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Contact Dermatitis

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1. Contact dermatitis

Contact dermatitis Contact dermatitis - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Contact dermatitis Last reviewed: February 2019 Last updated: June 2018 Summary Irritant contact dermatitis is caused by direct toxicity without prior sensitisation, and allergic contact dermatitis is a delayed hypersensitivity reaction. Results in localised burning, stinging, itching, blistering, redness, and swelling at the area (...) of contact with the allergen or irritant. Patch testing may aid identification of the causative agent. Skin biopsy may also be helpful, but may not be able to distinguish between other causes of dermatitis. Treatment involves removal of the causative agent, future avoidance of the causative agent, topical corticosteroids, and/or a short course of oral corticosteroids. Rarely, contact dermatitis can become generalised, leading to areas of dermatitis in locations distant from the site of contact

2018 BMJ Best Practice

3. Contact allergy to oxidized geraniol among Swedish dermatitis patients-A multicentre study by the Swedish Contact Dermatitis Research Group. Full Text available with Trip Pro

Contact allergy to oxidized geraniol among Swedish dermatitis patients-A multicentre study by the Swedish Contact Dermatitis Research Group. Geraniol is a widely used fragrance terpene, and is included in fragrance mix I. Geraniol is prone to autoxidation, forming the skin sensitizers geranial, neral, and geraniol-7-hydroperoxide. Oxidized geraniol has previously been patch tested in 1 clinic, giving 1% to 4.6% positive reactions in consecutive patients when tested at 2% to 11%.To compare test

2018 Contact Dermatitis

4. British Association of Dermatologists? guidelines for the management of contact dermatitis

British Association of Dermatologists? guidelines for the management of contact dermatitis GUIDELINES BJD British Journal of Dermatology British Association of Dermatologists’ guidelines for the management of contact dermatitis 2017 G.A. Johnston, 1 L.S. Exton, 2 M.F. Mohd Mustapa, 2 J.A. Slack, 1 I.H. Coulson, 3 J.S.C. English 4 and J.F. Bourke 5 1 Department of Dermatology, University Hospitals of Leicester NHS Trust, In?rmary Square, Leicester LE1 5WW, U.K. 2 British Association (...) and LILACS databases was conducted to identify key articles for contact dermatitis up to February 2016; search terms and strategies are detailed in the Support- ing Information. Additional references relevant to the topic were also isolated from citations in reviewed literature. Evi- dence from included studies was graded according to the GRADE system (high, moderate, low or very-low quality). Recommendations are based on evidence drawn from system- atic reviews of the literature pertaining

2017 British Association of Dermatologists

5. European Surveillance System on Contact Allergies (ESSCA): contact allergies in relation to body sites in patients with allergic contact dermatitis. Full Text available with Trip Pro

European Surveillance System on Contact Allergies (ESSCA): contact allergies in relation to body sites in patients with allergic contact dermatitis. Analyses of the European Surveillance System on Contact Allergies (ESSCA) database have focused primarily on the prevalence of contact allergies to the European baseline series, both overall and in subgroups of patients. However, affected body sites have hitherto not been addressed.To determine the prevalence of contact allergies for distinct body (...) sites in patients with allergic contact dermatitis (ACD).Analysis of data collected by the ESSCA (www.essca-dc.org) in consecutively patch tested patients, from 2009 to 2014, in eight European countries was performed. Cases were selected on the basis of the presence of minimally one positive patch test reaction to the baseline series, and a final diagnosis of ACD attributed to only one body site.Six thousand two hundred and fifty-five cases were analysed. The head and hand were the most common

2018 Contact Dermatitis

6. Variable impact of dupilumab on patch testing results and allergic contact dermatitis in adults with atopic dermatitis. (Abstract)

Variable impact of dupilumab on patch testing results and allergic contact dermatitis in adults with atopic dermatitis. Previous case reports and series suggested that dupilumab may be an effective treatment for allergic contact dermatitis (ACD). Little is known about the impact of dupilumab on patch test results and comorbid ACD in patients with atopic dermatitis (AD).Determine the impact of dupilumab on patch testing results and improvement of ACD in patients with AD.A retrospective study

2019 Journal of American Academy of Dermatology

7. Contact Allergy and Allergic Contact Dermatitis to Lavender: A Retrospective Study from an Australian Clinic. (Abstract)

Contact Allergy and Allergic Contact Dermatitis to Lavender: A Retrospective Study from an Australian Clinic. Lavender is commonly used in aromatherapy and in a broad range of personal and household products. It has been identified as a contact sensitizer and has been reported to cause allergic contact dermatitis (ACD).To report our experience with contact allergy and ACD to lavender and to raise awareness of lavender as a potential contact allergen.A retrospective database review was performed

2019 Contact Dermatitis

8. Pediatric Contact Dermatitis Registry Data on Contact Allergy in Children With Atopic Dermatitis. Full Text available with Trip Pro

Pediatric Contact Dermatitis Registry Data on Contact Allergy in Children With Atopic Dermatitis. Atopic dermatitis (AD) and allergic contact dermatitis (ACD) have a dynamic relationship not yet fully understood. Investigation has been limited thus far by a paucity of data on the overlap of these disorders in pediatric patients.To use data from the Pediatric Contact Dermatitis Registry to elucidate the associations and sensitizations among patients with concomitant AD and ACD.This retrospective (...) ; history of AD was noted by the patch-testing providers.Primary outcomes were sensitization rates to various patch-tested allergens.A total of 1142 patients were evaluated: 189 boys (34.2%) and 363 girls (65.8%) in the AD group and 198 boys (36.1%) and 350 girls (63.9%) in the non-AD group (data on gender identification were missing for 17 patients). Compared with those without AD, patch-tested patients with AD were 1.3 years younger (10.5 vs 11.8 years; P < .001) and had longer history of dermatitis

2017 JAMA dermatology (Chicago, Ill.)

9. Contact Dermatitis in Atopic Dermatitis Children-Past, Present, and Future. (Abstract)

Contact Dermatitis in Atopic Dermatitis Children-Past, Present, and Future. Allergic contact dermatitis (ACD) used to be considered a rarity in children, but recently has been estimated to effect 4.4 million children in the USA alone, with a notable rise in investigative research in the field of pediatric ACD. Researchers have shown that patch testing is safe and effective in afflicted children and that those with atopic dermatitis (AD) have similar sensitization rates, although they have (...) a higher sensitization to certain allergens, thought to be related to the inflammatory (IL-4) milieu. Patch testing assessment guidelines in children include five key considerations: if a patient's dermatitis worsens, changes distribution, fails to improve with topical therapy, or immediately rebounds after removal of topical treatments; if a patient has a particular distribution of dermatitis; if a working patient has hand eczema that fails to improve with therapy; if the patient has AD that started

2018 Clinical Reviews in Allergy & Immunology

10. Acacia seyal and Terminalia brownii associated airborne contact dermatitis (Dukhan dermatitis). (Abstract)

Acacia seyal and Terminalia brownii associated airborne contact dermatitis (Dukhan dermatitis). Taking scented smoke baths (Dukhan) is a universal custom among African women who indulge in it for pleasure, cleanliness, health, and for restoration after childbirth. The woods used in this procedure are usually Acacia seyal and Terminalia brownii. This report is a case series of 11 women with brown-erythematous excoriated papules, plaques, and lichenification confined to the sites of scented smoke (...) baths. They were diagnosed with airborne contact dermatitis on the basis of patient history, existence of dust agents, the morphology and distribution of the lesions, the results of epicutaneous tests (repeated open application test), and avoidance of further exposure leading to recovery from dermatitis.© 2018 The International Society of Dermatology.

2018 International Journal of Dermatology

11. The Role and Diagnosis of Allergic Contact Dermatitis in Patients with Atopic Dermatitis. Full Text available with Trip Pro

The Role and Diagnosis of Allergic Contact Dermatitis in Patients with Atopic Dermatitis. Patients with atopic dermatitis (AD) have increased penetration of allergens, immune dysregulation (including shared cytokine pathways), and frequent use of emollients and topical medications, all of which may predispose toward developing allergic contact dermatitis (ACD). Recent systematic reviews have suggested that ACD is a significant clinical problem in both children and adults with AD. While

2018 American journal of clinical dermatology

12. Allergic Contact Dermatitis To Personal Care Products And Topical Medications In Adults With Atopic Dermatitis. (Abstract)

Allergic Contact Dermatitis To Personal Care Products And Topical Medications In Adults With Atopic Dermatitis. Atopic dermatitis (AD) is associated with skin-barrier disruption, immune dysregulation, and application of emollients and topical medications that might predispose a person toward developing allergic contact dermatitis.To determine the predictors of allergic contact dermatitis and relevant allergens in AD.A retrospective chart review was performed for 502 adults (age ≥18 years) who

2018 Journal of American Academy of Dermatology

13. Both children and adult patients with difficult-to-treat atopic dermatitis have high prevalences of concomitant allergic contact dermatitis and are frequently polysensitized. Full Text available with Trip Pro

Both children and adult patients with difficult-to-treat atopic dermatitis have high prevalences of concomitant allergic contact dermatitis and are frequently polysensitized. Concomitant allergic contact dermatitis (ACD) has been described as a possible cause of atopic dermatitis (AD) becoming difficult-to-treat. However, contact sensitization in this patient group has barely been studied.To study the occurrence of ACD in a population of difficult-to-treat AD children and adults.Clinical (...) and patch test information of 48 patients with difficult-to-treat AD unresponsive to conventional outpatient treatments was gathered retrospectively. We studied prevalence and relevance of common allergens, performed dynamic patch test analysis and assessed occurrence of polysensitization.In 48 patients with difficult-to-treat AD, 75% (n = 36/48) had a concomitant contact allergy, and 39% (n = 14/36) of these patients were polysensitized. ACD and polysensitization prevalences were equal amongst children

2018 Journal of the European Academy of Dermatology and Venereology

14. Inhibitory Activity of Allergic Contact Dermatitis and Atopic Dermatitis-Like Skin in BALB/c Mouse through Oral Administration of Fermented Barks of Alnus sibirica Full Text available with Trip Pro

Inhibitory Activity of Allergic Contact Dermatitis and Atopic Dermatitis-Like Skin in BALB/c Mouse through Oral Administration of Fermented Barks of Alnus sibirica Phytochemical isolation of fermented Alnus sibirica (FAS) which was produced by using Lactobacillus plantarum subsp. argentoratensis, exhibited multiple and different composition compared with the original plant. Anti-allergic contact dermatitis (anti-ACD)/anti-atopic dermatitis (anti-AD) activities (visual observation and regulation

2018 Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry

15. Signs of atopic dermatitis and contact dermatitis affected by distinct H2-haplotype in the NC/Nga genetic background Full Text available with Trip Pro

Signs of atopic dermatitis and contact dermatitis affected by distinct H2-haplotype in the NC/Nga genetic background We recently advocated in favour of naming a novel H2-haplotype consisting of Kd, D/Ldm7, I-Ak and I-Ek in the atopic dermatitis (AD) mouse model NC/Nga as "H-2nc." The role of the H2-haplotype in AD development was investigated in H2 b -congenic NC/Nga mice (NC.h2 b/b and NC.h2 b/nc ) established by backcrossing. A severe 2,4-dinitrofluorobenzene (DNFB)-induced dermatitis in NC (...) /Nga was alleviated partially in NC.h2 b/nc and significantly in NC.h2 b/b . The AD phenotype was correlated with thymic stromal lymphopoietin (TSLP)-epidermal expression levels and serum levels of total IgE and IL-18/IL-33. Histologically, allergic contact dermatitis (ACD) was accompanied by lymphocytes and plasma cells-infiltrating perivasculitis in NC.h2 b/nc and NC.h2 b/b and clearly differed from AD accompanied by neutrophils, eosinophils and macrophages-infiltrating diffuse suppurative

2018 Scientific reports

16. Contact sensitization in dental technicians with occupational contact dermatitis. Data of the Information Network of Departments of Dermatology (IVDK) 2001-2015. (Abstract)

Contact sensitization in dental technicians with occupational contact dermatitis. Data of the Information Network of Departments of Dermatology (IVDK) 2001-2015. Dental technicians (DTs) are at increased risk for allergic contact sensitization.To assess the current spectrum of occupational sensitization in DTs with occupational contact dermatitis (OCD).A retrospective analysis of Information Network of Departments of Dermatology patch test data from the years 2001-2015 concerning DTs with OCD (...) was performed.Patients of the study group (226 DTs with OCD) were significantly more often diagnosed with allergic contact dermatitis (37.6% versus 18.5%; p = 0.0002) than patients of the control group (124 DTs without OCD). In the study group, positive reactions were most frequently observed to methacrylates and/or acrylates (n = 67). Of these, 61 patients showed positive reactions to at least one of the five most frequent allergens in this group, namely 2-hydroxyethyl methacrylate, 2-hydroxypropyl methacrylate

2018 Contact Dermatitis

17. Short contact with nickel causes allergic contact dermatitis: an experimental study. Full Text available with Trip Pro

Short contact with nickel causes allergic contact dermatitis: an experimental study. Knowledge about the required duration of exposure for elicitation of allergic nickel dermatitis in nickel-allergic individuals is limited. However, it often has been proposed that short skin contact is safe.To examine whether repeated skin contact with nickel over short time periods (3 × 10 min) can elicit allergic nickel dermatitis.Sixteen nickel-allergic adults and 10 controls were exposed to, respectively (...) on the earlobe. On the SLS-pretreated arms of nickel-allergic participants, blood flow increased significantly more on the nickel-exposed skin than on the aluminium-exposed skin on days 2 and 4. No change in clinical reactivity or blood flow was found on normal forearm skin in nickel-allergic participants or on any skin in controls.This experimental study showed that relatively short repeated skin contact (3 × 10 min) with metallic nickel elicits allergic nickel dermatitis in irritated skin and at sites

2018 British Journal of Dermatology

18. Food-Related Contact Dermatitis, Contact Urticaria, and Atopy Patch Test with Food. (Abstract)

Food-Related Contact Dermatitis, Contact Urticaria, and Atopy Patch Test with Food. A wide variety of foods may cause or aggravate skin diseases such as contact dermatitis, contact urticaria, or atopic dermatitis (AD), both in occupational and private settings. The mechanism of action underlying allergic disease to food, food additives, and spices may be immunologic and non-immunologic. The classification and understanding of these reactions is a complex field, and knowledge of the possible (...) reaction patterns and appropriate diagnostic test methods is essential. In addition, certain foods may cause worsening of atopic dermatitis lesions in children. The atopy patch test (APT) is a well-established, clinically useful tool for assessing delayed type reactions to protein allergens in patients and may be useful to detect protein allergens relevant for certain skin diseases. The APT may even detect sensitization against allergens in intrinsic atopic dermatitis patients, who show negative skin

2018 Clinical Reviews in Allergy & Immunology

19. Dermatitis - contact

Dermatitis - contact Dermatitis - contact - NICE CKS Share Dermatitis - contact: Summary Contact dermatitis is an inflammatory skin condition which occurs as a result of exposure to an external irritant or allergen. Allergic contact dermatitis is a type IV (delayed) hypersensitivity reaction that occurs after sensitization and subsequent re-exposure to a specific allergen or allergens. Common allergens include personal care products (such as cosmetics, skin care products, nail varnish (...) , fragrances, and hair dye), metals (such as nickel), topical medications (including antibiotics and corticosteroids) and certain plants (such as sunflower and primula). Irritant contact dermatitis is a non-immunological inflammatory reaction caused by the direct physical or toxic effects of an irritating substance on the skin — prior sensitisation is not required. Common irritants include repeated exposure to water (‘wet work’), detergents, cleaning agents, acids and alkalis and certain plants

2018 NICE Clinical Knowledge Summaries

20. Contact Dermatitis after Prescription of an Ophthalmic Ointment Containing Fradiomycin Sulfate: A Retrospective Database Study Using Japanese Health Insurance Claims Data Full Text available with Trip Pro

Contact Dermatitis after Prescription of an Ophthalmic Ointment Containing Fradiomycin Sulfate: A Retrospective Database Study Using Japanese Health Insurance Claims Data Topical ointments containing fradiomycin sulfate, such as fradiomycin sulfate/methylprednisolone (F/M) and fradiomycin sulfate/betamethasone sodium phosphate (F/B), are known to cause allergic contact dermatitis (CD) in some patients, especially when used for the periocular region. F/M is commonly prescribed to patients

2017 Drugs - real world outcomes

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