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Contraction Stress Test

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121. Insulin resistance improves metabolic and contractile efficiency in stressed rat heart (PubMed)

Insulin resistance improves metabolic and contractile efficiency in stressed rat heart Insulin resistance is a prominent feature in heart failure, while hyperglycemia impairs cardiac contraction. We propose that decreased insulin-mediated glucose uptake by the heart preserves cardiac function in response to metabolic and hemodynamic stress. To test this hypothesis, we fed rats a high-sucrose diet (HSD). Energy substrate metabolism and cardiac work were determined ex vivo in a sequential (...) protocol simulating metabolic and hemodynamic stress. Compared to chow-fed, control rats, HSD impaired myocardial insulin responsiveness and induced profound metabolic changes in the heart, characterized by reduced rates of glucose uptake (7.91 ± 0.30 vs. 10.73 ± 0.67 μmol/min/g dry weight; P<0.001) but increased rates of glucose oxidation (2.38 ± 0.17 vs. 1.50 ± 0.15 μmol/min/g dry weight; P<0.001) and oleate oxidation (2.29 ± 0.11 vs. 1.96 ± 0.12 μmol/min/g dry weight; P<0.05). Tight coupling

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2012 The FASEB Journal

122. [Effect the adding of biofeedback to the training of the pelvic floor muscles to treatment of stress urinary incontinence]. (PubMed)

[Effect the adding of biofeedback to the training of the pelvic floor muscles to treatment of stress urinary incontinence]. To investigate the effect of adding biofeedback (BF) to the training of pelvic floor muscles (PFMT) for the treatment of stress urinary incontinence (SUI).A prospective pilot study, randomized and controlled with women with SUI without sphincter deficiency, detected by urodynamic study and who performed the correct PFM contraction. Women with neuromuscular disorders (...) and grade III and IV genital prolapse were excluded. Forty women were randomized into a CONTROL GROUP and BF Group. The PFMT protocol with BF equipment consisted of three sets of ten slow contractions (tonic), with a holding time of six to eight seconds at each contraction followed by a rest period of equal duration. After each sustained contraction, they performed three to four fast contractions (phasic) in the supine and standing position twice a week, for a total of 12 sessions. We evaluated

2012 Revista brasileira de ginecologia e obstetrícia : revista da Federação Brasileira das Sociedades de Ginecologia e Obstetrícia Controlled trial quality: uncertain

123. Rectal balloon training as an adjunctive method for pelvic floor muscle training in conservative management of stress urinary incontinence: a pilot study. (PubMed)

Rectal balloon training as an adjunctive method for pelvic floor muscle training in conservative management of stress urinary incontinence: a pilot study. Pelvic floor muscle training (PFMT) is currently considered as the first line conservative management for women with stress urinary incontinence (SUI). However, it is difficult for some women to self-identify the contraction of the pelvic floor muscle after they were trained by verbal instruction. Various techniques including rectal balloon (...) probe have been developed to improve PFMT.To compare vaginal squeezing pressure, one-hour pad test, leakage episodes, rating scores about severity of SUI, and patient satisfaction between traditional PFMT and rectal balloon training (RBT).Twenty-eight patients with SUI were randomized into two groups, PFMT, and RBT groups. The PFMT group was verbally instructed to perform exercise as the traditional technique. In the RBT group, a Foley catheter filled with tap water to create balloon was inserted

2012 Journal of the Medical Association of Thailand = Chotmaihet thangphaet Controlled trial quality: uncertain

124. Selection against small males in utero: a test of the Wells hypothesis. (PubMed)

Selection against small males in utero: a test of the Wells hypothesis. The argument that women in stressful environments spontaneously abort their least fit fetuses enjoys wide dissemination despite the fact that several of its most intuitive predictions remain untested. The literature includes no tests, for example, of the hypothesis that these mechanisms select against small for gestational age (SGA) males.We apply time-series modeling to 4.9 million California male term births to test (...) the hypothesis that the rate of SGA infants in 1096 weekly birth cohorts varies inversely with labor market contraction, a known stressor of contemporary populations.We find support for the hypothesis that small size becomes less frequent among term male infants when the labor market contracts.Our findings contribute to the evidence supporting selection in utero. They also suggest that research into the association between maternal stress and adverse birth outcomes should acknowledge the possibility

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2012 Human Reproduction

125. Pilot Study of Losartan and N-acetylcysteine as Inhibitors of Muscle Oxidative Stress in Elderly

. Handgrip Strength of Non-dominant Hand as Measured by Handgrip Dynamometry at 100% Effort at Baseline [ Time Frame: baseline ] Handgrip Strength of non-dominant hand is measured by handgrip dynamometry at 100% effort with subjects performing one set of three contractions. Handgrip Fatigue of Dominant Hand as Measured by Handgrip Dynamometry at Baseline [ Time Frame: baseline ] Handgrip fatigue of dominant hand as measured by handgrip dynamometry fatigue test. The non-dominant hand hold a continuous (...) contraction at 20% of the subjects maximal voluntary contraction for 5 minutes. Data is reported as % of Maximal Voluntary Contraction after fatigue test. Handgrip Fatigue of Non-dominant Hand as Measured by Handgrip Dynamometry at Baseline [ Time Frame: baseline ] Handgrip fatigue of non-dominant hand as measured by handgrip dynamometry fatigue test. The non-dominant hand hold a continuous contraction at 20% of the subjects maximal voluntary contraction for 5 minutes. Data is reported as % of Maximal

2011 Clinical Trials

126. Pelvic Floor Muscle Evaluation in Women With Stress Urinary and Urgency Urinary Incontinence

void (i.e., the time period for which an urgent void could be voluntarily postponed), number of parity and vaginal deliveries were obtained using a clinical questionnaire. Objective urine loss was evaluated by 60-min Pad Test. Subjective [urine stream interruption test (UST), visual survey of perineal contraction and transvaginal digital palpation] and objective (vaginal manometry) evaluations of PFM were performed in all patients. Condition or disease Urinary Incontinence, Stress Urge Incontinence (...) Pelvic Floor Muscle Evaluation in Women With Stress Urinary and Urgency Urinary Incontinence Pelvic Floor Muscle Evaluation in Women With Stress Urinary and Urgency Urinary Incontinence - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more

2011 Clinical Trials

127. Pelvic floor muscle training for stress urinary incontinence: A randomized, controlled trial comparing different conservative therapies. (PubMed)

Pelvic floor muscle training for stress urinary incontinence: A randomized, controlled trial comparing different conservative therapies. Pelvic floor muscle training (PFMT) is an effective therapy for stress urinary incontinence (SUI). There is little and inconsistent data about different strategies of PFMT. Finding the right, patient-oriented treatment decision seems to be essential in order to achieve good results in conservative management of SUI. It was the aim of this prospective (...) randomized controlled trial (RCT) to compare three different strategies using electromyography (EMG) biofeedback-assisted PFMT with and without electrical stimulation (ES) for treatment of SUI in women capable of voluntarily contracting the pelvic floor when a home-training device with vaginal electrode was used.Three-arm RCT comparing 1) EMG biofeedback-assisted PFMT and conventional ES; 2) EMG biofeedback-assisted PFMT and dynamic ES; and 3) EMG biofeedback-assisted PFMT. Primary outcome measures were

2011 Physiotherapy research international : the journal for researchers and clinicians in physical therapy Controlled trial quality: uncertain

128. Does esophageal dysfunction affect the course of treadmill stress test in patients with recurrent angina-like chest pain? (PubMed)

with recurrent chest pain, 77 without significant coronary artery lesions in coronary angiography and 52 with myocardial ischemia, panendoscopy, pH-metry, manometry, and treadmill stress test were performed.The prevalence of esophageal disorders was similar in patients with and without significant coronary artery narrowing. Subjects with significant ST interval depression in the stress test had a higher rate of simultaneous esophageal contractions. There were no differences in the results of the treadmill (...) Does esophageal dysfunction affect the course of treadmill stress test in patients with recurrent angina-like chest pain? cardioesophageal reflex may increase severity of chest pain and signs of myocardial ischemia on electrocardiogram (ECG), both in patients with and without significant coronary artery stenosis.the aim of the study was to evaluate the relationships between esophageal pH and pressure and clinical and electrocardiographic signs of myocardial ischemia.in 129 consecutive patients

2010 Polskie Archiwum Medycyny Wewnetrznej

129. Human Annulus Fibrosus Material Properties from Biaxial Testing and Constitutive Modeling are Altered with Degeneration (PubMed)

Human Annulus Fibrosus Material Properties from Biaxial Testing and Constitutive Modeling are Altered with Degeneration The annulus fibrosus (AF) of the intervertebral disk undergoes large and multidirectional stresses and strains. Uniaxial tensile tests are limited for measuring AF material properties, because freely contracting edges can prevent fiber stretch and are not representative of in situ boundary conditions. The objectives of this study were to measure human AF biaxial tensile (...) mechanics and to apply and validate a constitutive model to determine material properties. Biaxial tensile tests were performed on samples oriented along the circumferential-axial and the radial-axial directions. Data were fit to a structurally motivated anisotropic hyperelastic model composed of isotropic extra-fibrillar matrix, nonlinear fibers, and fiber-matrix interactions (FMI) normal to the fibers. The validated model was used to simulate shear and uniaxial tensile behavior, to investigate AF

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2011 Biomechanics and modeling in mechanobiology

130. Effects of cell concentration and collagen concentration on contraction kinetics and mechanical properties in a bone marrow stromal cell-collagen construct (PubMed)

collagen lattices. To investigate the effects of both variables on the contraction kinetics, the construct contraction was monitored up to 13 days. Incremental stress- relaxation tests were carried out after a 2-week incubation to obtain the stress-strain profiles, which were subsequently assessed in a quasilinear viscoelastic (QLV) model. During contraction, aligned BMSCs were observed first in the interior portion of the ring, followed by the middle portion and finally in the exterior portion (...) . Constructs seeded with a higher initial cell concentration (higher than 1 x 10(5) cells/mL) or lower initial collagen concentration (lower than 2 mg/mL) exhibited faster contraction, higher ultimate stress, and superior elasticity and reduced relaxation behavior (p < 0.05). The cell-collagen model was successfully used to yield information regarding the initial cell concentration and the initial collagen concentration on contraction kinetics and mechanical behavior, which may have possible application

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2010 Journal of biomedical materials research. Part A

131. Lengthening-contractions in isolated myocardium impact force development and worsen cardiac contractile function in the mdx mouse model of muscular dystrophy (PubMed)

Lengthening-contractions in isolated myocardium impact force development and worsen cardiac contractile function in the mdx mouse model of muscular dystrophy Lengthening-contractions exert eccentric stress on myofibers in normal myocardium. In congestive heart failure caused by a variety of diseases, the impact of lengthening-contractions of myocardium likely becomes more prevalent and severe. The present study introduces a method to investigate the role of stretching imposed by repetitive (...) lengthening-contractions in myocardium under near-physiological conditions. By exerting various stretch-release ramps while the muscle is contracting, consecutive lengthening-contractions and their potential detrimental effect on cardiac function can be studied. We tested our model and hypothesis in age-matched (young and adult) mdx and wild-type mouse right ventricular trabeculae. These linear and ultrathin muscles possess all major cardiac cell types, and their contractile behavior very closely mimics

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2010 Journal of Applied Physiology

132. Urinary incontinence and pelvic organ prolapse in women: management

Surgery for women with both stress urinary incontinence and pelvic organ prolapse 34 1.10 Assessing complications associated with mesh surgery 35 1.11 Managing complications associated with mesh surgery 41 T erms used in this guideline 45 Recommendations for research 49 Key recommendations for research 49 Other recommendations for research 50 Rationale and impact 51 Organisation of specialist services 51 Collecting data on surgery and surgical complications 52 Urodynamic testing 52 Pelvic floor muscle (...) pelvic floor muscles 1.3.4 Undertake routine digital assessment to confirm pelvic floor muscle contraction before the use of supervised pelvic floor muscle training for the treatment of urinary incontinence. [2006, amended 2013] [2006, amended 2013] Urine testing Urine testing 1.3.5 Undertake a urine dipstick test in all women presenting with urinary incontinence to detect the presence of blood, glucose, protein, leucocytes and nitrites in the urine. [2006] [2006] 1.3.6 If women have symptoms

2019 National Institute for Health and Clinical Excellence - Clinical Guidelines

133. Suspected neurological conditions: recognition and referral

. Suspected neurological conditions: recognition and referral (NG127) © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 7 of 73Sudden-onset acute v Sudden-onset acute vestibular syndrome estibular syndrome 1.2.2 For adults with sudden-onset acute vestibular syndrome (vertigo, nausea or vomiting and gait unsteadiness), a HINTS (head-impulse–nystagmus–test-of- skew) test should be performed if a healthcare professional (...) with training and experience in the use of this test is available. 1.2.3 For adults with sudden-onset acute vestibular syndrome who have had a HINTS test: be aware that a negative HINTS test makes a diagnosis of stroke very unlikely refer immediately for neuroimaging if the HINTS test shows indications of stroke (a normal head impulse test, direction-changing nystagmus or skew deviation). 1.2.4 Refer immediately adults with sudden-onset acute vestibular syndrome in whom benign paroxysmal positional vertigo

2019 National Institute for Health and Clinical Excellence - Clinical Guidelines

134. Patient-specific blister packaging - rapid report

) V, Statutory Health Insurance, external experts who are involved in the Institute’s research commissions must disclose “all connections to interest groups and contract organizations, particularly in the pharmaceutical and medical devices industries, including details on the type and amount of any remuneration received”. The Institute received the completed Form for disclosure of potential conflicts of interest from each external expert. The information provided was reviewed by a Committee (...) the service of patient-specific blister packaging have 2 options: They can either perform the blister packaging themselves at the pharmacy or commission a contract manufacturer (known as blister centre) to do so [2,3]. Solid oral dosage forms such as tablets or capsules are generally suitable for blister packaging [4]. The blister packaging of these drugs is performed manually or automatically, usually using a computerized process. Blister packaging is suitable for outpatient and inpatient care and being

2019 Institute for Quality and Efficiency in Healthcare (IQWiG)

135. Canadian guidelines on benzodiazepine receptor agonist use disorder among older adults

in the creation of this publication disclaim any liability arising from contract, negligence, or any other cause of action, to any party, for the publication contents or any consequences arising from its use. The views expressed herein do not necessarily represent the views of Health Canada. We encourage the copy and distribution of these guidelines; provided that the appropriate attribution is given. Please see the suggested citation below. Suggested citation: Canadian Guidelines on Benzodiazepine Receptor

2019 CPG Infobase

136. Canadian guidelines on opioid use disorder among older adults

arising from contract, negligence, or any other cause of action, to any party, for the publication contents or any consequences arising from its use. The views expressed herein do not necessarily represent the views of Health Canada. We encourage the copy and distribution of these guidelines; provided that the appropriate attribution is given. Please see the suggested citation below. Suggested citation: Canadian Guidelines on Opioid Use Disorder Among Older Adults. Canadian Coalition for Seniors (...) , with an emphasis on signs of intoxication or withdrawal and the sequelae of substance use. Laboratory and other investigations (including urine drug tests) should be performed as appropriate for the medical conditions identified. Reassessment is essential and should be conducted episodically throughout long-term care. [GRADE Quality: Moderate; Strength: Strong]7 Canadian Guidelines on Opioid Use Disorder Among Older Adults QUESTION E: In older adults with or at risk for an OUD, what considerations

2019 CPG Infobase

137. Clinical Aggression Training: A Rapid Review

used methods which were noted once included reading assignments, case studies and workshop. Targeted outcomes The target outcomes included in the 13 interventional studies included empathy, staff efficacy, number of adverse events, work engagement, aggression, stress and patient satisfaction. Though all the studies were focused on communication skills, only quarter of the studies (25%) aimed to assess the impact of training on communication skills. The scales used to measure the change (...) No eligible studies addressed reductions in seclusion or restraints for staff training, risk assessment, multimodal, or environmental protocols. Harms of Strategies To Prevent Aggressive Behaviour No eligible studies examined risk assessments, multimodal interventions, environmental interventions, or medication protocols. Harms of Strategies To De-Escalate Aggressive Behaviour No eligible studies tested staff training, risk assessments, multimodal, or environmental protocols. Harms of Strategies To Reduce

2019 Monash Health Evidence Reviews

138. Public health guidance on prevention and control of blood-borne viruses in prison settings

was commissioned by the European Centre for Disease Prevention and Control (ECDC), coordinated by Lara Tavoschi with the support of Dagmar Hedrich from EMCDDA, Helena de Carvalho Gomes from ECDC and the ECDC Library, and produced by Pallas Health Research and Consultancy and Health Without Barriers (framework contract number ECDC/2015/028, specific contract number ECD.5855), in cooperation with Università degli Studi di Sassari (UNISS). Authors Anouk Oordt, Marije Vonk-Noordegraaf and Hilde Vroling (Pallas (...) a given intervention is accessible to the target population (availability of good health services within reasonable reach and when needed) Active case finding Interventions aimed at promoting early diagnosis by means of provider- initiated systematic offer for testing, at entrance and/or during stay (including at release) Client-initiated testing Testing which is voluntary and performed as the result of individual’s health- seeking behaviour, triggered by symptoms development or other reasons (i.e

2019 European Centre for Disease Prevention and Control - Public Health Guidance

139. Programmatic management of latent tuberculosis infection in the European Union

opinions; the evidence collection, appraisal and synthesis; the expert consultation and the first draft of this guidance were produced by Marije Vonk Noordegraaf-Schouten, Femke van Kessel and Anouk Oordt, members of a consortium of Pallas Health Research and Consultancy (Rotterdam) and Erasmus University Medical Center (framework contracts no ECDC/2013/005 and ECDC/2014/032). Invaluable input was received from ad hoc scientific panel chairs Gerard de Vries (the Netherlands) and Dominik Zenner (United (...) for risk of LTBI among vulnerable and hard-to-reach populations 13 Table 7. Evidence base on progression to active TB among vulnerable and hard-to-reach populations 13 Table 8. Evidence base for risk of LTBI and progression to active TB among occupational risk groups 14 Table 9. Evidence base for risk of LTBI and progression to active TB among other risk groups 15 Table 10. Evidence base for effectiveness of diagnostic test for LTBI 16 Table 11. Evidence base for cost-effectiveness of LTBI diagnostic

2019 European Centre for Disease Prevention and Control - Public Health Guidance

140. From innovation to implementation: team science two years on

contributions but do not have a university contract (e.g. senior postdoctoral researchers). 24 In addition, all named individuals on a grant will be encouraged to clarify their contribution.14 Team science and the funding community Future priorities Although the funding community has implemented welcome changes, and opportunities are being created and embraced, it was felt that challenges still remain. Participants suggested that the following issues should be addressed as a priority: • ‘Team science’ teams (...) commonly viewed as rewarding a single discipline mentality and therefore biasing against team science. Professor Iredale stressed that higher education institutes should not be deterred from submitting

2019 Academy of Medical Sciences

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