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Contraction Stress Test

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181. Management of Cardiovascular Diseases during Pregnancy

and offspring complications 3174 3.3.3 Pregnancy heart team 3176 3.4 Cardiovascular diagnosis in pregnancy 3176 3.4.1 Electrocardiography 3176 3.4.2 Echocardiography 3176 3.4.3 Exercise testing 3177 3.4.4 Ionizing radiation exposure 3177 3.4.5 Chest radiography and computed tomography 3177 3.4.6 Cardiac catheterization 3177 3.4.7 Magnetic resonance imaging 3177 3.5 Genetic testing and counselling 3177 3.5.1 Pre-natal diagnosis 3178 3.6 Foetal assessment 3178 3.6.1 Screening for congenital heart disease 3178 (...) Ventricular tachycardia 3203 9.7 Bradyarrhythmias 3204 9.7.1 Sinus node dysfunction 3204 9.7.2 Atrioventricular block 3204 9.8 Interventions 3204 9.8.1 Electrical cardioversion 3204 9.8.2 Catheter ablation 3204 9.8.3 Implantable cardioverter-defibrillator and pacing 3204 9.9 Recommendations 3206 10. Hypertensive disorders 3207 10.1 Diagnosis and risk assessment 3207 10.1.1 Blood pressure measurement 3207 10.1.2 Laboratory tests 3207 10.2 Definition and classification of hypertension in pregnancy 3207 10.3

2018 European Society of Cardiology

183. Recovery schools for improving behavioral and academic outcomes among students in recovery from substance use disorders: a systematic review

for students in recovery and that address recovery needs in addition to academic development. Types of comparisons: Traditional educational programs or services that did not explicitly have a substance use recovery focus. Types of outcome measures: The review focused on primary outcomes in the following two domains: academic performance (e.g., achievement test scores, grade-point average, high school completion, school attendance, college enrolment, college completion) and substance use (alcohol, marijuana (...) reported at least one binge drinking episode during the previous week and approximately 68% scored in the hazardous drinking range on the Alcohol Use Disorders Identification Test consumption scale (Kypri et al., 2009). In the United States, 35-39% of college students reported binge drinking (i.e., five/four or more drinks in one sitting for males/females, respectively) at least once in the past month (Monitoring the Future, 2013; SAMHSA, 2014) and research has documented a rapid escalation in alcohol

2018 Campbell Collaboration

184. Pneumonia induced by benzodiazepines

effects and Editorial C M ED HECK -The Informed Prescriber Translated from the Editorial in Med Check-TIP (in Japanese) May 2018 ; 18 (77) increase infectious diseases. Even if the substance is not tested in humans and adverse effects are not known yet, increase of infection can be predicted from its fundamental mechanisms of action. Secondly, in Japan, a large-scale database system is needed to study harms of drugs. All studies that showed association between benzodiazepines and pneumonia analysed (...) cells. It also inhibits MTP in the intestinal epithelial cells leading to their steatosis. ?Animal toxicity tests showed that one tenth of human dose of lomitapide induced liver cell steatosis and single cell necrosis of liver cells. Liver cancer and intestinal cancer (normally very rare) were also observed by administering one third of human dose of lomitapide in another animal toxicity test (male mice). ? It also causes diarrhea due to poor lipid absorption in the small intestine leading

2018 Med Check - The Informed Prescriber

185. ESC/ESH Management of Arterial Hypertension (Full text)

= transient ischaemic attack; PAD = peripheral artery disease; SCORE = Systematic COronary Risk Evaluation. Table 6 Risk modifiers increasing cardiovascular risk estimated by the Systemic COronary Risk Evaluation (SCORE) system Social deprivation, the origin of many causes of CVD Obesity (measured by BMI) and central obesity (measured by waist circumference) Physical inactivity Psychosocial stress, including vital exhaustion Family history of premature CVD (occurring at age <55 years in men and <60 years (...) in women) Autoimmune and other inflammatory disorders Major psychiatric disorders Treatment for infection with human immunodeficiency virus Atrial fibrillation LV hypertrophy CKD Obstructive sleep apnoea syndrome Social deprivation, the origin of many causes of CVD Obesity (measured by BMI) and central obesity (measured by waist circumference) Physical inactivity Psychosocial stress, including vital exhaustion Family history of premature CVD (occurring at age <55 years in men and <60 years in women

2018 European Society of Cardiology

186. School-based interventions for reducing disciplinary school exclusion

performance, increase motivation and promote more adaptive behaviour. Edmunds et al., (2012) tested an intervention to boost the academic progress of students in order to facilitate their future access to college while in the case of Cook et al., (2014), the intervention involved academic remediation plus social skills training. After-school programmes. Two effect sizes come from interventions that offered students after-school activities. While the intervention tested by Dynarski et al., (2003) was more (...) focused on academic support and recreational activities, Hirsch, Hedges, Stawicki, & Mekinda, (2011) tested an after-school programme offering students paid apprenticeships. Mentoring/monitoring programmes. Five effect sizes reported the impact of interventions focused on mentoring/monitoring. These programmes involved structured and supportive relationships between a young person who presents academic, emotional or behavioural difficulties and a non-parental adult, their mentor. Mentoring entails

2018 Campbell Collaboration

187. Guidelines on Diagnosis and Management of Syncope

biomarkers 1910 4.2.8 Echocardiography 1910 Exercise stress echocardiography 1910 4.2.9 Exercise stress testing 1911 4.2.10 Coronary angiography 1911 5. Treatment 1911 5.1 General principles of treatment of syncope 1911 5.2 Treatment of reflex syncope 1911 5.2.1 Education and lifestyle modifications 1912 5.2.2 Discontinuation/reduction of hypotensive therapy 1913 5.2.3 Physical counter-pressure manoeuvres 1914 5.2.4 Tilt training 1914 5.2.5 Pharmacological therapy 1914 Fludrocortisone (...) evaluation and management according to risk stratification 1892 4.1 Initial evaluation 1892 4.1.1 Diagnosis of syncope 1893 4.1.2 Management of syncope in the emergency department based on risk stratification 1895 4.2 Diagnostic tests 1900 4.2.1 Carotid sinus massage 1900 4.2.2 Orthostatic challenge 1901 Active standing 1901 Tilt testing 1903 4.2.3 Basic autonomic function tests 1904 Valsalva manoeuvre 1904 Deep breathing 1904 Other autonomic function tests 1904

2018 European Society of Cardiology

188. Comprehensive Care - Older people with frailty in hospital

. The results appear promising but it needs further testing. » Person-centred care that focuses on respecting the person’s identity, creating relationships and sharing decision making is important to provide high quality care. Creating therapeutic relationships allows support staff to manage the emotional climate of the ward, stimulating it when it becomes flat and dampening it down when stress rises. Only one third of NHS trusts provide training to healthcare assistants on building positive relationships (...) step in building or sustaining their resilience, but can also be associated with problems. Good early identification and communication between all members of the health and social care team can avoid potential problems being realised and support people to live well and independently for as long as possible. The new GP contract in England aims to respond positively to frailty and the challenges it poses through the routine identification of frailty. This information could be shared with hospitals

2018 NIHR Dissemination Centre - Themed Reviews

189. Guidelines For Professional Ultrasound Practice

Intimate examinations and chaperones 18 1.11 Examination times 20 1.12 Communication, ID and consent 21 1.13 Clinical governance 23 1.14 E-Learning for Healthcare (E-LfH) 25 1.15 Imaging Services Accreditation Scheme (ISAS) 25 1.16 Ultrasound equipment and quality assurance testing 26 1.17 Raising concerns; safeguarding; statutory requirements for reporting female genital mutilation; Duty of Candour. 1.18 Continuing professional development (CPD) 28 1.19 Codes of professional conduct for sonographers (...) Abdominal ultrasound examinations 50 Examination specific guidelines and common scenarios 2.8.1 General principles 50 2.8.2 Ultrasound examinations of the liver 54 2.8.3 Imaging of the gallbladder and biliary tree 55 2.8.4 Transabdominal ultrasound of the pancreas 56 2.8.5 Ultrasound of the spleen 57 2.8.6 Ultrasound of the bowel 60 2.9 Imaging of the uro-genital system including testes and scrotum 63 2.10 Ultrasound of the adult head and neck 66 2.11 Paediatric ultrasound examinations 2.11.1 Paediatric

2018 British Medical Ultrasound Society

190. The Effectiveness and Risks of Cranial Electrical Stimulation

in the former, sponge electrodes at the temples in the latter) and in the amount and type of current. Both are FDA-cleared for marketing for the treatment of anxiety, depression, and insomnia. One driver for the resurgence in interest in CES has been the Department of Defense and Department of Veterans Affairs authorizing practitioners to prescribe CES for anxiety, post- traumatic stress disorder, insomnia, depression and headache. One survey of active duty service members and veterans reported (...) randomized controlled trials were included Population(s): Adult patients with one or more of the following conditions: a chronic pain condition, depression, anxiety, insomnia, and posttraumatic stress disorder (PTSD) Intervention(s): Any cranial electrical stimulation (CES) device used in the home setting Comparator(s): Usual care including appropriate known treatments Outcome(s): Chronic pain: pain severity, use of opioid analgesic medication, quality of life, and daily functioning; Depression

2018 Veterans Affairs Evidence-based Synthesis Program Reports

191. The Foyer model for homeless youth: a systematic mapping review

(including life skills) • Assistance with seeking and securing employment • Sports, arts and social activities • Assistance with securing accommodation on exit from the foyer • Residents are required to sign an agreement or contract that commits them to participation in education, training or employment as a condition of their ac- ceptance into the foyer accommodation • Support workers act as mentors to the young residents setting goals, reviewing progress and providing information and support to access

2018 Norwegian Institute of Public Health

192. Optimisation of RIZIV – INAMI lump sums for incontinence

DRUGS (RIZIV – INAMI 2008-2017) 223 APPENDIX 6. ... – NUMBER OF IMPLANTS AND REIMBURSEMENTS FOR INCONTINENCE (DOC N 2016) 225 ? REFERENCES 228 8 Incontinence KCE Report 304 LIST OF FIGURES Figure 1 – Nocturnal enuresis prevalence in children and adolescents 21 Figure 2 – Incontinence as a geriatric symptom 25 Figure 3 – Sling operations for stress incontinence in women 36 Figure 4 – Injection of bulking agents 38 Figure 5 – ICS Initial management of urinary incontinence in men 42 Figure 6 – ICS (...) A recommendation 33 Table 9 – Drugs for stress incontinence 34 Table 10 – Indications for surgery in men 35 Table 11 – Cure rates for urgency urinary incontinence from individual studies 40 Table 12 – Cure rates for mixed urinary incontinence from individual studies 40 Table 13 – Summary of evidence for drugs in the frail elderly 51 Table 14 – ICS Level of evidence for incontinence surgery in the frail older person 52 Table 15 – ICS Recommendations for incontinence surgery in the frail older person 53 Table 16

2019 Belgian Health Care Knowledge Centre

193. Adalimumab (Halimatoz) - Juvenile Rheumatoid Arthritis, Psoriatic Arthritis, Rheumatoid Arthritis, Hidradenitis Suppurativa, Psoriasis, Ankylosing Spondylitis, Uveitis

FP PFS from Mylan to Cook using qualified shipment containers and shippers. A potential impact of mechanical stress on quality and integrity of Halimatoz bulk PFS was sufficiently addressed by a second transport validation study. A continued process verification program is in place to ensure process consistency throughout the life-cycle. To validate the assembly and packaging process three process runs were performed at Cook for each the NSD and AI. The presented AQL, IPC, functional testing (...) 5B and Q 5D guidelines. Questions raised on the monoclonality of the MCB, use of WCB, and protocol for establishment of future WCBs have been resolved during the procedure. Details of the various solutions and media used in the manufacturing process are described. Information and testing for raw materials are provided. The two AS manufacturing sites, Sandoz BPS and Cook, use different raw materials. The specifications of the raw materials of the two sites correspond. All raw materials are of non

2018 European Medicines Agency - EPARs

194. Adalimumab (Hefiya) - Juvenile Rheumatoid Arthritis, Hidradenitis Suppurativa, Psoriasis, Ankylosing Spondylitis, Uveitis

on the monoclonality of the MCB, use of WCB, and protocol for establishment of future WCBs have been resolved during the procedure. Details of the various solutions and media used in the manufacturing process are described. Information and testing for raw materials are provided. The two AS manufacturing sites, Sandoz BPS and Cook, use different raw materials. The specifications of the raw materials of the two sites correspond. All raw materials are of non-animal and non-human origin. Raw materials used (...) for manufacturing of GP2017 AS are controlled by specifications that assure their identity, strength and purity. They are obtained from established suppliers together with a Certificate of Analysis. Upon receipt, these products are released according to Pharmacopoeia monographs or internal test procedures. Container closure system The GP2017 AS bulk solution is filled and stored in 2,000 mL Polyethylene tetraphthalate copolymer (PETG) bottles, closed with a High density polyethylene (HDPE) screw closure. All

2018 European Medicines Agency - EPARs

195. Public health guidance on active case finding of communicable diseases in prison settings

was commissioned by ECDC and coordinated by Lara Tavoschi. Support was provided by Dagmar Hedrich (EMCDDA), Netta Beer (ECDC), Helena de Carvalho Gomes (ECDC), and the ECDC library staff. The systematic review for this report was performed by members of a consortium of Pallas Health Research and Consultancy and Health Without Barriers (framework contract ECDC/2015/028, specific contract ECD.5855), in cooperation with Università degli Studi di Sassari (UNISS): Anouk Oordt, Marije Vonk-Noordegraaf, Hilde Vroling (...) for Drugs and Drug Addiction GRADE Grading of recommendations assessment, development and evaluation HBV Hepatitis B virus HCV Hepatitis C virus HIV Human immunodeficiency virus IGRA Interferon gamma release assay LTBI Latent tuberculosis infection MSM Men who have sex with men PRISMA Preferred reporting items for systematic reviews and meta-analyses PWID People who inject drugs STI Sexually transmitted infection TasP Treatment as prevention TB Tuberculosis TST Tuberculin skin test UNODC United Nations

2018 European Centre for Disease Prevention and Control - Public Health Guidance

196. Anagrelide Mylan - essential thrombocythaemia

and impurities. No significant changes to any of the measured parameters were observed under either set of conditions. Photostability testing following the ICH guideline Q1B was performed on one pilot scale batch. No changes to any of the measured parameters were observed indicating that the active substance is photostable. The active substance was exposed to stressed conditions including acid, base and oxidants. Samples degraded under all conditions, more so in the presence of base or acid. The results (...) , 6.00 and 8.00 hours after study drug administration. Treatments were separated by a washout period of 7 days. Test and reference products Test Product: Anagrelide 1 mg hard capsules (equivalent to 1.22 mg of Anagrelide hydrochloride) by Synthon Hispania S.L., Spain; batch No.: 140023; batch size: 100.000 capsules; manufacturing date: Feb 2014, expiry date: Feb 2015 Assessment report EMA/63484/2018 Page 16/23 Reference Product: Xagrid 0.5 mg hard capsules by Shire Pharmaceutical Contracts Ltd., UK

2018 European Medicines Agency - EPARs

197. Ocrelizumab (Ocrevus) - multiple sclerosis

. The influence of different stress parameters on the biological activity of ocrelizumab has been studied. The biological activity of enriched fractions of variants for size, glycosylation, glycation, deaminidation, charge related variants and unpaired cysteine forms was analysed in detail. Assessment report EMA/790835/2017 Page 21/180 Specification The active substance specification (methods and acceptance criteria) is overall acceptable. The specification contains tests for pharmacopoeial methods as well (...) Assessment report EMA/790835/2017 Page 4/180 List of abbreviations Quality 95/99 TI 95% confidence/99% probability tolerance interval AC Acceptance Criteria; ADA Anti-Drug Antibodies ADCC Antibody-Dependent Cellular Cytotoxicity ADCP Antibody-Dependent Cellular Phagocytosis ADI Acceptable Daily Intake ADI/EDI Acceptable And Estimated Daily Intake AEX anion-exchange AGE Advanced Glycation End product AIM Automatic Inspection Machine AR Acceptable Range ATS Attribute Testing Strategy AUC Analytical

2018 European Medicines Agency - EPARs

198. Letermovir (Prevymis) - to prevent illness caused by cytomegalovirus (CMV) in adults having an allogeneic haematopoietic stem cell transplant

testing following the ICH guideline Q1B was performed on one batch. Letermovir has been exposed to acidic, basic, oxidative, thermal and photolytic stress conditions to induce the formation of potential degradation products and demonstrate the stability indicating nature of the analytical procedures. The stability results indicate that the active substance manufactured by the proposed supplier is sufficiently stable. The stability results justify the proposed retest period in the proposed container (...) contractile agonism or antagonism of KCl-induced contractions Safety pharmacology programme Safety pharmacology studies were performed in both in vitro and in vivo test systems to assess the potential cardiovascular, respiratory, and neurobehavioral effects of letermovir. In addition, renal function, lipid metabolism, haematology parameters, blood glucose concentrations, gastrointestinal motility were also investigated following administration of letermovir. The C max values in the phase 3 study in HSCT

2018 European Medicines Agency - EPARs

199. Programs and services for suicide prevention

, and if they otherwise did not meet the eligibility criteria, they were reported in the ‘promising program’ section of the report. Database search Before completing formal searches of the electronic databases, we trialled several test searches of the databases using a combination of keywords and subject headings. Testing of the search strategy in each of the databases offered two benefits. First, it provided evidence of which keywords would maximise the retrieval of relevant material. Second, the test searches (...) recommendation which includes: • The evidence base, in terms of number of studies, level of evidence and quality of studies (risk of bias) • The consistency of its findings to other similar studies • Clinical impact and generalisability of results to the target population • The applicability of results to the Australian and/or local health care setting Level I studies typically consist of systematic reviews of randomised controlled trials while Level IV studies largely refer to case series with post-test

2018 Sax Institute Evidence Check

200. Proposals for a more effective antibiotic policy in Belgium

PRESCRIPTION GUIDELINES 258 11.10 MAKE USE OF THE (FUTURE) MANDATORY IMPLEMENTATION OF E-PRESCRIBING TO IMPROVE THE PRUDENT PRESCRIPTION OF ANTIBIOTICS 259 11.11 CONSIDER TAKING STRUCTURAL MEASURES TO IMPROVE THE PRUDENT PRESCRIPTION AND USE OF ANTIBIOTICS 259 11.12 PERFORM A HEALTH TECHNOLOGY ASSESSMENT ON POINT OF CARE TESTING FOR THE DIAGNOSIS OF INFECTIOUS DISEASES IN THE BELGIAN AMBULATORY CARE CONTEXT 259 11.13 STIMULATE BEHAVIOURAL CHANGE AMONG THE GENERAL PUBLIC AS WELL AS THE PRESCRIBERS TOWARDS (...) AMU Antimicrobial Use AP Ambulatory Practitioner API Active Pharmaceutical Ingredient APQI Antibiotic Prescribing Quality Indicator APR-DRG All Patient Refined Diagnosis Related Group ARM Antimicrobial-Resistant Microorganisms ARSIA Animal health association (‘Association Régionale de Santé et d'Identification Animale’) ART Acute Respiratory Tract ASP Antimicrobial Stewardship Program(s) 14 Antibiotic policy in Belgium KCE Report 311 AST Antibiotic Sensitivity Testing ATC Anatomical Therapeutic

2019 Belgian Health Care Knowledge Centre

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