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Contraction Stress Test

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2561. Intramyocardial Injection of Autologous Aldehyde Dehydrogenase-Bright Stem Cells for Therapeutic Angiogenesis (FOCUS Br)

characteristics and blood flow in the heart and blood vessels. A normal heart pumps 50-75% of the blood with each contraction. Total Severity Score (Stress) [ Time Frame: baseline and 6 months ] For the stress test, cardiac SPECT polar mapping (gated dual-isotope) is used to evaluate perfusion, compared against a database with a statistically significant number of polar maps of healthy hearts based on gender, data acquisition method, stress vs rest and type of data (i.e. perfusion, wall motion or wall (...) score varies from 0 (normal) to several thousands although the upper limit is not well defined. A score greater than 1000 indicates poor perfusion. Total Severity Score (Reversible) [ Time Frame: baseline and 6 months ] For the severity test, cardiac SPECT polar mapping (gated dual-isotope) is used to evaluate myocardial cardiac perfusion, compared against a database with a statistically significant number of polar maps of healthy hearts and compared based on gender, data acquisition method, stress

2006 Clinical Trials

2562. Efficacy and Safety of OROS Oybutynin and TTS Oxybutynin in Middle-Aged and Elderly Women With Urinary Incontinence

: No Criteria Inclusion Criteria: Women, aged 40 years or older, with screening PUD demonstrating an average urinary frequency of 10 per 24 hours and urge incontinence episodes ³10 times per week and £ 60 times per week, and CMG demonstrating detrusor contraction and/or severe "must void" urge (score = 2) at a bladder filling volume of less than or equal to 400 mL Women with mixed incontinence provided that symptoms and/or signs of stress incontinence are not the predominant manifestation of UI and urge (...) . The primary hypothesis to be tested in this study is that the treatment difference in the change in incontinence episodes per week after 6 weeks of treatment in the double-blind phase between individual oxybutynin-treated group and combined placebo group is equal to zero. The patients will receive oral OROS® containing oxybutynin, immediate release oral oxybutynin (1.7 or 2.5 mg) or TTS oxybutynin (60 cm2) daily for 7 weeks. Study Design Go to Layout table for study information Study Type : Interventional

2006 Clinical Trials

2563. SPECS: Safe Pediatric Euglycemia in Cardiac Surgery

recovery in young children undergoing heart surgery. Condition or disease Intervention/treatment Phase Heart Defects, Congenital Hyperglycemia Drug: Insulin Other: Usual Care Not Applicable Detailed Description: Children undergoing heart surgery are under significant bodily stress, which can lead to higher than normal or lower than normal blood glucose levels. A synthetic form of insulin, a naturally occurring hormone in the body, can be injected into people to normalize blood glucose levels. Insulin (...) is most commonly used to treat people with diabetes, but it is also used in hospitals to control blood glucose levels in patients. Previous studies of adult intensive care unit (ICU) patients have shown that patients whose blood sugar levels are maintained at normal levels with the use of insulin contract fewer infections and are released more quickly from the ICU than patients who do not maintain normal blood glucose levels. This study will use a continuous blood glucose monitoring system to detect

2007 Clinical Trials

2564. Does Moderate Intensity Exercise Help Prevent Smoking Relapse Among Women?

of Fibromyalgia Abnormal exercise stress test Hypertension (anyone currently being followed and/or treated for hypertension) Cancer treatment (other than skin cancer) within the past 6 months Musculoskeletal problems such as osteoarthritis, gout, osteoporosis or back, hip or knee pain that can interfere with physical activity (i.e., walking at a brisk pace - about 3-mph) Any other serious medical condition that might make exercise unsafe or unwise Psychiatric Problems Hospitalization for a psychiatric (...) counseling and provision of nicotine patch plus an 8-week moderate intensity exercise program versus the same standard smoking cessation treatment plus equivalent contact control among 60 healthy women. A number of techniques will be used to increase compliance with the treatment program, thus more effectively isolating the effects of exercise. These include: (1) a two-week run-in period prior to randomization; (2) use of behavioral contracting prior to participant randomization; and (3) performance

2007 Clinical Trials

2565. The Influence of Hip Strengthening Exercises on Walking Patterns and Muscle Strength in Persons With Knee Osteoarthritis

. The hip joint and surrounding muscles have been shown to influence the amount of stress occurring at the knee joint during walking. In particular, the hip abductor muscles may have an effect on the knee joint by controlling the position of the pelvis and/or by acting as lateral stabilizers for the knee. Research suggests that the function of the hip muscles during walking may be decreased in people with knee osteoarthritis and that greater loads may be placed on the knee joint as a result. Thus (...) , interventions aimed at strengthening the hip abductor muscles may be effective for reducing stress on the arthritic knee and slowing the rate of progression of knee osteoarthritis. The design of the study is a two-group pretest-posttest design using an untreated control group. Thirty-five individuals with medial compartment knee osteoarthritis will be recruited through newspaper advertisements and from the practices of orthopedic surgeons in Kingston, Ontario. Each participant with knee osteoarthritis

2007 Clinical Trials

2566. Pelvic Floor Muscle Training for Incontinence in Older Women.

and Interventions Go to Outcome Measures Go to Primary Outcome Measures : Quantity of urine lost over a 7-day period measured by self-report. Urine lost on stress test measured by pad weigh test. Secondary Outcome Measures : Quality of life using King's Health Questionnaire. Degree of bother using a VAS. Severity of stress incontinence using the ICIQ-SF. Displacement of pelvic floor during muscle contraction measured using transabdominal ultrasound imaging. Eligibility Criteria Go to Information from (...) of Melbourne Information provided by: University of Melbourne Study Details Study Description Go to Brief Summary: To determine the effect of pelvic floor muscle training in women aged 70 years and over, who have proven stress urinary incontinence. The hypotheses to be tested are: That pelvic floor muscle training is effective in relief of symptoms of stress urinary incontinence as measured by a greater reduction in the number of episodes of incontinence, quantity of urine lost and improvement of quality

2005 Clinical Trials

2567. ZD6474 to Treat Advanced Brain Cancer in Patients

no significant coronary artery disease (i.e. a negative stress test) and no myocardial wall dysfunction. Concurrent use of other standard chemotherapeutics or investigative agents or vasoconstrictors for the treatment of migraine (ergotamine, zolmitriptan, sumatriptan) because of the potential for exacerbation of coronary vasoconstriction. Laboratory results sustained at: Neutrophils less than 1.5 10(9)/L or platelets less than 100,000/mm(3). Serum creatinine greater than 1.5 x ULRR. Potassium, calcium (...) . These tests must be performed within 14 days prior to registration. Eligibility level for hemoglobin may be reached by transfusion. Patients must either not be receiving steroids, or be on a stable dose of steroids for at least five days prior to registration. Patients with a history of any other cancer (except non-melanoma skin cancer or carcinoma in-situ of the cervix), unless in remission and off of all therapy for that disease for a minimum of 1 year are ineligible. This study was designed to include

2006 Clinical Trials

2568. Safety and Efficacy of AV608 in Subjects With Idiopathic Detrusor Overactivity

overactivity. Female subjects between 18 and 65 years of age with a diagnosis of Overactive Bladder Syndrome and urodynamic observation of involuntary detrusor contractions during the filling phase will be eligible for the trial. Eligible subjects will complete a baseline urodynamic assessment. All subjects who participate in the study will receive 3 weeks of treatment with AV608 or placebo. At the end of the treatment period, subjects will complete a second urodynamic assessment. Study Design Go to Layout (...) : September 2007 Arms and Interventions Go to Outcome Measures Go to Primary Outcome Measures : Comparison between treatment groups of the change from baseline in maximum cystometric bladder capacity Secondary Outcome Measures : Delay of the first involuntary detrusor contraction associated with symptomatic urgency Urgency, frequency and urge incontinence events as recorded in the Subject Micturition Diary Urgency Perception Scale Eligibility Criteria Go to Information from the National Library

2006 Clinical Trials

2569. Inner-City Anti-IgE Therapy for Asthma

perceived stress, home environment, physical activity, diet and nutrition, smoking habits, and quality of life. At study entry and monthly throughout the study, participants will complete questionnaires about their asthma symptoms and medical resource utilization. Some visits will include a physical examination, vital signs measurement, lung function tests, asthma medication evaluation, and an asthma action plan. Blood collection is required up to eight times during the study for safety labs. Study (...) Detailed Description: This study is testing a medication called omalizumab for the treatment of asthma. Immunoglobulin E (IgE) is produced when one is exposed to allergens and it can cause inflammation in the lungs. Omalizumab can reduce inflammation and asthma attacks by blocking IgE. Unlike other medications for asthma, omalizumab is not an inhaler medication or pill. Instead, omalizumab is dissolved in a liquid and given by injection. Studies indicate that people living in the inner-city areas

2006 Clinical Trials

2570. Genetic Analysis of African-Americans With High Blood Pressure

individuals, we will find an increased left ventricular mass in individuals who are heterozygous or homozygous for this kinase allele. In this study, patients with the allele can be matched to others in the cohort without the allele and evaluated by echocardiography and cardiac MRI to evaluate cardiac function and chamber size. In addition, metabolic stress testing will be performed to assess the implications of this allele on clinical performance. Another group of 75 Afro-Americans with dilated (...) of myocardial infarction History of significant valve disease History of primary hyperthropic or infiltrative cardiomyopathy History of rheumatic heart disease Chronic atrial arrhythmia, bundle branch block intraventricular conduction defect or definite myocardial infarction on EKG Inability to perform a metabolic stress test Inability to perform a cMRI Poor echocardiographic windows precluding accurate analysis Contacts and Locations Go to Information from the National Library of Medicine To learn more

2006 Clinical Trials

2571. Exercise in Chronically Paced Children

to assess their heart function. As part of the echocardiogram, they will also receive a Tissue Synchronization Imaging (TSI) evaluation to assess the level of uncoordinated contraction they have. The patients will then be subjected to a cardiac exercise stress test which will involve them running on a treadmill until they cannot continue while data is collected regarding their heart's response to exercise. All portions of the study are noninvasive, which means they work from probes and monitors outside (...) Description Go to Brief Summary: The purpose of this study is to evaluate the exercise capacity of patients with complete heart block who are chronically being paced from the right ventricle. Also, we hope to correlate the level of uncoordinated contraction with the patients exercise capacity. We will enroll patients with complete heart block as diagnosed by standard electrocardiographic means and now have a permanent pacemaker. All patients we approach for this study will receive an echocardiogram

2006 Clinical Trials

2572. Bupropion for Hospital-Based Smoking Cessation

eligibility has been ascertained, a research associate will visit the patient to obtain informed consent and to enroll them in the study. Study questionnaires and a Fagerstrom test for Nicotine Dependence will be completed and reviewed by a research associate for completeness at the time of enrollment. The associate will put in the prescription for the study drug and request the order for dispensing of the drug. The research pharmacist will randomize the patient to Study Arm 1 or Study Arm 2. Subjects (...) and smoking history and will be followed one week after their hospital discharge to record their blood pressure and to monitor possible side effects. Since quit rates tend to decline over time, relapse prevention approaches will be included in both study arms. Marlatt's theory of relapse, an extension of Bandura's social learning model, will be used to augment the quitter's perception of self-efficacy. Participants will be trained to resist and cope with the temptations and stresses likely

2005 Clinical Trials

2573. Magnetic Resonance Spectroscopy Studies of Cardiac Muscle Metabolism

or positive stress test Exclusion Criteria: contraindication to MRI Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its identifier (NCT number): NCT00181259 Contacts Layout table for location contacts Contact: Robert G. Weiss, MD 410-955-1703 Locations Layout table for location (...) : Johns Hopkins University Collaborator: National Heart, Lung, and Blood Institute (NHLBI) Information provided by (Responsible Party): Robert G. Weiss, Johns Hopkins University Study Details Study Description Go to Brief Summary: The metabolism of the heart provides the chemical energy needed to fuel ongoing normal heart contraction. Magnetic resonance spectroscopy is a technique used in a MRI scanner that can be used to measure and study heart metabolism directly but without blood sampling

2005 Clinical Trials

2574. Randomized Trial for Botox Urinary Incontinence

retention from Botox) The ability and willingness to return for surveillance evaluations A negative urine pregnancy test if at risk for pregnancy Competent to give signed consent and complete all of the study measures Exclusion Criteria: Children (< 21 years old), pregnant women and prisoners History of carcinoma of the bladder Absence of a measurable detrusor contraction on a pressure flow micturition study A foreign body in the bladder or other correctable etiology for the UUI Prior documented (...) Detailed Description: The prevalence of urinary incontinence in the US ranges from 3-14% with epidemiologic estimates ranging widely.1 Most urinary incontinence can be categorized into stress urinary incontinence (SUI) or UUI with UUI remaining more common and debilitating than SUI.2 A major cause of UUI is overactive bladder or detrusor instability (DI), and while DI is very common, its etiology remains unknown. DI is often successfully managed with behavioral therapy, physical therapy, medications

2005 Clinical Trials

2575. On Modeling Morphogenesis of the Looping Heart Following Mechanical Perturbations Full Text available with Trip Pro

looping. Next, the model is tested further using experiments in which looping is perturbed by removing structures that exert forces on the heart--a membrane (splanchnopleure (SPL)) that presses against the ventral surface of the heart and the left and right primitive atria. In all cases, the model predicts the correct qualitative behavior. Finally, a two-dimensional model of the HT cross section is used to study a feedback mechanism for stress-based regulation of looping. The model is tested using (...) torsion is likely caused by external forces acting on the heart. However, the specific mechanisms that drive and regulate looping are not yet completely understood. Here, we present new experimental data and finite element models to help define these mechanisms for the torsional component of c-looping. First, with regions of growth and contraction specified according to experiments on chick embryos, a three-dimensional model exhibits morphogenetic deformation consistent with observations for normal

2008 Journal of biomechanical engineering

2576. Role of the Acidic N′-Region of Cardiac Troponin I In Regulating Myocardial Function* Full Text available with Trip Pro

regulate myocardial function, we generated cardiac-specific transgenic mice in which residues 2-11 (cTnI(Delta2-11)) were deleted. The hearts displayed significantly decreased contraction and relaxation under basal and beta-adrenergic stress compared to nontransgenic hearts, with a reduction in maximal Ca(2+)-dependent force and maximal Ca(2+)-activated Mg(2+)-ATPase activity. However, Ca(2+) sensitivity of force development and cTnI-Ser(23/24) phosphorylation were not affected. Chemical shift mapping (...) Role of the Acidic N′-Region of Cardiac Troponin I In Regulating Myocardial Function* Cardiac troponin I (cTnI) phosphorylation modulates myocardial contractility and relaxation during beta-adrenergic stimulation. cTnI differs from the skeletal isoform in that it has a cardiac specific N' extension of 32 residues (N' extension). The role of the acidic N' region in modulating cardiac contractility has not been fully defined. To test the hypothesis that the acidic N' region of cTnI helps

2007 The FASEB journal : official publication of the Federation of American Societies for Experimental Biology

2577. Pelvic floor muscle training is effective in women with urinary incontinence after stroke: a randomised, controlled and blinded study. (Abstract)

, randomised study. The intervention included 12 weeks of standardised PFMT. The outcome measures were: (1) diary recording the frequency of voiding, the number of incontinence episodes and used pads; (2) 24-hr home pad test; and (3) vaginal palpation of pelvic floor muscle evaluating function, strength, static and dynamic endurance.Twenty-four subjects with urge, stress and mixed stress/urge incontinence, completed the study, 12 in each group. A significant improvement in frequency of voiding in daytime (...) (Treatment Group/Control Group: 7/8 at pre-test, 6/9 at post-test (median values), P=0.018), 24-hr pad test (Treatment Group/Control Group: 8/12 to 2/8 g P=0.013) and dynamic endurance of pelvic floor muscle (Treatment Group/Control Group: 11/20 to 20/8 contractions of Pelvic Floor Muscle, P=0.028) was demonstrated in the Treatment Group compared to the Control Group. A significant improvement in frequency of voiding in daytime (decreased from seven to six, P=0.036), pelvic floor muscle function (P=0.034

2005 Neurourology and urodynamics Controlled trial quality: uncertain

2578. Effect of LED curing modes on cusp deflection and hardness of composite restorations. (Abstract)

, 24 hours after and two weeks after completion of the restorations. The mean contraction of the cusps in microm at five minutes, 24 hours and two weeks, respectively, for each group was A: 25.4, 16.2 and 8.2, B: 6.4, 3.4 and 2.2, C: 11.6, 7.0 and 4.4, D: 33.0, 21.6 and 15.8. Group D resulted in the highest deflection, Group A was intermediate and Groups B and C were the lowest. Ten samples of the composite for each group with 2-mm thickness were prepared for the Vickers hardness test (...) Effect of LED curing modes on cusp deflection and hardness of composite restorations. This in vitro study measured cusp deflection associated with MOD resin composite restorations in maxillary premolars with different curing light modes. Soft-start polymerization may reduce cusp deflection by reducing polymerization shrinkage stress. Forty maxillary premolars were mounted in stone and slot MOD cavities were prepared. The teeth were randomized into four groups: Group A--cavities were etched

2005 Operative dentistry Controlled trial quality: uncertain

2579. Neural mechanisms underlying balance improvement with short term Tai Chi training. (Abstract)

Chi (TC) or control groups. Nineteen subjects (age 68-92, BERG 44 or less) completed the study. TC training included repetitive exercises using TC motor and biomechanical strategies, techniques, and postural elements. Control training included axial mobility exercises, balance/awareness education and stress reduction. Groups trained 1.5 hours/day, 5 days/week for 3 weeks. After post-testing the control group received TC training. Subjects walked across a force plate triggered to move forward 15 cm (...) at 40 cm/sec at heel strike. Tibialis anterior (TA) and medial gastrocnemius (GA) responses during balance recovery were measured with electromyograms (EMGs). Four clinical measures of balance were also recorded.TC subjects, but not controls, significantly reduced both TA response time from 148.92 +/- 45.11 ms to 98.67 +/- 17.22 ms (p < or = 0.004) and occurrence of co-contraction of antagonist muscles (p < or = 0.003) of the perturbed leg. Clinical balance measures also significantly improved after

2006 Aging clinical and experimental research Controlled trial quality: uncertain

2580. The effect of c-factor and flowable resin or fiber use at the interface on microtensile bond strength to dentin. (Abstract)

The effect of c-factor and flowable resin or fiber use at the interface on microtensile bond strength to dentin. As polymerization shrinkage is compensated by flow of the composite, several attempts have been performed for relief of the contraction stresses. The aim of this in vitro study was to evaluate the effect of flowable composite or fiber use under composite restorations on microtensile bond strength of composite to dentin in Class I cavities or flat dentin surfaces.Twenty-four sound (...) degrees C. Microtensile test specimens with a 0.9 x 0.9 (+/- 0.1) mm2 cross-sectional area were produced, and bond strength tests were carried out at a crosshead speed of 1 mm/min. Mean bond strengths were analyzed using two-way ANOVA and Bonferroni's test at a 95% significance level.Flowable composite decreased dentin bond strength in cavities with a high c-factor (p < 0.05). The group restored with everStick NET showed stable bond strengths regardless of the effect of c-factor. Ribbond THM used

2006 The journal of adhesive dentistry Controlled trial quality: uncertain

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