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301. Neonatal subcortical bruising Full Text available with Trip Pro

Neonatal subcortical bruising A specific type of acute brain injury can occur during birth, presenting on ultrasound examination with focal, unilateral, or asymmetrical change in the core of the superior frontal gyri. Ultrasound inspection of the superior gyri near the convexity of the frontal lobe is warranted following mechanically difficult delivery.

2018 Clinical Case Reports

302. Patient-Specific Alterations in CO2 Cerebrovascular Responsiveness in Acute and Sub-Acute Sports-Related Concussion Full Text available with Trip Pro

Patient-Specific Alterations in CO2 Cerebrovascular Responsiveness in Acute and Sub-Acute Sports-Related Concussion Preliminary studies suggest that sports-related concussion (SRC) is associated with alterations in cerebral blood flow (CBF) regulation. Here, we use advanced magnetic resonance imaging (MRI) techniques to measure CBF and cerebrovascular responsiveness (CVR) in individual SRC patients and healthy control subjects.15 SRC patients (mean age = 16.3, range 14-20 years) and 27 healthy

2018 Frontiers in neurology

303. Sex & gender considerations in concussion research Full Text available with Trip Pro

Sex & gender considerations in concussion research The study of concussion, a common form of mild traumatic brain injury, has received increased notice over the last decade. Recently, more researchers have been addressing the historic paucity of attention over sex and gender influences on recovery outcomes after concussion. This development has led to exciting progress in our understanding of concussion incidence and outcomes. In this review, we will report on new findings from varying studies (...) on sex differences in the epidemiology of concussion and clinical manifestations of mild traumatic brain injury/concussion, further discussing some key issues related to the integration of sex and gender in concussion research in a broad range of contexts, with recommendations to guide future research, along with sex- and gender-sensitive policy considerations.

2018 Concussion

304. Stuck in a State of Inattention? Functional Hyperconnectivity as an Indicator of Disturbed Intrinsic Brain Dynamics in Adolescents With Concussion: A Pilot Study Full Text available with Trip Pro

Stuck in a State of Inattention? Functional Hyperconnectivity as an Indicator of Disturbed Intrinsic Brain Dynamics in Adolescents With Concussion: A Pilot Study Sports-related concussion in youth is a major public health issue. Evaluating the diffuse and often subtle changes in structure and function that occur in the brain, particularly in this population, remains a significant challenge. The goal of this pilot study was to evaluate the relationship between the intrinsic dynamics of the brain (...) using resting-state functional magnetic resonance imaging (rs-fMRI) and relate these findings to structural brain correlates from diffusion tensor imaging in a group of adolescents with sports-related concussions ( n = 6) and a group of healthy adolescent athletes ( n = 6). We analyzed rs-fMRI data using a sliding windows approach and related the functional findings to structural brain correlates by applying graph theory analysis to the diffusion tensor imaging data. Within the resting-state

2018 ASN neuro

305. Bilateral medial rectus palsy due to midbrain infarction following concussion head injury Full Text available with Trip Pro

Bilateral medial rectus palsy due to midbrain infarction following concussion head injury Here, we report a rare case of bilateral medial rectus palsy following closed head injury. An adult male had an accidental fall which rendered him unconscious. This was followed by diplopia and restricted ocular motility. He received supportive medical therapy. He was examined for systemic medical and ophthalmic findings. Routine laboratory tests and imaging techniques were employed as per the symptoms

2018 Indian journal of ophthalmology

306. The role and diagnostic significance of cellular barriers after concussive head trauma Full Text available with Trip Pro

The role and diagnostic significance of cellular barriers after concussive head trauma The onset of concussive head trauma often triggers an intricate sequence of physical consequences and pathophysiological responses. These sequelae can be acute (i.e., hematoma) or chronic (i.e., autoimmune response, neurodegeneration, etc.), and may follow traumas of any severity. A critical factor for prognostication of postconcussion outcome is the pathophysiological response of cellular barriers, which can

2018 Concussion

307. Treatment for Patients With Chronic Post-Concussion Symptoms

Treatment for Patients With Chronic Post-Concussion Symptoms Treatment for Patients With Chronic Post-Concussion Symptoms - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Treatment for Patients With Chronic (...) Post-Concussion Symptoms The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03759808 Recruitment Status : Not yet recruiting First Posted : November 30, 2018 Last Update Posted : November 30, 2018 See Sponsor: University

2018 Clinical Trials

308. Assessment of Information on Concussion Available to Adolescents on Social Media Full Text available with Trip Pro

Assessment of Information on Concussion Available to Adolescents on Social Media Considering how many people obtain information about their health online, the aim of this study was to describe the content of the currently most widely viewed YouTube videos related to concussions and to test the hypothesis that consumer videos would be anecdotal, while other sources would be more informational.The term "concussion" was used to search for videos with 100,000 or more views on YouTube that were (...) than consumer or internet based videos. Consumer and television based videos were equally anecdotal. Many of the videos focused on adolescents and were related to sports injuries. The majority of the videos (70.4%) addressed concussion causes, with 48% stating sports. Few videos discussed symptoms of concussion and prevention.The potential for widespread misinformation necessitates caution when obtaining information on concussion on a freely accessible and editable medium, such as YouTube.

2018 International journal of preventive medicine

309. Connectomic markers of symptom severity in sport-related concussion: Whole-brain analysis of resting-state fMRI Full Text available with Trip Pro

Connectomic markers of symptom severity in sport-related concussion: Whole-brain analysis of resting-state fMRI Concussion is associated with significant adverse effects within the first week post-injury, including physical complaints and altered cognition, sleep and mood. It is currently unknown whether these subjective disturbances have reliable functional brain correlates. Resting-state functional magnetic resonance imaging (rs-fMRI) has been used to measure functional connectivity (...) of individuals after traumatic brain injury, but less is known about the relationship between functional connectivity and symptom assessments after a sport concussion. In this study, rs-fMRI was used to evaluate whole-brain functional connectivity for seventy (70) university-level athletes, including 35 with acute concussion and 35 healthy matched controls. Univariate analyses showed that greater symptom severity was mainly associated with lower pairwise connectivity in frontal, temporal and insular regions

2018 NeuroImage : Clinical

310. Effect of Concussions on Lower Extremity Injury Rates at a Division I Collegiate Football Program Full Text available with Trip Pro

Effect of Concussions on Lower Extremity Injury Rates at a Division I Collegiate Football Program Football has one of the highest injury rates (IRs) in sports, ranging from 4.1 to 8.6 per 1000 athlete-exposures (AEs). Previous research has reported that athletes may be at an increased risk of suffering lower extremity (LE) injuries after a concussion.The purpose of this study was to evaluate the rate of LE injuries in collegiate football athletes after a concussion. We predicted (...) that the overall LE IR would increase after a concussion and that each position group would also demonstrate a similar increase in LE injuries after a concussion.Cohort study; Level of evidence, 2.Daily attendance and injury records were prospectively collected by licensed team medical providers for the 2012 through 2016 college football regular seasons. Each injury report included the date of injury, position group, body part injured, and type of injury. IRs per 1000 AEs with 95% CIs were calculated

2018 Orthopaedic journal of sports medicine

311. Histological evaluation of experimental porcine bruises Full Text available with Trip Pro

Histological evaluation of experimental porcine bruises Age estimation is a crucial part of the forensic investigation of bruises in livestock pigs [1], [2], [3]. Currently, age estimations are based on histological evaluation of the lesions in the skin and underlying muscle tissue [2]. However, the intensity of inflammation and tissue damage depends not only on the age of bruises but also on sampling site, anatomical location and the speed, mass and force used to inflict the lesions [1], [4 (...) ], [5]. Twelve experimental slaughter pigs were anesthetized and on each animal, four blunt traumas were inflicted on the back (area of impact Nos. 1-4). The pigs were euthanized at 2, 5 or 8 h after infliction. Skin and underlying muscle tissue were sampled from the center (B) and both ends of bruises (A, C) and evaluated histologically. Descriptive statistics were performed on the data obtained and presented in figures and tables. Differences (odds ratios) between sampling sites (A, B and C

2018 Data in brief

312. Single cell molecular alterations reveal target cells and pathways of concussive brain injury Full Text available with Trip Pro

Single cell molecular alterations reveal target cells and pathways of concussive brain injury The complex neuropathology of traumatic brain injury (TBI) is difficult to dissect, given the convoluted cytoarchitecture of affected brain regions such as the hippocampus. Hippocampal dysfunction during TBI results in cognitive decline that may escalate to other neurological disorders, the molecular basis of which is hidden in the genomic programs of individual cells. Using the unbiased single cell (...) sequencing method Drop-seq, we report that concussive TBI affects previously undefined cell populations, in addition to classical hippocampal cell types. TBI also impacts cell type-specific genes and pathways and alters gene co-expression across cell types, suggesting hidden pathogenic mechanisms and therapeutic target pathways. Modulating the thyroid hormone pathway as informed by the T4 transporter transthyretin Ttr mitigates TBI-associated genomic and behavioral abnormalities. Thus, single cell

2018 Nature communications

313. Autonomic Function Following Concussion in Youth Athletes: An Exploration of Heart Rate Variability Using 24-hour Recording Methodology Full Text available with Trip Pro

Autonomic Function Following Concussion in Youth Athletes: An Exploration of Heart Rate Variability Using 24-hour Recording Methodology Participation in organized sports makes a significant contribution to youth development, but places youth at a higher risk for sustaining a concussion. To date, return-to-activity decision-making has been anchored in the monitoring of self-reported concussion symptoms and neurocognitive testing. However, multi-modal assessments that corroborate objective (...) physiological measures with traditional subjective symptom reporting are needed and can be valuable. Heart rate variability (HRV) is a non-invasive physiological indicator of the autonomic nervous system, capturing the reciprocal interplay between the sympathetic and parasympathetic nervous systems. There is a dearth of literature exploring the effect of concussion on HRV in youth athletes, and developmental differences preclude the application of adult findings to a pediatric population. Further

2018 Journal of visualized experiments : JoVE

314. The synergistic effect of concussions and aging in women? Disparities and perspectives on moving forward Full Text available with Trip Pro

The synergistic effect of concussions and aging in women? Disparities and perspectives on moving forward 30364380 2018 11 14 2056-3299 3 2 2018 Aug Concussion (London, England) Concussion The synergistic effect of concussions and aging in women? Disparities and perspectives on moving forward. CNC55 10.2217/cnc-2018-0004 Esopenko Carrie C Department of Rehabilitation & Movement Sciences, School of Health Professions, Rutgers, The State University of New Jersey, New Brunswick, NJ, 08901, USA (...) , Rutgers, The State University of New Jersey, New Brunswick, NJ, 08901, USA. Department of Rehabilitation & Movement Sciences, School of Health Professions, Rutgers, The State University of New Jersey, New Brunswick, NJ, 08901, USA. Department of Health Informatics, School of Health Professions, Rutgers, The State University of New Jersey, New Brunswick, NJ, 08901, USA. eng Editorial 2018 08 15 England Concussion 101672433 2056-3299 aging chronic traumatic encephalopathy concussion dementia women

2018 Concussion

315. Perceptual-cognitive three-dimensional multiple-object tracking task can help the monitoring of sport-related concussion Full Text available with Trip Pro

Perceptual-cognitive three-dimensional multiple-object tracking task can help the monitoring of sport-related concussion While the rate of sport-related concussion is increasing, more effective tools are needed to help monitor the diagnosis and return to play of athletes. The three-dimensional multiple-object tracking (3D-MOT) exercise is a perceptual-cognitive task that has shown predictive power towards the dynamic requirements of real-world activities such as sport. This study introduced (...) the use of the 3D-MOT task, along with the Standardized Assessment of Concussion (SAC) and Modified Balance Error Scoring System (M-BESS) tests, for diagnosis and return to play in professional sports.Fifty-nine professional athletes were tested with the 3D-MOT, SAC and M-BESS tests at 48 hours following the injury. The same measures were employed to evaluate the return to play following the standard concussion management protocol. The SAC and M-BESS tests were also performed in pre-season (baseline

2018 BMJ Open Sport — Exercise Medicine

316. Investigating the validity and reliability of Electrovestibulography (EVestG) for detecting post-concussion syndrome (PCS) with and without comorbid depression Full Text available with Trip Pro

Investigating the validity and reliability of Electrovestibulography (EVestG) for detecting post-concussion syndrome (PCS) with and without comorbid depression Features from Electrovestibulography (EVestG) recordings have been used to classify and measure the severity of both persistent post-concussion syndrome (PCS) and major depressive disorder. Herein, we examined the effect of comorbid depression on the detection of persistent PCS using EVestG. To validate our previously developed EVestG (...) , separation accuracy of each PCS subgroup from controls was >90%. A four and three-group (excluding mild-depression subgroup) classification, achieved an accuracy of 74% and 81%, respectively. Correlation analysis indicated a significant correlation (R = 0.67) between the depression feature and the MADRS depression score as well as between the PCS-specific feature and Rivermead Post-Concussion Questionnaire (RPQ) (R = -0.48). No significant correlation was found between the PCS-specific feature

2018 Scientific reports

317. A comparison of four different imaging modalities – Conventional, cross polarized, infra-red and ultra-violet in the assessment of childhood bruising Full Text available with Trip Pro

A comparison of four different imaging modalities – Conventional, cross polarized, infra-red and ultra-violet in the assessment of childhood bruising It is standard practice to image concerning bruises in children. We aim to compare the clarity and measurements of bruises using cross polarized, infra-red (IR) and ultra-violet (UV) images to conventional images.Children aged <11 years with incidental bruising were recruited. Demographics, skin and bruise details were recorded. Bruises were (...) imaged by standard protocols in conventional, cross-polarized, IR and UV lights. Bruises were assessed in vivo for contrast, uniformity and diffuseness, and these characteristics were then compared across image modalities. Color images (conventional, cross polarized) were segmented and measured by ImageJ. Bruises of grey scale images (IR, UV) were measured by a 'plug in' of ImageJ. The maximum and minimum Feret's diameter, area and aspect ratio, were determined. Comparison of measurements across

2018 Journal of forensic and legal medicine

318. Chinese translation and validation of the Sport Concussion Assessment Tool 3 (SCAT3) Full Text available with Trip Pro

Chinese translation and validation of the Sport Concussion Assessment Tool 3 (SCAT3) The aim of this study was to translate, adapt and validate the Sport Concussion Assessment Tool 3rd edition (SCAT3), a test for assessing athletes for concussion, into the Chinese context.Translation and adaptation were performed in several stages, which included forward translation by two independent teams, translation merging, backward translation, reviews by both native Cantonese-speaking and Mandarin (...) -speaking multidisciplinary expert panels (n=49) for semantic and conceptual equivalence and reviews by pitch-side physiotherapists (n=18) as end-users of the SCAT3 and rugby players (n=11) for face validity. The Serial 3  s subtraction test was used as a substitute for the Months Backward Test (MBT) for measures of concentration in the Standardized Assessment of Concussion subscale. English-speaking and Chinese-speaking rugby players (n=52) were recruited to perform these tests to assess the level

2018 BMJ Open Sport — Exercise Medicine

319. Using sideline concussion tests in the emergency department Full Text available with Trip Pro

Using sideline concussion tests in the emergency department Traumatic brain injury (TBI) is a significant cause of death and disability in the United States. Many patients with TBI are initially treated in the emergency department (ED), but there is no evidence-based method of detecting or grading TBI in patients who have normal structural neuroimaging. This study aims to evaluate the validity of two common sideline concussion tests. The Concussion Symptom Severity Score (CSSS) and modified (...) Balance Error Scoring System (mBESS) tests are well-validated sideline tests for concussion, but have not been validated in the setting of non-sport-related concussion, in settings other than the sideline or athletic training room or in moderate or severe TBI.One hundred forty-eight subjects who had sustained a TBI within the previous 72 hours and 53 healthy control subjects were enrolled. CSSS and mBESS were administered. Clinical outcomes were followed up prospectively.The CSSS was collected in 147

2018 Open access emergency medicine : OAEM

320. No change in plasma tau and serum neurofilament light concentrations in adolescent athletes following sport-related concussion Full Text available with Trip Pro

No change in plasma tau and serum neurofilament light concentrations in adolescent athletes following sport-related concussion Sport-related concussion (SRC), a mild form of traumatic brain injury (TBI), is a common injury in contact sports. Health care professionals rely on subjective criteria (e.g., symptoms), as there is no objective marker for identification of athletes with SRC. Blood-based biomarkers have shown promise as diagnostic and prognostic tools following TBI and SRC (...) . In the present study, we examined plasma tau and serum NF-L, two biomarkers for neuronal/axonal injury, concentrations at preseason and following SRC in contact sport athletes (n = 11) using ultrasensitive single molecule array (Simoa) assays. Preseason baseline samples were collected, and post-concussion samples were obtained at 6- and 14-days following injury. We found no difference between baseline, 6-day and 14-day post-concussion concentrations of tau (p = 0.14) or NF-L (p = 0.53). Further

2018 PloS one

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