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141. Small bowel gastrointestinal stromal tumor: a retrospective study of 32 cases at a single center and review of the literature (PubMed)

cases.Retrospective review of data from patient clinical records, endoscopic and imaging findings, surgical procedures, tumor histology and immunohistochemistry, and clinical outcome was conducted.Data of 32 patients with a median age of 56 years including 50% men and women were reviewed. The majority (29/32) were symptomatic at presentation, with the main symptom being gastrointestinal bleeding (15/32). Imaging detection rates included ultrasound (0%), magnetic resonance imaging (0%), computed tomography (54.8 (...) Small bowel gastrointestinal stromal tumor: a retrospective study of 32 cases at a single center and review of the literature Gastrointestinal stromal tumor (GIST) is a rare tumor of the small bowel, which can be difficult to diagnose and has a varied clinical outcome.This is a retrospective review of the diagnosis, management, and clinical outcome of 32 patients diagnosed with primary small bowel GIST from a single center and a comparison of the findings with previously published

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2018 Therapeutics and clinical risk management

142. Image Quality Evaluation in Clinical Research: A Case Study on Brain and Cardiac MRI Images in Multi-Center Clinical Trials (PubMed)

Image Quality Evaluation in Clinical Research: A Case Study on Brain and Cardiac MRI Images in Multi-Center Clinical Trials Magnetic resonance imaging (MRI) system images are important components in the development of drugs because it can reveal the underlying pathology in diseases. Unfortunately, the processes of image acquisition, storage, transmission, processing, and analysis can influence image quality with the risk of compromising the reliability of MRI-based data. Therefore (...) . The second step computes the mean and standard deviation of the feature image. The third step separately standardizes each normal distribution using the mean and standard deviation computed from the feature image. This gives two separate z-scores. The fourth step predicts the lightness contrast quality score and the texture contrast quality score from cumulative distribution function of the appropriate normal distribution. The proposed method was evaluated objectively on brain and cardiac MRI volume data

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2018 IEEE journal of translational engineering in health and medicine

143. Adherence to postresection colorectal cancer surveillance at National Cancer Institute‐designated Comprehensive Cancer Centers (PubMed)

visits, carcinoembryonic antigen (CEA), computed tomography (CT), and colonoscopy after CRC resection at three NCI-designated centers. Data on patients with resected CRC from 2010 to 2017 were reviewed. Adherence to physician visits was defined as having at least two visits within 14 months after surgical resection. CEA adherence was defined as having at least four CEA levels drawn within 14 months. CT and colonoscopy adherence were defined as completing each between 10 and 14 months from surgical (...) Adherence to postresection colorectal cancer surveillance at National Cancer Institute‐designated Comprehensive Cancer Centers Guidelines recommend surveillance after resection of colorectal cancer (CRC), but rates of adherence to surveillance are variable and have not been studied at National Cancer Institute (NCI)-designated Comprehensive Cancer Centers. The aim of this study was to determine rates of adherence to standard postresection CRC surveillance recommendations including physician

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2018 Cancer medicine

144. Short-term disability progression in two multiethnic multiple sclerosis centers in the treatment era (PubMed)

Short-term disability progression in two multiethnic multiple sclerosis centers in the treatment era Short-term disease progression is well documented in clinical trials, but there are limited published data on disease course in real-life practice.Patient-derived Multiple Sclerosis Severity Score (PMSSS), a disease severity rank score, was computed at each visit for consecutive MS patients attending two large, ethnically diverse MS centers in New York metropolitan area. Disability was assessed (...) York University (n = 1079) and Barnabas (n = 661) MS Care Centers were included. During follow up (mean 2.4 ± 0.82 years, range 1-4 years), mean PDDS score increased from 1.9 ± 2.2 to 2.3 ± 2.2 (p < 0.0001), while PMSSS remained roughly unchanged (initial PMSSS = 3.71 ± 2.73, last PMSSS = 3.81 ± 2.76, paired t test, p = 0.28). The only major predictor of final PMSSS was the initial PMSSS. Demographic variables (age, sex, race) or relapse status did not predict final severity score.Baseline

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2018 Therapeutic advances in neurological disorders

145. Unsupervised Medical Image Segmentation Based on the Local Center of Mass (PubMed)

Unsupervised Medical Image Segmentation Based on the Local Center of Mass Image segmentation is a critical step in numerous medical imaging studies, which can be facilitated by automatic computational techniques. Supervised methods, although highly effective, require large training datasets of manually labeled images that are labor-intensive to produce. Unsupervised methods, on the contrary, can be used in the absence of training data to segment new images. We introduce a new approach (...) to unsupervised image segmentation that is based on the computation of the local center of mass. We propose an efficient method to group the pixels of a one-dimensional signal, which we then use in an iterative algorithm for two- and three-dimensional image segmentation. We validate our method on a 2D X-ray image, a 3D abdominal magnetic resonance (MR) image and a dataset of 3D cardiovascular MR images.

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2018 Scientific reports

146. Feasibility of radical hysterectomy in women with FIGO stage IIB cervical cancer: an observation study of 10-year experience in a tertiary center (PubMed)

Feasibility of radical hysterectomy in women with FIGO stage IIB cervical cancer: an observation study of 10-year experience in a tertiary center Although definitive chemoradiotherapy is considered as a standard of care for FIGO stage IIB cervical cancer in many countries, the role of surgery remains controversial. We aimed to evaluate the feasibility and outcomes of patients with FIGO stage IIB cervical cancer who received radical surgery in China.A total of 74 women with FIGO stage IIB (...) cervical cancer were treated with radical hysterectomy, with or without adjuvant radio/chemoradiotherapy, at the Obstetrics and Gynecology Hospital of Fudan University between 2004 and 2015. Medical charts and clinical data were retrospectively reviewed. The Kaplan-Meier method and Cox regression models were used for survival analyses. In addition, prognostic nomograms predicting overall survival (OS) and progression-free survival (PFS) were constructed.Pathological parametrial involvement (PMI

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2018 OncoTargets and therapy

147. An Instrumented Wobble Board to Present the Distribution and Center of Pressure in Dynamic Balance

: Recruiting First Posted : November 16, 2018 Last Update Posted : November 21, 2018 See Sponsor: University of Mogi das Cruzes Information provided by (Responsible Party): Terigi Augusto Scardovelli, University of Mogi das Cruzes Study Details Study Description Go to Brief Summary: This study quantified the displacement of the center of pressure in the computer in real time and record this data for future analyzes Condition or disease Intervention/treatment Phase Balancing Interference Diagnostic Test (...) An Instrumented Wobble Board to Present the Distribution and Center of Pressure in Dynamic Balance An Instrumented Wobble Board to Present the Distribution and Center of Pressure in Dynamic Balance - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove

2018 Clinical Trials

148. Evaluation of Intraoperative Testing During Cochlear Implantation From a Time and Cost Perspective: A Single-Center Experience in the United States. (PubMed)

in testing (ECAPs/EIs in all cases) was 6.7 minutes (range, 2-26 min). No correlation was found between testing time and preoperative computed tomography findings, the audiologist performing testing, or the electrode type used (p > 0.05). Based on billing data, including time spent in the operating room (OR), 5/22 (23%) cases incurred greater charges than if intraoperative testing had not been performed.Our data suggest that intraoperative testing increases time in the OR and can contribute to increased (...) Evaluation of Intraoperative Testing During Cochlear Implantation From a Time and Cost Perspective: A Single-Center Experience in the United States. To measure the time spent performing intraoperative testing during cochlear implantation (CI) and determine the impact on hospital charges.Prospective study.Tertiary referral hospital.Twenty-two children (7 mo-18 yr) who underwent a total of 22 consecutive primary and/or revision CIs by a single surgeon from December 2016 to July 2017.The time

2018 Otology and Neurotology

149. Cryobiopsies are diagnostic in Pleuroparenchymal and Airway-centered Fibroelastosis. (PubMed)

Cryobiopsies are diagnostic in Pleuroparenchymal and Airway-centered Fibroelastosis. Idiopathic pulmonary fibroelastosis (iPPFE) is a rare lung lesion characterized by pleural and subpleural parenchymal thickening due to accumulation of fibroelastotic tissue. Only recently, a few cases with a peribronchiolar distribution of fibroelastotic tissue have been reported. These lesions are more prominent in the upper lobes. Even though high resolution computed tomography (HRCT) scan features (...) an ongoing interstitial lung disease registry. Data on patient demographics, HRCT patterns, size and number of biopsies, histology patterns and complications were registered.Seven patients were diagnosed with iPPFE and one patient was diagnosed with airway-centered FE. Pneumothorax was documented in three cases, but none of them required a chest tube. No other complications during or after the procedure were observed.This study suggests that using cryobiopsies in the diagnostics of PPFE and airway

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2018 Respiratory research

150. Severe Varicella Pneumonia in Adults: Seven Years’ Single-center Experience from India (PubMed)

Severe Varicella Pneumonia in Adults: Seven Years’ Single-center Experience from India Varicella pneumonia is a rare but a serious complication of chickenpox in adults. There is paucity of data on varicella pneumonia from India.The aim of this study is to describe the clinical manifestations, hospital course, treatment, and outcome of adult patients with severe varicella pneumonia.This was a retrospective, observational study of patients with severe varicella pneumonia attending a tertiary (...) care teaching hospital.The cases of varicella were identified by a computerized search of the medical record for the period between January 2010 and December 2016. During this period, 137 patients got admitted with varicella of which 22 had severe varicella pneumonia.Mean and standard deviation were computed. Fisher's Z-test of proportions and analysis of variance were applied.There were 17 (77.3%) men and 5 (22.7%) women. The mean age of the patients was 33.4 ± 10.8 years. History of contact

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2018 Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine

151. Does routine repeat imaging change management in high-grade renal trauma? Results from three level 1 trauma centers. (PubMed)

Does routine repeat imaging change management in high-grade renal trauma? Results from three level 1 trauma centers. Guidelines call for routine reimaging of Grade 4-5 renal injuries at 48-72 h. The aim of the current study is to evaluate the clinical utility of computed tomography (CT) reimaging in high-grade renal injuries.We assembled data on 216 trauma patients with high-grade renal trauma at three level 1 trauma centers over a 19-year span between 1999 and 2017 in retrospectively collected

2018 World journal of urology

152. A Multi-Center Clinical Trial to Determine the Impact of a Mobile Health Application on Rheumatoid Arthritis Shared Decision Making

A Multi-Center Clinical Trial to Determine the Impact of a Mobile Health Application on Rheumatoid Arthritis Shared Decision Making A Multi-Center Clinical Trial to Determine the Impact of a Mobile Health Application on Rheumatoid Arthritis Shared Decision Making - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have (...) reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A Multi-Center Clinical Trial to Determine the Impact of a Mobile Health Application on Rheumatoid Arthritis Shared Decision Making The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03773471

2018 Clinical Trials

153. Pediatric hydrocephalus: systematic literature review and evidence-based guidelines. Part 3: Endoscopic computer-assisted electromagnetic navigation and ultrasonography as technical adjuvants for shunt placement

” OR elec- tromagnetic OR ultrasound OR Endoscopy[MeSH] OR endoscop*)) 4. Limit to English and Humans Cochrane Database 1. MeSH descriptor Child 2. MeSH descriptor Infant 3. 1 or 2 and (MeSH descriptor Cerebrospinal Fluid Shunts) 4. 3 and (MeSH descriptor Hydrocephalus) 5. 4 and (ventricular NEAR/2 (catheter OR shunt)) 6. (computer OR ultrasound OR endoscop*) 7. 5 and 6 Search Strategies Articles meeting specific criteria that had been delin - eated a priori were then examined, and the data yielded were (...) of electromagnetic image guidance in the placement of ventricular catheters: summary of evidence Authors & Year Study Description Data Class, Quality, & Reason(s) Results & Conclusions Hayhurst et al., 2010 3 centers, new shunts, adult & pediatric pts followed up for 1 yr or to shunt failure. Graded by observer blinded to place- ment method. Pediatric pts: 20 w/o navigation, 15 w/ EM image navigation. Class II Cohort, good-quality prospective study. Follow-up for EM image navigation group was shorter (6 mos

2014 Congress of Neurological Surgeons

154. Maximizing the healthcare environment: a systematic review exploring the potential of computer technology to promote self-management of chronic illness in healthcare settings

Education as Topic; Patient-Centered Care; Randomized Controlled Trials as Topic; Self Care /methods; Software; Therapy, Computer-Assisted; Young Adult AccessionNumber 12013020619 Date bibliographic record published 24/04/2013 Date abstract record published 05/11/2013 Record Status This is a critical abstract of a systematic review that meets the criteria for inclusion on DARE. Each critical abstract contains a brief summary of the review methods, results and conclusions followed by a detailed critical (...) Maximizing the healthcare environment: a systematic review exploring the potential of computer technology to promote self-management of chronic illness in healthcare settings Maximizing the healthcare environment: a systematic review exploring the potential of computer technology to promote self-management of chronic illness in healthcare settings Maximizing the healthcare environment: a systematic review exploring the potential of computer technology to promote self-management of chronic

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2013 DARE.

155. Does Immediate Total-Body Computed Tomography Reduce Mortality and Time in the Emergency Department for Trauma Patients?

Society. Effect of whole-body CT during trauma resuscitation on survival: a retrospective, multicentre study. Lancet. 2009;373:1455-1461. 2. Weninger P, Mauritz W, Fridrich P, et al. Emergency room management of patients with blunt major trauma: evaluation of the multislice computed tomography protocol exempli?ed by an urban trauma center. J Trauma. 2007;62:584-591. 3. Wurmb TE, Frühwald P, Hopfner W, et al. Whole-body multislice computed tomography as the ?rst line diagnostic tool in patients (...) Does Immediate Total-Body Computed Tomography Reduce Mortality and Time in the Emergency Department for Trauma Patients? Systematic Review Snapshot TAKE-HOME MESSAGE Based only on retrospective observational cohort studies, immediate total-body computedtomography(CT)reducestimeintheemergencydepartment(ED)andto theoperatingroombutdoesnotreducemortalitycomparedwithselectiveimaging. Does Immediate Total-Body Computed Tomography Reduce Mortality and Time in the Emergency Department for Trauma

2013 Annals of Emergency Medicine Systematic Review Snapshots

156. Utilization of Landsat-8 data for the estimation of carrot and maize crop water footprint under the arid climate of Saudi Arabia. (PubMed)

the spatiotemporal variation of the WF of silage maize and carrot crops. The WF of each crop was estimated in two ways, namely agro-meteorological (WFAgro) and remote sensing (WFRS) methods. The blue, green and grey components of WFAgro were computed with the use of weather station/Eddy covariance measurements and field recorded crop yield datasets. The WFRS estimated by applying surface energy balance principles on Landsat-8 imageries. However, due to non-availability of Landsat-8 data on the event of rainy (...) %) and carrot (68%) crops. This is due to the high crop water demand combined with a very erratic rainfall, the irrigation is totally provided using groundwater delivered by center pivot irrigation systems. On the other hand, the WFRS-b estimated using Landsat-8 data was varied from 276 (±73) m3 t-1 (carrot) and 2885 (±441) m3 t-1 (silage maize). The variation (RMSE) between WFRS-b and WFAgro-b was about 17% and 14% for silage maize and carrot crops, respectively.

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2018 PLoS ONE

157. Evaluation of an Algorithm for Identifying Ocular Conditions in Electronic Health Record Data. (PubMed)

of patients (n = 122 339) in the Sight Outcomes Research Collaborative Ophthalmology Data Repository who received eye care at participating academic medical centers between August 1, 2012, and August 31, 2017. An algorithm that searches structured and unstructured (free-text) EHR data for conditions of interest was developed and then tested to determine how well it could detect the presence or absence of exfoliation syndrome (XFS). The algorithm was trained to search for evidence of XFS among a sample (...) . The EHR data of all patients were run through the algorithm to generate an XFS probability score for each patient. The algorithm was validated with review of EHRs by glaucoma specialists.Positive predictive value (PPV) and negative predictive value (NPV) of the algorithm were computed as the proportion of patients correctly classified with XFS or without XFS.This study included 122 339 patients, with a mean (SD) age of 52.4 (25.1) years. Of these patients, 69 002 (56.4%) were female and 99 579 (81.4

2019 JAMA ophthalmology

158. An integrative approach using real-world data to identify alternative therapeutic uses of existing drugs. (PubMed)

An integrative approach using real-world data to identify alternative therapeutic uses of existing drugs. Different computational approaches are employed to efficiently identify novel repositioning possibilities utilizing different sources of information and algorithms. It is critical to propose high-valued candidate-repositioning possibilities before conducting lengthy in vivo validation studies that consume significant resources. Here we report a novel multi-methodological approach (...) to identify opportunities for drug repositioning. We performed analyses of real-world data (RWD) acquired from the United States Food and Drug Administration's Adverse Event Reporting System (FAERS) and the claims database maintained by the Japan Medical Data Center (JMDC). These analyses were followed by cross-validation through bioinformatics analyses of gene expression data. Inverse associations revealed using disproportionality analysis (DPA) and sequence symmetry analysis (SSA) were used to detect

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2018 PLoS ONE

159. Integration of genomic and clinical data augments surveillance of healthcare-acquired infections. (PubMed)

Integration of genomic and clinical data augments surveillance of healthcare-acquired infections. Determining infectious cross-transmission events in healthcare settings involves manual surveillance of case clusters by infection control personnel, followed by strain typing of clinical/environmental isolates suspected in said clusters. Recent advances in genomic sequencing and cloud computing now allow for the rapid molecular typing of infecting isolates.To facilitate rapid recognition (...) -computing platform was used for whole-genome sequence analysis and cluster identification.Most strains of the 4 studied pathogens were unrelated, and 34 potential transmission clusters were present. The characteristics of the potential clusters were complex and likely not identifiable by traditional surveillance alone. Notably, only 1 cluster had been suspected by routine manual surveillance.Our work supports the assertion that integration of genomic and clinical epidemiologic data can augment infection

2019 Infection control and hospital epidemiology

160. A systematic review of natural language processing and text mining of symptoms from electronic patient-authored text data. (PubMed)

-measure for symptom-specific research questions.NLP and text mining have been used to extract and analyze patient-authored symptom data in a wide variety of online communities. Though there are computational challenges with accessing ePAT, the depth of information provided directly from patients offers new horizons for precision medicine, characterization of sub-clinical symptoms, and the creation of personal health libraries as outlined by the National Library of Medicine.Future research should (...) A systematic review of natural language processing and text mining of symptoms from electronic patient-authored text data. In this systematic review, we aim to synthesize the literature on the use of natural language processing (NLP) and text mining as they apply to symptom extraction and processing in electronic patient-authored text (ePAT).A comprehensive literature search of 1964 articles from PubMed and EMBASE was narrowed to 21 eligible articles. Data related to purpose, text source

2019 International journal of medical informatics

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