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Constitutional Short Stature

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61. Clinical practice guidelines for the care of girls and women with Turner syndrome: proceedings from the 2016 Cincinnati International Turner Syndrome Meeting

systematic review of the literature. These four questions related to the efficacy and most optimal treatment of short stature, infertility, hypertension, and hormonal replacement therapy. The guidelines project was initiated by the European Society of Endocrinology and the Pediatric Endocrine Society, in collaboration with the European Society for Paediatric Endocrinology, the Endocrine Society, the European Society of Human Reproduction and Embryology, the American Heart Association, the Society (...) with a separate systematic review of the literature. These four questions related to the efficacy and most optimal treatment of short stature, infertility, hypertension, and hormonal replacement therapy. The guidelines project was initiated by the European Society of Endocrinology and the Pediatric Endocrine Society, in collaboration with the European Society for Paediatric Endocrinology, the Endocrine Society, the European Society of Human Reproduction and Embryology, the American Heart Association

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2016 European Society of Human Reproduction and Embryology

62. Faltering growth: recognition and management of faltering growth in children.

short stature (see recommendation above) Rapid weight loss or severe undernutrition Features that cause safeguarding concerns (see the NICE guideline on ). Organisation of Care Ensure there is a pathway of care for infants and children where there are concerns about faltering growth or weight loss in the early days of life that: Clearly sets out the roles of healthcare professionals in primary and secondary care settings Establishes and makes clear the process for referral to and coordination (...) , based on the assessment, advise on food choices for infants and children that: Are appropriate to the child's developmental stage in terms of quantity, type and food texture Optimise energy and nutrient density. In infants or children who need a further increase in the nutrient density of their diet beyond that achieved through advice on food choices, consider: Short-term dietary fortification using energy-dense foods Referral to a paediatric dietitian. Advise the parents or carers of infants

2017 National Guideline Clearinghouse (partial archive)

64. Obesity in Adolescents

in preventing short-term and long-term morbidity. The obstetrician–gynecologist who is knowledgeable about the behavioral and environmental factors that influence obesity may be better able to educate parents, guardians, and adolescents and advocate for programs that increase physical activity and improve nutrition. The obstetrician–gynecologist should be able to identify obese adolescents, particularly those at risk of comorbid conditions. They may have the opportunity to initiate behavioral counseling (...) , and psychologist or psychiatrist, should be used to select appropriate candidates for surgical intervention and provide postoperative support. Introduction Rates of obesity among adolescents in the United States have increased at a dramatic rate along with the prevalence of weight-related diseases. Because the obese female adolescent faces medical, psychologic, and reproductive health challenges, early intervention is imperative in preventing short-term and long-term morbidity. The obstetrician–gynecologist

2017 American College of Obstetricians and Gynecologists

66. European Society of Endocrinology Clinical practice guidelines for the care of girls and women with Turner syndrome

of the literature. These four questions related to the efficacy and most optimal treatment of short stature, infertility, hypertension, and hormonal replacement therapy. The guidelines project was initiated by the European Society of Endocrinology and the Pediatric Endocrine Society, in collaboration with the European Society for Paediatric Endocrinology, the Endocrine Society, the European Society of Human Reproduction and Embryology, the American Heart Association, the Society for Endocrinology (...) review of the literature. These four questions related to the efficacy and most optimal treatment of short stature, infertility, hypertension, and hormonal replacement therapy. The guidelines project was initiated by the European Society of Endocrinology and the Pediatric Endocrine Society, in collaboration with the European Society for Paediatric Endocrinology, the Endocrine Society, the European Society of Human Reproduction and Embryology, the American Heart Association, the Society

2017 European Society of Endocrinology

67. Clinical Practice Guidelines From the Cystic Fibrosis Foundation for Preschoolers With Cystic Fibrosis

heterogeneity and appears to be more sensitive than spirometry in detecting pulmonary function abnormalities in young children with CF. Two prospective studies that included preschool-aged children reported that MBW indices, specifically lung clearance index (LCI), was more sensitive than spirometry in detecting abnormal lung function , and was generally abnormal in preschoolers with CF compared with healthy controls. The utility of MBW in the clinical setting and what constitutes a clinically significant (...) , it is recommended that weight-for-age of preschoolers with CF be maintained at ≥10th percentile. : Recommendation 32. Measurement of height and weight, with calculation of BMI percentile using Centers for Disease Control and Prevention growth charts, should be performed to assess weight-for-stature. , Weight-for-height and BMI must be evaluated in the context of the child’s height. Stunting is a risk in CF and can obscure nutritional risk in a child. Preschoolers with CF should maintain a BMI ≥50th percentile

2016 Cystic Fibrosis Foundation

68. NASPGHAN Clinical Report on the Diagnosis and Treatment of Gluten-related Disorders

be associated with CD. Anemia, most commonly as a result of iron deficiency, has been reported in 12% to 69% of newly diagnosed patients (15–18) and appears more prevalent in celiac patients with an atrophic mucosa compared with those with mild enteropathy (19). Linear growth failure as an isolated initial presentation of CD is well described and can be found in up to 10% of children undergoing investigation for short stature (20,21). Dermatitis herpetiformis (DH) is considered a skin presen- tation of CD (...) Gastroenterol 1998;33:1280–3. 18. Hin H, Bird G, Fisher P, et al. Coeliac disease in primary care: case ?nding study. BMJ 1999;318:164–7. 19. Zanini B, Caselani F, Magni A, et al. Celiac disease with mild entero- pathy is not mild disease. Clin Gastroenterol Hepatol 2013;11:253–8. 20. Troncone R, Kosova R. Short stature and catch-up growth in celiac disease. J Pediatr Gastroenterol Nutr 2010;51:S137–8. 21. CacciariE,SalardiS,LazzariR,etal.Shortstatureandceliacdisease:a relationship to consider even

2016 North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition

69. Enteral tube feeding for individuals with cystic fibrosis: Cystic Fibrosis Foundation evidence-informed guidelines

and weight-for-length percentile for 0–2 years; weight/age percentile, stature/age percentile and body mass index (BMI) percentile for 2–20 years; and BMI value for adults [ x [21] Grummer-Strawn, L.M., Reinold, C., and Krebs, N.F. Centers for disease control and prevention. Use of World Health Organization and CDC growth charts for children aged 0–59 months in the United States. MMWR Recomm Rep . 2010 ; 59 : 1–15 | , x [22] Ogden, C.L., Kuczmarski, R.J., Flegal, K.M. et al. Centers for disease control (...) in patients with severe pulmonary dysfunction. Optimal lung function should be attained prior to anesthesia. 7. The CF Foundation recommends nasoenteral tube feeding in individuals with CF who require short-term (less than 3 months) nutritional repletion. NG feeding avoids the risk of surgery, and placement is easily reversible. In selected patients NG feeds may be suitable for short-term nutritional rehabilitation during an acute illness or as a trial of feeding tolerance prior to GT placement. While

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2016 Cystic Fibrosis Foundation

70. Term small for gestational age baby

associated with term gestation moderate and severe SGA Odds ratio [95% Confidence Interval]* Variable 6 Moderate SGA 6 Severe SGA 6 Primiparity 1.7 [1.1, 2.5] 1.9 [1.0, 3.7] Short maternal stature 2.9 [1.9, 4.3] 2.2 [1.1, 4.6] Antenatal smoking 1.8 [1.1, 3.1] 4.0 [1.9, 8.1] Preeclampsia 0.3 [0.0, 2.2] 7.3 [3.1, 17.3] Threatened preterm labour 0.9 [0.3, 2.6] 4.7 [1.9, 11.6] Low placental weight 16.4 [10.4, 26.0] 22.0 [11.0, 44.3] * Univariable associations with severe and moderate term SGA: results (...) the fetus to survive but may result in adverse sequelae for the baby and potentially for the adult if prolonged. 13,14 The diagnosis of reduced fetal growth rate is important. Once detected, further obstetric assessment is required to determine the cause and guide pregnancy management. Small size may be constitutional and reflect a normal physiological variance, however, reduced growth rate may occur secondary to maternal, placental and/or fetal factors. Queensland Clinical Guideline: Term small

2016 Queensland Health

71. Management of Carpal Tunnel Syndrome

LOCATION Strong evidence supports that surgical release of the transverse carpal ligament should relieve symptoms and improve function. Strength of Recommendation: Strong Evidence Description: Evidence from two or more “High” strength studies with consistent findings for recommending for or against the intervention. SURGICAL RELEASE PROCEDURE Limited evidence supports that if surgery is chosen, a practitioner might consider using endoscopic carpal tunnel release based on possible short term benefits

2016 American Academy of Orthopaedic Surgeons

72. Enhancing Literacy in Cardiovascular Genetics: A Scientific Statement From the American Heart Association

genetic syndrome with multisystem involvement: Syndrome diagnosis, care coordination, and implementation of health supervision guidelines Intellectual or learning disability; autism; other cognitive impairment Dysmorphic features Short stature Features of connective tissue disease Any congenital anomaly Endocrine abnormalities Sensory deficits such as hearing loss or visual impairment Neurological deficits or psychiatric illness Unexplained medical conditions Family history of heritable cardiac (...) arrhythmias, which include long-QT syndrome (LQTS), Brugada syndrome, catecholaminergic polymorphic ventricular tachycardia, and short-QT syndrome. In the young, LQTS is an important cause of SCD caused by ventricular arrhythmias, generally attributed to torsade de pointes. It is inherited in an autosomal dominant manner, and numerous genes have been identified. Although LQTS most often occurs in an isolated manner, it can occur in the setting of well-described syndromes including the autosomal recessive

2016 American Heart Association

73. Clinical Practice Guidelines on Obesity

be relatively high before initiating therapy. Proper evaluation of issues related to motivation should be undertaken. (pg 40) Grade C, Level 2 + Treatment: Introduction A A multi-faceted or a multi-disciplinary strategy should be utilised to achieve and maintain weight loss. This could be adequately achieved at the primary health care level depending on the patient’s response. (pg 41) Grade A, Level 2 + A The appropriate short-term treatment goals are an initial 5–10% weight loss over 6 months (...) , and if this is not attainable, then a prevention of further weight gain may be recommended, which can improve mechanical symptoms and metabolic parameters. Long-term goals should continue in the same vein as the short-term goals, and the patient should be encouraged to lose more weight if possible (e.g. 10–20% of initial body weight). (pg 42) Grade A, Level 1 ++ A Realistic weight loss should be safe and should preferably not exceed 0.5–1 kg a week. (pg 42) Grade A, Level 1 ++4 Treatment: Diet C Nutritional counselling

2016 Ministry of Health, Singapore

74. American Association of Clinical Endocrinologists and American College of Endocrinology Clinical Practice Guidelines for Comprehensive Medical Care of Patients with Obesity

of lifestyle therapy are associated with efficacy? 91 Q6.1. Meal plan and macronutrient composition 92 Q6.2. Physical activity 93 Q6.3. Behavior interventions 96 Q7. Is pharmacotherapy effective to treat overweight and obesity? 102 Q7.1. Should pharmacotherapy be used as an adjunct to lifestyle therapy? 102 Q7.2. Does the addition of pharmacotherapy produce greater weight loss and weight-loss maintenance than lifestyle therapy alone? 102 Q7.3. Should pharmacotherapy only be used in the short term to help (...) with efficacy? • Q6.1. Meal plan and macronutrient composition • Q6.2. Physical activity • Q6.3. Behavior interventions Pharmacotherapy for Overweight and Obesity • Q7. Is pharmacotherapy effective to treat overweight and obesity? • Q7.1. Should pharmacotherapy be used as an adjunct to lifestyle therapy? • Q7.2. Does the addition of pharmacotherapy pro- duce greater weight loss and weight-loss mainte- nance compared with lifestyle therapy alone? • Q7.3. Should pharmacotherapy only be used in the short term

2016 American Association of Clinical Endocrinologists

75. Guideline on the management of premature ovarian insufficiency

and to keep it up-to-date, it cannot, however, guarantee the correctness, completeness, and accuracy of the guideline in every respect. In any event, these clinical practice guidelines do not necessarily represent the views of all clinicians that are member of ESHRE. The information provided in this document does not constitute business, medical or other professional advice, and is subject to change. 3 CONTENTS Introduction to the Guideline 5 Summary 7 Interpretation on the grades of recommendations 7 (...) be made to reduce the incidence of POI. Modifiable factors may include: ? gynaecological surgical practice ? lifestyle – smoking ? modified treatment regimens for malignant and chronic diseases. References Albright F, Smith P, Fraser R. A syndrome characterized by primary ovarian insufficiency and decreased stature. Am J Med Sci 1942;204: 625- 648. Alexandru Dan Corlan. Medline trend: automated yearly statistics of PubMed results for any query, 2004. . Retrieved 13 november 2015, from http

2015 European Society of Human Reproduction and Embryology

76. Genetics of Skin Cancer (PDQ®): Health Professional Version

of vertebral bodies), modeling defects of the hands and feet, or flame-shaped lucencies of hands and feet Bridging of sella turcica, vertebral abnormalities (hemivertebrae, fusion or elongation of vertebral bodies), modeling defects of the hands and feet Skeletal malformations (vertebral, short 4th metacarpals, postaxial polydactyly) (Rib abnormalities listed as major criterion; see above.) (Rib abnormalities listed as major criterion; see above.) Rib abnormalities Cardiac or ovarian fibroma Ovarian

2018 PDQ - NCI's Comprehensive Cancer Database

77. Childhood Cancer Genomics (PDQ®): Health Professional Version

alterations in RAS and PTEN. The French Acute Lymphoblastic Leukaemia Study Group (FRALLE) and the Group for Research on Adult Acute Lymphoblastic Leukemia groups reported that patients having mutated NOTCH1 / FBXW7 and wild-type PTEN / RAS constituted a favorable-risk group while patients with PTEN or RAS mutations, regardless of NOTCH1/FBXW7 status, have a significantly higher risk of treatment failure.[ , ] In the FRALLE study, 5-year cumulative incidence of relapse and disease-free survival (DFS) were

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2018 PDQ - NCI's Comprehensive Cancer Database

78. Genetics of Breast and Gynecologic Cancers (PDQ®): Health Professional Version

in the and sections of this summary for more information.) Oral contraceptives Oral contraceptives (OCs) may produce a slight increase in breast cancer risk among long-term users, but this appears to be a short-term effect. In a meta-analysis of data from 54 studies, the risk of breast cancer associated with OC use did not vary in relationship to a family history of breast cancer.[ ] OCs are sometimes recommended for ovarian cancer prevention in carriers of BRCA1 and BRCA2 pathogenic variants. (Refer (...) tested for BRCA1/BRCA2 pathogenic variants.[ ] Short-term use of hormones for treatment of menopausal symptoms appears to confer little or no breast cancer risk.[ , ] The effect of HRT on breast cancer risk among carriers of BRCA1 or BRCA2 pathogenic variants has been studied in the context of bilateral risk-reducing oophorectomy, in which short-term replacement does not appear to reduce the protective effect of oophorectomy on breast cancer risk.[ ] (Refer to the section of this summary for more

2018 PDQ - NCI's Comprehensive Cancer Database

79. Late Effects of Treatment for Childhood Cancer (PDQ®): Health Professional Version

the following:[ , , ] A short latency (<10 years from primary cancer diagnosis). The risk of t-MDS/AML plateaus after 10 to 15 years. Although the risk of subsequent leukemia remains significantly elevated beyond 15 years from primary diagnosis (standardized incidence ratio [SIR], 3.5; 95% CI, 1.9–6.0), these events are relatively rare, with an absolute excess risk of 0.02 cases per 1,000 person-years.[ ] An association with alkylating agents and/or topoisomerase II inhibitors. t-MDS/AML is a clonal

2018 PDQ - NCI's Comprehensive Cancer Database

80. Aortic Diseases

be clinically silent in many cases, a broad rangeofsymptomsmayberelatedtodifferentaorticdiseases: † Acutedeep,achingorthrobbingchestorabdominalpainthatcan spread to the back, buttocks, groin or legs, suggestive of AD or otherAAS,andbestdescribedas‘feelingofrupture’. † Cough, shortness of breath, or dif?cult or painful swallowing in largeTAAs. † Constantorintermittentabdominalpainordiscomfort,apulsat- ing feeling in the abdomen, or feeling of fullness after minimal foodintakeinlargeAAAs. † Stroke, transient (...) . 61 Compared with axial short-axis or minor-axis diameter measurements, maximum diam- eter measurements perpendicular to the vessel centreline have higher reproducibility. 60 Inter- and intra-observer variability of CT for AAA—de?ned as Bland-Altman limits of agreement—are ap- proximately 5 mm and 3 mm, respectively. 43,61–63 Thus, any change of .5 mm on serial CT can be considered a signi?cant change, but smaller changes are dif?cult to interpret. Compared withCT

2014 European Society of Cardiology

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