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Contusion

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61. Traumatic Transient Herniation Concomitant with Tonsillar Hemorrhagic Contusion in a Child (PubMed)

Traumatic Transient Herniation Concomitant with Tonsillar Hemorrhagic Contusion in a Child Downward displacement of cerebellar tonsils more than 5 mm below the foramen magnum is named as Chiari type I malformation and named benign tonsillar ectopia if herniation is less than 3 mm. It does not just depend on congenital causes. There are also some reasons for acquired Chiari Type 1 and benign tonsillar ectopia/herniation. Trauma is one of them. Trauma may increase tonsillar ectopia or may (...) be the cause of new-onset Chiari type 1. The relationship between the tonsil contusion and its position is unclear. We present a case of pediatric age group with tonsillar herniation with a hemorrhagic contusion. Only 1 case has been presented so far in the literature. A case with unilateral tonsil contusion has not been presented to date. We will discuss the possible reasons for taking the place of the tonsils to the above level of the foramen magnum in the follow-up period, by looking at the literature.

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2017 Open access Macedonian journal of medical sciences

62. Pulmonary Contusion and Flail Chest, Management of

Pulmonary Contusion and Flail Chest, Management of Pulmonary Contusion and Flail Chest, Management of - Practice Management Guideline Search » Pulmonary Contusion and Flail Chest, Management of Published 2012 Citation: Authors Simon, Bruce MD; Ebert, James MD; Bokhari, Faran MD; Capella, Jeannette MD; Emhoff, Timothy MD; Hayward, Thomas III MD; Rodriguez, Aurelio MD; Smith, Lou MD Author Information From the Division of Trauma and Critical Care (B.S., T.E.), University of Massachusetts Medical (...) Simon, MD, UMass Memorial Medical Center, Worcester, MA. Statement of Problem Thoracic injury and the ensuing complications are responsible for as much as 25% of blunt trauma mortality. [1] Pulmonary contusion (PC) in turn is the most common injury identified in the setting of blunt thoracic trauma, occurring in 30% to 75% of all cases. [1] Isolated PC may occur consequent to explosion injury, but most patients with multiple injuries have concurrent injury to the chest wall. [2] Conversely, flail

2012 Eastern Association for the Surgery of Trauma

63. Delayed diagnosis of single compartment muscle contusion after radical hysterectomy in the lithotomy position: A case report (PubMed)

Delayed diagnosis of single compartment muscle contusion after radical hysterectomy in the lithotomy position: A case report Muscle contusions usually occur as a result of blunt trauma, which damages the muscle fibers and connective tissue without breaking the skin. Rapid bleeding can cause an increase in pressure that requires surgical intervention, commonly referred to as compartment syndrome. Here, we report a case with delayed diagnosis of single compartment muscle contusion in which (...) the lithotomy position during surgery, muscle contusion might occur, without general symptoms.Magnetic resonance imaging is useful for diagnosis. For patients who complain of edema and tenderness in the lower leg after surgery in the lithotomy position, muscle contusions should be considered.Copyright © 2016 The Author(s). Published by Elsevier Ltd.. All rights reserved.

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2016 International journal of surgery case reports

64. Valproic acid preserves motoneurons following contusion in organotypic spinal cord slice culture (PubMed)

Valproic acid preserves motoneurons following contusion in organotypic spinal cord slice culture Spinal cord injury (SCI) is a devastating condition causing neuronal loss. A key challenge in treatment of SCI is how to retain neurons after injury. Valproic acid (VPA) is a drug recently has been appreciated for its neuroprotective and neurotrophic properties in various SCI models. In this study the role of VPA was assessed in organotypic spinal cord slice culture following the contusion.The

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2016 The journal of spinal cord medicine

65. Aberrant LncRNA Expression Profile in a Contusion Spinal Cord Injury Mouse Model (PubMed)

Aberrant LncRNA Expression Profile in a Contusion Spinal Cord Injury Mouse Model Long noncoding RNAs (LncRNAs) play a crucial role in cell growth, development, and various diseases related to the central nervous system. However, LncRNA differential expression profiles in spinal cord injury are yet to be reported. In this study, we profiled the expression pattern of LncRNAs using a microarray method in a contusion spinal cord injury (SCI) mouse model. Compared with a spinal cord without injury (...) in a contusion SCI mouse model.

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2016 BioMed research international

66. Differential Histopathological and Behavioral Outcomes Eight Weeks after Rat Spinal Cord Injury by Contusion, Dislocation, and Distraction Mechanisms (PubMed)

Differential Histopathological and Behavioral Outcomes Eight Weeks after Rat Spinal Cord Injury by Contusion, Dislocation, and Distraction Mechanisms The objective of this study was to compare the long-term histological and behavioral outcomes after spinal cord injury (SCI) induced by one of three distinct biomechanical mechanisms: dislocation, contusion, and distraction. Thirty male Sprague-Dawley rats were randomized to incur a traumatic cervical SCI by one of these three clinically relevant (...) but spared the most myelinated axons overall. Contusion caused the most severe loss of myelinated axons in the dorsal white matter. Immunohistochemistry for the neuronal marker NeuN combined with Fluoro Nissl revealed that the dislocation mechanism resulted in the greatest neuronal cell losses in both the ventral and dorsal horns. After the distraction injury mechanism, animals displayed no recovery of grip strength over time, in contrast to the animals subjected to contusion or dislocation injuries

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2016 Journal of neurotrauma

67. Relating Histopathology and Mechanical Strain in Experimental Contusion Spinal Cord Injury in a Rat Model (PubMed)

Relating Histopathology and Mechanical Strain in Experimental Contusion Spinal Cord Injury in a Rat Model During traumatic spinal cord injury (SCI), the spinal cord is subject to external displacements that result in damage of neural tissues. These displacements produce complex internal deformations, or strains, of the spinal cord parenchyma. The aim of this study is to determine a relationship between these internal strains during SCI and primary damage to spinal cord gray matter (GM (...) ) in an in vivo rat contusion model. Using magnetic resonance imaging and novel image registration methods, we measured three-dimensional (3D) mechanical strain in in vivo rat cervical spinal cord (n = 12) during an imposed contusion injury. We then assessed expression of the neuronal transcription factor, neuronal nuclei (NeuN), in ventral horns of GM (at the epicenter of injury as well as at intervals cranially and caudally), immediately post-injury. We found that minimum principal strain was most strongly

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2016 Journal of neurotrauma

68. Imaging Mass Spectrometry Reveals Loss of Polyunsaturated Cardiolipins in the Cortical Contusion, Hippocampus and Thalamus after Traumatic Brain Injury (PubMed)

Imaging Mass Spectrometry Reveals Loss of Polyunsaturated Cardiolipins in the Cortical Contusion, Hippocampus and Thalamus after Traumatic Brain Injury Traumatic brain injury (TBI) leads to changes in ion fluxes, alterations in mitochondrial function, and increased generation of reactive oxygen species, resulting in secondary tissue damage. Mitochondria play important signaling roles in coordination of multiple metabolic platforms in addition to their well-known role in bioenergetics

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2016 Journal of neurochemistry

69. Diffusion-Weighted Magnetic Resonance Imaging Characterization of White Matter Injury Produced by Axon-Sparing Demyelination and Severe Contusion Spinal Cord Injury in Rats (PubMed)

Diffusion-Weighted Magnetic Resonance Imaging Characterization of White Matter Injury Produced by Axon-Sparing Demyelination and Severe Contusion Spinal Cord Injury in Rats Alterations in magnetic resonance imaging (MRI)-derived measurements of water diffusion parallel (D∥) and perpendicular (D⊥) to white matter tracts have been specifically attributed to pathology of axons and myelin, respectively. We test the hypothesis that directional diffusion measurements can distinguish between axon (...) -sparing chemical demyelination and severe contusion spinal cord white matter injury. Adult rats received either unilateral ethidium bromide (EB) microinjections (chemical demyelination) into the lateral funiculus of the spinal cord at C5 or were subjected to unilateral severe contusion spinal cord injury (SCI). Diffusion MRI metrics in the lateral funiculus were analyzed at early and late time-points following injury and correlated with histology. Early EB-demyelination resulted in a significant

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2016 Journal of neurotrauma

70. Mitigation of sensory and motor deficits by acrolein scavenger phenelzine in a rat model of spinal cord contusive injury (PubMed)

Mitigation of sensory and motor deficits by acrolein scavenger phenelzine in a rat model of spinal cord contusive injury Currently there are no effective therapies available for the excruciating neuropathic pain that develops after spinal cord injuries (SCI). As such, a great deal of effort is being put into the investigation of novel therapeutic targets that can alleviate this pain. One such target is acrolein, a highly reactive aldehyde produced as a byproduct of oxidative stress

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2016 Journal of neurochemistry

71. Hemodynamic Instability after Low-Energy Thigh Contusion Caused by Injury to the Femoral Artery: A Case Report and Literature Review (PubMed)

Hemodynamic Instability after Low-Energy Thigh Contusion Caused by Injury to the Femoral Artery: A Case Report and Literature Review Acute vascular injuries have been described in relation to high-energy trauma accidents or in patients undergoing surgery in the femoral area. We describe a healthy patient who sustained a direct, low-energy contusion in the thigh and presented haemodynamic instability. Arteriography was used to locate the point of bleeding, and embolisation and vessel occlusion

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2016 Case reports in orthopedics

72. Toll Like Receptor-9 (TLR9) Is Requisite for Acute Inflammatory Response and Injury Following Lung Contusion (PubMed)

Toll Like Receptor-9 (TLR9) Is Requisite for Acute Inflammatory Response and Injury Following Lung Contusion Lung contusion (LC) is a significant risk factor for the development of acute respiratory distress syndrome. Toll-like receptor 9 (TLR9) recognizes specific unmethylated CpG motifs, which are prevalent in microbial but not vertebrate genomic DNA, leading to innate and acquired immune responses. TLR9 signaling has recently been implicated as a critical component of the inflammatory

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2016 Shock (Augusta, Ga.)

73. Clonidine Reduces Norepinephrine and Improves Bone Marrow Function in a Rodent Model of Lung Contusion, Hemorrhagic Shock and Chronic Stress (PubMed)

Clonidine Reduces Norepinephrine and Improves Bone Marrow Function in a Rodent Model of Lung Contusion, Hemorrhagic Shock and Chronic Stress Propranolol has been shown previously to restore bone marrow function and improve anemia after lung contusion/hemorrhagic shock. We hypothesized that daily clonidine administration would inhibit central sympathetic outflow and restore bone marrow function in our rodent model of lung contusion/hemorrhagic shock with chronic stress.Male Sprague-Dawley rats (...) underwent 6 days of restraint stress after lung contusion/hemorrhagic shock during which the animals received clonidine (75 μg/kg) after the restraint stress. On postinjury day 7, we assessed urine norepinephrine, blood hemoglobin, plasma granulocyte colony stimulating factor, and peripheral blood mobilization of hematopoietic progenitor cells, as well as bone marrow cellularity and erythroid progenitor cell growth.The addition of clonidine to lung contusion/hemorrhagic shock with chronic restraint

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2016 Surgery

74. The diagnostic value of serum pentraxin 3 levels in pulmonary contusion. (PubMed)

The diagnostic value of serum pentraxin 3 levels in pulmonary contusion. To investigate the difference in pentraxin 3 (PTX 3) levels between patients with pulmonary contusion and healthy volunteers.This study was conducted with a group of 20 trauma patients diagnosed with pulmonary contusion and 30 healthy individuals enrolled as a control group in a tertiary university hospital.Median PTX 3 levels were 7.05 (3.29-13.1), ng/ml in the contusion group and 1.03 (0.7-1.58) ng/ml in the control (...) group. PTX 3 titers were significantly higher in patients with pulmonary contusion compared to those of the control group (p<0.001). An area under the curve (AUC) value of 0.968 investigated using ROC analysis to determine the diagnostic value of the PTX-3 in pulmonary contusion patients was measured. A PTX-3 cut-off value of 2.06 produced 95.5% sensitivity and 86.7% specificity.PTX 3 levels in pulmonary contusion increased significantly compared to the healthy control group. If supported by wider

2016 American Journal of Emergency Medicine

75. Pulmonary Contusion and Traumatic Pneumatoceles in a Platform Diver with Hemoptysis. (PubMed)

Pulmonary Contusion and Traumatic Pneumatoceles in a Platform Diver with Hemoptysis. Injuries in divers resulting purely from impact with the water are uncommon in the published literature. We present a case report of pulmonary contusion in a young diver.A young, healthy competitive platform diver landed flat on his back in the water from a dive of 10 meters. He complained of upper back pain and had an episode of hemoptysis after the dive. He was initially observed for 15 hours postinjury (...) , and was discharged when three chest radiographs (CXRs) taken at 1, 7, and 11 hours postinjury did not show significant abnormalities. Thirty-six hours postinjury, the patient experienced repeat hemoptysis and returned to the emergency department, where a fourth CXR performed 43 hours postinjury was normal. A computed tomography (CT) scan revealed pulmonary contusion and traumatic subpleural pneumatoceles. The patient was admitted to the cardiothoracic ward for observation. He recovered well with conservative

2016 Journal of Emergency Medicine

76. Investigation of surfactant protein-D and interleukin-6 levels in patients with blunt chest trauma with multiple rib fractures and pulmonary contusions: a cross-sectional study in Black Sea Region of Turkey. (PubMed)

Investigation of surfactant protein-D and interleukin-6 levels in patients with blunt chest trauma with multiple rib fractures and pulmonary contusions: a cross-sectional study in Black Sea Region of Turkey. Multiple rib fractures (RFs) and pulmonary contusions (PCs), with resulting systemic lung inflammation, are the most common injuries caused by blunt chest trauma (BCT) in motor vehicle accidents. This study examined levels of the inflammation marker interleukin (IL)-6 and those of the acute

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2016 BMJ open

77. Factors Predicting Lung Contusions in Critically Ill Trauma Children: A Multivariate Analysis of 330 Cases. (PubMed)

Factors Predicting Lung Contusions in Critically Ill Trauma Children: A Multivariate Analysis of 330 Cases. The aim of the study was to identify factors predicting lung contusion in trauma children.Retrospective study conducted for a period of 8 years (January 01, 2005-December 31, 2012) in a medical surgical intensive care unit. All trauma patients younger than 15 years were included. Two groups were compared: those with lung contusions (C+ group) and those without lung contusions (C- group (...) ).We included 330 patients. The mean (SD) age was 7.6 (4.3) years. Chest injury was diagnosed in 70 patients (21.2%). All our patients needed mechanical ventilation. Lung contusions were diagnosed in 43 patients (13% of all patients and 61.4% of patients with chest trauma). In multivariate analysis, independent factors predicting lung contusion were road traffic accident (odds ratio [OR], 3.2; 95% confidence interval [CI], 1.2-8.6; P = 0.019), increased Pediatric Risk of Mortality (PRISM) score

2016 Pediatric Emergency Care

78. Bone Contusions After Acute Noncontact Anterior Cruciate Ligament Injury Are Associated With Knee Joint Laxity, Concomitant Meniscal Lesions, and Anterolateral Ligament Abnormality. (PubMed)

Bone Contusions After Acute Noncontact Anterior Cruciate Ligament Injury Are Associated With Knee Joint Laxity, Concomitant Meniscal Lesions, and Anterolateral Ligament Abnormality. To examine the associated findings with bone contusions in patients after acute noncontact anterior cruciate ligament (ACL) injuries.From January 1, 2011, to December 31, 2013, patients who underwent ACL reconstructions performed by the senior author (H.F.) were retrospectively analyzed. Presence and severity (...) of bone contusion were determined from preoperative magnetic resonance images (MRIs) for each anatomic site including the lateral femoral condyle (LFC), lateral tibial plateau (LTP), medial femoral condyle (MFC), and medial tibial plateau (MTP). Multivariable logistic regression was used to calculate adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for the associated findings (demographic data, preoperative physical examinations, concomitant meniscal lesions, intra-articular cartilage

2016 Arthroscopy

79. The Impact of Midcervical Contusion Injury on Diaphragm Muscle Function (PubMed)

The Impact of Midcervical Contusion Injury on Diaphragm Muscle Function Midcervical contusion injuries disrupt descending ipsilateral excitatory bulbospinal projections to phrenic motoneurons, compromising ventilation. We hypothesized that a unilateral contusion injury at C3 versus C5 would differentially impact phrenic activity reflecting more prominent disruption of ipsilateral descending excitatory drive to more caudal segments of the phrenic motor pool with more cranial injuries. Phrenic (...) motoneuron counts and evidence of diaphragm muscle denervation at individual neuromuscular junctions (NMJ) were evaluated at 14 days post-injury after unilateral contusion injury (100 kDynes). Whole body plethysmography and chronic diaphragm EMG were measured before the injury and at 3, 7, and 14 days post-injury. Contusion injuries at either level resulted in a similarly sized cavity. C3 contusion resulted in loss of 39 ± 13% of ipsilateral phrenic motoneurons compared with 13 ± 21% after C5 contusion

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2016 Journal of neurotrauma

80. A Unilateral Cervical Spinal Cord Contusion Injury Model in Non-Human Primates (Macaca mulatta) (PubMed)

A Unilateral Cervical Spinal Cord Contusion Injury Model in Non-Human Primates (Macaca mulatta) The development of a non-human primate (NHP) model of spinal cord injury (SCI) based on mechanical and computational modeling is described. We scaled up from a rodent model to a larger primate model using a highly controllable, friction-free, electronically-driven actuator to generate unilateral C6-C7 spinal cord injuries. Graded contusion lesions with varying degrees of functional recovery

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2016 Journal of neurotrauma

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