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Contraction Stress Test

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241. Effectiveness of interventions to reduce homelessness: a systematic review and meta?analysis Full Text available with Trip Pro

, or a person with short‐term subletting contracts who has applied to social services or another organization for assistance in solving their housing situation. There were no population restrictions regarding mental illness, addiction problems, age, gender, ethnicity, race, national contexts, etc. However, distinct subgroups were separated in our analyses when there was sufficient information in included studies. Intervention: Housing programs or case management or a combination of the two types (...) analysed the data using (standardized) mean difference ((S)MD) with the corresponding 95% CI. We used SMD when length of time was measured different between pooled studies (e.g. in days versus months, etc.). We conducted meta‐analyses using RevMan 5,using a random‐effects model and inverse‐variance approach(38). This method allowed us to weight each study according to the degree of variation in the confidence in the effect estimate. In cases where the means, number of participants and test statistics

2018 Campbell Collaboration

242. School?based interventions for reducing disciplinary school exclusion: a systematic review Full Text available with Trip Pro

to have a clear role in predicting exclusion. For other variables of interest such as sex, age or socio‐economic status most of the evidence is limited to bivariate associations. Regarding the outcomes, while there is a stark link between misbehaviour (e.g., school drop‐out and delinquency) and school exclusion, there is no clear causal relationship. Notwithstanding decades of research on school exclusion and its impact on later behaviour, we are still at an initial stage for testing causal (...) , tested data from 365 schools and a total number of 43,320 students. They concluded that when comparing those students eligible for free or reduced‐cost lunches with their non‐eligible peers, the first were more likely to get out‐of‐school exclusions (OR= 1.27; p<.05). However, contrary to expectations, the eligibility for free or reduced meals resulted in a negative predictor of permanent exclusion (OR= 0.03; p<.05). Special educational needs (SEN) Although an increasing amount of research has

2018 Campbell Collaboration

243. Human Papillomavirus (HPV), Cervical Screening and Cervical Cancer

/04.” (Cancer Research UK, 2014b) Key findings supporting the UK NSC recommendations • The HPV vaccination offered to girls aged 12 to 13 strengthens the rationale for primary HPV screening. The vaccination will offer prevention of HPV and result in a falling number of women who remain at risk of [contracting] HPV and developing cervical cancer. • A primary test for HPV will save more lives by determining a woman’s risk earlier. Work to assess extending the screening interval with HPV screening (...) informed of the reason for the procedure and the implications for their future health and wellbeing. A screening test should be taken in such a way as to provide an adequate sample for assessment, with the minimum of distress or discomfort. The importance of action, regular screening and effective follow up cannot be over emphasised – early diagnosis and treatment saves lives, plus reduces stress and anxiety for the woman and her family. Access to services should be local and easily accessible

2018 Royal College of Nursing

244. Thinking ahead: Exploring support provided by employers to help staff plan for their future

in some workplaces. l Strengthening capability to support others, for example training employees to be career coaches or mental health ?rst-aiders. l Networks and peer support. Some employers united colleagues with a common interest or concern to discuss their experiences, provide support to each other, and feedback any organisational issues. Networks could be face-to-face or virtual. l Service provision. Employers contracted with a range of service providers. These included providers of health (...) supported networks for employees living with speci?c health conditions or caring for a family member. Recently, in recognition of workplace stress, and from a desire to combat the stigma of mental health conditions in the workplace, a few employers had trained and con?gured sta? as mental health ?rst-aiders. Some aspects of employer interventions o?ered on this theme were delivered by external providers, such as via an Employee Assistance Programme (eg a 24 hour helpline) or the o?er of a Healthy Heart

2018 The Centre for Ageing Better

245. Adapting for ageing: Good practice and innovation in home adaptations

of this information, advice, and associated support, falls well short of the Care Act Guidance in many areas. A number of the good-practice localities provide this information, advice and help as a core part of their service, including for those people who are not eligible for DFG or means- tested financial assistance. b There is an urgent need to ensure all local authorities are meeting the legislative requirement to provide these services. The Care Quality Commission could conduct a themed report (...) (e.g. using grab rails, stairlifts, ramps) and/or take care of their own personal care (e.g. modified bathrooms). Such adaptations can reduce anxiety and depression, impacting on mental as well as physical health. Home modifications can also benefit carers, improve confidence and help to reduce the risk of physical injury and stress. Home adaptations can help to prevent accidents, particularly injury from falls. Through extending older people’s ability to live safely and well at home, and they can

2018 The Centre for Ageing Better

246. Cost-effectiveness analysis of HPV vaccination of boys in Belgium

in Belgium in 2015 and those due to the HPV types included in each vaccine, per gender (Table 4). These numbers are approximations as no systematic HPV testing is applied on cancer cases in Belgium and we used different sources for cases (Cancer Registry) and for the proportion of HPV types by disease (literature). For penile cancers, we selected the Belgian study for the proportion of HPV-attributable penile cancers, i.e. 61%, although this might be an overestimation. 27 . Overall, we estimated

2019 Belgian Health Care Knowledge Centre

247. Fetal Health Surveillance: Antepartum Consensus Guideline

or amniotic fluid volume assessment within 24 hours. The woman should continue with daily fetal movement counting (III-B). • Non-stress test is atypical/abnormal: further testing (biophysical profile and/or contraction stress test and assessment of amniotic fluid volume) should be performed as soon as possible (III-B). Recommendation 2: Non-Stress Test 1. Antepartum non-stress testing may be considered when risk factors for adverse perinatal outcome are present (III-B). 2. In the presence of a normal non (...) -stress test, usual fetal movement patterns, and absence of suspected oligohydramnios, it is not necessary to conduct a biophysical profile or contraction stress test (III-B). 3. A normal non-stress test should be classified and documented by an appropriately trained and designated individual as soon as possible, (ideally within 24 hours). For atypical or abnormal non-stress tests, the nurse should inform the attending physician (or primary care provider) at the time that the classification

2018 Society of Obstetricians and Gynaecologists of Canada

248. Management of Cardiovascular Diseases during Pregnancy Full Text available with Trip Pro

and offspring complications 3174 3.3.3 Pregnancy heart team 3176 3.4 Cardiovascular diagnosis in pregnancy 3176 3.4.1 Electrocardiography 3176 3.4.2 Echocardiography 3176 3.4.3 Exercise testing 3177 3.4.4 Ionizing radiation exposure 3177 3.4.5 Chest radiography and computed tomography 3177 3.4.6 Cardiac catheterization 3177 3.4.7 Magnetic resonance imaging 3177 3.5 Genetic testing and counselling 3177 3.5.1 Pre-natal diagnosis 3178 3.6 Foetal assessment 3178 3.6.1 Screening for congenital heart disease 3178 (...) Ventricular tachycardia 3203 9.7 Bradyarrhythmias 3204 9.7.1 Sinus node dysfunction 3204 9.7.2 Atrioventricular block 3204 9.8 Interventions 3204 9.8.1 Electrical cardioversion 3204 9.8.2 Catheter ablation 3204 9.8.3 Implantable cardioverter-defibrillator and pacing 3204 9.9 Recommendations 3206 10. Hypertensive disorders 3207 10.1 Diagnosis and risk assessment 3207 10.1.1 Blood pressure measurement 3207 10.1.2 Laboratory tests 3207 10.2 Definition and classification of hypertension in pregnancy 3207 10.3

2018 European Society of Cardiology

249. Adalimumab (Hefiya) - Juvenile Rheumatoid Arthritis, Hidradenitis Suppurativa, Psoriasis, Ankylosing Spondylitis, Uveitis

on the monoclonality of the MCB, use of WCB, and protocol for establishment of future WCBs have been resolved during the procedure. Details of the various solutions and media used in the manufacturing process are described. Information and testing for raw materials are provided. The two AS manufacturing sites, Sandoz BPS and Cook, use different raw materials. The specifications of the raw materials of the two sites correspond. All raw materials are of non-animal and non-human origin. Raw materials used (...) for manufacturing of GP2017 AS are controlled by specifications that assure their identity, strength and purity. They are obtained from established suppliers together with a Certificate of Analysis. Upon receipt, these products are released according to Pharmacopoeia monographs or internal test procedures. Container closure system The GP2017 AS bulk solution is filled and stored in 2,000 mL Polyethylene tetraphthalate copolymer (PETG) bottles, closed with a High density polyethylene (HDPE) screw closure. All

2018 European Medicines Agency - EPARs

250. Adalimumab (Halimatoz) - Juvenile Rheumatoid Arthritis, Psoriatic Arthritis, Rheumatoid Arthritis, Hidradenitis Suppurativa, Psoriasis, Ankylosing Spondylitis, Uveitis

FP PFS from Mylan to Cook using qualified shipment containers and shippers. A potential impact of mechanical stress on quality and integrity of Halimatoz bulk PFS was sufficiently addressed by a second transport validation study. A continued process verification program is in place to ensure process consistency throughout the life-cycle. To validate the assembly and packaging process three process runs were performed at Cook for each the NSD and AI. The presented AQL, IPC, functional testing (...) 5B and Q 5D guidelines. Questions raised on the monoclonality of the MCB, use of WCB, and protocol for establishment of future WCBs have been resolved during the procedure. Details of the various solutions and media used in the manufacturing process are described. Information and testing for raw materials are provided. The two AS manufacturing sites, Sandoz BPS and Cook, use different raw materials. The specifications of the raw materials of the two sites correspond. All raw materials are of non

2018 European Medicines Agency - EPARs

251. Public health guidance on active case finding of communicable diseases in prison settings

was commissioned by ECDC and coordinated by Lara Tavoschi. Support was provided by Dagmar Hedrich (EMCDDA), Netta Beer (ECDC), Helena de Carvalho Gomes (ECDC), and the ECDC library staff. The systematic review for this report was performed by members of a consortium of Pallas Health Research and Consultancy and Health Without Barriers (framework contract ECDC/2015/028, specific contract ECD.5855), in cooperation with Università degli Studi di Sassari (UNISS): Anouk Oordt, Marije Vonk-Noordegraaf, Hilde Vroling (...) for Drugs and Drug Addiction GRADE Grading of recommendations assessment, development and evaluation HBV Hepatitis B virus HCV Hepatitis C virus HIV Human immunodeficiency virus IGRA Interferon gamma release assay LTBI Latent tuberculosis infection MSM Men who have sex with men PRISMA Preferred reporting items for systematic reviews and meta-analyses PWID People who inject drugs STI Sexually transmitted infection TasP Treatment as prevention TB Tuberculosis TST Tuberculin skin test UNODC United Nations

2018 European Centre for Disease Prevention and Control - Public Health Guidance

252. ESC/ESH Management of Arterial Hypertension Full Text available with Trip Pro

= transient ischaemic attack; PAD = peripheral artery disease; SCORE = Systematic COronary Risk Evaluation. Table 6 Risk modifiers increasing cardiovascular risk estimated by the Systemic COronary Risk Evaluation (SCORE) system Social deprivation, the origin of many causes of CVD Obesity (measured by BMI) and central obesity (measured by waist circumference) Physical inactivity Psychosocial stress, including vital exhaustion Family history of premature CVD (occurring at age <55 years in men and <60 years (...) in women) Autoimmune and other inflammatory disorders Major psychiatric disorders Treatment for infection with human immunodeficiency virus Atrial fibrillation LV hypertrophy CKD Obstructive sleep apnoea syndrome Social deprivation, the origin of many causes of CVD Obesity (measured by BMI) and central obesity (measured by waist circumference) Physical inactivity Psychosocial stress, including vital exhaustion Family history of premature CVD (occurring at age <55 years in men and <60 years in women

2018 European Society of Cardiology

253. Pneumonia induced by benzodiazepines

effects and Editorial C M ED HECK -The Informed Prescriber Translated from the Editorial in Med Check-TIP (in Japanese) May 2018 ; 18 (77) increase infectious diseases. Even if the substance is not tested in humans and adverse effects are not known yet, increase of infection can be predicted from its fundamental mechanisms of action. Secondly, in Japan, a large-scale database system is needed to study harms of drugs. All studies that showed association between benzodiazepines and pneumonia analysed (...) cells. It also inhibits MTP in the intestinal epithelial cells leading to their steatosis. ?Animal toxicity tests showed that one tenth of human dose of lomitapide induced liver cell steatosis and single cell necrosis of liver cells. Liver cancer and intestinal cancer (normally very rare) were also observed by administering one third of human dose of lomitapide in another animal toxicity test (male mice). ? It also causes diarrhea due to poor lipid absorption in the small intestine leading

2018 Med Check - The Informed Prescriber

254. The Foyer model for homeless youth: a systematic mapping review

(including life skills) • Assistance with seeking and securing employment • Sports, arts and social activities • Assistance with securing accommodation on exit from the foyer • Residents are required to sign an agreement or contract that commits them to participation in education, training or employment as a condition of their ac- ceptance into the foyer accommodation • Support workers act as mentors to the young residents setting goals, reviewing progress and providing information and support to access

2018 Norwegian Institute of Public Health

255. The Effectiveness and Risks of Cranial Electrical Stimulation

in the former, sponge electrodes at the temples in the latter) and in the amount and type of current. Both are FDA-cleared for marketing for the treatment of anxiety, depression, and insomnia. One driver for the resurgence in interest in CES has been the Department of Defense and Department of Veterans Affairs authorizing practitioners to prescribe CES for anxiety, post- traumatic stress disorder, insomnia, depression and headache. One survey of active duty service members and veterans reported (...) randomized controlled trials were included Population(s): Adult patients with one or more of the following conditions: a chronic pain condition, depression, anxiety, insomnia, and posttraumatic stress disorder (PTSD) Intervention(s): Any cranial electrical stimulation (CES) device used in the home setting Comparator(s): Usual care including appropriate known treatments Outcome(s): Chronic pain: pain severity, use of opioid analgesic medication, quality of life, and daily functioning; Depression

2018 Veterans Affairs Evidence-based Synthesis Program Reports

256. Ocrelizumab (Ocrevus) - multiple sclerosis

. The influence of different stress parameters on the biological activity of ocrelizumab has been studied. The biological activity of enriched fractions of variants for size, glycosylation, glycation, deaminidation, charge related variants and unpaired cysteine forms was analysed in detail. Assessment report EMA/790835/2017 Page 21/180 Specification The active substance specification (methods and acceptance criteria) is overall acceptable. The specification contains tests for pharmacopoeial methods as well (...) Assessment report EMA/790835/2017 Page 4/180 List of abbreviations Quality 95/99 TI 95% confidence/99% probability tolerance interval AC Acceptance Criteria; ADA Anti-Drug Antibodies ADCC Antibody-Dependent Cellular Cytotoxicity ADCP Antibody-Dependent Cellular Phagocytosis ADI Acceptable Daily Intake ADI/EDI Acceptable And Estimated Daily Intake AEX anion-exchange AGE Advanced Glycation End product AIM Automatic Inspection Machine AR Acceptable Range ATS Attribute Testing Strategy AUC Analytical

2018 European Medicines Agency - EPARs

257. Letermovir (Prevymis) - to prevent illness caused by cytomegalovirus (CMV) in adults having an allogeneic haematopoietic stem cell transplant

testing following the ICH guideline Q1B was performed on one batch. Letermovir has been exposed to acidic, basic, oxidative, thermal and photolytic stress conditions to induce the formation of potential degradation products and demonstrate the stability indicating nature of the analytical procedures. The stability results indicate that the active substance manufactured by the proposed supplier is sufficiently stable. The stability results justify the proposed retest period in the proposed container (...) contractile agonism or antagonism of KCl-induced contractions Safety pharmacology programme Safety pharmacology studies were performed in both in vitro and in vivo test systems to assess the potential cardiovascular, respiratory, and neurobehavioral effects of letermovir. In addition, renal function, lipid metabolism, haematology parameters, blood glucose concentrations, gastrointestinal motility were also investigated following administration of letermovir. The C max values in the phase 3 study in HSCT

2018 European Medicines Agency - EPARs

258. Comprehensive Care - Older people with frailty in hospital

. The results appear promising but it needs further testing. » Person-centred care that focuses on respecting the person’s identity, creating relationships and sharing decision making is important to provide high quality care. Creating therapeutic relationships allows support staff to manage the emotional climate of the ward, stimulating it when it becomes flat and dampening it down when stress rises. Only one third of NHS trusts provide training to healthcare assistants on building positive relationships (...) step in building or sustaining their resilience, but can also be associated with problems. Good early identification and communication between all members of the health and social care team can avoid potential problems being realised and support people to live well and independently for as long as possible. The new GP contract in England aims to respond positively to frailty and the challenges it poses through the routine identification of frailty. This information could be shared with hospitals

2018 Publication 4887694

259. Guidelines For Professional Ultrasound Practice

Intimate examinations and chaperones 18 1.11 Examination times 20 1.12 Communication, ID and consent 21 1.13 Clinical governance 23 1.14 E-Learning for Healthcare (E-LfH) 25 1.15 Imaging Services Accreditation Scheme (ISAS) 25 1.16 Ultrasound equipment and quality assurance testing 26 1.17 Raising concerns; safeguarding; statutory requirements for reporting female genital mutilation; Duty of Candour. 1.18 Continuing professional development (CPD) 28 1.19 Codes of professional conduct for sonographers (...) Abdominal ultrasound examinations 50 Examination specific guidelines and common scenarios 2.8.1 General principles 50 2.8.2 Ultrasound examinations of the liver 54 2.8.3 Imaging of the gallbladder and biliary tree 55 2.8.4 Transabdominal ultrasound of the pancreas 56 2.8.5 Ultrasound of the spleen 57 2.8.6 Ultrasound of the bowel 60 2.9 Imaging of the uro-genital system including testes and scrotum 63 2.10 Ultrasound of the adult head and neck 66 2.11 Paediatric ultrasound examinations 2.11.1 Paediatric

2018 British Medical Ultrasound Society

260. Anagrelide Mylan - essential thrombocythaemia

and impurities. No significant changes to any of the measured parameters were observed under either set of conditions. Photostability testing following the ICH guideline Q1B was performed on one pilot scale batch. No changes to any of the measured parameters were observed indicating that the active substance is photostable. The active substance was exposed to stressed conditions including acid, base and oxidants. Samples degraded under all conditions, more so in the presence of base or acid. The results (...) , 6.00 and 8.00 hours after study drug administration. Treatments were separated by a washout period of 7 days. Test and reference products Test Product: Anagrelide 1 mg hard capsules (equivalent to 1.22 mg of Anagrelide hydrochloride) by Synthon Hispania S.L., Spain; batch No.: 140023; batch size: 100.000 capsules; manufacturing date: Feb 2014, expiry date: Feb 2015 Assessment report EMA/63484/2018 Page 16/23 Reference Product: Xagrid 0.5 mg hard capsules by Shire Pharmaceutical Contracts Ltd., UK

2018 European Medicines Agency - EPARs

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