Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 or #4)
How to Trip Rapid Review
Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)
Step 2: press
Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.
susceptibility to ARF. 3 ARF is a condition seen predominantly in children aged 5–14 years, although recurrent episodes may continue well into the fourth decade of life. Because RHD represents the cumulative heart damage of previous ARF episodes, the prevalence of RHD peaks in the third and fourth decades of life. 3 Therefore, although ARF is a disease with roots in childhood, its effects are felt throughout adulthood, especially in the young adult years when people might otherwise be at their most (...) ) Australian Indigenous Doctors’ Association (AIDA) Australasian Society for Infectious Diseases (ASID) Council of Remote Area Nurses (CRANA) Cardiac Society of Australia and New Zealand (CSANZ) Internal Medicine Society of Australia and New Zealand (IMSANZ) National Aboriginal Community Controlled Health Organisation (NACCHO) National Heart Foundation of Australia Public Health Association of Australia (PHAA) Royal Australian College of General Practitioners (RACGP) Society of Obstetric Medicine
laboratory in infectious disease diagnosis calls for a close, positive working relationship between the physician/advanced practice provider and the microbiologists who provide enormous value to the healthcare team. This document, developed by experts in laboratory and adult and pediatric clinical medicine, provides information on which tests are valuable and in which contexts, and on tests that add little or no value for diagnostic decisions. This document presents a system-based approach rather than (...) and collecting specimens for analysis for a disease process. It is very easy to access critical information about a specific body site just by consulting the table of contents. Within each chapter, there is a table describing the specimen needs regarding a variety of etiologic agents that one may suspect as causing the illness. The test methods in the tables are listed in priority order according to the recommendations of the authors and reviewers. When room temperature is specified for a certain time period
, nonobstructive, or no coronary artery disease, which may present with chest pain elevated troponin wall motion abnormalities ST segment elevation or depression T-wave abnormalities heart failure with or without cardiogenic shock, which may present as de novo heart failure with reduced ejection fraction (HFrEF) myocarditis/myopericarditis stress-induced cardiomyopathy (such as Takotsubo syndrome) acute on chronic decompensated HFrEF heart failure with preserved left ventricular ejection fraction (HFpEF (...) studySummary Cohort Study based on retrospective cohort study 138 adults (median age 56 years) hospitalized with confirmed COVID-19 pneumonia in Wuhan, China evaluated prevalence of most common preexisting comorbidities hypertension in 31.2% cardiovascular disease in 14.5% diabetes in 10.1% malignancy in 7.2% cerebrovascular disease in 5.1% PubMed 32031570 JAMA JAMA 20200207 Reference - , commentary can be found in Study Summary prevalence of preexisting hypertension 15%, coronaryheartdisease 2.5
White Matter Microstructure and Cognition in Adolescents with CongenitalHeartDisease. To describe the relationship between altered white matter microstructure and neurodevelopment in children with dextro-transposition of the great arteries (d-TGA).We report correlations between regional white matter microstructure as measured by fractional anisotropy (FA) and cognitive outcome in a homogeneous group of adolescents with d-TGA. Subjects with d-TGA (n = 49) and controls (n = 29) underwent (...) diffusion tensor imaging and neurocognitive testing. In the group with d-TGA, we correlated neurocognitive scores with FA in 14 composite regions of interest in which subjects with d-TGA had lower FA than controls.Among the patients with d-TGA, mathematics achievement correlated with left parietal FA (r = 0.39; P = .006), inattention/hyperactivity symptoms correlated with right precentral FA (r = -0.39; P = .006) and left parietal FA (r = -0.30; P = .04), executive function correlated with right
Cardiovascular management in pregnancy: congenitalheartdisease. The population of adults with CHD continues to expand,and thus the number of women with CHD who contemplate pregnancy or become pregnant is also growing. Mothers with low-risk defects can be managed by general cardiologist,whereas those with more complex defects should be managed by or with the assistance of ACHD cardiologists. It is important to acknowledge that all patients with CHD may have unique anatomy or physiology (...) , despite their classification as having a simple, moderate, or complex defect. As such, clinicians evaluating these patients should have adequate knowledge and expertise when assessing patient's risk for pregnancy,when performing imaging or hemodynamic studies, and when managing these patients during pregnancy. The American Board of Medical Specialties has recently recognized ACHD as a subspecialty of cardiovascular disease to treat the specialized needs of these patients in adulthood. ACHD experts can
Multimodality Imaging in an Adult Patient with Scimitar Syndrome The "Scimitar syndrome" is a rare congenital anomaly characterized by combination of partial or complete pulmonary venous return from the right lung to the inferior vena cava either above or below the diaphragm together with hypoplasia of the right lung and sometimes systemic arterial supply to the right lung. In this case, multimodality imaging findings such as the vein draining into the inferior vena cava, the presence (...) of hypertrophied and dilated right ventricle, the absence of other cardiac abnormalities, displacement of the heart without malrotation and the mediastinum to the right, normal bronchial and vascular continuity in the whole lung, absence of pulmonary sequestration and systemic collaterals, normal perfusion and systolic functions of the left ventricle were reported.
disease after mantlefield irradiation for Hodgkin's disease in long-term follow-up. Radiother Oncol 51 (1): 35-42, 1999. [ ] Hancock SL, Tucker MA, Hoppe RT: Factors affecting late mortality from heartdisease after treatment of Hodgkin's disease. JAMA 270 (16): 1949-55, 1993. [ ] Heidenreich PA, Schnittger I, Strauss HW, et al.: Screening for coronary artery disease after mediastinal irradiation for Hodgkin's disease. J Clin Oncol 25 (1): 43-9, 2007. [ ] Dabaja B, Cox JD, Buchholz TA: Radiation (...) therapy can still be used safely in combined modality approaches in patients with Hodgkin's lymphoma. J Clin Oncol 25 (1): 3-5, 2007. [ ] Swerdlow AJ, Higgins CD, Smith P, et al.: Myocardial infarction mortality risk after treatment for Hodgkin disease: a collaborative British cohort study. J Natl Cancer Inst 99 (3): 206-14, 2007. [ ] van Nimwegen FA, Schaapveld M, Cutter DJ, et al.: Radiation Dose-Response Relationship for Risk of CoronaryHeartDisease in Survivors of Hodgkin Lymphoma. J Clin Oncol
of cardiovascular disease after treatment for aggressive non-Hodgkin lymphoma. Blood 107 (7): 2912-9, 2006. [ ] Darrington DL, Vose JM, Anderson JR, et al.: Incidence and characterization of secondary myelodysplastic syndrome and acute myelogenous leukemia following high-dose chemoradiotherapy and autologous stem-cell transplantation for lymphoid malignancies. J Clin Oncol 12 (12): 2527-34, 1994. [ ] Stone RM, Neuberg D, Soiffer R, et al.: Myelodysplastic syndrome as a late complication following autologous (...) : PDQ modification of REAL classification of lymphoproliferative diseases Plasma cell disorders. (Refer to the PDQ summary on for more information.) Bone. Extramedullary. Monoclonal gammopathy of undetermined significance. Plasmacytoma. Multiple myeloma. Amyloidosis. HL. (Refer to the PDQ summary on for more information.) Nodular sclerosis HL. Lymphocyte-rich classical HL. Mixed-cellularity HL. Lymphocyte-depleted HL. Indolent lymphoma/leukemia. Follicular lymphoma (follicular small-cleaved cell
of the innovative technology IQ-SPECT during a SCINTI-CT imaging in patients suspected of coronarydisease . Condition or disease Intervention/treatment Phase Coronary Artery Disease Device: myocardial IQ-SPECT imaging applied to scintigraphic imaging Device: scintigraphic imaging Not Applicable Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 103 participants Intervention Model: Single Group Assignment Masking: None (Open Label) Primary (...) ; or in symptomatic patients, but with a high risk of coronaryheartdisease: diabetes and / or with multiple cardiovascular risk factors and / or having a peripheral vascular disease Exclusion Criteria: Patients with a recent history (<21 days) acute coronary failure (myocardial infarction, unstable angina); Patients with an irregular heartbeat, because of the impossibility of achieving a good quality ECG synchronization (atrial fibrillation, ventricular extra-systole or supraventricular over 25% of cardiac
visible on imaging include gland atrophy with fatty replacement of the parenchyma, pancreatic calcifications, and cystosis (refer to section Neoplasms and Cysts). Shwachman-Diamond syndrome represents the second most frequent cause of EPI in children. This disease is characterized by diffuse fatty replacement of the pancreatic glandular tissue. Findings in both of these conditions are well visualized by TUS, CT, MRI/MRCP, and EUS, and hence TUS is frequently used as initial modality. In?ammatory (...) , but has primarily What Is Known Transabdominal ultrasonography, computed tom- ography, magnetic resonance imaging/magnetic resonance cholangiopancreatography, endoscopic ultrasonography, endoscopic retrograde cholangio- pancreatography are all modalities used to evaluate (adult) pancreaticohepatobiliary abnormalities and disorders. The literature is limited on the use of these technol- ogies for pediatric pancreatology indications. What Is New This article reviews the pediatric literature regarding
Diagnosis and Treatment of Lymphatic Plastic Bronchitis in Adults Using Advanced Lymphatic Imaging and Percutaneous Embolization. Plastic bronchitis is a condition characterized by expectoration of branching bronchial casts. Although the mechanism of cast formation in adults with plastic bronchitis remains poorly understood, abnormal pulmonary lymphatic flow resulting in molding of congealing lymphatic fluids in the airway has been documented as a cause of the disease in children (...) with congenitalheart disease.To use advanced lymphatic imaging techniques, including dynamic contrast-enhanced magnetic resonance (MR) lymphangiography (DCMRL) and intranodal lymphangiography, to investigate the mechanism of cast formation in adult patients with plastic bronchitis, and to evaluate the therapeutic outcome of percutaneous lymphatic embolization for these patients.Seven adults (male/female = 3/4, mean age = 50 yr) who presented with expectoration of branching bronchial casts were evaluated
disease, and Walker–Warburg syndrome. Other rare CMDs do not fit into any of the classic categories. list these CMDs with their associated genes and clinical phenotypes. More recently, several other genes have been associated with CMDs, including GTDC2 , TMEM5 , B3GALNT2 , SGK196 , B3GNT1 , GMPPB , and DAG1 . View this table: Table 1 The congenital muscular dystrophies View this table: Table 2 Clinical features of the congenital muscular dystrophies Whereas the genetic, pathophysiologic (...) in 100% of patients (2 Class III studies). ,e32 In Walker–Warburg syndrome, only 40% of patients have mutations in the known genes (1 large Class III study e33 and 2 smaller Class III studies e34,e35 ). How often do patients with CMD experience cognitive, respiratory, or cardiac complications? Numerous reports highlight a wide spectrum of complications in children and young adults with CMD. Functional CNS complications. One Class II study found that 58% of patients with CMD had cognitive impairment
Recomme n d a tion s 2.5.1 A thorough physical examination should be car- ried out in all neonates with high TSH concentrations for the detection of congenital malformations, particularly those affecting the heart, and in children for the identifi- cation of any underlying dysmorphic syndrome or neu- rodevelopmental disorders (1 | ? ? ? ). 2 . 5 . 1 E v id e n ce The prevalence of congenital malformations, particu- larly cardiac malformations, including septal defects, re- nal abnormalities (...) in patients with ectopic or normally sized and sited thyroid gland to date) Kidney agenesis or any malformation of the genitourinary tract Athyreosis, ectopic thyroid gland, normally located thyroid +/– hypoplasia PAX8 PAX8 Choreoathetosis or neurological disease Normally located thyroid, hypoplasia (athyreosis) NKX2–1 (no mutations described in ectopic cases so far) NKX2–1 Lung disorders (surfactant deficiency syndrome at term, interstitial lung disease) Normally located thyroid, hypoplasia (athyreosis
, diabetes, a sedentary lifestyle, increased low-density lipoprotein cholesterol levels and hypertension (Zipes et al. 2006). Heartconditions such as coronaryheartdisease, heart attack, cardiomyopathy, valvular heartdisease, congenitalheartdisease and electrical problems in the heart (such as Brugada syndrome and long QT syndrome) can lead to sudden cardiac arrest. Common non-cardiac causes of cardiac arrest include trauma, non-traumatic bleeding, intoxication, near drowning and pulmonary embolism (...) of 18.4% (Nolan et al. 2014). Out-of-hospital cardiac arrest affects approximately 60,000 people in the UK each year (Malhotra and Rakhit 2013), with an estimated survival to discharge rate of 2.2 to12% (Perkins and Cooke 2012). Non-modifiable risk factors for sudden cardiac arrest include coronaryheartdisease, a family history of coronaryheartdisease, age (incidence increases with age) and sex (men are at higher risk of sudden cardiac arrest). Modifiable risk factors include smoking, obesity
Adult patent ductus arteriosus: An unusual cause of heart failure in an octogenarian female Patent ductus arteriosus (PDA) is the third most common congenital abnormality in which the arterial duct, which normally closes spontaneously after birth within 24-48 h in full-term infants, remains permanently open. Breathlessness is very common in elderly patients and can be caused by several comorbidities, mostly cardiac and pulmonary diseases. PDA as a cause of heart failure in this patient (...) population is very rare and diagnosis depends on high clinical awareness. Here we present a case diagnosed with multimodality imaging including 3‑dimensional (3D) transthoracic and transesophageal echocardiography and 3D-volume rendering technique (VRT) computed tomography.
Healing Hearts and Mending Minds in Older Adults Living With HIV Healing Hearts and Mending Minds in Older Adults Living With HIV - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Healing Hearts and Mending (...) : Emory University Information provided by (Responsible Party): Drenna Waldrop-Valverde, Emory University Study Details Study Description Go to Brief Summary: The purpose of this study is to see if exercise is helpful for improving memory, concentration thinking abilities, physical function, and quality of life for adults aged 50 to 89 years living with HIV and who have two or more cardiovascular disease risk factors. The study will test two kinds of intervention exercises: one group will walk
transesophageal echocardiography; and TTE, transthoracic echocardiography. Figure. An approach to the diagnostic use of echocardiography (echo). Rx indicates prescription; TEE, transesophageal echocardiography; and TTE, transthoracic echocardiography. *For example, a patient with fever and a previously known heart murmur and no other stigmata of infective endocarditis (IE). †High initial patient risks include prosthetic heart valves, many congenitalheartdiseases, previous endocarditis, new murmur, heart (...) . These echocardiographic findings can occur in patients who have no heart failure symptoms. Both TEE and TTE may produce false-negative results if vegetations are small or have embolized. Even TEE may miss initial perivalvular abscesses, particularly when the study is performed early in the patient’s illness. In such cases, the incipient abscess may be seen only as nonspecific perivalvular thickening, which on repeat imaging across several days may become more recognizable as it expands and develops a cavity
for these events. Secondary prevention ICD (S2.2.2-2) ICD placement in a patient with prior SCA, sustained VT, or syncope caused by VA. Structural heartdisease* This term encompasses IHD, all types of cardiomyopathy, valvular heartdisease, and adultcongenitalheartdisease. Cardiac channelopathy (S2.2.2-4) Arrhythmogenic disease due to a genetic abnormality that results in dysfunction of a cardiac ion channel (e.g., long-QT syndrome, catecholaminergic polymorphic VT). *The de?nition of this term may differ (...) acute coronarysyndromes AED automated external de?brillator AMI acute myocardial infarction BNP B-type natriuretic peptide CABG coronary artery bypass graft CKD chronic kidney disease CPR cardiopulmonary resuscitation CRT cardiac resynchronization therapy CT computed tomography ECG electrocardiogram ERC evidence review committee ESRD end-stage renal disease GDMT guideline-directed management and therapy HCM hypertrophic cardiomyopathy HF heart failure HFpEF heart failure with preserved ejection
motion in critically ill children and can also be used for the diagnosis or exclusion of congenital/critical heartdisease. Widmer and colleagues prospectively validated remote interpretation of echocardiograms performed in a remote hospital by a sonographer experienced in pediatric echocardiography. The quality of transmitted echocardiographic images was sufficient for evaluation except in 1 case. In 191 (98%) children, he remote echocardiographic diagnosis was correct, as confirmed by follow-up (...) with congenitalheartdisease requires explanation of how to visualize shunts at the atrial, ventricular, and ductal levels from several different echocardiographic views and a basic understanding of aortic arch abnormalities. It should also incorporate the ability to image ≥1 pulmonary vein connections to rule out total anomalous pulmonary venous return. In general, adult sonographers are less likely to be familiar and comfortable with suprasternal notch and subcostal views; therefore, it is suggested