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Contraction Stress Test

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81. Involuntary reflexive pelvic floor muscle training in addition to standard training versus standard training alone for women with stress urinary incontinence: study protocol for a randomized controlled trial. (PubMed)

Involuntary reflexive pelvic floor muscle training in addition to standard training versus standard training alone for women with stress urinary incontinence: study protocol for a randomized controlled trial. Pelvic floor muscle training is effective and recommended as first-line therapy for female patients with stress urinary incontinence. However, standard pelvic floor physiotherapy concentrates on voluntary contractions even though the situations provoking stress urinary incontinence (...) developed physiotherapy program (experimental group) and the standard physiotherapy program (control group) regarding their effect on stress urinary incontinence. The working hypothesis is that the experimental group focusing on involuntary reflexive muscle contractions will have a higher improvement of continence measured by the International Consultation on Incontinence Modular Questionnaire Urinary Incontinence (short form), and - regarding secondary and tertiary outcomes - higher pelvic floor muscle

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2015 Trials Controlled trial quality: uncertain

82. Oxidative stress and dystrophy Facioscapulohumeral: Effects of vitamin C, vitamin E, zinc gluconate and selenomethionine supplementation. (PubMed)

conducted a pilot randomized double-blind placebo-controlled study to test whether oral administration of vitamins and minerals could improve the physical performance of patients with FSHD. The results of this randomized double-blind placebo-controlled trial show that supplementation with vitamin C, vitamin E (as alpha tocopherol), zinc gluconate and selenomethionine in patients with FSHD significantly improves the maximal voluntary contraction and endurance of both quadriceps by enhancing (...) Oxidative stress and dystrophy Facioscapulohumeral: Effects of vitamin C, vitamin E, zinc gluconate and selenomethionine supplementation. Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal dominant disease characterized by progressive weakness and atrophy of specific skeletal muscles. Despite major progress in the understanding of the genetic basis of FSHD, the exact mechanisms that lead to FSHD defects are not completely understood and no curative treatment is available. However

2015 Free radical biology & medicine Controlled trial quality: predicted high

83. Tissue length modulates “stimulated actin polymerization,” force augmentation, and the rate of swine carotid arterial contraction (PubMed)

by reduced prior S3 cofilin phosphorylation without changes in Y118 paxillin or cross-bridge phosphorylation. At long tissue length (1.4 L(o)), force augmentation was not observed, and there were no prior changes in Y118 paxillin, S3 cofilin, or cross-bridge phosphorylation. There were no significant differences in the cross-bridge phosphorylation transients before and after the force augmentation protocol at all three lengths tested. Tissues contracted faster at longer tissue lengths; contractile rate (...) correlated with prior Y118 paxillin phosphorylation. Total stress, per se, predicted Y118 paxillin phosphorylation. These data suggest that force augmentation is regulated by stimulated actin polymerization and that stimulated actin polymerization is regulated by total arterial stress. We suggest that K(+) depolarization first leads to cross-bridge phosphorylation and contraction, and the contraction-induced increase in mechanical strain increases Y118 paxillin phosphorylation, leading to stimulated

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2011 American Journal of Physiology - Cell Physiology

84. A POROELASTIC MODEL FOR CELL CRAWLING INCLUDING MECHANICAL COUPLING BETWEEN CYTOSKELETAL CONTRACTION AND ACTIN POLYMERIZATION (PubMed)

pushes the leading edge forward. The contraction, in turn, is regulated by stress in the cytoskeleton. To test this hypothesis, finite element models for a crawling cell are presented. These models are based on nonlinear poroelasticity theory, modified to include the effects of active contraction and growth, which are regulated by mechanical feedback laws. Results from the models agree reasonably well with published experimental data for cell speed, actin flow, and cytoskeletal deformation (...) A POROELASTIC MODEL FOR CELL CRAWLING INCLUDING MECHANICAL COUPLING BETWEEN CYTOSKELETAL CONTRACTION AND ACTIN POLYMERIZATION Much is known about the biophysical mechanisms involved in cell crawling, but how these processes are coordinated to produce directed motion is not well understood. Here, we propose a new hypothesis whereby local cytoskeletal contraction generates fluid flow through the lamellipodium, with the pressure at the front of the cell facilitating actin polymerization which

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2011 Journal of mechanics of materials and structures

85. Narrative Exposure Therapy in Women With Borderline Personality Disorder and Posttraumatic Stress Disorder

Narrative Exposure Therapy in Women With Borderline Personality Disorder and Posttraumatic Stress Disorder Narrative Exposure Therapy in Women With Borderline Personality Disorder and Posttraumatic Stress Disorder - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100 (...) ). Please remove one or more studies before adding more. Narrative Exposure Therapy in Women With Borderline Personality Disorder and Posttraumatic Stress Disorder The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02517723 Recruitment Status : Active, not recruiting First Posted : August 7, 2015 Last

2014 Clinical Trials

86. Hyperactive Adverse Mechanical-Stress Responses in Dystrophic Heart are Coupled to TRPC6 and Blocked by cGMP-PKG Modulation. (PubMed)

Hyperactive Adverse Mechanical-Stress Responses in Dystrophic Heart are Coupled to TRPC6 and Blocked by cGMP-PKG Modulation. The heart is exquisitely sensitive to mechanical stimuli to adapt rapidly to physiological demands. In muscle lacking dystrophin, such as Duchenne muscular dystrophy, increased load during contraction triggers pathological responses thought to worsen the disease. The relevant mechanotransducers and therapies to target them remain unclear.We tested the role of transient (...) receptor potential canonical (TRPC) channels TRPC3 and TRPC6 and their modulation by protein kinase G (PKG) in controlling cardiac systolic mechanosensing and determined their pathophysiological relevance in an experimental model of Duchenne muscular dystrophy.Contracting isolated papillary muscles and cardiomyocytes from controls and mice genetically lacking either TRPC3 or TRPC6 were subjected to auxotonic load to induce stress-stimulated contractility (SSC, gradual rise in force and intracellular Ca

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2014 Circulation Research

87. Pelvic floor muscle activation and strength components influencing female urinary continence and stress incontinence: A systematic review. (PubMed)

Pelvic floor muscle activation and strength components influencing female urinary continence and stress incontinence: A systematic review. A better understanding of pelvic floor muscle (PFM) activation and strength components is a prerequisite to get better insight in PFM contraction mechanisms and develop more specific PFM-training regimens for female stress urinary incontinence (SUI) patients. The aim of this systematic review (2012:CRD42012002547) was to evaluate and summarize existing (...) , measurement methods, study outcomes, as well as quality measures, based on the Cochrane risk of bias tool, were independently extracted. The high heterogeneity of the retrieved data made pooling of results impossible and therefore restricted the analysis to a systematic review.Cross-sectional studies showed group differences in favor of the continent women compared to SUI patients for PFM activation or PFM maximal strength, mean strength or sustained contraction. All intervention studies showed

2014 Neurourology and urodynamics

88. Ultrasound assessment of urethral support in women with stress urinary incontinence during and after first pregnancy. (PubMed)

, and 6 months postpartum. At each visit, symptoms of SUI were assessed and transperineal ultrasound examination was performed at rest, on pelvic floor contraction, and on Valsalva maneuver. Bladder neck position, bladder neck mobility, and levator hiatal dimensions were determined offline. Independent-samples t tests were used to compare ultrasound data between women with and without SUI. Because multiple t tests were performed, the statistical significance level was corrected using the Bonferroni (...) Ultrasound assessment of urethral support in women with stress urinary incontinence during and after first pregnancy. To investigate the association of bladder neck position, bladder neck mobility, and levator hiatal dimensions with symptoms of stress urinary incontinence (SUI) using transperineal ultrasonography in women during and after their first pregnancy.In this prospective observational study, 280 nulliparous pregnant women were evaluated at 12 weeks of gestation, 36 weeks of gestation

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2014 Obstetrics and Gynecology

89. Efficacy Study of "Imaginative Distention", a Self Managed Tool to Cope With Fatigue,Insomnia and Stress in pw Insomnia and pw MS

disability, as already seen in stroke patients. The principal end point of the trial is verify ID efficacy on fatigue and its specificity on pw MS at the end of the training. For this reason, ID efficacy will be tested in comparative terms too. Among all possible comparison populations, we selected: pw insomnia, which is stress related disease and health personnel, because at risk of stress. The control groups comparison permits to evaluate the specificity of ID on pw MS. The three groups are randomised (...) Efficacy Study of "Imaginative Distention", a Self Managed Tool to Cope With Fatigue,Insomnia and Stress in pw Insomnia and pw MS Efficacy Study of "Imaginative Distention", a Self Managed Tool to Cope With Fatigue,Insomnia and Stress in pw Insomnia and pw MS - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have

2014 Clinical Trials

90. Pelvic Floor Muscle Training With and Without Biofeedback in Women With Stress Urinary Incontinence

of pelvic floor muscle strength with "Oxford Scale" [ Time Frame: 1 month ] The evaluation consists in bidigital intravaginal test which evaluates the pelvic floor muscle strength using the following 0-5 scale, where 0 = no contraction and 5 = maximal contraction with support against gravity The graduates range from 0 - 5 = 0 has no muscle contraction, 1 = outline of muscle contraction, 2 = contracts without support against gravity, 3 = contracts and holds little against gravity, 4 = contracts and holds (...) up to 6 seconds against gravity and 5 = contracts and holds more than 6 seconds against gravity ntravaginal bidigital test that evaluates scale of pelvic floor muscle strength. The graduates range from 0 - 5 = 0 has no muscle contraction, 1 = outline of muscle contraction, 2 = contracts without support against gravity, 3 = contracts and holds little against gravity, 4 = contracts and holds up to 6 seconds against gravity and 5 = contracts and holds more than 6 seconds against gravity Secondary

2014 Clinical Trials

91. Stress Management Programs in Fire-fighters

Stress Anxiety Behavioral: techniques to optimize potential (TOP) Behavioral: heart coherence (HC) Not Applicable Detailed Description: The army's FFPs unit recruits new FFPs each month who received a twelve-month contract comprising of a six-month induction program (1st month to 6th month) and a six-month active duty period (6th month to 12th month). Within our study, volunteers will be included at the 4th month (baseline measurements after the first four months of training), in order to avoid (...) ) and at the 18th month. Enrolment will set to end when 180 FFPs (60 per group) will be included. We estimated that with 55 participants in each group, the study would have more than 80% power to detect a clinically important difference among the groups in the change of perceived stress, at an alpha level of 5%. Gaussian distribution of the data wil be tested by the Kolmogorov-Smirnov test. Data will be presented as mean ± standard deviation (SD). Comparisons between groups will be made with Wilcoxon matched

2014 Clinical Trials

92. Solace Stress Urinary inContinence Control Efficacy and Safety Study

Criteria: Female 18 years of age or older with stress urinary incontinence (SUI) Experienced SUI for at least 12 months and attempted and failed prior noninvasive treatment Willing to undergo cystoscopic procedures required and 36 month follow-up On stable medication for a minimum of 3 months Free of local genital skin infection Positive Pad Weight Test Free of impassable urethral strictures, trauma or necrosis Exclusion Criteria: Pregnant or planning to become pregnant during the study period Non (...) Solace Stress Urinary inContinence Control Efficacy and Safety Study Solace Stress Urinary inContinence Control Efficacy and Safety Study - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Solace Stress

2014 Clinical Trials

93. Stress Urinary Incontinence Physiotherapy

Radlinger, Bern University of Applied Sciences Study Details Study Description Go to Brief Summary: The purpose of the present study is to compare two different physiotherapy programs regarding their effect on stress urinary incontinence. Condition or disease Intervention/treatment Phase Urinary Incontinence, Stress Other: Involuntary muscle contractions Other: Voluntary muscle contractions Not Applicable Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial (...) on quality of life and outcome of treatment Secondary Outcome Measures : Pelvic floor muscle electromyography [ Time Frame: up to 6 months follow up ] Electromyography (EMG) activity measurements during rest, during maximal Voluntary contraction, fast voluntary contractions and during involuntary contractions (squat jumps, counter movement jumps, drop jumps), and during running at 7,9,11 km/h) 20-minute PAD-test [ Time Frame: up to 6 months follow up ] The 20 min Pad Test assesses urine loss and leakage

2014 Clinical Trials

94. Pomegranate to Reduce Maternal and Fetal Oxidative Stress and to Improve Outcome in Pregnancies Complicated With Preterm Premature Rupture of Membranes

related topics: Arms and Interventions Go to Arm Intervention/treatment Experimental: Pomegranate The women in this group will drink pomegranate juice Dietary Supplement: pomegranate Other Name: Pomegranate juice Outcome Measures Go to Primary Outcome Measures : Maternal and fetal oxidative stress [ Time Frame: 10 weeks ] Maternal and fetal oxidative stress will be determined by blood tests. Maternal and fetal oxidative stress [ Time Frame: 10 weeks ] Maternal blood and umbilical cord blodd (...) Pomegranate to Reduce Maternal and Fetal Oxidative Stress and to Improve Outcome in Pregnancies Complicated With Preterm Premature Rupture of Membranes Pomegranate to Reduce Maternal and Fetal Oxidative Stress and to Improve Outcome in Pregnancies Complicated With Preterm Premature Rupture of Membranes - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved

2014 Clinical Trials

95. Transobturator Subtrigonal Tape vs Transobturator Suburethral Tape for Stress Urinary Incontinence

. The results (efficacy) will be compared between the two groups using chi2 (group a/b versus success/lack of success). In all cases, p <0.05 will be considered significant. The data will be obtained with clinical evaluation, laboratory and radiological/imaging tests and the respective questionnaires during the visits before surgery, and at 2 and 6 weeks, and 6, 12, and 24 months after surgery. Condition or disease Intervention/treatment Phase Stress Urinary Incontinence Procedure: transobturator (...) : ≤20ml/s, provided there is a reduction compared to the baseline AND/ OR Blaivas Nomogram: The intersection of Qmax (abscissa) and maximum contraction of the detrusor (ordinate) will fall in one of four possible areas: not obstructed, mild obstruction, moderate obstruction or severe obstruction Secondary Outcome Measures : Complications [ Time Frame: Two Years ] Presence of: Recurrent Urinary Infection: Symptoms, irregular general urine test and urine culture with bacterial growth >1 occurrence per

2014 Clinical Trials

96. Prevention of postpartum stress incontinence in primigravidae with increased bladder neck mobility: a randomised controlled trial of antenatal pelvic floor exercises. (PubMed)

Prevention of postpartum stress incontinence in primigravidae with increased bladder neck mobility: a randomised controlled trial of antenatal pelvic floor exercises. To test whether supervised pelvic floor exercises antenatally will reduce the incidence of postpartum stress incontinence in at-risk primigravidae with bladder neck mobility, ultrasonically proven.Single blind, randomised controlled trial.Antenatal clinic in a UK NHS Trust Hospital.Two hundred and sixty-eight primigravidae (...) twice daily. At 34 weeks of gestation the number of contractions per repetition was increased to 12. Both the untreated control group and the study group received verbal advice on pelvic floor exercises from their midwives antenatally.Subjective reporting of stress incontinence at three months postpartum. Pelvic floor strength, using perineometry, and bladder neck mobility measured by perineal ultrasound.Of the 268 women enrolled, information on the main outcome variable was available for 110

2014 BJOG Controlled trial quality: predicted high

97. Prevention of postpartum stress incontinence in primigravidae with increased bladder neck mobility: a randomised controlled trial of antenatal pelvic floor exercises. (PubMed)

Prevention of postpartum stress incontinence in primigravidae with increased bladder neck mobility: a randomised controlled trial of antenatal pelvic floor exercises. To test whether supervised pelvic floor exercises antenatally will reduce the incidence of postpartum stress incontinence in at-risk primigravidae with bladder neck mobility, ultrasonically proven.Single blind, randomised controlled trial.Antenatal clinic in a UK NHS Trust Hospital.Two hundred and sixty-eight primigravidae (...) twice daily. At 34 weeks of gestation the number of contractions per repetition was increased to 12. Both the untreated control group and the study group received verbal advice on pelvic floor exercises from their midwives antenatally.Subjective reporting of stress incontinence at three months postpartum. Pelvic floor strength, using perineometry, and bladder neck mobility measured by perineal ultrasound.Of the 268 women enrolled, information on the main outcome variable was available for 110

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2014 BJOG Controlled trial quality: predicted high

98. Influence of endodontic treatment on systemic oxidative stress. (PubMed)

was determined using a biological antioxidant potential (BAP) test. Both these tests were carried on plasma samples taken from enrolled patients. Values were measured both before the endodontic treatment of the patients with chronic apical periodontitis, and 30 and 90 days after treatment, and compared to those obtained from healthy control patients.It was found that, on recruitment, the patients with chronic apical periodontitis exhibited significantly higher levels of oxidative stress than control patients (...) , as determined by the d-ROMs and BAP tests. Furthermore, the d-ROMs test values were shown to decrease and the BAP test values to increase over time in patients with chronic apical periodontitis following endodontic therapy. As the levels of oxidative stress in these patients tended to reduce and return to normal by 90 days following treatment.This study has demonstrated a positive association between chronic apical periodontitis and oxidative stress. Subjects affected by chronic apical periodontitis

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2014 International journal of medical sciences Controlled trial quality: uncertain

99. Effects of surface and intravaginal electrical stimulation in the treatment of women with stress urinary incontinence: randomized controlled trial. (PubMed)

-five women completed the study and were included in the analysis. Statistical analysis was performed using the Wilcoxon test for intragroup analysis and Kruskal-Wallis and Mann-Whitney tests for intergroup analysis (p<0.05).There was significant improvement in urinary loss and pressure of contraction in the SESG and IVESG. PFM strength increased only in the IVESG. Intergroup analysis found differences after the treatment in: urinary leakage between the SESG and CG (p<0.001) and the IVESG and CG (p (...) Effects of surface and intravaginal electrical stimulation in the treatment of women with stress urinary incontinence: randomized controlled trial. To evaluate the effects of surface electrical stimulation (SES) and to compare them with the effects of the intravaginal electrical stimulation (IVES) in women with stress urinary incontinence (SUI).This randomized controlled study included 48 women aged over 50 years, who complained of SUI evaluated according to two structured questions of King's

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2014 European journal of obstetrics, gynecology, and reproductive biology Controlled trial quality: uncertain

100. Test your medicine knowledge: 48-year-old woman with type 2 diabetes mellitus

cholesterol level of 37 mg/dL (0.96 mmol/L). Urinalysis is negative for albuminuria. Her estimated 10-year cardiovascular risk by the Pooled Cohort Equations is 2.7%. Which of the following is the most appropriate cardiovascular disease risk management? A. Aspirin B. Coronary artery calcium scoring C. Exercise stress testing D. Folic acid supplementation E. No further testing or therapy MKSAP Answer and Critique The correct answer is E. No further testing or therapy. No further testing or therapy would (...) Test your medicine knowledge: 48-year-old woman with type 2 diabetes mellitus Should aspirin be routinely be given to patients with diabetes mellitus? Test your medicine knowledge: 48-year-old woman with type 2 diabetes mellitus | | October 31, 2015 10 Shares Test your medicine knowledge with the , in partnership with the . A 48-year-old woman is evaluated during a follow-up visit. She has a 5-year history of type 2 diabetes mellitus. She has no other significant medical history. Medications

2015 KevinMD blog

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