic but initially

2003 Journal of Urology

9140. Alcohol intoxication increases allopregnanolone levels in female adolescent humans. Full Text available with Trip Pro

adolescents. Blood samples were drawn from female adolescents who arrived at the emergency department. One study group was formed by those who arrived with evident behavioral symptoms of AAI and the other by those arriving for mild trauma (contusions, sprains) after no consumption of alcohol (controls). Our results demonstrate that AAI significantly increases serum progesterone and allopregnanolone levels in both follicular and luteal phases of the ovarian cycle. Since alcohol and allopregnanolone

2003 Neuropsychopharmacology

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