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282. What is the evidence on the role of the arts in improving health and well-being? A scoping review

disorder CVD cardiovascular diseases LGBTQ lesbian, gay, bisexual, transgender and queer PD Parkinson’s disease PTSD post-traumatic stress disorderv ACKNOWLEDGEMENTS The authors would like to acknowledge Dr Simon Chaplin from the Wellcome Trust for providing the introduction to the Cultural contexts of health project that led to the writing of this report, and also the Wellcome Trust for funding Daisy Fancourt through a Wellcome Research Fellowship (205407/Z/16/Z). This report has been produced (...) Psychological (e.g. enhanced self-ecacy, coping and emotional regulation) Physiological (e.g. lower stress hormone response, enhanced immune function and higher cardiovascular reactivity) Social (e.g. reduced loneliness and isolation, enhanced social support and improved social behaviours) Behavioural (e.g. increased exercise, adoption of healthier behaviours, skills development) Outcomes Prevention Promotion Management Treatment Components Aesthetic engagement Involvement of the imagination

2019 WHO Health Evidence Network

283. Primary Prevention of ASCVD and T2DM in Patients at Metabolic Risk Full Text available with Trip Pro

of blood pressure, waist circumference, fasting lipid profile, and blood glucose. Individuals identified at metabolic risk should undergo 10-year global risk assessment for ASCVD or coronary heart disease to determine targets of therapy for reduction of apolipoprotein B–containing lipoproteins. Hypertension should be treated to targets outlined in this guideline. Individuals with prediabetes should be tested at least annually for progression to diabetes and referred to intensive diet and physical (...) glucose, or 2-hour glucose with a second test for confirmation using a new blood sample. Testing for additional biological markers ( e.g., high-sensitivity C-reactive protein) associated with metabolic risk should be limited to subpopulations. This recommendation is specifically for adults aged 40 to 75 years, those for whom the interventions have the greatest impact and evidence for efficacy. This does not restrict screening for appropriate individuals outside of this age range, especially those who

2019 The Endocrine Society

284. Sepsis Management

to detect, but in the course of time, not having been either detected or treated in the beginning, it becomes easy to detect but difficult to cure”. A full history and examination with appropriate blood tests and radiological examinations will aid in making the diagnosis. A 2010 report by the Scottish Trauma Audit Group of sepsis management in Scotland reported that 1.7% of new patient hospitals attendances developed the criteria for sepsis within two days of initial attendance, 34% of patients

2019 National Clinical Guidelines (Ireland)

285. Development of Harmonized Outcome Measures for Use in Patient Registries and Clinical Practice: Methods and Lessons Learned

5600 Fishers Lane Rockville, MD 20857 Contract No. 290-2014-0004-C Prepared by: L&M Policy Research, LLC Washington, DC 20009 With partners: OM1, AcademyHealth Investigators: Michelle B. Leavy, MPH 1 Claudia Schur, PhD 2 Ferhat Q. Kassamali, MSc, MPH 2 Margaret Edder Johnson, MBA 2 Raj Sabharwal, MPH 3 Paul Wallace, MD 3 Richard E. Gliklich, MD 1 1 OM1, Inc. 2 L&M Policy Research, LLC 3 AcademyHealth AHRQ Publication No. 19-EHC008-EF February 2019 ii This report is based on research (...) . For assistance contact Suggested citation: Leavy MB, Schur C, Kassamali FQ, Johnson ME, Sabharwal R, Wallace P, Gliklich RE. Development of Harmonized Outcome Measures for Use in Patient Registries and Clinical Practice: Methods and Lessons Learned. Final Report. (Prepared by L&M Policy Research, LLC under Contract No. 290-2014-00004-C) AHRQ Publication No. 19-EHC008-EF. Rockville, MD: Agency for Healthcare Research and Quality; February 2019. Posted final reports are located

2019 Effective Health Care Program (AHRQ)

286. ACC/AATS/AHA/ASE/ASNC/HRS/SCAI/SCCT/SCMR/STS 2019 Appropriate Use Criteria for Multimodality Imaging in the Assessment of Cardiac Structure and Function in Nonvalvular Heart Disease

of a Patient With Clinical Signs and/or Symptoms of Heart Disease .. - 6.2. Evaluation of Cardiac Structure and Function in Patients Who Had Prior Testing .. - Table 3. Sequential or Follow-Up Testing to Clarify Initial Diagnostic Testing .. - Table 4. Sequential or Follow-Up Testing: Asymptomatic or Stable Symptoms ... .. - Table 5. Sequential or Follow-Up Testing: New or Worsening Symptoms or to Guide Therapy .. - 6.3. Evaluation of Cardiac Structure and Function in Patients Undergoing Transcatheter (...) create, review, and categorize clinical situations in which diagnostic tests and procedures are utilized by physicians caring for patients with cardiovas- cular diseases. The process is based on the current un- derstanding of the technical capabilities of the imaging modalities examined. PREFACE Structural and valvular heart disease (VHD) encompass a signi?cant proportion of cardiovascular disease condi- tions. Initial diagnosis and subsequent follow-up frequently rely on imaging with more than 1

2019 Heart Rhythm Society

287. Addressing Social Isolation To Improve the Health of Older Adults: A Rapid Review

Addressing Social Isolation To Improve the Health of Older Adults: A Rapid Review Rapid Evidence Product Addressing Social Isolation To Improve the Health of Older Adults: A Rapid Review eRapid Evidence Product Addressing Social Isolation To Improve the Health of Older Adults: A Rapid Review Prepared for: Agency for Healthcare Research and Quality U.S. Department of Health and Human Services 5600 Fishers Lane Rockville, MD 20857 Contract No. 290-2017-00003-C Prepared by: Scientific (...) on research conducted by the Scientific Resource Center under contract to the Agency for Healthcare Research and Quality (AHRQ), Rockville, MD (Contract No. 290- 2017-00003-C). The findings and conclusions in this document are those of the authors, who are responsible for its contents; the findings and conclusions do not necessarily represent the views of AHRQ. Therefore, no statement in this report should be construed as an official position of AHRQ or of the U.S. Department of Health and Human Services

2019 Effective Health Care Program (AHRQ)

288. Dabrafenib (Tafinlar) - In combination with trametinib for the adjuvant treatment of adult patients with Stage III melanoma with a BRAF V600 mutation

surveillance however the EMA noted that health-related quality of life outcomes from COMBI-AD suggest that the treatment has no negative impact on quality of life. Prior to initiation of dabrafenib plus trametinib patients must have confirmed BRAF V600 positive mutation using a validated test. Clinical experts consulted by SMC considered that the introduction of this medicine may impact on service delivery as capacity in oncology clinics would be required although patient numbers will be small. 6 Summary (...) which can have an enormous impact on a family, especially a family with young children on a low income. The disease can also have a massive psychological impact, especially when it comes to scarring - scarring and lymphedema are huge issues for patients. Often, patients who are living with this disease suffer greatly, the stress of reaching stage 3 and knowing that there are limited options available is a terrifying situation for a patient to be in. ? In many other cancers there is an adjuvant

2019 Scottish Medicines Consortium

289. Heart Disease and Stroke Statistics Full Text available with Trip Pro

of Medicine, Cardiology Medtronic Philanthropy ; Gilead Sciences None None None None None None Matthew Shane Loop University of North Carolina at Chapel Hill NHLBI (HCHS/SOL contract) ; NHLBI (ARIC contract) ; DENKA-SEIKEN ; Puget Sound Bloodworks None None None None None None Pamela L. Lutsey University of Minnesota, Division of Epidemiology and Community Health NIH None None None None None None Seth S. Martin Johns Hopkins School of Medicine, Department of Cardiology None None None None None None None

2019 American Heart Association

290. AIM Clinical Appropriateness Guidelines for Advanced Imaging of the Heart.

2019. AIM Specialty Health. All Rights Reserved. 2 Table of Contents Description and Application of the Guidelines 3 Administrative Guidelines 4 Ordering of Multiple Studies 4 Pre-test Requirements 5 Cardiac Imaging 6 Myocardial Perfusion Imaging 6 Cardiac Blood Pool Imaging 12 Infarct Imaging 15 Stress Echocardiography (SE) 16 Transesophageal Echocardiography (TEE) 23 Resting Transthoracic Echocardiography (TTE) 25 Cardiac CT - Quantitative Evaluation of Coronary Calcification 33 CT Cardiac (...) but are thought to contribute to CAD risk. ? Selection of the optimal diagnostic work-up for evaluation or exclusion of coronary artery disease should be made within the context of available studies (which include treadmill stress test, stress myocardial perfusion imaging, stress echocardiography, cardiac PET imaging and invasive cardiac/coronary angiography), so that the resulting information facilitates patient management decisions and does not merely add a new layer of testing. ? Occasionally, it may

2019 AIM Specialty Health

291. Letermovir (Prevymis) - for prophylaxis of cytomegalovirus (CMV) reactivation and disease in adult CMV-seropositive recipients [R+] of an allogeneic haematopoietic stem cell transplant (HSCT)

on the patient and carer resulting from the patient being well, able to contribute to family, work and social life. They would also avoid the stress of facing a prolonged unpleasant treatment associated with CMV reactivation, which is particularly difficult in the context of having already undergone extensive treatment for their initial serious diagnosis and endured the complex and risky treatment of stem cell transplant. Additional Patient and Carer Involvement We received patient group submissions from (...) actual medicine use from the pivotal study but rather data on the length of treatment on letermovir for the UK cohort (n = 12, randomized 2:1 to letermovir or placebo) of PN001 (72 days). Using the mean medicine usage in the study increased the ICERs to £18,956 with the PAS discount. More minor weaknesses, the effects of which were tested through sensitivity analysis, include: ? Use of 24-week data in the model when week 48 data were sometimes available. The ICER with PAS increased to £15,682 when

2019 Scottish Medicines Consortium

292. Anaesthetic practice in the independent sector

to be flexible and available. Consultants will normally need to be available/on-call for their patients for a period of time postoperatively and will work more often on their own. If caring for patients with private medical insurance or who are self-funded, the doctor will be required to pay a higher medical indemnity subscription, have more complicated accounts, arrange for the billing of patients and must make sure that their independent practice does not conflict with their NHS contract. Anyone (...) private hospitals only award practising privileges to doctors who hold or who have held a substantive consultant appointment in an NHS hospital; others consider this not to be necessary. All doctors should undergo regular appraisal and revalidation in line with national recommendations and standards. Processes for appraisal vary locally but if the anaesthetist holds an NHS contract, appraisal is usually undertaken within the NHS hospital. Practice within the independent sector should be addressed

2019 Association of Anaesthetists of GB and Ireland

293. Ertugliflozin (Steglatro) - type 2 diabetes mellitus

means for all endpoints except for proportions of participants with HbA1c <7.0% and glycaemic rescue. N=number of patients, HbA1c=glycosylated haemoglobin, FPG=fasting plasma glucose, SBP=systolic blood pressure, DBP=diastolic blood pressure. p values versus placebo: A p<0.001, B p=0.002, C p=0.013, D p=0.001, E no statistical test performed. Table 3: Triple therapy setting VERTIS SITA2 efficacy results at 26 weeks (excludes data post glycaemic rescue) 3, 6 Outcome Ertugliflozin 5mg N=156 (...) plasma glucose, SBP=systolic blood pressure, HbA1c=glycosylated haemoglobin. p values versus placebo: A p<0.001, B p=0.019, C p=0.002, D no statistical test performed. In VERTIS FACTORIAL, patients were randomised equally to receive one of five daily blinded treatments: ertugliflozin 5mg, ertugliflozin 15mg, sitagliptin 100mg, ertugliflozin 5mg plus sitagliptin 100mg or ertugliflozin 15mg plus sitagliptin 100mg. 4 5 Table 4: Mixed dual, triple therapy setting VERTIS FACTORIAL efficacy results at week

2019 Scottish Medicines Consortium

294. BTS Guideline for Bronchiectasis in adults

disease Section 6 14 Investigations for causes of bronchiectasis 14 Standard laboratory tests 15 Tests for specific disease groups with associated bronchiectasis 15 Allergic bronchopulmonary aspergillosis 16 Immune dysfunction 16 Serum immunoglobulins (IgG, IgA, & IgM) and electrophoresis 16 Full blood count (FBC) 16 Measurement of baseline specific antibody levels against capsular polysaccharides of Streptococcus pneumonia 17 Rheumatoid Arthritis 17 Recurrent aspiration 17 Cystic fibrosis 17 Ciliary (...) and advertisers and not authors’ institutions, the BMJ Publishing Group Ltd, the British Thoracic Society or theBMAunless otherwise specified or determined by law. Acceptance of advertising does not imply endorsement. To the fullest extent permitted by law, the BMJ Publishing Group Ltd shall not be liable for any loss, injury or damage resulting from the use of Thorax or any information in it whether based on contract, tort or otherwise. Readers are advised to verify any information they choose to rely

2019 British Thoracic Society

295. ShortGuide: Fetal movements

that women may recognise only 40% FM near term 14 · Maternal–anxiety/stress 18,19 , mental distraction 20 , exercise 21 , medication use · Placenta position 22 · Fetal–anterior position of the fetal spine (presentation has no effect on maternal perception 11 ); akinesia syndromes 5 short GUIDE Queensland Clinical Guidelines Fetal movements Available from: © State of Queensland (Queensland Health) 2018 Page 2 of 5 Assessing fetal movements Aspect Consideration Assessing fetal (...) transfusion assessment · Consider testing for feto-maternal transfusion 5 by flow cytometry or Kleihauer-Betke test o Perform urgently if signs of fetal anaemia or if sudden cessation of FM · Feto-maternal transfusions o Cause fetal anaemia o Are typically silent events 31,32 o May not be suspected based on CTG 33 or USS unless severe anaemia has occurred o Massive feto-maternal transfusion has been reported in up to 4% stillbirths and 0.04% neonatal deaths 34,35 · Recurrent, small to moderate feto

2019 Queensland Health

296. 2019 AHA/ACC Clinical Performance and Quality Measures for Adults With High Blood Pressure: A Report of the American College of Cardiology/American Heart Association Task Force on Performance Measures Full Text available with Trip Pro

support a measure, the writing committee may feel it is necessary to have the measure tested to identify the consequences of measure implementation. Quality measures may then be promoted to the status of performance measures as supporting evidence becomes available. Gregg C. Fonarow, MD, FACC, FAHA Chair, ACC/AHA Task Force on Performance Measures 1. Introduction In 2018, the Task Force convened the writing committee to begin the process of revising the existing performance measures set (...) , the writing committee paid very close attention to the current Class of Recommendation (COR) and Level of Evidence (LOE) guideline classification scheme used by ACC and AHA in all of its guidelines, as shown in . Table 1. Applying Class of Recommendation and Level of Evidence to Clinical Strategies, Interventions, Treatments, or Diagnostic Testing in Patient Care (Updated August 2015)* Generally, performance measures are developed from Class 1 CORs and Level A and B LOEs (ie, strong recommendations based

2019 American Heart Association

297. Pediatric Post–Cardiac Arrest Care: A Scientific Statement From the American Heart Association

with energy deprivation. With ROSC, there is a burst of reactive oxygen species, and oxidative stress may ensue in tissue that is depleted of antioxidants. As a result, reperfusion is associated with excitotoxicity, calcium accumulation, and free radical–mediated cell injury or death. Both neuronal cellular necrosis and apoptosis result from this cascading injury and can continue in the days to weeks after ROSC. A variety of post–cardiac arrest clinical conditions, including hyperoxia, hypoxemia (...) and the proximal cause of arrest and management of critical abnormalities. Monitoring in the field continues through transport and includes ECG, pulse oximetry, capnography, noninvasive blood pressure measurement, and point-of-care glucose testing. General Intensive Care Monitoring General intensive care monitoring includes continuous cardiac telemetry, pulse oximetry, continuous capnography, continuous temperature monitoring, and measurement of blood pressure and urine output. Monitoring includes laboratory

2019 American Heart Association

298. Child Abuse, Elder Abuse, and Intimate Partner Violence

NS, Wolford JE, Berger RP . Missed opportunities to diagnose child physical abuse. Pediatr Emerg Care. 2014; 30(11): 771-6. ASSESSMENT CLINICAL SCREENING Key Points z A positive clinical screen identifies patients with higher probability of physical abuse that requires additional testing or evaluation. z Screening tools with reasonable validity evidence include TEN-4 FACESp BCDR, burns, and head injury (PEDIBIRN, PIBIS, PredAHT). z Ongoing education about child abuse screening is important (...) by the application of tests, examinations, history or other procedures which can be applied rapidly.” 1 A positive screen identifies patients with higher probability of abuse that require additional testing or evaluation. However, screening does not lead to a diagnosis of abuse, and an initial negative screen does not “rule out” abuse. Screening must occur across the trauma/emergency care continuum (emergency department [ED], intensive care unit [ICU], medical-surgical units, and rehabilitation

2019 American College of Surgeons

299. Trauma-informed models in out-of-home care: Frameworks used at an organisational level to enable trauma-informed practice.

used in a variety of settings. They include, residential, non-residential, child protection teams, adoption teams, residential care homes and psychiatric hospitals. The relative effectiveness in different settings has not been tested. It is suggested that for the models to work they must be implemented at an organisational level with change occurring through all levels of staff. What are the costs and benefits? No economic analysis was conducted as part of the review. How is it implemented? ARC How (...) is it implemented? The three domains of intervention in the ARC model are: Attachment : Strengthening the caregiving system surrounding children through enhancing supports, skills, and relational resources for adult caregivers. Regulation : Cultivating awareness and skill in identifying, understanding, tolerating, and managing internal experience. Competency: Building resilience in stress-impacted populations. ARC is a framework that includes a set of principles that organisations integrate into their approach

2019 What Works for Children’s Social Care

300. Consensus statement for perioperative care in total hip replacement and total knee replacement surgery: Enhanced Recovery After Surgery (ERAS) Society recommendations Full Text available with Trip Pro

examined on the ability of different interventions to reduce perioperative stress, maintain and support homeostasis and physiological function, and importantly accelerate the achievement of discharge criteria, including minimizing complications. Whilst the site of replacement is an independent factor for recovery, wherever possible we have prioritized procedure level evidence and applied critical analysis to studies that have included both THR and TKR. This article represents the efforts of the ERAS

2019 ERAS Society

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