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101. Nerve Blocks for Pain Management in Patients with Hip Fractures

Sep;19(3):155-9. (4) Kaye AD, Baluch A, Scott JT. Pain management in the elderly population: a review. Ochsner J. 2010;10(3):179-87. (5) Griffiths R, Alper J, Beckingsale A, Goldhill D, Heyburn G, Holloway J, et al. Management of proximal femoral fractures 2011. Anaesthesia. 2012;67:85-98. (6) Review Manager (RevMan) [Computer program]. Version 5.1. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2011. (7) Shea BJ, Grimshaw JM, Wells GA, Boers M, Andersson N, Hamel C, et al (...) Fractures: A Rapid Review. April 2013; pp. 1–20 20 Health Quality Ontario 130 Bloor Street West, 10 th Floor Toronto, Ontario M5S 1N5 Tel: 416-323-6868 Toll Free: 1-866-623-6868 Fax: 416-323-9261 Email: © Queen’s Printer for Ontario, 2013

2013 Health Quality Ontario

102. Vasodilators for Inhospital Heart Failure Management

and Placebo Author, Year Allocation Concealment Blinding Complete Accounting of Patients and Outcome Events Selective Reporting Bias Other Limitations O’Connor et al, 2011 (16) No limitations a No limitations b No limitations c No limitations d No limitations a A centralized randomization procedure with a computer-generated randomization schedule was used to assign subject number and treatment code. Medication code numbers were preprinted on the study drug labels prior to distribution to sites. b Study (...) -6868 Fax: 416-323-9261 Email: © Queen’s Printer for Ontario, 2013

2013 Health Quality Ontario

103. Chest X-rays for Diagnosing Pulmonary Infection as a Precipitant of Acute Heart Failure

lung ultrasound (sensitivity 93.4%, specificity 97.7%), (10) and high resolution computed topography (sensitivity 40%, specificity 95%). (11) As legislated in Ontario’s Excellent Care for All Act, Health Quality Ontario’s mandate includes the provision of objective, evidence-informed advice about health care funding mechanisms, incentives, and opportunities to improve quality and efficiency in the health care system. As part of its Quality- Based Funding (QBF) initiative, Health Quality Ontario (...) . A prospective multicentre diagnostic accuracy study. Chest. 2012 Jun 14. (11) Mink SN, Maycher B. Comparative manifestations and diagnostic accuracy of high-resolution computed tomography in usual interstitial pneumonia and nonspecific interstitial pneumonia. Curr Opin Pulm Med. 2012 Sep;18(5):530-4. (12) Shea BJ, Grimshaw JM, Wells GA, Boers M, Andersson N, Hamel C, et al. Development of AMSTAR: a measurement tool to assess the methodological quality of systematic reviews. BMC Med Res Methodol. 2007;7:10

2013 Health Quality Ontario

104. Coronary Revascularization in Ischemic Heart Failure Patients

tomography RCT Randomized controlled trial SPECT Single photon emission computed tomography SVR Surgical ventricular reconstruction Coronary Revascularization in Ischemic Heart Failure Patients: A Rapid Review. January 2013; pp. 1–28. 6 Background Objective of Analysis The objective of this analysis was to evaluate the effectiveness of coronary revascularization in ischemic heart failure (HF) patients. Clinical Need and Target Population Coronary artery disease (CAD), particularly the occurrence (...) Society of Echocardiography, the Heart Failure Society of America, and the Society of Cardiovascular Computed Tomography. J Am Coll Cardiol. 2009 Feb 10;53(6):530-53. Coronary Revascularization in Ischemic Heart Failure Patients: A Rapid Review. January 2013; pp. 1–28. 27 (22) Lawson EH, Gibbons MM, Ko CY, Shekelle PG. The appropriateness method has acceptable reliability and validity for assessing overuse and underuse of surgical procedures. J Clin Epidemiol. 2012 Nov;65(11):1133-43. (23) Levine GN

2013 Health Quality Ontario

105. Xpert MTB/RIF implementation manual

multidisease platform. The GeneXpert system was launched in 2004, and it simplifies molecular testing by fully integrating and automating the three processes required for real-time PCR-based molecular testing (that is, specimen preparation, amplification and detection). The system consists of an instrument, personal computer, barcode scanner and preloaded software; single-use disposable cartridges contain lyophilized reagents, buffers and washes. Target detection and characterization is performed in real (...) supply to avoid interruptions to the procedure and the subsequent loss of results, waste of cartridges and possible damage to or failure of the modules; • to be secured against theft, particularly the accompanying computer; • an ambient temperature of 15–30 °C in the room where the instrument is placed; • adequate storage space for the cartridges with an ambient temperature of 2–28 °C; • trained staff to perform the test; • biosafety precautions similar to those needed for direct smear microscopy

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2014 World Health Organisation Guidelines

106. Framework for conducting reviews of tuberculosis programmes

payments for national team members and support staff ? Make travel arrangements for national team members ? Make hotel reservations ? Hire interpreters, if needed ? Arrange meeting rooms for briefing, debriefing and preparing the final report ? Arrange for secretarial and administrative support as appropriate (for example, access to computers, printers, telephones, fax facilities, e-mail) ? Make arrangements for travel to sites within the country and notify the facilities that will be visited ? Arrange

2014 World Health Organisation Guidelines

107. March 2014 supplement to the 2013 consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection

and regularly evaluated. Other policy and programme considerations HIV self-testing may provide an additional pathway for people to obtain care and treatment. Ways to facilitate links to care following HIV self-testing include pre-test information, counselling, post-test referrals and follow-up such as face-to- face counselling, telephone hotlines (2,21), videos, Skype, short message service (SMS) (32) and computer programmes (33). An individual with a reactive self-test result should be advised to seek (...) of more robust maternal combination antiretroviral regimens, prolonged infant antiviral prophylaxis and improved sensitivity of current HIV DNA- and RNA-based polymerase chain reaction (PCR) assays. • HIV serological assays, including rapid diagnostic tests, are underused to detect HIV exposure, and their use should be encouraged to fast-track children to a definitive diagnosis, particularly if they are sick. • Key innovations such as SMS printers and improved laboratory systems can greatly reduce

2014 World Health Organisation HIV Guidelines

109. Development of three-dimensional brain arteriovenous malformation model for patient communication and young neurosurgeon education. (PubMed)

on personal computer and the rapid prototyping process was completed using a 3D printer. The size and morphology of the models were compared to brain digital subtraction arteriography of the same patients. 3D brain AVM models were used for preoperative patient communication and young neurosurgeon education.Two brain AVM models were successfully produced. By neurosurgeons' evaluation, the printed models have high fidelity with the actual brain AVM structures of the patients. The patient responded

2018 British Journal of Neurosurgery

110. Impact of 3D printing technology on the comprehension of surgical liver anatomy. (PubMed)

multi-detector computed tomography (MDCT) and was prototyped using a 3D printer. Forty-five surgical residents were evenly assigned to each group (3DP, VIR, and MDCT groups). After evaluation of the MDCT scans, VIR model, or 3DP model of each tumor, surgical residents were asked to assign hepatic tumor locations and state surgical resection proposals. The time used to specify the tumor location was recorded. The correct responses and time spent were compared between the three groups.The assignment

2018 Surgical endoscopy

111. Assessment of a Patient-Specific, 3-Dimensionally Printed Endoscopic Sinus and Skull Base Surgical Model. (PubMed)

performed from April 1, 2017, through June 1, 2017, a total of 7 otolaryngology residents and 2 attending physicians at a tertiary academic center were recruited to evaluate the procedural anatomical accuracy and haptic feedback of the printed model.A 3D model of sinus and skull base anatomy with high-resolution, 3D printed material (VeroWhite) was printed using a 3D printer. Anatomical accuracy was assessed by comparing a computed tomogram of the original patient with that of the 3D model across set (...) and navigation and haptic evaluation by the study participants.Seven otolaryngology residents (3 postgraduate year [PGY]-5 residents, 2 PGY-4 residents, 1 PGY-3 resident, and 1 PGY-2 resident) and 2 attending physicians evaluated the haptic feedback of the 3D model. Computed tomographic comparison demonstrated a less than 5% difference between patient and 3D model measurements. Image-guided navigation confirmed accuracy of 13 landmarks to within 1 mm. Likert scores were a mean (SD) of 4.00 (0.71) for overall

2018 JAMA otolaryngology-- head & neck surgery

112. Low-cost customized cranioplasty using a 3D digital printing model: a case report (PubMed)

-dimensional (3D) printing technique for cranial reconstruction. A digital prosthesis model is designed and manufactured with the aid of a 3D computed tomography. Both the data of large sized cranial defects and the prosthesis are transferred to a 3D printer to obtain a physical model in poly-lactic acid which is then used in a laboratory to cast the final customised prosthesis in polymethyl methacrylate (PMMA).A precise compliance of the prosthesis to the osseous defect was achieved. At the 6 month

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2018 3D Printing in Medicine

113. The subresolution DaTSCAN phantom: a cost-effective, flexible alternative to traditional phantom technology (PubMed)

slabs of attenuating material generated through additive manufacturing, and paper sheets with radioactive ink patterns printed on their surface, created with a conventional inkjet printer. The paper sheets and attenuating slabs are interleaved before scanning. Use of thin layers ensures that they cannot be individually resolved on reconstructed images. An investigation was carried out to demonstrate the performance of such a phantom in producing simplified I-FP-CIT uptake patterns. Single photon (...) emission computed tomography imaging was carried out on an assembled phantom designed to mimic a healthy patient. Striatal binding ratio results and linear striatal dimensions were calculated from the reconstructed data and compared with that of 22 clinical patients without evidence of Parkinsonian syndrome, determined from clinical follow-up. Striatal binding ratio results for the fully assembled phantom were: 3.1, 3.3, 2.9 and 2.6 for the right caudate, left caudate, right putamen and right caudate

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2018 Nuclear medicine communications

114. Three-Dimensional Printing-based Reconstruction of a Maxillary Bone Defect in a Dog Following Tumor Removal (PubMed)

. Based on computed tomography images, a defect was confirmed on the maxillary bone due to the oral mass, and a surgical plan was designed to remove the oral mass and graft the 3D printed scaffold. Customized polycaprolactone/ beta-tracalciumphosphate (PCL/β-TCP) scaffold was fabricated using the micro-extrusion-based 3D printer. In the operation, after the removal of the oral mass, the scaffold was grafted onto the defect site. At follow-up, 8 months after surgery, the result was successful without

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2018 In Vivo

115. Enhanced Preoperative Deep Inferior Epigastric Artery Perforator Flap Planning with a 3D-Printed Perforasome Template: Technique and Case Report (PubMed)

. Routine preoperative computed tomographic angiography was performed, with open-source software (3D Slicer, Autodesk MeshMixer and Cura) and a desktop 3D printer (Ultimaker 3E) used to create a template used to mark intra-flap, subcutaneous branches of deep inferior epigastric artery (DIEA) perforators on the abdomen. An individualized 3D printed template was used to estimate the size and boundaries of a perforasome and perfusion map. The information was used to aid flap design. We describe a new

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2018 Plastic and Reconstructive Surgery Global Open

116. Assemble-And-Match: A Novel Hybrid Tool for Enhancing Education and Research in Rational Structure Based Drug Design (PubMed)

Assemble-And-Match: A Novel Hybrid Tool for Enhancing Education and Research in Rational Structure Based Drug Design Rational drug design is the process of finding new medication that can activate or inhibit the biofunction of a target molecule by binding to it and forming a molecular complex. Here, shape and charge complementarities between drug and target are key. To help find effective drug molecules out of a huge pool of possibilities, physical and computer aided tools have been developed (...) . Former offers a tangible experience of the molecular interactions yet lacks measurement and evaluation capabilities. Latter enables accurate and fast evaluations, but does not deliver the interactive tangible experience of physical models. We introduce a novel hybrid model called "Assemble-And-Match" where, we enhance and combine the unique features of the two categories. Assemble-And-Match works based on fabrication of customized molecular fragments using our developed software and a 3D printer

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2018 Scientific reports

117. Application of 3D printing in the surgical planning of hypertrophic obstructive cardiomyopathy and physician-patient communication: a preliminary study (PubMed)

Application of 3D printing in the surgical planning of hypertrophic obstructive cardiomyopathy and physician-patient communication: a preliminary study The aim of this study was to evaluate the effect of 3-dimensional (3D) printing in treatment of hypertrophic obstructive cardiomyopathy (HOCM) and its roles in doctor-patient communication.3D-printed models were constructed preoperatively and postoperatively in seven HOCM patients received surgical treatment. Based on multi-slice computed (...) tomography (CT) images, regions of disorder were segmented using the Mimics 19.0 software (Materialise, Leuven, Belgium). After generating an STL-file (StereoLithography file) with patients' data, the 3D printer (Objet350 Connex3, Stratasys Ltd., USA) created a 3D model. The pre- and post-operative 3D-printed models were used to make the surgical plan preoperatively and evaluate the outcome postoperatively. Meanwhile, a questionnaire was designed for patients and their relatives to learn

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2018 Journal of thoracic disease

118. Three‐dimensional printing CT‐derived objects with controllable radiopacity (PubMed)

Three‐dimensional printing CT‐derived objects with controllable radiopacity The goal of this work was to develop phantoms for the optimization of pre-operative computed tomography (CT) scans of the prostate artery, which are used for embolization planning.Acrylonitrile butadiene styrene (ABS) pellets were doped with barium sulfate and extruded into filaments suitable for 3D printing on a fused deposition modeling (FDM) printer. Cylinder phantoms were created to evaluate radiopacity (...) as a function of doping percentage. Small-diameter tree phantoms were created to assess their composition and dimensional accuracy. A half-pelvis phantom was created using clinical CT images, to assess the printer's control over cortical bone thickness and cancellous bone attenuation. CT-derived prostate artery phantoms were created to simulate complex, contrast-filled arteries.A linear relationship (R = 0.998) was observed between barium sulfate added (0%-10% by weight), and radiopacity (-31 to 1454

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2018 Journal of Applied Clinical Medical Physics

119. Towards Additive Manufacture of Functional, Spline-Based Morphometric Models of Healthy and Diseased Coronary Arteries: In Vitro Proof-of-Concept Using a Porcine Template (PubMed)

Towards Additive Manufacture of Functional, Spline-Based Morphometric Models of Healthy and Diseased Coronary Arteries: In Vitro Proof-of-Concept Using a Porcine Template The aim of this study is to assess the additive manufacture of morphometric models of healthy and diseased coronary arteries. Using a dissected porcine coronary artery, a model was developed with the use of computer aided engineering, with splines used to design arteries in health and disease. The model was altered (...) to demonstrate four cases of stenosis displaying varying severity, based on published morphometric data available. Both an Objet Eden 250 printer and a Solidscape 3Z Pro printer were used in this analysis. A wax printed model was set into a flexible thermoplastic and was valuable for experimental testing with helical flow patterns observed in healthy models, dominating the distal LAD (left anterior descending) and left circumflex arteries. Recirculation zones were detected in all models, but were visibly

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2018 Journal of functional biomaterials

120. HOPE: Hybrid-Drive Combining Optogenetics, Pharmacology and Electrophysiology (PubMed)

injection cannulas for drug-delivery experiments. Because it can be printed with a latest-generation desktop 3D printer, the production cost is low compared to classical electrophysiology implants, and it can be built within a few hours. The HOPE implant is also reconfigurable to specific needs as it has been created in a computer-aided design (CAD) software and all the files used for its construction are open-source.

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2018 Frontiers in neural circuits

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