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Contraction Stress Test

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2601. N-acetylcysteine inhibits muscle fatigue in humans. (Full text)

unchanged. During fatiguing contractions stimulated at 10 Hz, NAC increased force output by approximately 15% (P < 0.0001), an effect that was evident after 3 min of repetitive contraction (P < 0.0125) and persisted throughout the 30-min protocol. NAC had no effect on fatigue induced using 40 Hz stimuli or on recovery from fatigue. N-acetylcysteine pretreatment can improve performance of human limb muscle during fatiguing exercise, suggesting that oxidative stress plays a causal role in the fatigue (...) N-acetylcysteine inhibits muscle fatigue in humans. N-acetylcysteine (NAC) is a nonspecific antioxidant that selectively inhibits acute fatigue of rodent skeletal muscle stimulated at low (but not high) tetanic frequencies and that decreases contractile function of unfatigued muscle in a dose-dependent manner. The present experiments test the hypothesis that NAC pretreatment can inhibit acute muscular fatigue in humans. Healthy volunteers were studied on two occasions each. Subjects were

1994 Journal of Clinical Investigation

2602. In vivo human tendon mechanical properties (Full text)

, and (c) magnetic resonance imaging for estimation of the TA tendon length and moment arm. 3. From the measured joint moments and estimated moment arms, the values of tendon force were calculated and divided by cross-sectional area to obtain stress values. The displacements of the TA tendon origin from rest to all contraction intensities were normalized to tendon length to obtain strain values. From the data obtained, the tendon force-displacement and stress-strain relationships were determined (...) In vivo human tendon mechanical properties 1. The aim of the present study was to measure the mechanical properties of human tibialis anterior (TA) tendon in vivo. 2. Measurements were taken in five males at the neutral ankle position and involved: (a) isometric dynamometry upon increasing the voltage of percutaneous electrical stimulation of the TA muscle, (b) real-time ultrasonography for measurements of the TA tendon origin displacement during contraction and tendon cross-sectional area

1999 The Journal of physiology

2603. Provision of services for the diagnosis and treatment of heart disease in England and Wales. Third report of a Joint Cardiology Committee. Royal College of Physicians of London and the Royal College of Surgeons of England. (Full text)

medicine but having a special expertise and training in cardiology. He should undertake echocardiography, stress testing, ambulatory monitoring, emergency pacing, rehabilitation, and cardiac intensive care, with the necessary facilities and staff. He will also play an important part in the follow up of patients assessed and treated at cardiac centres. Paediatricians should continue to evaluate children with heart disease and their training should include periods at cardiac centres. Cardiac centres (...) . Facilities for older children should continue to be provided, as at present, at all cardiac centres. (8) Cardiac transplantation should be funded supraregionally. (9) The medical audit of cardiac work should be supported by the Department of Health and Social Security (DHSS). (10) Research remains a high priority, and cardiac centres should be provided with the facilities, and staff with the contracts and time, to undertake it. (11) A revision of this report is recommended within five years.

1985 British Heart Journal

2604. Anterior cruciate ligament functional brace use in sports. (PubMed)

in five chronically unstable anterior cruciate ligament-deficient knees. A knee stress test was performed on a specially designed device that allowed free tibial movement while monitoring anterior tibial translation and muscle function in the quadriceps, hamstring, and gastrocnemius muscles. Results show that braces can decrease anterior tibial translation between 28.8% and 39.1% without the stabilizing contractions of the hamstring, quadriceps, and gastrocnemius muscles. With lower extremity muscle

1996 American Journal of Sports Medicine Controlled trial quality: uncertain

2605. UK National STI Screening and Testing Guideline

, and all comments reviewed before final publication. 4. Presentation. A standard format was set by the BSIG editors and has been followed throughout. 5. Applicability. The authors were asked to comment on the organisational and the cost implications of applying each guideline and have identified issues that may be problematic for routine GU medicine departments and laboratories. The cost of specific tests are not included as these vary according to individual contracts. Each guideline suggests (...) UK National STI Screening and Testing Guideline Sexually Transmitted Infections: UK National Screening and Testing Guidelines August 2006 Screening Guideline Steering Group Jonathan Ross (co-chair) Cathy Ison (co-chair) Caroline Carder David Lewis Danielle Mercey Hugh Young Screening Guidelines Steering Committee commissioned by Clinical Effectiveness Group Contents page Introduction 3 Summary Tables 5 Testing guidelines for individual sexually transmitted infections: gonorrhoea 16 chlamydia 26

2006 British Association for Sexual Health and HIV

2606. Effect of electrical stimulation on stress and urge urinary incontinence: clinical outcome and practical recommendations based on randomized controlled trials

Effect of electrical stimulation on stress and urge urinary incontinence: clinical outcome and practical recommendations based on randomized controlled trials Effect of electrical stimulation on stress and urge urinary incontinence: clinical outcome and practical recommendations based on randomized controlled trials Effect of electrical stimulation on stress and urge urinary incontinence: clinical outcome and practical recommendations based on randomized controlled trials Bo K Authors (...) ' objectives To review the literature on randomised controlled trials (RCTs) on the effectiveness of electrical stimulation to treat urge and stress urinary incontinence. Searching MEDLINE was searched from 1980 (end date unclear) for full-length articles published in the English, German or Scandinavian languages. Abstracts were excluded from the review; however, any supportive or conflicting results published in abstracts were referred to in the discussion. The proceedings of the International Continence

1998 DARE.

2607. Pelvic floor muscle exercise therapy with myofeedback for women with stress urinary incontinence: a meta-analysis

in the review The primary outcomes were reduction of incontinence compared with a baseline record, the frequency and quantity of urine loss (this was assessed via record-keeping in a diary, the use of a visual analogue scale or through a self-assessment of continence). Two additional outcomes were assessed: contractional force of the peri-vaginal musculature and the amount of urine lost during a 'stress test'. How were decisions on the relevance of primary studies made? The authors do not state how (...) with stress urinary incontinence. Searching MEDLINE and Excerpta Medica were searched. Study selection Study designs of evaluations included in the review Randomised controlled trials (RCTs), quasi-experimental studies and uncontrolled studies were included. Specific interventions included in the review Pelvic floor muscle exercise therapy (ranging from 5 contractions every 2 hours to 200 contractions per day, and duration of the contractions ranged from one to 30 seconds, the length of the exercise

1996 DARE.

2608. When Should You Order a T Wave Alternans Test?

When Should You Order a T Wave Alternans Test? When Should You Order a T Wave Alternans Test? – Clinical Correlations Search When Should You Order a T Wave Alternans Test? January 25, 2007 3 min read A 58 year old male is admitted for "presyncope". He has not had chest pain and his baseline ECG is unchanged. The patient has an ischemic cardiomyopathy with an ejection fraction of 39% with mild reversible changes on a stress echo that was done 5 months prior to admission. On telemetry (...) , the patient has frequent polymorphic premature ventricular contractions. The cardiology consult recommends a T wave alternans test. What is the reason for this test? Commentary By: Neil Bernstein, MD Assistant Professor of Medicine, Cardiology/EPS Firstly, the patient needs to be assessed as to whether there is any ongoing ischemia to account for the ectopy, especially in the setting of reversible changes that were seen 5 months ago (albeit mild back then). Secondly, he should be assessed for the presence

2007 Clinical Correlations Q&A

2609. Flu Tests

diagnose their current patient. He may also order a flu test along with other viral studies, such as RSV (respiratory syncytial virus - a virus that often infects young children and the elderly), or with bacterial tests, such as a streptococcus test (to check for group A streptococcus, the bacteria that cause a sore throat) if the cause of the infection is unclear. In rare instances, someone will contract influenza outside of the normal flu season. (This may happen when someone travels outside (...) Flu Tests Influenza Test Produced by In partnership with User Top Links Menu Search User Top Links Search Influenza (Flu) Tests Also Known As Flu PCR Rapid flu test Flu antigen test Flu subtyping Formal Name Influenza nucleic acid amplification test; Influenza polymerase chain reaction; Rapid influenza antigen test; Influenza point of care test; Influenza A and B culture; influenza direct immunofluorescence test; Influenza A subtype-specific PCR This article was last reviewed on 19 January 2015

2004 Lab Tests Online UK

2610. Pain during ice water test distinguishes clinical bladder hypersensitivity from overactivity disorders (Full text)

Pain during ice water test distinguishes clinical bladder hypersensitivity from overactivity disorders The Bladder cooling reflex (BCR) i.e. uninhibited detrusor contractions evoked by intravesical instillation of cold saline, is a segmental reflex believed to be triggered by menthol sensitive cold receptors in the bladder wall, with the afferent signals transmitted by C fibres. The BCR is a neonatal reflex that becomes suppressed by descending signals from higher centres at approximately (...) cooling reflex and associated sensory symptoms in patients with PBS and overactivity disorders.The BCR, elicited by ice water test (IWT) was performed in patients with painful bladder syndrome (PBS, n = 17), idiopathic detrusor overactivity (IDO, n = 22), neurogenic detrusor overactivity (NDO, n = 4) and stress urinary incontinence (as controls, n = 21). The IWT was performed by intravesical instillation of cold saline (0 - 4 degrees C). A positive IWT was defined as presence of uninhibited detrusor

2006 BMC urology

2611. Treatment for Female Stress Urinary Incontinence

to assess the discount dependent variables. Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 168 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: Single (Outcomes Assessor) Primary Purpose: Treatment Official Title: Treatment for Stress Urinary Incontinence—Indirect Training of Pelvic Floor Muscle Via Transversus Abdominis Muscle Contraction Study Start Date : December 2005 Actual Primary Completion (...) Treatment for Female Stress Urinary Incontinence Treatment for Female Stress Urinary Incontinence - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Treatment for Female Stress Urinary Incontinence The safety

2005 Clinical Trials

2612. Pelvic floor muscle behavior during Valsalva leak point pressure measurement in males and females affected by stress urinary incontinence. (Full text)

Pelvic floor muscle behavior during Valsalva leak point pressure measurement in males and females affected by stress urinary incontinence. We evaluated pelvic floor muscle (PFM) behavior during Valsalva leak point pressure (VLPP) measurement in males and females affected by stress urinary incontinence and investigated whether VLPP results are influenced by PFM contraction.A total of 25 females and 14 males underwent surface electromyographic (EMG) recording of PFM activity while performing VLPP (...) . We investigated 2 conditions, VLPP during spontaneous strain (test A), and with simultaneous relaxation of the pelvic floor (test B). We analyzed average EMG activity (microV) at rest and during VLPP in tests A and B, the increasing EMG activity during tests A and B (the difference between average EMG activity during tests A and B and at rest), and the mean duration (seconds) of EMG activity during tests A and B.We detected a significant increase in EMG activity during tests A and B as compared

2003 Journal of Urology

2613. beta(1) Receptors protect the renal afferent arteriole of angiotensin-infused rabbits from norepinephrine-induced oxidative stress. (Full text)

beta(1) Receptors protect the renal afferent arteriole of angiotensin-infused rabbits from norepinephrine-induced oxidative stress. Renal afferent arterioles (Aff) from angiotensin II (AngII)-infused rabbits have enhanced contractions to AngII that are normalized by tempol (superoxide dismutase mimetic), whereas contractions to norepinephrine (NE) are normal and unaffected by tempol. Tested was the hypothesis that beta-receptor stimulation with NE prevents enhanced reactivity and superoxide (...) +/- 4%); were normalized by tempol; but were unaffected by ICI-118,551 (selective beta(2)-receptor antagonist) or SR-59,230A (selective beta(3)-receptor antagonist). Superoxide generation in Aff from AngII-infused rabbits that were assessed from ethidium:dihydroethidium was enhanced by addition of CGP-20,712A to NE but was normalized by tempol. Aff have robust alpha(1)-receptor contraction and beta(1)-receptor dilation. NE elicits beta(1) signaling via cAMP that moderates oxidative stress

2006 Journal of the American Society of Nephrology

2614. Stress radiography for quantifying posterior cruciate ligament deficiency. (PubMed)

and a series of stress radiographs that included a radiographic posterior drawer test with Telos (Telos, Weterstadt, Germany) at 90 degrees and 25 degrees of knee flexion, an active radiograph at 90 degrees of knee flexion, and an axial view radiograph.Stress radiography performed with Telos showed an average posterior tibial displacement of 11.54 +/- 4.93 mm and 7.97 +/- 3.16 mm at 90 degrees and 25 degrees, respectively. The active radiographs showed an average posterior tibial displacement of 11.48 (...) +/- 5.14 mm.Stress radiographs were shown to be superior to arthrometric evaluation in quantifying posterior tibial translation. The techniques performed with the knee at 90 degrees of knee flexion allowed for greater posterior tibial displacement and, consequently, an easier quantification of the degree of ligament insufficiency. Stress radiographs performed through hamstring contraction gave the same results as those performed with Telos at 90 degrees of knee flexion.

2003 Arthroscopy

2615. Transcutaneous mechanical nerve stimulation using perineal vibration: a novel method for the treatment of female stress urinary incontinence. (PubMed)

mechanical nerve stimulation in the subjects with stress urinary incontinence, there was a significant reduction in daily incontinence episodes (2.6 +/- 1.1 vs 0.5 +/- 1.1, paired t test p <0.001) and pad use (3.5 +/- 0.9 vs 0.6 +/- 1.3, paired t test p <0.001). At 6 weeks the cure rate (no incontinence episodes) was 73%, with durability through 3 months with 67% still reporting persistent resolution.Perineal transcutaneous mechanical nerve stimulation has promise as a noninvasive and well tolerated (...) Transcutaneous mechanical nerve stimulation using perineal vibration: a novel method for the treatment of female stress urinary incontinence. We defined basic guidelines for transcutaneous mechanical nerve stimulation in modifying pelvic floor responses in women and determined the efficacy of transcutaneous mechanical nerve stimulation in treating stress urinary incontinence.Perineal and clitoral transcutaneous mechanical nerve stimulation was performed in healthy volunteers while measuring

2007 Journal of Urology

2616. Enhanced contractility of renal afferent arterioles from angiotensin-infused rabbits: roles of oxidative stress, thromboxane prostanoid receptors, and endothelium. (Full text)

Enhanced contractility of renal afferent arterioles from angiotensin-infused rabbits: roles of oxidative stress, thromboxane prostanoid receptors, and endothelium. We tested the hypothesis that cyclooxygenase (COX), thromboxane A2 synthase (TxA2-S), thromboxane prostanoid receptors (TP-Rs), or superoxide anion (O2-) mediates enhanced contractions of renal afferent arterioles (Aff) of angiotensin II (Ang II)-infused rabbits. Rabbits were infused with vehicle (sham), Ang II 60 ng x kg(-1) x min (...) . Endothelium removal enhanced Ang II responses of Affs from sham rabbits but blunted responses from Ang II 200 rabbits and abolished responses to ifetroban. Affs from Ang II 200 rabbits had an endothelium-dependent contraction factor (EDCF) response to that was blunted (P<0.001) by a SOD mimetic or antagonists of COX-1 or TxA2-S but normalized by antagonists of COX-2 or TP-R. Thus, enhanced Ang II responses in Affs from rabbits infused with slow pressor Ang II are mediated independently by O2

2004 Circulation Research

2617. Strain rate imaging after dynamic stress provides objective evidence of persistent regional myocardial dysfunction in ischaemic myocardium: regional stunning identified? (Full text)

Strain rate imaging after dynamic stress provides objective evidence of persistent regional myocardial dysfunction in ischaemic myocardium: regional stunning identified? To investigate whether persistent ischaemic dysfunction of the myocardium after dynamic stress can be diagnosed from changes in ultrasonic strain rate and strain.Prospective observational study, with age matched controls.University hospital.26 patients (23 men, mean (SD) age 58.9 (8.1) years) with coronary artery disease (...) but no infarction and 12 controls (9 men, aged 56.1 (8.8) years) with normal coronary arteriography and negative exercise test underwent treadmill exercise (Bruce protocol). Tissue Doppler echocardiography was performed at baseline, at peak exercise, and at intervals up to one hour. Systolic and diastolic velocity, strain, and strain rate were recorded in the basal anterior segment of 16 patients with proximal left anterior descending coronary artery disease.Patients developed ischaemia, since they experienced

2005 Heart

2618. Dobutamine stress magnetic resonance imaging suffices for the demonstration of myocardial ischaemia and viability (Full text)

pain at rest for 15 minutes. The ECG showed a complete left bundle branch block (LBBB). Patient C was referred for heart failure of unknown origin. There were no symptoms of chest pain during rest or exercise. Echocardiography in this patient demonstrated global left ventricular (LV) dilatation, systolic dysfunction and a small dyskinetic segment in the inferior wall. In all these patients exercise stress testing had failed to demonstrate myocardial ischaemia. Patients A and C produced normal (...) Dobutamine stress magnetic resonance imaging suffices for the demonstration of myocardial ischaemia and viability We report three patients in whom dobutamine stress magnetic imaging (DS-MRI) was essential in assessing myocardial ischaemia. Two patients were referred to the cardiologist because of chest pain. Patient A had typical exertional angina and a normal resting electrocardiogram (ECG). Patient B had typical exercise-induced angina and had recently experienced an attack of severe chest

2003 Netherlands Heart Journal

2619. Myocardial cell membrane stress ionic dyskinesia reversal by diltiazem (Full text)

diltiazem impeded the occurrence of the silent ST segment depression, previously induced by exercise stress testing in patients without confirmed obstructive coronary artery disease, supporting the involvement of calcium-dependent myocardial contraction ionic dyskinesia in the genesis of silent ST segment depression. (...) Myocardial cell membrane stress ionic dyskinesia reversal by diltiazem Based on previous observations of cardioplegic ionic myocardial distress, myocardial stress dyskinesia was investigated as another possible cause of exercise stress testing-induced silent myocardial ischemia by analyzing the efficacy of the myocytic calcium channel blocker diltiazem in normalizing the results of patients who previously tested positive.From October 2004 to February 2006, 25 patients (13 women [52%]; aged

2006 Experimental & Clinical Cardiology

2620. Periurethral cellular injection: comparison of muscle-derived progenitor cells and fibroblasts with regard to efficacy and tissue contractility in an animal model of stress urinary incontinence. (PubMed)

Periurethral cellular injection: comparison of muscle-derived progenitor cells and fibroblasts with regard to efficacy and tissue contractility in an animal model of stress urinary incontinence. To compare muscle-derived cells (MDCs) and fibroblasts with regard to their potential for restoration of urethral function on injection in a previously established animal model of stress urinary incontinence.The animals were divided into four (dosage) or five (cell concentration) experimental groups (...) : normal, nontreated controls (normal group) or bilateral sciatic nerve transection with either periurethral injection of saline (saline group), MDCs (MDC group), fibroblasts (fibroblast group), or MDC/fibroblast mixture (mixed group). At 4 weeks after injection, the leak point pressure (LPP) was measured and contractility testing and histologic analysis were performed.The histologic examination demonstrated muscular atrophy in the saline group and new striated muscle fibers at the sites of MDC

2006 Urology

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