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Congenital Melanocytic Nevus

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1. Atypical Proliferative Nodule with Melanocytic Intraepidermal Pagetoid Spreading Arising within a Congenital Melanocytic Nevus in a Pregnant Woman (PubMed)

Atypical Proliferative Nodule with Melanocytic Intraepidermal Pagetoid Spreading Arising within a Congenital Melanocytic Nevus in a Pregnant Woman 29606826 2018 11 14 1013-9087 30 2 2018 Apr Annals of dermatology Ann Dermatol Atypical Proliferative Nodule with Melanocytic Intraepidermal Pagetoid Spreading Arising within a Congenital Melanocytic Nevus in a Pregnant Woman. 234-236 10.5021/ad.2018.30.2.234 Moon Hye-Rim HR Department of Dermatology, Asan Medical Center, University of Ulsan College

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2018 Annals of dermatology

2. Giant Congenital Melanocytic Nevus Treated With Trametinib. (PubMed)

Giant Congenital Melanocytic Nevus Treated With Trametinib. Giant congenital nevi are melanocytic proliferations of the skin that may be complicated by melanoma, neurocutaneous melanocytosis, pain, pruritus, and disfigurement. Current treatment options include surgical resection and medical management of associated symptoms. There is limited efficacy in these modalities. No effective pharmacologic treatments are available for the treatment of these lesions. We present the case of a 7-year-old (...) girl with a giant congenital melanocytic nevus that had an AKAP9-BRAF fusion and was treated with trametinib, which resulted in rapid resolution of the patient's lifelong, intractable pain and pruritus as well as dramatic improvement in the extent of her nevus.Copyright © 2019 by the American Academy of Pediatrics.

2019 Pediatrics

3. Giant congenital melanocytic nevus in a Cameroonian child: a case report (PubMed)

Giant congenital melanocytic nevus in a Cameroonian child: a case report Giant congenital melanocytic nevus is a very rare condition characterized by a large skin lesion and an increased risk of complications like neurocutaneous melanosis and malignant transformation. Reports of giant congenital melanocytic nevus are scarce in the sub-Saharan African literature and here we present a case of this disease in a Cameroonian adolescent.A 12-year-old Cameroonian girl from the "Baka" ethnic group (...) , with no relevant family and medical histories presented with a progressively extensive brownish-black nodular hypertrophic skin lesion of approximately 45 cm, which she had had since she was 2-days old. The lesion covered her entire back giving an appearance of "turtle child", which was highly suggestive of a giant congenital melanocytic nevus. She was booked in for a surgical intervention organized by a health campaign within her community. Meanwhile she was provided with psychological support and her family

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2018 Journal of medical case reports

4. Long-term outcomes of laser treatment for congenital melanocytic nevus. (PubMed)

Long-term outcomes of laser treatment for congenital melanocytic nevus. Although various laser treatments have been tried for congenital melanocytic nevi (CMNs), only small retrospective studies with short-term follow-up had been done to assess outcomes.We analyzed the long-term outcomes of laser treatment for CMN and compared these outcomes with those of a combination treatment including partial excision and lasers.Patients with CMN treated with lasers were retrospectively reviewed

2018 Journal of American Academy of Dermatology

5. Congenital Melanocytic Nevus with Distinctive Nevus Cell Proliferation within Multiple Epidermal Cyst-Like Changes (PubMed)

Congenital Melanocytic Nevus with Distinctive Nevus Cell Proliferation within Multiple Epidermal Cyst-Like Changes 26848235 2016 02 05 2018 11 13 1013-9087 28 1 2016 Feb Annals of dermatology Ann Dermatol Congenital Melanocytic Nevus with Distinctive Nevus Cell Proliferation within Multiple Epidermal Cyst-Like Changes. 123-4 10.5021/ad.2016.28.1.123 Joo Hong Jin HJ Department of Dermatology, St. Paul's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. Kim Jung Eun

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2016 Annals of dermatology

6. "Congenital dermatofibrosarcoma protuberans clinically mimicking a melanocytic nevus treated with serial excisions". (PubMed)

"Congenital dermatofibrosarcoma protuberans clinically mimicking a melanocytic nevus treated with serial excisions". 28622423 2017 12 27 1468-3083 31 12 2017 Dec Journal of the European Academy of Dermatology and Venereology : JEADV J Eur Acad Dermatol Venereol Congenital dermatofibrosarcoma protuberans clinically mimicking a melanocytic naevus treated with serial excisions. e541-e542 10.1111/jdv.14412 Laske J J Klinik für Dermatologie, Universitätsklinikum Dresden, Dresden, Germany. Sergon M M

2017 Journal of the European Academy of Dermatology and Venereology

7. Color Doppler Ultrasound Early Diagnoses Simulator of Proliferative Nodule in Congenital Melanocytic Nevus. (PubMed)

Color Doppler Ultrasound Early Diagnoses Simulator of Proliferative Nodule in Congenital Melanocytic Nevus. 28319285 2017 09 14 1468-3083 31 9 2017 Sep Journal of the European Academy of Dermatology and Venereology : JEADV J Eur Acad Dermatol Venereol Colour Doppler ultrasound early diagnoses simulator of proliferative nodule in congenital melanocytic nevus. e416-e418 10.1111/jdv.14231 Giavedoni P P Department of Dermatology, Hospital Clinic, 08036, Barcelona, Spain. Aranibar L L Department

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2017 Journal of the European Academy of Dermatology and Venereology

8. An Exploratory Clinical Trial of a Novel Treatment for Giant Congenital Melanocytic Nevi Combining Inactivated Autologous Nevus Tissue by High Hydrostatic Pressure and a Cultured Epidermal Autograft: Study Protocol (PubMed)

An Exploratory Clinical Trial of a Novel Treatment for Giant Congenital Melanocytic Nevi Combining Inactivated Autologous Nevus Tissue by High Hydrostatic Pressure and a Cultured Epidermal Autograft: Study Protocol Giant congenital melanocytic nevi (GCMNs) are large brown to black skin lesions that appear at birth and are associated with a risk of malignant transformation. It is often difficult to reconstruct large full-thickness skin defects after the removal of GCMNs.To overcome (...) this difficulty we developed a novel treatment to inactivate nevus tissue and reconstruct the skin defect using the nevus tissue itself. For this research, we designed an exploratory clinical study to investigate the safety and efficacy of a novel treatment combining the engraftment of autologous nevus tissue inactivated by high hydrostatic pressurization with a cultured epidermal autograft (CEA).Patients with congenital melanocytic nevi that were not expected to be closed by primary closure will be recruited

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2016 JMIR Research Protocols

9. Prepubertal melanoma arising within a medium-sized congenital melanocytic nevus (PubMed)

Prepubertal melanoma arising within a medium-sized congenital melanocytic nevus We report the case of an 8-year-old child who developed a 9.4-mm-deep melanoma within a medium-sized congenital melanocytic nevus on the scalp. Genetic analysis revealed an activating NRAS Q61R mutation within the melanoma, which is more commonly associated with large or giant congenital melanocytic nevi. This case demonstrates that even a "low-risk" congenital melanocytic nevus at a "low-risk" age must be monitored

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2016 Pediatric dermatology

10. Congenital Melanocytic Nevus

Congenital Melanocytic Nevus Congenital Melanocytic Nevus Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Congenital Melanocytic Nevus (...) Congenital Melanocytic Nevus Aka: Congenital Melanocytic Nevus , Congenital Melanocytic Nevi , Garment Nevi , Giant Congenital Nevi , Birthmark , Giant Hairy Nevi , Bathing Trunk Nevi , Congenital Nevus , Congenital Nevi II. Epidemiology : Up to 2% of newborns III. Pathophysiology Neural crest s and their precursors with disrupted migration IV. Signs Brown to black lesions that are typically flat (but can be elevated, and may thicken as children get older) Size can vary from a few millimeters to several

2018 FP Notebook

11. Case report of nodular melanoma within congenital melanocytic nevus- primary closure challenge (PubMed)

Case report of nodular melanoma within congenital melanocytic nevus- primary closure challenge Congenital melanocytic nevi (CMN) are present in 1-2% of newborn infants. The size of CMN defines the risk of developing melanoma which is estimated from 5-10%, especially in lesions that are located across the spine.Herein we report a case where nodular melanoma was discovered on the periphery of medium sized CMN in a high risk patient. After complete excision, the defect was reconstructed

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2016 International journal of surgery case reports

12. Medium Sized Congenital Melanocytic Nevus with Suspected Progression to Melanoma during Pregnancy: What’s the Best for the Patient? (PubMed)

Medium Sized Congenital Melanocytic Nevus with Suspected Progression to Melanoma during Pregnancy: What’s the Best for the Patient? Congenital melanocytic nevi (CMN) are pigmented skin lesions usually present at birth. Rare varieties can develop and become clinically very large. Although they are benign nevomelanocytic neoplasms, all CMN may be precursors of the melanoma, regardless of their size. Individual risk of malignant transformation of melanocyte is determined by simultaneous action (...) of exogenous and endogenous factors. The major exogenous risk factor is ultraviolet radiation. Leading roles among the endogenous factors are attributed to skin phenotype, gene mutation, sex hormones and their significance.We present a case of a 27 - year - old pregnant female patient with a congenital melanocytic nevus, which increased significantly in size, during her pregnancy. Estrogen levels increase during pregnancy and clinical evidence has suggested that melanocytes are estrogen - responsive. Nevi

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2018 Open access Macedonian journal of medical sciences

13. Efficacy of Cultured Epithelial Autograft after Curettage for Giant Melanocytic Nevus of the Head (PubMed)

Efficacy of Cultured Epithelial Autograft after Curettage for Giant Melanocytic Nevus of the Head Cultured epithelial autograft (CEA) is an epithelial sheet prepared from a patient's own skin using cell culture. In Japan, CEA (JACE; Japan Tissue Engineering Co., Ltd., Gamagori, Japan) was approved and covered by public health care insurance for use in the treatment of giant congenital melanocytic nevus (GCMN) in 2016. There are several treatment options for GCMN; however, the complete removal

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2018 Plastic and Reconstructive Surgery Global Open

14. Giant Congenital Melanocytic Nevus (GCMN) - A New Hope for Targeted Therapy? (PubMed)

Giant Congenital Melanocytic Nevus (GCMN) - A New Hope for Targeted Therapy? We present a 6-month-old male patient, who was consulted with dermatologist by his parents, because of a pigmented lesion, present since birth, covering almost the all skin of the back and buttocks. A sharply bordered, unequally coloured congenital pigmented nevus, measuring approximately 21 cm in diameter was observed in the whole body skin examination. The lesion was affecting the lower 2/3 of the skin of the back (...) and the top half of the gluteus area, extending to the lateral part of the tors, forward the abdomen and the upper lateral part of the hips, composed by multiple darker-pigmented nests and several lighter areas, with single depigmented zones, hairy surface, irregularly infiltrated on palpation. Congenital melanocytic nevi are presented in approximately 1% of newborns, while giant congenital melanocytic nevi (GCMN) are the most uncommon subtype of them; with occurrence rate 1 in 50,000 births. They affect

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2017 Open access Macedonian journal of medical sciences

15. Late Onset Achromatic Melanoma Arising in a Giant Congenital Melanocytic Nevus (PubMed)

Late Onset Achromatic Melanoma Arising in a Giant Congenital Melanocytic Nevus A 61-year-old woman, with a lifelong history of a giant congenital melanocytic nevus in the occipital region with secondary development of giant melanoma is presented. Surgical excision was performed, and the histopathological evaluation confirmed the diagnosis of Giant Malignant Melanoma (GMM) with a maximum tumour thickness of 16 mm. Nowadays, there is tremendous uncertainty regarding how giant congenital (...) melanocytic nevi (GCMN) should be treated. The standard approach to patients with late onset giant congenital melanocytic nevi (GCMN is based on two main considerations: (1) obtain an acceptable cosmetic results with the purpose to decrease the psychosocial inconvenience to each patient, and (2) to attempt to minimise the risk of development of malignant transformation. Unfortunately complete surgical removal of the GCMN is usually difficult and very often impossible without subsequent functional

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2017 Open access Macedonian journal of medical sciences

16. Can Combination MEK and Akt Inhibition Slay the Giant Congenital Nevus? (PubMed)

Can Combination MEK and Akt Inhibition Slay the Giant Congenital Nevus? The clinical management of large and giant congenital melanocytic nevi (lgCMN) relies heavily upon iterative surgical procedures. In this issue Rouille et al. (2019) use lgCMN explants and a newly developed patient-derived xenograft model to show that the local administration of MEK and Akt inhibitors limits the lgCMN proliferative potential. These findings, along with emerging reports, support continued investigation

2019 Journal of Investigative Dermatology

17. Local inhibition of MEK/AKT prevents cellular growth in human congenital melanocytic nevi. (PubMed)

Local inhibition of MEK/AKT prevents cellular growth in human congenital melanocytic nevi. Large congenital melanocytic nevi (lCMN) management is based exclusively on iterative surgical procedures in the absence of validated medical therapy. The aim of our study was to develop an intra-lesional medical treatment for lCMN. Seventeen patients harboring NRAS-mutated lCMN were included. Nevocytes obtained from lCMN displayed an overactivation of MAPK and AKT pathways. MEK and AKT inhibitors reduced (...) of treatment. Using original nevus explant and xenograft preclinical models, we demonstrated that intradermal MEK/AKT inhibition might serve as neo-adjuvant therapy for the treatment of NRAS-mutated CMN to avoid iterative surgeries.Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.

2019 Journal of Investigative Dermatology

18. Spontaneous Involution of Congenital Melanocytic Nevus With Halo Phenomenon (PubMed)

Spontaneous Involution of Congenital Melanocytic Nevus With Halo Phenomenon Congenital melanocytic nevus (CMN) is a neural crest-derived hamartoma, which appear at or soon after birth. CMN has a dynamic course and may show variable changes over time, including spontaneous involution. Spontaneous involution of CMN is a rare phenomenon and is often reported in association with halo phenomenon or vitiligo. The mechanism of halo phenomenon is yet to be investigated but is suggested (...) to be a destruction of melanocytes by immune responses of cytotoxic T cells or IgM autoantibodies. Here, the authors report an interesting case of spontaneously regressed medium-sized CMN with halo phenomenon and without vitiligo, which provides evidence that cytotoxic T cells account for the halo formation and pigmentary regression of CMN.

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2015 The American Journal of dermatopathology

19. Acute Inhibition of MEK Suppresses Congenital Melanocytic Nevus Syndrome in a Murine Model Driven by Activated NRAS and Wnt Signaling. (PubMed)

Acute Inhibition of MEK Suppresses Congenital Melanocytic Nevus Syndrome in a Murine Model Driven by Activated NRAS and Wnt Signaling. Congenital melanocytic nevus (CMN) syndrome is the association of pigmented melanocytic nevi with extra-cutaneous features, classically melanotic cells within the central nervous system, most frequently caused by a mutation of NRAS codon 61. This condition is currently untreatable and carries a significant risk of melanoma within the skin, brain (...) or undescribed Wnt-signaling alterations. A murine model harboring activated NRAS(Q61K) and Wnt signaling in melanocytes exhibited striking features of CMN syndrome, in particular neurological involvement. In the first model of treatment for this condition, these congenital, and previously assumed permanent, features were profoundly suppressed by acute post-natal treatment with a MEK inhibitor. These data suggest that activated NRAS and aberrant Wnt signaling conspire to drive CMN syndrome. Post-natal MEK

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2015 Journal of Investigative Dermatology

20. Giant Congenital Melanocytic Nevus of the Buttock (PubMed)

Giant Congenital Melanocytic Nevus of the Buttock 26171106 2015 07 14 2019 02 26 1937-5719 15 2015 Eplasty Eplasty Giant Congenital Melanocytic Nevus of the Buttock. ic31 Marano Andrew A AA Division of Plastic Surgery, Department of Surgery, Rutgers New Jersey Medical School, Newark. Feintisch Adam M AM Division of Plastic Surgery, Department of Surgery, Rutgers New Jersey Medical School, Newark. Datiashvili Ramazi R Division of Plastic Surgery, Department of Surgery, Rutgers New Jersey Medical (...) School, Newark. eng Case Reports 2015 06 17 United States Eplasty 101316107 1937-5719 buttock congenital melanocytic nevus dermal matrix serial excision skin graft 2015 7 15 6 0 2015 7 15 6 0 2015 7 15 6 1 epublish 26171106 PMC4473815 J Craniofac Surg. 2005 Sep;16(5):886-93 16192877 J Pediatr. 1992 Jun;120(6):906-11 1593350 Arch Dermatol. 1996 Feb;132(2):170-5 8629825 Pediatrics. 2000 Oct;106(4):736-41 11015516 Plast Reconstr Surg. 2007 Aug;120(2):26e-40e 17632335 J Plast Reconstr Aesthet Surg. 2010

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2015 Eplasty

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