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311 results for

Constitutional Short Stature

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301. Final height in boys with untreated constitutional delay in growth and puberty. (PubMed)

Final height in boys with untreated constitutional delay in growth and puberty. To determine the natural history and psychological impact of the growth pattern in boys with constitutional delay in growth and puberty (CDGP), 43 boys presenting with short stature due to CDGP were followed up to final height. At presentation mean (SD) chronological age was 14.0 (1.9) years, bone age delay 2.7 (1.0) years, standing height standard deviation score (SDS) -3.4 (0.6), and predicted adult height SDS (...) delay had affected their success either at school, work, or socially and 20 would rather have had treatment to advance their growth spurt. This study supports the more frequent use of active medical treatment to advance growth in boys with CDGP, and shows that although boys with CDGP reach their predicted heights, this is short for their families.

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1990 Archives of Disease in Childhood

302. Method for the earlier recognition of abnormal stature. (PubMed)

--but the rest had genetic short stature or 'constitutional' delay in puberty. Many children who could have been treated effectively were referred too late, for effective treatment to ensure normal adult height because of this we have developed full sized percentile charts to screen populations of children so that abnormal stature can be recognised immediately. (...) Method for the earlier recognition of abnormal stature. Two hundred and twenty seven children with a height below the 3rd or above the 97th centile were seen consecutively in the Oxford growth clinic. Their referral ages were analysed to determine the pattern of referral. Eighty seven per cent of the children had short stature. In 40% of these there was an organic reason for abnormal growth--the most common conditions being growth hormone deficiency, hypothyroidism, and Turner's syndrome

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1983 Archives of Disease in Childhood

303. What are the causes of short stature and what investigations need to be done?

: "chronic disease (including undernutrition genetic disorders), familial short stature, and constitutional delay of growth and development. Endocrine diseases are rare causes of short stature. The hallmark of endocrine disease is linear GF occurring to a greater degree than weight loss. Most short children evaluated by clinicians in developed countries have familial short stature and/or constitutional delay of growth, both of which are diagnoses of exclusion. The hallmarks of familial short stature (...) (also referred to as genetic short stature) include bone age appropriate for chronologic age, normal growth velocity, and predicted adult height appropriate to the familial pattern (using the Bayley-Pinneau or Tanner-Goldstein-Whitehouse tables). By contrast, constitutional delay is characterized by delayed bone age, normal growth velocity, and predicted adult height appropriate to the familial pattern. Patients with constitutional delay typically have a first-degree or second-degree relative

2003 TRIP Answers

304. rhGH and rhIGF-1 Combination Therapy in Children With Short Stature Associated With IGF-1 Deficiency

rhGH and rhIGF-1 Combination Therapy in Children With Short Stature Associated With IGF-1 Deficiency rhGH and rhIGF-1 Combination Therapy in Children With Short Stature Associated With IGF-1 Deficiency - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please (...) remove one or more studies before adding more. rhGH and rhIGF-1 Combination Therapy in Children With Short Stature Associated With IGF-1 Deficiency The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00572156 Recruitment Status : Terminated (The study was prematurely terminated due to strategic reasons

2007 Clinical Trials

305. Short stature and functional impairment: a systematic review. (PubMed)

Short stature and functional impairment: a systematic review. To review the available evidence on the association between primary short stature and intellectual and physical dysfunction among children.Systematic searches were performed through October 2001 of English-language studies of children with short stature and functional limitations. Included studies evaluated children with isolated short stature, constitutional growth delay, growth hormone deficiency, or multiple hormone deficiency (...) . Evaluated outcomes included intelligence, academic achievement, visual-motor skills, psychomotor development, and behavior problems.Eleven studies evaluated academic achievement, and 22 evaluated intelligence. No substantial deviation from normal was seen among short children, but many studies found that children with short stature had significantly lower intelligence and academic achievement scores than controls. Three studies found significant visual-motor skill reduction among short children. One

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2004 Archives of Pediatrics & Adolescent Medicine

306. Novel treatment of short stature with aromatase inhibitors. (PubMed)

Novel treatment of short stature with aromatase inhibitors. Estrogens have an essential role in the regulation of bone maturation and importantly in the closure of growth plates in both sexes. This prospective, randomized, placebo-controlled study was undertaken to evaluate whether suppression of estrogen synthesis in pubertal boys delays bone maturation and ultimately results in increased adult height. A total of 23 boys with constitutional delay of puberty (CDP) received a conventional, low

2003 The Journal of steroid biochemistry and molecular biology Controlled trial quality: uncertain

307. The effect of short-term growth hormone or low-dose oxandrolone treatment in boys with constitutional growth delay. (PubMed)

The effect of short-term growth hormone or low-dose oxandrolone treatment in boys with constitutional growth delay. We evaluated the effect of six-month treatment with growth hormone (GH) or low-dose oxandrolone in a group of boys with constitutional growth delay (CGD). Sixteen boys were randomly assigned to two treatment groups. Group 1 received GH (0.6 U/kg/week sc 5-6 times/week) and Group 2 received oxandrolone (0.07 mg/kg po). The boys of the two groups were closely matched for age (13.7 (...) +/- 0.5 and 12.8 +/- 0.4 years) (mean +/- SE), chronologic age/bone age ratio (1.15 +/- 0.04 and 1.16 +/- 0.02), height standard deviation score (SDS; -2.7 +/- 0.4 and -2.5 +/- 0.3) and pretreatment height velocity (HV) (3.7 +/- 0.8 and 4.0 +/- 0.4 cm/year). Other known causes of short stature were excluded in all subjects, and none had taken long-term medication prior to the study. After 6 months of treatment HV increased to 7.5 +/- 0.4 and to 8.1 +/- 0.5 cm/year in group 1 and 2, respectively

1991 Journal of endocrinological investigation Controlled trial quality: uncertain

308. Short Stature in Childhood and Adolescence: Part 1: Medical management (PubMed)

Short Stature in Childhood and Adolescence: Part 1: Medical management Childhood short stature is common in family practice. Familial short stature and constitutional growth delay account for most cases, and there are clear guidelines for differentiating these from each other and from less common pathologic conditions. Appropriate investigation, treatment, and referral are delineated, and growth hormone therapy is described. An integrated medical-psychosocial approach to care is recommended.

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1991 Canadian Family Physician

309. Idiopathic short stature: results of a one-year controlled study of human growth hormone treatment. Genentech Collaborative Study Group. (PubMed)

, whereas untreated children's growth rate did not change significantly (4.2 +/- 1.3 vs 5.0 +/- 1.4 cm/yr). There was a 1-year advance in bone age for each group; thus there was a significant increase in the predicted height of the treated but not the control group. Among the treated children, the growth response did not differ among those classified on the basis of parental height and bone age as having familial short stature or constitutional delay of growth and development. Prestudy anthropomorphic (...) Idiopathic short stature: results of a one-year controlled study of human growth hormone treatment. Genentech Collaborative Study Group. A multicenter randomized trial of human growth hormone treatment was carried out in 121 children with short stature who did not meet the classic criteria for growth hormone deficiency. Patients treated for 1 year with recombinant somatropin, 0.1 mg/kg three times a week, had a significant increase in mean growth rate from 4.6 +/- 1.1 to 7.5 +/- 1.2 cm/yr

1989 The Journal of pediatrics Controlled trial quality: uncertain

310. Loss of constitutive activity of the growth hormone secretagogue receptor in familial short stature (PubMed)

Loss of constitutive activity of the growth hormone secretagogue receptor in familial short stature The growth hormone (GH) secretagogue receptor (GHSR) was cloned as the target of a family of synthetic molecules endowed with GH release properties. As shown recently through in vitro means, this receptor displays a constitutive activity whose clinical relevance is unknown. Although pharmacological studies have demonstrated that its endogenous ligand--ghrelin--stimulates, through the GHSR, GH (...) secretion and appetite, the physiological importance of the GHSR-dependent pathways remains an open question that gives rise to much controversy. We report the identification of a GHSR missense mutation that segregates with short stature within 2 unrelated families. This mutation, which results in decreased cell-surface expression of the receptor, selectively impairs the constitutive activity of the GHSR, while preserving its ability to respond to ghrelin. This first description, to our knowledge

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2006 Journal of Clinical Investigation

311. Differences in physical characteristics, perinatal histories, and social backgrounds between children with growth hormone deficiency and constitutional short stature. (PubMed)

Differences in physical characteristics, perinatal histories, and social backgrounds between children with growth hormone deficiency and constitutional short stature. Four hundred and forty-nine children with heights below -2.5 SD were identified by screening for height a total population of 48221 in three Scottish cities. Children participating in the study could be classified into 5 groups: severe growth hormone deficiency (n = 13), partial growth hormone deficiency (n = 25), low birthweight (...) short stature (n = 34), constitutional short stature (n = 178), and short stature associated with some underlying disease (n = 106). Children with growth hormone deficiency tended to be shorter, were more likely to be obese, were growing more slowly, more often were the products of an abnormal pregnancy, and were less socially disadvantaged than constitutionally short children. Their parents were also more likely to have sought medical advice about the short stature. These findings have important

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1981 Archives of Disease in Childhood

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