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Congenital Heart Disease Imaging in Adults

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3701. Rosiglitazone (Extended Release Tablets) As Adjunctive Therapy For Subjects With Mild To Moderate Alzheimer's Disease

had started. An adverse event was therefore any unfavourable and unintended sign, symptom, or disease temporally associated with the use of study drug, whether or not considered related to the study drug. A Serious Adverse Event (SAE) is any untoward medical occurrence that at any dose results in death, are life threatening, requires hospitalization or prolongation of hospitalization or results in disability/incapacity, and congenital anomaly/birth defect. The data was reported for prospective (...) of the study. Female subjects who are pre-menopausal or who have been post-menopausal for <1 year must undertake pregnancy testing (urine test) at Visit 1, which must be negative. Brain CT or MRI scan performed within the past 12 months or at Screening, showing no evidence of any other potential cause of dementia other than Alzheimer's disease. (Note: Questionable CT or MRI scans should be discussed with the medical monitor, using central imaging guidelines.) Neurological exam without focal changes

2006 Clinical Trials

3702. Safety and Tolerability of E5555 and Its Effects on Markers of Intravascular Inflammation in Subjects With Coronary Artery Disease

may contact the study research staff using the contacts provided below. For general information, Layout table for eligibility information Ages Eligible for Study: 45 Years to 80 Years (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria INCLUSION CRITERIA: Males or Females, 45 - 80 years of age Confirmed coronary artery disease defined as one of the following: Post-acute coronary syndrome or myocardial infarction or Post percutaneous coronary intervention (...) or coronary artery bypass graft or oAngina pectoris with documented (electrocardiogram or imaging study) ischemia or Angiographically documented lesion occluding ≥70% of a coronary vessel And at high risk as defined as one or more of the following: Elevated hsCRP (high-sensitivity C-reactive protein) Diabetes mellitus History of carotid artery disease and/or peripheral artery disease Thrombo-embolic transient ischemic attack or stroke >1 year prior to screening All subjects must be receiving low dose

2006 Clinical Trials

3703. Cardiovascular Disease Screening

test. X-ray contrast studies of the heart and blood vessels. (These may be excluded in patients with kidney risk factors.) Condition or disease Congenital Heart Disease Atherosclerosis Myocardial Ischemia Myocardial Infarction Acquired Heart Disease Detailed Description: This is a screening protocol. This protocol allows two functions: 1) the protocol allows physicians in the Suburban/NHLBI Cardiovascular Imaging program to evaluate patients referred to the program with clinically indicated studies (...) information Studies a U.S. FDA-regulated Drug Product: No Studies a U.S. FDA-regulated Device Product: No Keywords provided by National Institutes of Health Clinical Center (CC) ( National Heart, Lung, and Blood Institute (NHLBI) ): Transthoracic echocardiography Ischemia Cardiovascular Disease Heart Disease Congenital Heart Disease Heart Valve Disease Atherosclerosis Additional relevant MeSH terms: Layout table for MeSH terms Infarction Cardiovascular Diseases Heart Diseases Myocardial Infarction

2007 Clinical Trials

3704. Therapeutic Application of Intravascular Nitrite for Sickle Cell Disease

a negative pregnancy test may be eligible for this study. Adults with any other disease that puts them at risk for reduced circulation are not eligible. Women who are breastfeeding are not eligible. Participants will undergo a medical history, including family medical history, and a detailed physical evaluation, to take about 1 hour. There will be a collection of blood; echocardiogram, which involves taking a picture of the heart and its four chambers; and measurement of exhaled carbon monoxide, carbon (...) Application of Intravascular Nitrite for Sickle Cell Disease The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00095472 Recruitment Status : Completed First Posted : November 5, 2004 Last Update Posted : March 11, 2019 Sponsor: National Heart, Lung, and Blood Institute (NHLBI) Information provided

2004 Clinical Trials

3705. Study of Deferasirox Relative to Subcutaneous Deferoxamine in Sickle Cell Disease Patients

the contacts provided below. For general information, Layout table for eligibility information Ages Eligible for Study: 2 Years and older (Child, Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Age greater than or equal to 2 years Male or female patients with sickle cell disease (SS, SC, SD, Sβo or Sβ+ thalassemia) Iron overload from repeated blood transfusion, as defined by one of the following: For patients > 16 years old receiving simple (...) : Serum creatinine above the upper limit of normal Significant proteinuria History of nephrotic syndrome Alanine aminotransferase (ALT) ≥ 250 U/L at screening Clinical evidence of active hepatitis B or hepatitis C History of HIV Fever or other signs/symptoms of infection within 10 days prior to the screening visit Uncontrolled systemic hypertension History of Myocardial Infarction, Congestive Heart Failure or unstable cardiac disease not controlled by standard medical therapy Clinically relevant

2005 Clinical Trials

3706. 17AAG to Treat Kidney Tumors in Von Hippel-Lindau Disease

and metabolic changes in renal tumors before and during therapy Eligibility: Adults with clinical diagnosis of von Hippel Lindau disease Presence of one or more localized renal tumors for which surgical resection would be considered the standard approach Design: Patients will receive 17 AAG as an intravenous infusion at a dose of 300mg/m(2) on days 1, 8, and 15 of 28 day cycles. The study will follow a two-stage MinMax phase II design and will accrue a maximum of 26 patients. Study Design Go to Layout table (...) Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Patients must satisfy all of the following inclusion criteria to be eligible for study enrollment. Clinical diagnosis of von Hippel Lindau disease. Presence of one or more localized renal tumors for which surgical resection would be considered the standard approach. Age greater than or equal to 18 years. Because no dosing or adverse event data

2004 Clinical Trials

3707. Atorvastatin Therapy to Improve Endothelial Function in Sickle Cell Disease

not had an acute pain episode within the previous week, and who are not pregnant or lactating may be eligible for this study. They will undergo a complete medical history; physical examination; baseline blood tests; and echocardiogram, in which an ultrasound wand is placed against the chest wall to get images inside the heart and blood vessels. In addition, patients will have blood flow studies. During the procedure, they will lie in an adjustable reclining chair for 5 to 6 hours. There will be 20 (...) : 18 Years to 65 Years (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria ELIGIBILITY: All volunteer subjects must be at least 18 years of age and have provided informed, written consent for participation in this study. Eligibility in the study is determined prior to enrollment on the basis of the following inclusion and exclusion criteria. INCLUSION CRITERIA FOR CONTROLS: For each enrolled study patient with sickle cell disease, we will recruit an African

2003 Clinical Trials

3708. RTA 744 Injection in Patients With Leptomeningeal Disease

RTA 744 Injection in Patients With Leptomeningeal Disease RTA 744 Injection in Patients With Leptomeningeal Disease - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. RTA 744 Injection in Patients (...) With Leptomeningeal Disease The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00512460 Recruitment Status : Terminated (Study was closed due to loss of industry sponsorship) First Posted : August 7, 2007 Last Update Posted : May 16, 2016 Sponsor: M.D. Anderson Cancer Center Collaborator: Reata Pharmaceuticals, Inc

2007 Clinical Trials

3709. The Link Between Anemia and Deficits in Memory and Attention in Individuals With Sickle Cell Disease

Posted: August 19, 2016 Last Verified: October 2013 Keywords provided by National Heart, Lung, and Blood Institute (NHLBI): MRI Neuropsychology Additional relevant MeSH terms: Layout table for MeSH terms Anemia, Sickle Cell Anemia, Hemolytic, Congenital Anemia, Hemolytic Anemia Hematologic Diseases Hemoglobinopathies Genetic Diseases, Inborn (...) Sponsor: National Heart, Lung, and Blood Institute (NHLBI) Collaborator: University of California, San Francisco Information provided by: National Heart, Lung, and Blood Institute (NHLBI) Study Details Study Description Go to Brief Summary: Sickle cell disease is an inherited blood disorder that affects red blood cells (RBCs). People with sickle cell disease frequently experience anemia, or a low number of RBCs. RBCs are responsible for carrying oxygen to the brain and other body tissues that need

2007 Clinical Trials

3710. Evaluating the Genetic Causes and Progression of Cholestatic Liver Diseases (LOGIC)

Tract Diseases Lung Diseases Respiratory Tract Diseases Genetic Diseases, Inborn Subcutaneous Emphysema Emphysema Pathologic Processes Heart Defects, Congenital Cardiovascular Abnormalities Cardiovascular Diseases Abnormalities, Multiple Congenital Abnormalities (...) , and the development of simpler diagnostic tests would facilitate early diagnosis and treatment. This study will investigate the natural history and progression of the four previously mentioned cholestatic liver diseases to provide a better understanding of the causes and effects of the diseases. Participation in this study will last 10 years and will consist of a baseline visit and five annual follow-up visits. The study will enroll infants through adults 25 years of age who have, or are suspected of having, one

2007 Clinical Trials

3711. Exercise Therapy to Treat Adults With Abdominal Aortic Aneurysms

Adults With Abdominal Aortic Aneurysms (AAA:STOP) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00349947 Recruitment Status : Completed First Posted : July 10, 2006 Last Update Posted : June 7, 2013 Sponsor: Stanford University Collaborator: National Heart, Lung, and Blood Institute (NHLBI (...) Exercise Therapy to Treat Adults With Abdominal Aortic Aneurysms Exercise Therapy to Treat Adults With Abdominal Aortic Aneurysms - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Exercise Therapy to Treat

2006 Clinical Trials

3712. Follow-up of adults with coarctation of the aorta: comparison of helical CT and MRI, and impact on assessing diameter changes. (PubMed)

Follow-up of adults with coarctation of the aorta: comparison of helical CT and MRI, and impact on assessing diameter changes. To compare images of the aorta obtained with helical CT (HCT) scanning and MRI for the follow-up of adults with coarctation of the aorta (CoA).Longitudinal study.Department of adult congenital heart disease in a tertiary university hospital.A total of 37 adults (age range, 16 to 68 years; women, 13) with CoA (after surgery, 34 patients; native, 2 patients; after balloon

2004 Chest

3713. Usefulness of multidetector row computed tomography to quantify right ventricular size and function in adults with either tetralogy of Fallot or transposition of the great arteries. (PubMed)

Usefulness of multidetector row computed tomography to quantify right ventricular size and function in adults with either tetralogy of Fallot or transposition of the great arteries. An ever-increasing number of patients with congenital heart disease are reaching adulthood; follow-up often requires right ventricular (RV) quantification. Complex anatomy, acoustic window, and active implants such as pacemakers may limit modalities, such as echocardiography and cardiac magnetic resonance imaging

2005 American Journal of Cardiology

3714. Non-compaction cardiomyopathy in an adult with hereditary spherocytosis. (PubMed)

Non-compaction cardiomyopathy in an adult with hereditary spherocytosis. A 23-year old male (199 cm, 88 kg) presented muscular weakness due to skeletal myopathy and symptoms of heart failure NYHA functional class II. Total creatine kinase was increased up to 830 U/l, but troponin was negative. Prior episodes of intermittent atrial fibrillation were reported and 6 years ago splenectomy was performed due to hereditary spherocytosis. Cardiac magnetic resonance imaging revealed the spongy (...) appearance of non-compacted left ventricular myocardium. This impaired fetal morphogenesis occurred predominantly in the apical to midventricular anterior, lateral and inferior segments. Non-compaction cardiomyopathy was initially described in paediatric patients. Occasional associations with other congenital disorders are known, e.g., Barth syndrome, which is an X-linked disease characterized by cardio-skeletal myopathy of variable severity and neutropenia. To our knowledge, combined occurrence of non

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2007 European Journal of Heart Failure

3715. Low pressure giant pulmonary artery aneurysms in the adult: natural history and management strategies. (PubMed)

Low pressure giant pulmonary artery aneurysms in the adult: natural history and management strategies. To describe aspects of the natural history and pathophysiology of giant low pressure pulmonary artery aneurysms and to propose potential surgical strategies.Cross sectional retrospective review.Supraregional tertiary referral centre.All adult patients referred for assessment of giant pulmonary artery aneurysm retrospectively identified from the Mayo Adult Congenital Heart Disease Clinic (...) database.Patient data were reviewed from hospital records, including echocardiograms, magnetic resonance images, radiographs, and histology slides.Four patients were identified with a median age of 52 years (range 37-64 years). Presenting symptoms were effort related dyspnoea, chest discomfort, and hoarseness in one patient. All patients had pulmonary regurgitation and clinical evidence of right ventricular enlargement in association with a pulsatile mass at the upper left sternal edge. Transthoracic

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2003 Heart

3716. Long term consequences of regressed coronary aneurysms after Kawasaki disease: vascular wall morphology and function (PubMed)

, 27 with previous Kawasaki disease and six with congenital heart disease. All Kawasaki disease patients were followed for more than 10 years from disease onset. The 33 patients comprised four groups: group 1 included 13 Kawasaki disease patients with a total of 23 sites of regressed large sized (>/= 4 mm) coronary aneurysms; group 2 included 13 Kawasaki disease patients with 22 sites of regressed small sized (< 4 mm) coronary aneurysms (four patients had sites of both large and small sized (...) aneurysms); group 3 included a further five Kawasaki disease patients with 25 normal coronary angiography sites in the acute stage of Kawasaki disease; and group 4 comprised the six patients with congenital heart disease as controls, with a total of 27 normal coronary angiography sites. During coronary angiography, 15 microg of acetylcholine and 0.5 mg isosorbide dinitrate were infused into the coronary artery. The luminal diameter at the sites was measured using a cine-videodensitometric analyser

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2000 Heart

3717. Radiation Therapy and Chemotherapy in Treating Patients With Hodgkin's Disease

are not eligible.) Cardiac disease defined as symptomatic congestive heart failure or coronary artery disease, known valvular (other than asymptomatic mitral valve prolapse) or congenital heart disease (other than asymptomatic atrial septal defects) or need for cardiac medications. Hypertension controlled with drug therapy is not an exclusion criterion. Other major medical illness judged likely by the local investigator to preclude safe administration of protocol treatment or required follow-up. Patients (...) with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Layout table for eligibility information Ages Eligible for Study: 16 Years and older (Child, Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Eligibility Criteria Histologically proven Hodgkin's Disease. A needle aspirate specimen

1999 Clinical Trials

3718. Cerebrovascular Involvement in Sickle Cell Disease

Involvement in Sickle Cell Disease - Comprehensive Sickle Cell Center The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00005326 Recruitment Status : Completed First Posted : May 26, 2000 Last Update Posted : March 16, 2016 Sponsor: National Heart, Lung, and Blood Institute (NHLBI) Information provided (...) by: National Heart, Lung, and Blood Institute (NHLBI) Study Details Study Description Go to Brief Summary: To continue studies on the two major neurological complications of sickle cell disease (SCD): namely, stroke and chronic encephalopathy. Condition or disease Anemia, Sickle Cell Blood Disease Cerebrovascular Accident Detailed Description: BACKGROUND: Stroke represents a focal brain insult whereas chronic encephalopathy represents a diffuse brain disturbance involving cognition and memory

2000 Clinical Trials

3719. Investigation of Selected Patient Groups From The Cooperative Study of Sickle Cell Disease

studies before adding more. Investigation of Selected Patient Groups From The Cooperative Study of Sickle Cell Disease The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00005300 Recruitment Status : Completed First Posted : May 26, 2000 Last Update Posted : April 14, 2016 Sponsor: National Heart, Lung (...) , and Blood Institute (NHLBI) Information provided by: National Heart, Lung, and Blood Institute (NHLBI) Study Details Study Description Go to Brief Summary: To continue to follow the newborn cohort and the over-35 years of age cohort from the Cooperative Study of Sickle Cell Disease (CSSCD), a study of the natural history of sickle cell disease. Condition or disease Anemia, Sickle Cell Blood Disease Detailed Description: BACKGROUND: The Cooperative Study of Sickle Cell Disease was initiated in 1977

2000 Clinical Trials

3720. Role of Genetic Factors in the Development of Lung Disease

in the Development of Lung Disease The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT00001532 Recruitment Status : Recruiting First Posted : November 4, 1999 Last Update Posted : March 20, 2019 See Sponsor: National Heart, Lung (...) , and Blood Institute (NHLBI) Collaborator: Suburban Hospital Information provided by (Responsible Party): National Institutes of Health Clinical Center (CC) ( National Heart, Lung, and Blood Institute (NHLBI) ) Study Details Study Description Go to Brief Summary: This study is designed to evaluate the genetics involved in the development of lung disease by surveying genes involved in the process of breathing and examining the genes in lung cells of patients with lung disease. The study will focus

1999 Clinical Trials

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