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Contusion

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181. Posttraumatic Epilepsy: What's Contusion Got to Do With It? (PubMed)

Posttraumatic Epilepsy: What's Contusion Got to Do With It? Text of Abstract Liability to develop posttraumatic epilepsy (PTE) correlates in a general way with trauma dose. While contusion of the brain produces an admixture of extravasated blood, edema fluid and necrotic tissue at the site of skull trauma and in regions remote from the direct force, an unpredictable cascade of shearing injury, torsion and rotation and a myriad of physiological changes occur in structures subject

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2012 Epilepsy Currents

182. Human Umbilical Cord Blood-Derived Mesenchymal Stem Cell Therapy Promotes Functional Recovery of Contused Rat Spinal Cord through Enhancement of Endogenous Cell Proliferation and Oligogenesis (PubMed)

Human Umbilical Cord Blood-Derived Mesenchymal Stem Cell Therapy Promotes Functional Recovery of Contused Rat Spinal Cord through Enhancement of Endogenous Cell Proliferation and Oligogenesis Numerous studies have shown the benefits of mesenchymal stem cells (MSCs) on the repair of spinal cord injury (SCI) model and on behavioral improvement, but the underlying mechanisms remain unclear. In this study, to investigate possible mechanisms by which MSCs contribute to the alleviation of neurologic (...) deficits, we examined the potential effect of human umbilical cord blood-derived MSCs (hUCB-MSCs) on the endogenous cell proliferation and oligogenesis after SCI. SCI was injured by contusion using a weight-drop impactor and hUCB-MSCs were transplanted into the boundary zone of the injured site. Animals received a daily injection of bromodeoxyuridine (BrdU) for 7 days after treatment to identity newly synthesized cells of ependymal and periependymal cells that immunohistochemically resembled stem

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2012 Journal of Biomedicine and Biotechnology

183. The timing of administration of a clinically relevant dose of losartan influences the healing process after contusion induced muscle injury (PubMed)

The timing of administration of a clinically relevant dose of losartan influences the healing process after contusion induced muscle injury Losartan (Los) is a Food and Drug Administration-approved antihypertensive medication that has a well-tolerated side effect profile. We have demonstrated that treatment with Los immediately after injury was effective at promoting muscle healing and inducing an antifibrotic effect in a murine model of skeletal muscle injury. We initially investigated

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2012 Journal of Applied Physiology

184. Myocardial Contusion

Myocardial Contusion Myocardial Contusion Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Myocardial Contusion Myocardial Contusion (...) Aka: Myocardial Contusion From Related Chapters II. Causes Chest III. History Bent stearing wheel in a IV. Signs Anterior chest wall injury signs Sternal tenderness Sternal deformity V. Labs Serial levels Serum myoglobin Serum VI. Diagnostics Telemetry monitoring Serial Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Myocardial Contusion." Click on the image (or right click) to open the source website in a new browser window

2015 FP Notebook

185. Quadriceps Contusion

Quadriceps Contusion Quadriceps Contusion Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Quadriceps Contusion Quadriceps Contusion (...) Aka: Quadriceps Contusion , Thigh Contusion From Related Chapters II. Mechanism Direct blow to thigh III. Signs: Limited knee flexion (Assess at 12 to 24 hour) Mild Injury flexion >90 degrees Moderate flexion 45-90 degrees Severe flexion <45 degrees IV. Management Phase 1: Wrap knee, extended to 130 degrees Phase 2: Range of Motion Phase 3: Return to Play Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Quadriceps Contusion

2015 FP Notebook

186. Contusion

Contusion Contusion Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Contusion Contusion Aka: Contusion , Bruise , Soft Tissue Hematoma (...) , Subcutaneous Hematoma , Subepidermal Hemorrhage , Bruising II. Pathophysiology Blunt injury disrupts soft tissue (skin, muscle) capillaries and venules, resulting in into local interstitial tissue III. Risk Factors (e.g. Ehlers-Danlos Syndrome) s IV. Exam Do not blanch on pressure Contrast with a ( , ) which does blanch Compare with or which like a Contusion does not blanch Color (unreliable as an indicator of injury timing) Days 0-2: Swelling and tenderness Days 2-5: Red, blue or purple coloration Days 5

2015 FP Notebook

187. Brain Contusion

Brain Contusion Brain Contusion Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Brain Contusion Brain Contusion Aka: Brain Contusion (...) From Related Chapters II. Pathophysiology III. Signs ral Focal neurologic deficits Prolonged coma Decerebrate rigidity Unequal dilated pupils IV. Imaging (at presention and repeated in 12 hours) Cerebral Necrosis Intraparenchymal V. Management Emergent Neurosurgical Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Brain Contusion." Click on the image (or right click) to open the source website in a new browser window. Related

2015 FP Notebook

188. Pulmonary Contusion

Pulmonary Contusion Pulmonary Contusion Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Pulmonary Contusion Pulmonary Contusion Aka (...) : Pulmonary Contusion , Lung Contusion , Chest Contusion From Related Chapters II. Epidemiology Pulmonary Contusion is the most common potentially lethal III. Risk Factors: Increased Morbidity ( ) IV. Pathophysiology to chest results in Lung Contusion May occur without Slow, insidious may ensue resulting in V. Indications: Early Intubation with <65 mmHg or <90% VI. Management: Disposition Admit most patients (especially elderly) Respiratory status can deteriorate rapidly Discharge indications Young

2015 FP Notebook

189. Efficacy and tolerability of DHEP-heparin plaster in reducing pain in mild-to-moderate muscle contusions: a double-blind, randomized trial. (PubMed)

Efficacy and tolerability of DHEP-heparin plaster in reducing pain in mild-to-moderate muscle contusions: a double-blind, randomized trial. To investigate if the 180-mg diclofenac epolamine and heparin sodium 5600 IU medicated plaster (DHEP-heparin) is more effective for pain reduction in mild-to-moderate contusions than the reference diclofenac epolamine 180 mg plaster (DHEP).This multicenter, multinational, prospective, double-blind versus reference comparator and versus placebo, controlled (...) trial had balanced random assignment in three parallel treatment groups. The DHEP-heparin medicated plaster was compared to the DHEP medicated plaster and a placebo medicated plaster. A total of 331 outpatients, aged ≥18 and ≤65 years, with unilateral mild-to-moderate muscle contusion, pain on standardized movement of ≥50 mm, and superficial hematoma of ≤10 × 14 cm(2) completed the study. Plasters were applied each morning, for ≥20 hours daily for 14 consecutive days. Outcomes were assessed in three

2012 Current medical research and opinion Controlled trial quality: predicted high

190. [Clinical study on pulmonary circulation changes in patients with acute respiratory distress syndrome induced by lung contusion].

[Clinical study on pulmonary circulation changes in patients with acute respiratory distress syndrome induced by lung contusion]. To analyze the variation and significance of pulmonary circulation in patients with acute respiratory distress syndrome (ARDS) induced by lung contusion by means of Swan-Ganz catheter and the pulse index continuous cardiac output (PiCCO) monitoring.A prospective, randomized, non-blinded clinical trial was conducted. All patients admitted hospital from August 2009 (...) to August 2011 met the inclusion criteria, were divided into the group with ARDS induced by lung contusion (contusion group, n = 18) and the group without lung contusion and ARDS (control group, n = 22). The measured parameters included pulmonary artery systolic pressure (PAS), pulmonary artery diastolic pressure (PAD), pulmonary artery wedge pressure (PAWP), pulmonary artery diastolic-pulmonary wedge pressure gradient (PAD-PAWP), and extravascular lung water index (ELWI) of each group at 0 hour after

2012 Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue

191. Differential Effects of Injury Severity on Cognition and Cellular Pathology after Contusive Brain Trauma in the Immature Rat (PubMed)

Differential Effects of Injury Severity on Cognition and Cellular Pathology after Contusive Brain Trauma in the Immature Rat Although diffuse brain damage has been suggested to be the predominant predictor of neurological morbidity following closed head injury in infants and children, the presence of contusions also predicts long-term neurobehavioral dysfunction. Contusive brain trauma in the 17-day-old rat resulted in neurodegeneration and caspase activation in the cortex at 1 day

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2011 Journal of neurotrauma

192. Robotic assistance that encourages the generation of stepping rather than fully assisting movements is best for learning to step in spinally contused rats (PubMed)

Robotic assistance that encourages the generation of stepping rather than fully assisting movements is best for learning to step in spinally contused rats Robotic devices have been developed to assist body weight-supported treadmill training (BWSTT) in individuals with spinal cord injuries (SCIs) and stroke. Recent findings have raised questions about the effectiveness of robotic training that fully assisted (FA) stepping movements. The purpose of this study was to examine whether assist (...) -as-needed robotic (AAN) training was better than FA movements in rats with incomplete SCI. Electromyography (EMG) electrodes were implanted in the tibialis anterior and medial gastrocnemius hindlimb muscles of 14 adult rats. Afterward, the rats received a severe midthoracic spinal cord contusion and began daily weight-supported treadmill training 1 wk later using a rodent robotic system. During training, assistive forces were applied to the ankle when it strayed from a desired stepping trajectory

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2011 Journal of neurophysiology

193. Characterizing Phospholipase A2-Induced Spinal Cord Injury—A Comparison with Contusive Spinal Cord Injury in Adult Rats (PubMed)

Characterizing Phospholipase A2-Induced Spinal Cord Injury—A Comparison with Contusive Spinal Cord Injury in Adult Rats To assess whether phospholipase A2 (PLA2) plays a role in the pathogenesis of spinal cord injury (SCI), we compared lesions either induced by PLA2 alone or by a contusive SCI. At 24-h post-injury, both methods induced a focal hemorrhagic pathology. The PLA2 injury was mainly confined within the ventrolateral white matter, whereas the contusion injury widely affected both (...) the gray and white matter. A prominent difference between the two models was that PLA2 induced a massive demyelination with axons remaining in the lesion area, whereas the contusion injury induced axonal damage and myelin breakdown. At 4 weeks, no cavitation was found within the PLA2 lesion, and numerous axons were myelinated by host-migrated Schwann cells. Among them, 45% of animals had early transcranial magnetic motor-evoked potential (tcMMEP) responses. In contrast, the contusive SCI induced

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2011 Translational stroke research

194. Hindlimb Immobilization in a Wheelchair Alters Functional Recovery Following Contusive Spinal Cord Injury in the Adult Rat (PubMed)

Hindlimb Immobilization in a Wheelchair Alters Functional Recovery Following Contusive Spinal Cord Injury in the Adult Rat Locomotor training of rats with thoracic contusion spinal cord injuries can induce task-specific changes in stepping but rarely results in improved overground locomotion, possibly due to a ceiling effect. Thus, the authors hypothesize that incompletely injured rats maximally retrain themselves while moving about in their cages over the first few weeks postinjury.To test (...) the hypothesis using hindlimb immobilization after mild thoracic contusion spinal cord injury in adult female rats. A passive stretch protocol was included as an independent treatment.Wheelchairs were used to hold the hindlimbs stationary in an extended position leaving the forelimbs free. The wheelchairs were used for 15 to 18 hours per day, 5 days per week for 8 weeks, beginning at 4 days postinjury. A 20-minute passive hindlimb stretch therapy was applied to half of the animals.Hindlimb locomotor function

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2011 Neurorehabilitation and neural repair

195. Role of intra-aortic balloon pump in myocardial contusion (PubMed)

Role of intra-aortic balloon pump in myocardial contusion 21929927 2011 12 13 2018 11 13 1478-7083 93 6 2011 Sep Annals of the Royal College of Surgeons of England Ann R Coll Surg Engl Role of intra-aortic balloon pump in myocardial contusion. 490-1 10.1308/003588411X592130h Vu T T Department of Surgery, University of Miami School of Medicine, Miami, Florida, USA. tvu@med.miami.edu Stahl K D KD Asensio J A JA eng Journal Article England Ann R Coll Surg Engl 7506860 0035-8843 IM Contusions

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2011 Annals of the Royal College of Surgeons of England

196. Vector-mediated expression of erythropoietin improves functional outcome after cervical spinal cord contusion injury (PubMed)

Vector-mediated expression of erythropoietin improves functional outcome after cervical spinal cord contusion injury We evaluated the therapeutic effect of erythropoietin (EPO) delivered by direct injection of a nonreplicating herpes simplex virus (HSV)-based vector coding for EPO (vEPO) in a model of cervical hemicord contusion at C7. At 1 h after spinal cord injury (SCI), either vEPO or control vector carrying a reporter gene (vC) was injected into the cord above and below the lesion. Animals

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2011 Gene therapy

197. Differential Expression of Wnts after Spinal Cord Contusion Injury in Adult Rats (PubMed)

Differential Expression of Wnts after Spinal Cord Contusion Injury in Adult Rats Spinal cord injury is a major cause of disability that has no clinically accepted treatment. Functional decline following spinal cord injury is caused by mechanical damage, secondary cell death, reactive gliosis and a poor regenerative capacity of damaged axons. Wnt proteins are a family of secreted glycoproteins that play key roles in different developmental processes although little is known of the expression (...) patterns and functions of Wnts in the adult central nervous system in normal or diseased states.Using qRT-PCR analysis, we demonstrate that mRNA encoding most Wnt ligands and soluble inhibitors are constitutively expressed in the healthy adult spinal cord. Strikingly, contusion spinal cord injury induced a time-dependent increase in Wnt mRNA expression from 6 hours until 28 days post-injury, and a narrow peak in the expression of soluble Wnt inhibitors between 1 and 3 days post-injury. These results

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2011 PloS one

198. Bone contusion and associated meniscal and medial collateral ligament injury in patients with anterior cruciate ligament rupture. (PubMed)

Bone contusion and associated meniscal and medial collateral ligament injury in patients with anterior cruciate ligament rupture. The present study examined the prevalence of bone contusions in patients with anterior cruciate ligament (ACL) injury as well as its association with tears of the lateral meniscus, medial meniscus, and medial collateral ligament (MCL).Eighty-one patients with an arthroscopy-proven ACL rupture for whom magnetic resonance images (MRI) were acquired within six weeks (...) after the initial trauma were examined. The bone contusions on the lateral femoral condyle, lateral aspect of the tibial plateau, medial femoral condyle, and medial aspect of the tibial plateau were documented. The injury to MCL was also observed with MRI. The tears of the lateral meniscus and medial meniscus were detected during arthroscopy. The prevalence of lateral meniscus, medial meniscus, and MCL injuries was compared with the existence of the bone contusions.Sixty-eight (84%) of the eighty

2011 The Journal of Bone and Joint Surgery. American Volume

199. Talk and die revisited: bifrontal contusions and late deterioration. (PubMed)

Talk and die revisited: bifrontal contusions and late deterioration. Severe bifrontal contusions in an awake traumatic brain injury (TBI) patient is a challenging clinical picture, as they are prone to late deterioration. We evaluated our series of patients with severe bifrontal contusions, characterizing their clinical course and suggestions for management.We examined a prospectively collected database of TBIs for patients with severe bifrontal contusions, defined as >30 cm. Only patients (...) of 4.5 days postinjury. Of those managed with immediate surgical decompression, all had good outcomes and returned to work. There was no difference in contusion or edema volumes between the two groups.Awake patients with bifrontal contusions represent a unique cohort of TBI patients who are prone to rapid deterioration late in their clinical course. They have extensive frontal edema and mass effect, yet we were unable to find a correlation between edema volumes and incidence of deterioration. Based

2011 Journal of Trauma

200. Early Parenchymal Contrast Extravasation Predicts Subsequent Hemorrhage Progression, Clinical Deterioration, and Need for Surgery in Patients With Traumatic Cerebral Contusion. (PubMed)

Early Parenchymal Contrast Extravasation Predicts Subsequent Hemorrhage Progression, Clinical Deterioration, and Need for Surgery in Patients With Traumatic Cerebral Contusion. This study aimed to identify early radiologic signs that are predictive of hemorrhage progression and clinical deterioration in patients with traumatic cerebral contusion. We hypothesized that contrast extravasation (CE) and blood-brain barrier disruption might be associated with hemorrhage progression, brain edema (...) , and clinical deterioration in these patients.Twenty-two patients with traumatic cerebral contusion (diagnosed on initial noncontrast head computed tomography [CT]) who initially did not require surgical intervention were enrolled in this study. Contrast-enhanced and perfusion CT scans were performed within 6 hours of injury, and follow-up noncontrast CT scans were performed at 24 hours and 72 hours.In each noncontrast CT scan, the volumes of the contusion hemorrhage and edema were calculated using

2011 Journal of Trauma

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