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Congenital Melanocytic Nevus

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1. Atypical Proliferative Nodule with Melanocytic Intraepidermal Pagetoid Spreading Arising within a Congenital Melanocytic Nevus in a Pregnant Woman Full Text available with Trip Pro

Atypical Proliferative Nodule with Melanocytic Intraepidermal Pagetoid Spreading Arising within a Congenital Melanocytic Nevus in a Pregnant Woman 29606826 2018 11 14 1013-9087 30 2 2018 Apr Annals of dermatology Ann Dermatol Atypical Proliferative Nodule with Melanocytic Intraepidermal Pagetoid Spreading Arising within a Congenital Melanocytic Nevus in a Pregnant Woman. 234-236 10.5021/ad.2018.30.2.234 Moon Hye-Rim HR Department of Dermatology, Asan Medical Center, University of Ulsan College

2018 Annals of dermatology

2. Does the gene matter? Genotype-phenotype and genotype-outcome associations in congenital melanocytic naevi. Full Text available with Trip Pro

Does the gene matter? Genotype-phenotype and genotype-outcome associations in congenital melanocytic naevi. Genotype-phenotype studies can identify subgroups of patients with specific clinical features or differing outcomes, which can help shape management. We undertook MC1R genotyping from blood, and high-sensitivity genotyping of NRAS and BRAF hotspots in 156 naevus biopsies from 134 patients with Congenital Melanocytic Naevi (CMN) (male 40%, multiple CMN 76%, projected adult size (PAS) >20 (...) cm 59%). Mosaic NRAS mutations were detected in 68%, mutually exclusive with BRAF mutations in 7%, with neither in 25%. Two separate naevi were sequenced in 5/7 patients with BRAF mutations, confirming clonality. 5/7 BRAF-mutated patients had a dramatic multi-nodular phenotype, with characteristic histology distinct from classical proliferative nodules. NRAS was the commonest mutation in all sizes of CMN, but was particularly common in PAS >60cm, implying more tolerance to that mutation early

2019 British Journal of Dermatology

3. Longitudinal study of congenital melanocytic naevi reveals that final colour is determined by normal skin colour, and is unaltered by superficial removal techniques. (Abstract)

Longitudinal study of congenital melanocytic naevi reveals that final colour is determined by normal skin colour, and is unaltered by superficial removal techniques. Spontaneous lightening of Congenital Melanocytic Naevi (CMN) has not been studied systematically. Final colour is considered an important outcome after superficial removal techniques such as curettage, dermabrasion or laser ablation, and is often compared to colour at birth.To quantify the natural history of CMN lightening over

2019 British Journal of Dermatology

4. Protocol for the development of core set of domains of the core outcome set for patients with congenital melanocytic naevi (OCOMEN project). (Abstract)

Protocol for the development of core set of domains of the core outcome set for patients with congenital melanocytic naevi (OCOMEN project). Having large congenital melanocytic naevi (CMN) is associated with a psychosocial burden on patients and their parents because of its remarkable appearance and the extra care it may require. Large CMN also pose an increased risk of malignant melanoma or neurocutaneous melanosis. There is a lack of international consensus on what important outcome domains (...) to measure in relation to treatment. This makes it difficult to compare options, to properly inform patients and their parents, and to set up treatment policy for CMN. Therefore, we aim to develop a core outcome set (COS), i.e. the minimum set of outcomes that are recommended to be measured and reported in all clinical trials of a specific health condition. This COS can be used in the follow-up of CMN patients with or without treatment, in clinical research and practice.In the Outcomes for Congenital

2019 Journal of the European Academy of Dermatology and Venereology

5. Giant Congenital Melanocytic Nevus Treated With Trametinib. Full Text available with Trip Pro

Giant Congenital Melanocytic Nevus Treated With Trametinib. Giant congenital nevi are melanocytic proliferations of the skin that may be complicated by melanoma, neurocutaneous melanocytosis, pain, pruritus, and disfigurement. Current treatment options include surgical resection and medical management of associated symptoms. There is limited efficacy in these modalities. No effective pharmacologic treatments are available for the treatment of these lesions. We present the case of a 7-year-old (...) girl with a giant congenital melanocytic nevus that had an AKAP9-BRAF fusion and was treated with trametinib, which resulted in rapid resolution of the patient's lifelong, intractable pain and pruritus as well as dramatic improvement in the extent of her nevus.Copyright © 2019 by the American Academy of Pediatrics.

2019 Pediatrics

6. Use of sedation instead of general anaesthesia for screening MRI in congenital melanocytic naevi under the age of 1 year is a successful, safe, and economical first line approach. Full Text available with Trip Pro

Use of sedation instead of general anaesthesia for screening MRI in congenital melanocytic naevi under the age of 1 year is a successful, safe, and economical first line approach. 30281787 2019 03 01 1365-2133 180 3 2019 Mar The British journal of dermatology Br. J. Dermatol. Sedation for screening MRI in patients with congenital melanocytic naevi under the age of one is a successful, safe and economical first-line approach. 668-669 10.1111/bjd.17263 Plumptre I I http://orcid.org/0000-0002-2226

2018 British Journal of Dermatology

7. Long-term outcomes of laser treatment for congenital melanocytic nevus. (Abstract)

Long-term outcomes of laser treatment for congenital melanocytic nevus. Although various laser treatments have been tried for congenital melanocytic nevi (CMNs), only small retrospective studies with short-term follow-up had been done to assess outcomes.We analyzed the long-term outcomes of laser treatment for CMN and compared these outcomes with those of a combination treatment including partial excision and lasers.Patients with CMN treated with lasers were retrospectively reviewed

2018 Journal of American Academy of Dermatology

8. Medium Sized Congenital Melanocytic Nevus with Suspected Progression to Melanoma during Pregnancy: What’s the Best for the Patient? Full Text available with Trip Pro

Medium Sized Congenital Melanocytic Nevus with Suspected Progression to Melanoma during Pregnancy: What’s the Best for the Patient? Congenital melanocytic nevi (CMN) are pigmented skin lesions usually present at birth. Rare varieties can develop and become clinically very large. Although they are benign nevomelanocytic neoplasms, all CMN may be precursors of the melanoma, regardless of their size. Individual risk of malignant transformation of melanocyte is determined by simultaneous action (...) of exogenous and endogenous factors. The major exogenous risk factor is ultraviolet radiation. Leading roles among the endogenous factors are attributed to skin phenotype, gene mutation, sex hormones and their significance.We present a case of a 27 - year - old pregnant female patient with a congenital melanocytic nevus, which increased significantly in size, during her pregnancy. Estrogen levels increase during pregnancy and clinical evidence has suggested that melanocytes are estrogen - responsive. Nevi

2018 Open access Macedonian journal of medical sciences

9. Mosaic NRASopathy n a child with giant melanocytic congenital naevus, epidermal hamartoma and bilateral nephroblastomatosis: clinical implication for follow-up. (Abstract)

Mosaic NRASopathy n a child with giant melanocytic congenital naevus, epidermal hamartoma and bilateral nephroblastomatosis: clinical implication for follow-up. 29314428 2018 06 26 1468-3083 32 7 2018 Jul Journal of the European Academy of Dermatology and Venereology : JEADV J Eur Acad Dermatol Venereol Mosaic NRASopathy n a child with giant melanocytic congenital naevus, epidermal hamartoma and bilateral nephroblastomatosis: clinical implication for follow-up. e258-e260 10.1111/jdv.14780

2018 Journal of the European Academy of Dermatology and Venereology

10. Giant congenital melanocytic nevus in a Cameroonian child: a case report Full Text available with Trip Pro

Giant congenital melanocytic nevus in a Cameroonian child: a case report Giant congenital melanocytic nevus is a very rare condition characterized by a large skin lesion and an increased risk of complications like neurocutaneous melanosis and malignant transformation. Reports of giant congenital melanocytic nevus are scarce in the sub-Saharan African literature and here we present a case of this disease in a Cameroonian adolescent.A 12-year-old Cameroonian girl from the "Baka" ethnic group (...) , with no relevant family and medical histories presented with a progressively extensive brownish-black nodular hypertrophic skin lesion of approximately 45 cm, which she had had since she was 2-days old. The lesion covered her entire back giving an appearance of "turtle child", which was highly suggestive of a giant congenital melanocytic nevus. She was booked in for a surgical intervention organized by a health campaign within her community. Meanwhile she was provided with psychological support and her family

2018 Journal of medical case reports

11. Late Onset Achromatic Melanoma Arising in a Giant Congenital Melanocytic Nevus Full Text available with Trip Pro

Late Onset Achromatic Melanoma Arising in a Giant Congenital Melanocytic Nevus A 61-year-old woman, with a lifelong history of a giant congenital melanocytic nevus in the occipital region with secondary development of giant melanoma is presented. Surgical excision was performed, and the histopathological evaluation confirmed the diagnosis of Giant Malignant Melanoma (GMM) with a maximum tumour thickness of 16 mm. Nowadays, there is tremendous uncertainty regarding how giant congenital (...) melanocytic nevi (GCMN) should be treated. The standard approach to patients with late onset giant congenital melanocytic nevi (GCMN is based on two main considerations: (1) obtain an acceptable cosmetic results with the purpose to decrease the psychosocial inconvenience to each patient, and (2) to attempt to minimise the risk of development of malignant transformation. Unfortunately complete surgical removal of the GCMN is usually difficult and very often impossible without subsequent functional

2017 Open access Macedonian journal of medical sciences

12. Giant Congenital Melanocytic Nevus (GCMN) - A New Hope for Targeted Therapy? Full Text available with Trip Pro

Giant Congenital Melanocytic Nevus (GCMN) - A New Hope for Targeted Therapy? We present a 6-month-old male patient, who was consulted with dermatologist by his parents, because of a pigmented lesion, present since birth, covering almost the all skin of the back and buttocks. A sharply bordered, unequally coloured congenital pigmented nevus, measuring approximately 21 cm in diameter was observed in the whole body skin examination. The lesion was affecting the lower 2/3 of the skin of the back (...) and the top half of the gluteus area, extending to the lateral part of the tors, forward the abdomen and the upper lateral part of the hips, composed by multiple darker-pigmented nests and several lighter areas, with single depigmented zones, hairy surface, irregularly infiltrated on palpation. Congenital melanocytic nevi are presented in approximately 1% of newborns, while giant congenital melanocytic nevi (GCMN) are the most uncommon subtype of them; with occurrence rate 1 in 50,000 births. They affect

2017 Open access Macedonian journal of medical sciences

13. Melanoma in congenital melanocytic naevi. Full Text available with Trip Pro

Melanoma in congenital melanocytic naevi. Congenital melanocytic naevi (CMN) are a known risk factor for melanoma, with the greatest risk currently thought to be in childhood. There has been controversy over the years about the incidence of melanoma, and therefore over the clinical management of CMN, due partly to the difficulties of histological diagnosis and partly to publishing bias towards cases of malignancy. Large cohort studies have demonstrated that melanoma risk in childhood is related (...) to the severity of the congenital phenotype. New understanding of the genetics of CMN offers the possibility of improvement in diagnosis of melanoma, identification of those at highest risk, and new treatment options. We review the world literature and our centre's experience over the last 25 years, including the molecular characteristics of melanoma in these patients and new melanoma incidence and outcome data from our prospective cohort. Management strategies are proposed for presentation of suspected

2017 British Journal of Dermatology

14. "Congenital dermatofibrosarcoma protuberans clinically mimicking a melanocytic nevus treated with serial excisions". (Abstract)

"Congenital dermatofibrosarcoma protuberans clinically mimicking a melanocytic nevus treated with serial excisions". 28622423 2017 12 27 1468-3083 31 12 2017 Dec Journal of the European Academy of Dermatology and Venereology : JEADV J Eur Acad Dermatol Venereol Congenital dermatofibrosarcoma protuberans clinically mimicking a melanocytic naevus treated with serial excisions. e541-e542 10.1111/jdv.14412 Laske J J Klinik für Dermatologie, Universitätsklinikum Dresden, Dresden, Germany. Sergon M M

2017 Journal of the European Academy of Dermatology and Venereology

15. Color Doppler Ultrasound Early Diagnoses Simulator of Proliferative Nodule in Congenital Melanocytic Nevus. (Abstract)

Color Doppler Ultrasound Early Diagnoses Simulator of Proliferative Nodule in Congenital Melanocytic Nevus. 28319285 2017 09 14 1468-3083 31 9 2017 Sep Journal of the European Academy of Dermatology and Venereology : JEADV J Eur Acad Dermatol Venereol Colour Doppler ultrasound early diagnoses simulator of proliferative nodule in congenital melanocytic nevus. e416-e418 10.1111/jdv.14231 Giavedoni P P Department of Dermatology, Hospital Clinic, 08036, Barcelona, Spain. Aranibar L L Department

2017 Journal of the European Academy of Dermatology and Venereology

16. Congenital Melanocytic Nevus

. Concepts Neoplastic Process ( T191 ) SnomedCT 254203006 , 84953004 , 400151006 , 398696001 , 398943008 English Congen melanocytic naevus skin , Congen melanocytic nevus skin , Congen pigmented naevus skin , Congen pigmented nevus skin , Congenital Nevus of the Skin , Congenital Nevus of Skin , Congenital Skin Nevus , Congenital Melanocytic Nevus , congenital pigmented naevus , congenital melanocytic naevus , congenital melanocytic nevus , nevus pigmented congenital , congenital pigmented nevus (...) , Congenital melanocytic nevus of skin (disorder) , Congenital melanocytic nevus (disorder) , Congenital Melanocytic Nevi , Congenital Pigmented Melanocytic Nevus , Congenital melanocytic naevus , Congenital melanocytic naevus of skin , Congenital melanocytic nevus of skin , Congenital pigmented naevus , Congenital pigmented naevus of skin , Congenital pigmented nevus , Congenital pigmented nevus of skin , Congenital dermal melanocytic naevus , Congenital dermal melanocytic nevus , Congenital melanocytic

2018 FP Notebook

17. Heterogeneity in reported outcome measures in congenital melanocytic naevi research: systematic review for development of core outcome set

Heterogeneity in reported outcome measures in congenital melanocytic naevi research: systematic review for development of core outcome set Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne

2018 PROSPERO

18. Mosaic NRAS Q61R mutation in a child with giant congenital melanocytic naevus, epidermal naevus syndrome and hypophosphataemic rickets. (Abstract)

Mosaic NRAS Q61R mutation in a child with giant congenital melanocytic naevus, epidermal naevus syndrome and hypophosphataemic rickets. The association of hypophosphataemic rickets with verrucous epidermal naevus (EN) and elevated fibroblast growth factor 23 levels is known as cutaneous-skeletal hypophosphataemia syndrome (CSHS), and can be caused by somatic activating mutations in RAS genes. We report a unique patient with CSHS associated with giant congenital melanocytic naevus (CMN (...) ), neurocutaneous melanosis and EN syndrome, manifesting as facial linear sebaceous naevus, developmental delay and ocular dermoids. An activating mutation Q61R in the NRAS gene was found in affected skin and ocular tissue but not blood, implying that the disparate manifestations are due to a multilineage activating mutation (mosaic RASopathy). We speculate on the apparently rare association of CSHS with CMN compared with EN. We also report the favourable outcome of this patient at the age of 8 years after

2016 Clinical & Experimental Dermatology

19. Congenital Melanocytic Nevus with Distinctive Nevus Cell Proliferation within Multiple Epidermal Cyst-Like Changes Full Text available with Trip Pro

Congenital Melanocytic Nevus with Distinctive Nevus Cell Proliferation within Multiple Epidermal Cyst-Like Changes 26848235 2016 02 05 2018 11 13 1013-9087 28 1 2016 Feb Annals of dermatology Ann Dermatol Congenital Melanocytic Nevus with Distinctive Nevus Cell Proliferation within Multiple Epidermal Cyst-Like Changes. 123-4 10.5021/ad.2016.28.1.123 Joo Hong Jin HJ Department of Dermatology, St. Paul's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. Kim Jung Eun

2016 Annals of dermatology

20. Efficacy of Cultured Epithelial Autograft after Curettage for Giant Melanocytic Nevus of the Head Full Text available with Trip Pro

Efficacy of Cultured Epithelial Autograft after Curettage for Giant Melanocytic Nevus of the Head Cultured epithelial autograft (CEA) is an epithelial sheet prepared from a patient's own skin using cell culture. In Japan, CEA (JACE; Japan Tissue Engineering Co., Ltd., Gamagori, Japan) was approved and covered by public health care insurance for use in the treatment of giant congenital melanocytic nevus (GCMN) in 2016. There are several treatment options for GCMN; however, the complete removal

2018 Plastic and Reconstructive Surgery Global Open

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