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Contraction Stress Test

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81. Effects of vitamin C, vitamin E, zinc gluconate, and selenomethionine supplementation on muscle function and oxidative stress biomarkers in patients with facioscapulohumeral dystrophy: A double-blind randomized controlled clinical trial. Full Text available with Trip Pro

vitamin E, 25mg zinc gluconate and 200 μg selenomethionine (n=26), or matching placebo (n=27) once a day for 17 weeks. Primary outcomes were changes in the two-minute walking test (2-MWT), maximal voluntary contraction, and endurance limit time of the dominant and nondominant quadriceps (MVCQD, MVCQND, TlimQD, and TlimQND, respectively) after 17 weeks of treatment. Secondary outcomes were changes in the antioxidant status and oxidative stress markers. Although 2-MWT, MVCQ, and TlimQ were all (...) Effects of vitamin C, vitamin E, zinc gluconate, and selenomethionine supplementation on muscle function and oxidative stress biomarkers in patients with facioscapulohumeral dystrophy: A double-blind randomized controlled clinical trial. Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal dominant disease characterized by progressive weakness and atrophy of specific skeletal muscles. As growing evidence suggests that oxidative stress may contribute to FSHD pathology, antioxidants

2015 Free radical biology & medicine Controlled trial quality: predicted high

82. Vortioxetine for Posttraumatic Stress Disorder

Vortioxetine for Posttraumatic Stress Disorder Vortioxetine for Posttraumatic Stress Disorder - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Vortioxetine for Posttraumatic Stress Disorder The safety (...) Information provided by (Responsible Party): Philip D. Harvey, University of Miami Study Details Study Description Go to Brief Summary: Post-traumatic stress disorder (PTSD) can result from having experienced or witnessed a traumatic event. Patients with PTSD symptoms can sometimes experience symptom relief after treatment with antidepressants; however, few patients experience complete symptom relief. There is a need to develop new treatments for PTSD. This study will evaluate if 12 weeks of using

2015 Clinical Trials

83. Individual Pelvic Floor Muscle Training Versus Individual With Group Versus Group for Stress Urinary Incontinence

Individual Pelvic Floor Muscle Training Versus Individual With Group Versus Group for Stress Urinary Incontinence Individual Pelvic Floor Muscle Training Versus Individual With Group Versus Group for Stress Urinary Incontinence - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved (...) studies (100). Please remove one or more studies before adding more. Individual Pelvic Floor Muscle Training Versus Individual With Group Versus Group for Stress Urinary Incontinence The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02664714 Recruitment Status : Unknown Verified January 2016 by Vilena

2015 Clinical Trials

84. A Chinese Herbal Decoction for Stress Urinary Incontinence

. For comparison between two time points, paired t-test or Wilcoxon signed rank test will be used as appropriate. A statistically significant difference was set at P<0.05. Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 72 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: Single (Outcomes Assessor) Primary Purpose: Treatment Official Title: Effect of Yiqi Suoquan Tang, a Chinese Herbal Decoction, on Stress (...) the muscles, they are asked to do a set consists of 10 contractions, each lasting 5 seconds, with a 5 seconds break between contractions. Then they need to do same procedure 3 times daily as the home exercises. Other Name: Kegel Exercise Outcome Measures Go to Primary Outcome Measures : Change in 24h pad testing [ Time Frame: 12 weeks ] Secondary Outcome Measures : Change in ICIQ-SF questionnaire [ Time Frame: 12 weeks ] Change in abdominal leak-point pressure [ Time Frame: 12 weeks ] Change in I-QOL

2015 Clinical Trials

85. Oxidative stress and dystrophy Facioscapulohumeral: Effects of vitamin C, vitamin E, zinc gluconate and selenomethionine supplementation. (Abstract)

conducted a pilot randomized double-blind placebo-controlled study to test whether oral administration of vitamins and minerals could improve the physical performance of patients with FSHD. The results of this randomized double-blind placebo-controlled trial show that supplementation with vitamin C, vitamin E (as alpha tocopherol), zinc gluconate and selenomethionine in patients with FSHD significantly improves the maximal voluntary contraction and endurance of both quadriceps by enhancing (...) Oxidative stress and dystrophy Facioscapulohumeral: Effects of vitamin C, vitamin E, zinc gluconate and selenomethionine supplementation. Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal dominant disease characterized by progressive weakness and atrophy of specific skeletal muscles. Despite major progress in the understanding of the genetic basis of FSHD, the exact mechanisms that lead to FSHD defects are not completely understood and no curative treatment is available. However

2015 Free radical biology & medicine Controlled trial quality: predicted high

86. A Study on Effect of Electroacupuncture on Gene Expression in Hypothalamus of Rats with Stress-Induced Prehypertension Based on Gene Chip Technology. Full Text available with Trip Pro

. The PCR results of the key genes including HSPB1, P2RX4, PPP1R14A, and TH are consistent with that of gene chip test. Conclusion. EA could significantly lower blood pressure of stress-induced prehypertension rats and affect its gene expression profile in hypothalamus. Genes and their signal transduction pathway that related to the contraction of vascular smooth muscle, concentration of Ca(2+), and excitability of sympathetic nerve may be involved in EA's antihypertensive mechanism. (...) A Study on Effect of Electroacupuncture on Gene Expression in Hypothalamus of Rats with Stress-Induced Prehypertension Based on Gene Chip Technology. Objective. To explore the effect of electroacupuncture (EA) on gene expression in the hypothalamus of rats with stress-induced prehypertension and try to reveal its biological mechanism with gene chip technology. Methods. The stress-induced hypertensive rat model was prepared by combining electric foot-shocks with generated noise. Molding cycle

2015 Evidence-based Complementary and Alternative Medicine (eCAM)

87. Involuntary reflexive pelvic floor muscle training in addition to standard training versus standard training alone for women with stress urinary incontinence: study protocol for a randomized controlled trial. Full Text available with Trip Pro

Involuntary reflexive pelvic floor muscle training in addition to standard training versus standard training alone for women with stress urinary incontinence: study protocol for a randomized controlled trial. Pelvic floor muscle training is effective and recommended as first-line therapy for female patients with stress urinary incontinence. However, standard pelvic floor physiotherapy concentrates on voluntary contractions even though the situations provoking stress urinary incontinence (...) developed physiotherapy program (experimental group) and the standard physiotherapy program (control group) regarding their effect on stress urinary incontinence. The working hypothesis is that the experimental group focusing on involuntary reflexive muscle contractions will have a higher improvement of continence measured by the International Consultation on Incontinence Modular Questionnaire Urinary Incontinence (short form), and - regarding secondary and tertiary outcomes - higher pelvic floor muscle

2015 Trials Controlled trial quality: uncertain

88. The use of behavioral contracting to increase exercise activity. (Abstract)

The use of behavioral contracting to increase exercise activity. Abstract A cardiovascular risk reduction program used a submaximal treadmill stress test to evaluate physical fitness. Of the 179 individuals who participated in the health education counseling activities which followed testing, 96 signed a behavioral contract to engage in a 12-week aerobic exercise program. Forty-one contractors fully met contract goals, and 21 reported increased activity levels. Analyses examined demographic (...) , risk factor, and attitudinal predictors of contract signing and contract adherence. Contract signing was related to education, smoking, and women's mean body weight. Only women's body weight was related to contract adherence. Attitudes toward exercise were related to neither. Level of contract adherence was significantly related to a decrease in exercising heart rate at the six-month follow-up assessment. These data suggest that contract signing may be a useful device for assessing client

2012 American journal of health promotion : AJHP Controlled trial quality: uncertain

89. Early Elimination of Premature Ventricular Contractions in Heart Failure

may contact the study research staff using the contacts provided below. For general information, Layout table for eligibility information Ages Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Patients with reduced ejection fraction (EF ≤45%) demonstrated by transthoracic echocardiogram and deemed to be non-ischemic by nuclear stress test or cardiac catheterization. Patients with >20% PVCs on 24 (...) Early Elimination of Premature Ventricular Contractions in Heart Failure Early Elimination of Premature Ventricular Contractions in Heart Failure - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Early

2012 Clinical Trials

90. An Exploratory Study to Investigate Bladder Contractions in the Storage Phase and Related Bladder Sensations in Healthy Females and Females With Overactive Bladder (OAB) Using High Resolution and Conventional Urodynamics

An Exploratory Study to Investigate Bladder Contractions in the Storage Phase and Related Bladder Sensations in Healthy Females and Females With Overactive Bladder (OAB) Using High Resolution and Conventional Urodynamics An Exploratory Study to Investigate Bladder Contractions in the Storage Phase and Related Bladder Sensations in Healthy Females and Females With Overactive Bladder (OAB) Using High Resolution and Conventional Urodynamics - Full Text View - ClinicalTrials.gov Hide glossary (...) Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. An Exploratory Study to Investigate Bladder Contractions in the Storage Phase and Related Bladder Sensations in Healthy Females and Females With Overactive Bladder (OAB) Using High Resolution and Conventional

2012 Clinical Trials

91. Corneal surface asphericity, roughness, and transverse contraction following uniform scanning excimer laser ablation. Full Text available with Trip Pro

Corneal surface asphericity, roughness, and transverse contraction following uniform scanning excimer laser ablation. To examine the interaction between the excimer laser and residual tissue.Ten cadaveric porcine eyes with exposed corneal stroma and plastic test spheres underwent uniform 6-mm ablation with a scanning excimer laser. Corneal profilometry of the central 3 mm was measured with submicrometer resolution optical interferometry, before and after uniform excimer ablation. Eleven surface (...) not seen with isotropic, inorganic material. Increases in asphericity, surface roughness, surface contraction, and stromal morphologic changes are supportive of this interaction. The surface changes demonstrated may be indicative of temperature-induced transverse collagen fibril contraction and stress redistribution, or the ablation threshold of the stromal surface may be altered. This phenomenon may be of increased importance using lasers with increased thermal load.

2012 Investigative Ophthalmology & Visual Science

92. Reflex contraction of the levator ani in women symptomatic for pelvic floor disorders. Full Text available with Trip Pro

Reflex contraction of the levator ani in women symptomatic for pelvic floor disorders. Stress urinary incontinence (SUI) is a common health problem in women. Reflex activation of muscular pelvic floor structures may play a role in preserving continence. In this study we aimed to analyze reflex pelvic floor activity on coughing in women seen for urodynamic testing.In a retrospective cohort study we analyzed the data sets of 191 women who attended a tertiary referral service for multichannel (...) urodynamic testing and four-dimensional pelvic floor ultrasound scan between May 2009 and February 2010. Coughs were registered on volume ultrasound at a minimum of 16 Hz and analyzed by postprocessing at a later date, the operator being blinded against all clinical data.Of 175 analyzable cough volume datasets, a levator reflex was seen in 138 (79%), and clitoral reflex movement in 160 (91%). On multivariable analysis there was a significant relationship between urodynamic stress incontinence (USI

2012 Ultrasound in Obstetrics and Gynecology

93. Ventricular premature contractions: a randomized non-drug intervention trial in normal men. (Abstract)

Ventricular premature contractions: a randomized non-drug intervention trial in normal men. The influence of a 6-week intervention on factors thought to be related to ectopic cardiac rhythms was tested in normal men with frequent ventricular premature contractions (VPCs), using a randomized, controlled and partial crossover design. The VPC intervention trial experimental regimen included total abstinence from caffeine and smoking, reduction of alcohol intake, and a physical conditioning program (...) . Effects were studied in detail among 81 healthy men with persistent VPCs. VPCs were measured during standard states of rest, dynamic and isometric exercise and other stresses, and 24-hour ambulatory monitoring. Adherence to the treatment was excellent. The experimental group achieved more than 80% of activities asked of them, and little "contamination" occurred in the control group. VPCs were analyzed according to VPC/min, VPC/man and VPC/total number of heart beats. Moderate changes in VPC rates

1979 Circulation Controlled trial quality: uncertain

94. Narrative Exposure Therapy in Women With Borderline Personality Disorder and Posttraumatic Stress Disorder

Narrative Exposure Therapy in Women With Borderline Personality Disorder and Posttraumatic Stress Disorder Narrative Exposure Therapy in Women With Borderline Personality Disorder and Posttraumatic Stress Disorder - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100 (...) ). Please remove one or more studies before adding more. Narrative Exposure Therapy in Women With Borderline Personality Disorder and Posttraumatic Stress Disorder The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02517723 Recruitment Status : Active, not recruiting First Posted : August 7, 2015 Last

2014 Clinical Trials

95. Ultrasound assessment of urethral support in women with stress urinary incontinence during and after first pregnancy. (Abstract)

, and 6 months postpartum. At each visit, symptoms of SUI were assessed and transperineal ultrasound examination was performed at rest, on pelvic floor contraction, and on Valsalva maneuver. Bladder neck position, bladder neck mobility, and levator hiatal dimensions were determined offline. Independent-samples t tests were used to compare ultrasound data between women with and without SUI. Because multiple t tests were performed, the statistical significance level was corrected using the Bonferroni (...) Ultrasound assessment of urethral support in women with stress urinary incontinence during and after first pregnancy. To investigate the association of bladder neck position, bladder neck mobility, and levator hiatal dimensions with symptoms of stress urinary incontinence (SUI) using transperineal ultrasonography in women during and after their first pregnancy.In this prospective observational study, 280 nulliparous pregnant women were evaluated at 12 weeks of gestation, 36 weeks of gestation

2014 Obstetrics and Gynecology

96. Influence of endodontic treatment on systemic oxidative stress. Full Text available with Trip Pro

was determined using a biological antioxidant potential (BAP) test. Both these tests were carried on plasma samples taken from enrolled patients. Values were measured both before the endodontic treatment of the patients with chronic apical periodontitis, and 30 and 90 days after treatment, and compared to those obtained from healthy control patients.It was found that, on recruitment, the patients with chronic apical periodontitis exhibited significantly higher levels of oxidative stress than control patients (...) , as determined by the d-ROMs and BAP tests. Furthermore, the d-ROMs test values were shown to decrease and the BAP test values to increase over time in patients with chronic apical periodontitis following endodontic therapy. As the levels of oxidative stress in these patients tended to reduce and return to normal by 90 days following treatment.This study has demonstrated a positive association between chronic apical periodontitis and oxidative stress. Subjects affected by chronic apical periodontitis

2014 International journal of medical sciences Controlled trial quality: uncertain

97. Prevention of postpartum stress incontinence in primigravidae with increased bladder neck mobility: a randomised controlled trial of antenatal pelvic floor exercises. (Abstract)

Prevention of postpartum stress incontinence in primigravidae with increased bladder neck mobility: a randomised controlled trial of antenatal pelvic floor exercises. To test whether supervised pelvic floor exercises antenatally will reduce the incidence of postpartum stress incontinence in at-risk primigravidae with bladder neck mobility, ultrasonically proven.Single blind, randomised controlled trial.Antenatal clinic in a UK NHS Trust Hospital.Two hundred and sixty-eight primigravidae (...) twice daily. At 34 weeks of gestation the number of contractions per repetition was increased to 12. Both the untreated control group and the study group received verbal advice on pelvic floor exercises from their midwives antenatally.Subjective reporting of stress incontinence at three months postpartum. Pelvic floor strength, using perineometry, and bladder neck mobility measured by perineal ultrasound.Of the 268 women enrolled, information on the main outcome variable was available for 110

2014 BJOG Controlled trial quality: predicted high

98. Hyperactive Adverse Mechanical-Stress Responses in Dystrophic Heart are Coupled to TRPC6 and Blocked by cGMP-PKG Modulation. Full Text available with Trip Pro

Hyperactive Adverse Mechanical-Stress Responses in Dystrophic Heart are Coupled to TRPC6 and Blocked by cGMP-PKG Modulation. The heart is exquisitely sensitive to mechanical stimuli to adapt rapidly to physiological demands. In muscle lacking dystrophin, such as Duchenne muscular dystrophy, increased load during contraction triggers pathological responses thought to worsen the disease. The relevant mechanotransducers and therapies to target them remain unclear.We tested the role of transient (...) receptor potential canonical (TRPC) channels TRPC3 and TRPC6 and their modulation by protein kinase G (PKG) in controlling cardiac systolic mechanosensing and determined their pathophysiological relevance in an experimental model of Duchenne muscular dystrophy.Contracting isolated papillary muscles and cardiomyocytes from controls and mice genetically lacking either TRPC3 or TRPC6 were subjected to auxotonic load to induce stress-stimulated contractility (SSC, gradual rise in force and intracellular Ca

2014 Circulation Research

99. Stress Urinary Incontinence Physiotherapy

Radlinger, Bern University of Applied Sciences Study Details Study Description Go to Brief Summary: The purpose of the present study is to compare two different physiotherapy programs regarding their effect on stress urinary incontinence. Condition or disease Intervention/treatment Phase Urinary Incontinence, Stress Other: Involuntary muscle contractions Other: Voluntary muscle contractions Not Applicable Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial (...) on quality of life and outcome of treatment Secondary Outcome Measures : Pelvic floor muscle electromyography [ Time Frame: up to 6 months follow up ] Electromyography (EMG) activity measurements during rest, during maximal Voluntary contraction, fast voluntary contractions and during involuntary contractions (squat jumps, counter movement jumps, drop jumps), and during running at 7,9,11 km/h) 20-minute PAD-test [ Time Frame: up to 6 months follow up ] The 20 min Pad Test assesses urine loss and leakage

2014 Clinical Trials

100. Efficacy Study of "Imaginative Distention", a Self Managed Tool to Cope With Fatigue,Insomnia and Stress in pw Insomnia and pw MS

disability, as already seen in stroke patients. The principal end point of the trial is verify ID efficacy on fatigue and its specificity on pw MS at the end of the training. For this reason, ID efficacy will be tested in comparative terms too. Among all possible comparison populations, we selected: pw insomnia, which is stress related disease and health personnel, because at risk of stress. The control groups comparison permits to evaluate the specificity of ID on pw MS. The three groups are randomised (...) Efficacy Study of "Imaginative Distention", a Self Managed Tool to Cope With Fatigue,Insomnia and Stress in pw Insomnia and pw MS Efficacy Study of "Imaginative Distention", a Self Managed Tool to Cope With Fatigue,Insomnia and Stress in pw Insomnia and pw MS - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have

2014 Clinical Trials

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