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13321. Common object request broker architecture (CORBA)-based security services for the Virtual Radiology Environment (PubMed)

policy in the DoD is described by the Trusted Computer System Evaluation Criteria (TCSEC), Army Regulation (AR) 380-19, Defense Information Infrastructure Common Operating Environment (DII COE), Military Health Services System Automated Information Systems Security Policy Manual, and National Computer Security Center-TG-005, "Trusted Network Interpretation." These documents were used to develop a security policy that defines information protection requirements that are made with respect to those laws (...) information consists of Digital Imaging and Communications in Medicine (DICOM)-formatted fields. The patient information resides in the digital imaging network picture archiving and communication system (DIN-PACS) networks in the database archive systems and includes (a) patient demographics; (b) patient images from x-ray, computed tomography (CT), magnetic resonance imaging (MRI), and ultrasound (US); and (c) prior patient images and related patient history. (2) Meta-Manager information to be protected

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2000 Journal of Digital Imaging

13322. Demystifying the hospital information system/radiology information system integration process (PubMed)

Demystifying the hospital information system/radiology information system integration process Most organizations planning to implement picture archiving and communications systems (PACS) are aware of the need to integrate the hospital information system (HIS) and radiology information system (RIS) with the PACS, yet few are acutely aware of the challenges associated with this requirement. This report highlights the results of collaborative efforts between Children's Hospital Medical Center (...) -Cincinnati (CHMC) applications specialists with expertise in the HIS and CHMC information system, radiology staff familiar with the enterprise and radiology workflow and data flow requirements; and General Electric integration engineers familiar with the SMS HIS and RIS, and GE PACS. CHMC received Board approval, including full funding of the entire PACS project, in October 1998. An aggressive time frame for installation was established, as CHMC's PACS leadership committed to the selection, design

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2000 Journal of Digital Imaging

13323. Future directions in quantitative pathology: digital knowledge in diagnostic pathology (PubMed)

Techniques Forecasting Mathematical Computing Pathology statistics & numerical data trends 0 2000 4 18 9 0 2000 4 25 9 0 2000 4 18 9 0 ppublish 10767853 PMC1731072 (...) Future directions in quantitative pathology: digital knowledge in diagnostic pathology 10767853 2000 04 19 2008 11 20 0021-9746 53 1 2000 Jan Journal of clinical pathology J. Clin. Pathol. Future directions in quantitative pathology: digital knowledge in diagnostic pathology. 31-7 Bartels P H PH Optical Sciences Center, University of Arizona, Tucson 85721, USA. peter@catalina.opt-sci.arizona.edu eng Journal Article Review England J Clin Pathol 0376601 0021-9746 AIM IM Decision Support

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2000 Journal of Clinical Pathology

13324. Weaving the Web into legacy information systems. (PubMed)

Weaving the Web into legacy information systems. For many years, client-server systems were developed as the backbone of clinical computing in leading hospitals around the country. Beth Israel Deaconess Medical Center now faces the challenge of bridging the technology gap between such systems and the Internet. While developing Web interfaces to legacy clinical systems gives a taste of the future, it is clear that complete institutional migration to the Web is not imminent. Asking clinicians (...) . Using the system, we can gradually expose clinicians to new Web-based applications and resources without forcing them to operate two computing environments simultaneously. The service achieves these goals by means of linkage and coordination rather than by code-translation, data exchange or replication.

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2000 Proceedings of the AMIA Symposium

13325. Dummy Measurement of Chest Injuries Induced by Two-Point Shoulder Belts (PubMed)

in crash investigation, crash reconstruction, computer graphics, biomechanics of injuries, crash data analysis, trauma care, and all of the medical specialties associated with the Ryder Trauma Center at Jackson Memorial Hospital. More than 350 injured occupants and their crashes have been studied in depth. The purpose of this paper is to report on an observed pattern of liver lacerations suffered by drivers wearing shoulder belts, without the lap belt fastened and to assess the ability of existing (...) no difference in chest injury measures. Finite element computer modeling demonstrated that the high deflection of the right lower rib on the Hybrid III dummy predicts the liver injuries in the 1 o'clock crashes. These higher deflections were less apparent at the location of the center chest deflection measurement device on the Hybrid III.

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2000 Annual Proceedings / Association for the Advancement of Automotive Medicine

13326. Internet based repository of medical records that retains patient confidentiality (PubMed)

Internet based repository of medical records that retains patient confidentiality 11073513 2000 12 14 2018 11 13 0959-8138 321 7270 2000 Nov 11 BMJ (Clinical research ed.) BMJ Internet based repository of medical records that retains patient confidentiality. 1199-203 Schoenberg R R Center for Clinical Computing, Beth Israel Deaconess Medical Center, Harvard Medical School, 21 Autumn Street, Boston, MA 02155, USA. rschoenb@caregroup.harvard.edu Safran C C eng Journal Article England BMJ 8900488 (...) 0959-8138 AIM E IM Computer Security Confidentiality Data Collection Humans Information Storage and Retrieval standards Internet Medical Records Systems, Computerized organization & administration standards Risk Factors Workload 103695 Professional Patient Relationship 21 refs. KIE Bib: confidentiality 2000 11 10 11 0 2001 2 28 10 1 2000 11 10 11 0 ppublish 11073513 PMC1118958 JAMA. 1994 Dec 21;272(23):1851-7 7503827 Int J Med Inform. 1999 Jun;54(3):183-96 10405878 J Am Med Inform Assoc. 1996 Mar

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2000 BMJ : British Medical Journal

13327. Telerobotic Laparoscopic Cholecystectomy: Initial Clinical Experience With 25 Patients (PubMed)

, especially when using microinstruments. Clinical trials have shown the improved microsurgical precision afforded by CAS in the minimally invasive setting in cardiac and gynecologic surgery. Future applications would allow integration of preoperative data and augmented-reality simulation onto the actual procedure.Beginning in September 1999, CAS was used to perform cholecystectomies on 25 patients at a single medical center in this nonrandomized, prospective study. The operations were performed by one (...) Telerobotic Laparoscopic Cholecystectomy: Initial Clinical Experience With 25 Patients To determine the safety and feasibility of performing telerobotic laparoscopic cholecystectomies. This will serve as a preliminary step toward the integration of computer-rendered three-dimensional preoperative imaging studies of anatomy and pathology onto the patient's own anatomy during surgery.Computer-assisted surgery (CAS) increases the surgeon's dexterity and precision during minimally invasive surgery

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2001 Annals of Surgery

13328. Frequency and impact of high-resolution monitor failure in a filmless imaging department (PubMed)

Frequency and impact of high-resolution monitor failure in a filmless imaging department The purpose of this study was to assess the image quality and the rate of failure of the high-resolution (2,048 x 1536 pixel) monitors used for primary diagnosis in a filmless radiology department and to analyze the type of problems encountered as well as the action taken to repair the monitors. Data were collected from Picture Archival and Communication System (PACS) service logs to determine rates (...) of monitor adjustment and replacement, the symptoms reported, and the action taken. Additionally, random surveys of the high-resolution monitors were performed using a standard test pattern to assess spatial and contrast resolution in the center and outer corners of the monitors. Analysis of monitor service records showed a high rate of monitor replacement (41% per year) resulting in a relatively short "life expectancy" (defined as average time required before replacement) of 2.4 years. Random surveys

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2000 Journal of Digital Imaging

13329. Automated Finishing with Autofinish (PubMed)

Automated Finishing with Autofinish Currently, the genome sequencing community is producing shotgun sequence data at a very high rate, but finishing (collecting additional directed sequence data to close gaps and improve the quality of the data) is not matching that rate. One reason for the difference is that shotgun sequencing is highly automated but finishing is not: Most finishing decisions, such as which directed reads to obtain and which specialized sequencing techniques to use, are made (...) by people. If finishing rates are to increase to match shotgun sequencing rates, most finishing decisions also must be automated. The Autofinish computer program (which is part of the computer software package) does this by automatically choosing finishing reads. Autofinish is able to suggest most finishing reads required for completion of each sequencing project, greatly reducing the amount of human attention needed. sometimes completely finishes the project, with no human decisions required. It cannot

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2001 Genome Research

13330. Quantitative EEG amplitude across REM sleep periods in depression: preliminary report (PubMed)

consecutive nights in the Sleep Study Unit of the University of Texas Southwestern Medical Center at Dallas, the first of which served as adaptation. The average amplitude in each of 5 conventional EEG frequency bands was computed for each REM period across the second night. Data were then coded for group and sex.Aside from REM latency, none of the key sleep macroarchitectural variables differentiated MDD patients from controls. REM latency was longest in men with MDD. Sleep microarchitecture, however (...) Quantitative EEG amplitude across REM sleep periods in depression: preliminary report To determine if there are significant differences in the temporal organization of rapid eye movement (REM) sleep microarchitecture between healthy controls and outpatients with major depressive disorder (MDD).Forty age-matched subjects, 20 men and 20 women, half with MDD, were selected from an archive of sleep electroencephalography (EEG) data collected under identical conditions. Each participant spent 2

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2002 Journal of Psychiatry and Neuroscience

13331. What is the role of walk-in centres in the NHS? (PubMed)

and Schedules Child Child, Preschool Community Health Centers organization & administration statistics & numerical data Community Health Nursing organization & administration Decision Making, Computer-Assisted Female Health Services Accessibility organization & administration Humans Infant Infant, Newborn Male Middle Aged Patient Acceptance of Health Care statistics & numerical data Primary Health Care organization & administration Software State Medicine organization & administration Time Factors United

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2002 BMJ : British Medical Journal

13332. Comparing Vertebrate Whole-Genome Shotgun Reads to the Human Genome (PubMed)

-quality rat WGS reads (covering 7.5% of the rat genome) generated at the Baylor College of Medicine Human Genome Sequencing Center were compared with the human genome. Using computer-generated random reads as a negative control, a set of parameters was determined for reliable interpretation of BLAST search results. About 10% of the rat reads contain regions that are conserved in the human genomic sequence and about one-third of these include known gene-coding regions. Mapping the conserved regions (...) Comparing Vertebrate Whole-Genome Shotgun Reads to the Human Genome Multi-species sequence comparisons are a very efficient way to reveal conserved genes. Because sequence finishing is expensive and time consuming, many genome sequences are likely to stay incomplete. A challenge is to use these fragmented data for understanding the human genome. Methods for using cross-species whole-genome shotgun sequence (WGS) for genome annotation are described in this paper. About one-half million high

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2001 Genome Research

13333. FOUNTAIN: A JAVA open-source package to assist large sequencing projects (PubMed)

of clones, templates and sequencing reactions, and the storage, annotation and analysis of the large number of generated sequences.We describe here a new program, named FOUNTAIN, for the management of large sequencing projects http://genetics.hpi.uni-hamburg.de/FOUNTAIN.html. FOUNTAIN uses the JAVA computer language and data storage in a relational database. Starting with a collection of sequencing objects (clones), the program generates and stores information related to the different stages (...) FOUNTAIN: A JAVA open-source package to assist large sequencing projects Better automation, lower cost per reaction and a heightened interest in comparative genomics has led to a dramatic increase in DNA sequencing activities. Although the large sequencing projects of specialized centers are supported by in-house bioinformatics groups, many smaller laboratories face difficulties managing the appropriate processing and storage of their sequencing output. The challenges include documentation

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2001 BMC bioinformatics

13334. The RESID Database of protein structure modifications and the NRL-3D Sequence–Structure Database (PubMed)

accessible through the National Cancer Institute-Frederick Advanced Biomedical Computing Center at these web sites: http://www. ncifcrf.gov/RESID, http://www.ncifcrf.gov/NRL-3D; or at these National Biomedical Research Foundation Protein Information Resource web sites: http://pir.georgetown.edu/pirwww/dbinfo/resid .html, http://pir.georgetown.edu/pirwww/dbinfo/nrl3d .html (...) , literature citations with database cross-references, structural diagrams and molecular models. The NRL-3D Sequence-Structure Database is derived from the three-dimensional structure of proteins deposited with the Research Collaboratory for Structural Bioinformatics Protein Data Bank. The NRL-3D Database includes standardized and frequently observed alternate names, sources, keywords, literature citations, experimental conditions and searchable sequences from model coordinates. These databases are freely

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2001 Nucleic acids research

13335. Advances in Determination of a High-Resolution Three-Dimensional Structure of Rhodopsin, a Model of G-Protein-Coupled Receptors (GPCRs) (PubMed)

Advances in Determination of a High-Resolution Three-Dimensional Structure of Rhodopsin, a Model of G-Protein-Coupled Receptors (GPCRs) 11425302 2001 09 20 2018 11 13 0006-2960 40 26 2001 Jul 03 Biochemistry Biochemistry Advances in determination of a high-resolution three-dimensional structure of rhodopsin, a model of G-protein-coupled receptors (GPCRs). 7761-72 Teller D C DC Department of Ophthalmology, and Biological Structure and Biomolecular Structure Center, University of Washington (...) , Seattle, Washington 98195, USA. teller@u.washington.edu Okada T T Behnke C A CA Palczewski K K Stenkamp R E RE eng PDB 1HZX R01 EY009339 EY NEI NIH HHS United States EY-09339 EY NEI NIH HHS United States Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review United States Biochemistry 0370623 0006-2960 0 Receptors, Cell Surface 9009-81-8 Rhodopsin EC 3.6.1.- GTP-Binding Proteins IM Amino Acid Sequence Animals Cattle Computer Simulation Crystallography, X-Ray GTP

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2001 Biochemistry

13336. Spatiotemporal features of Ca2+ buffering and diffusion in atrial cardiac myocytes with inhibited sarcoplasmic reticulum. (PubMed)

+) movement from the cell membrane to the center of the cells relies strongly on the presence of mobile Ca(2+) buffers, particularly when the sarcoplasmic reticulum is inhibited pharmacologically. Furthermore, during the influx of Ca(2+) large and steep concentration gradients are predicted between the cytosol and the submicroscopically narrow subsarcolemmal space. In addition, the computations revealed that, despite its low Ca(2+) affinity, ATP acts as a significant buffer and carrier for Ca(2+), even (...) , a myofilament space, and the cytosol. The model was used to quantitatively simulate experimental Ca(2+) signals in terms of amplitude, time course, and spatial features. For experimental reference data, L-type Ca(2+) currents were recorded from atrial cells with the whole-cell voltage-clamp technique. Ca(2+) signals were simultaneously imaged with the fluorescent Ca(2+) indicator Fluo-3 and a laser-scanning confocal microscope. The simulations indicate that in atrial myocytes lacking T-tubules, Ca(2

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2002 Biophysical journal

13337. MD Simulation of Protein-Ligand Interaction: Formation and Dissociation of an Insulin-Phenol Complex (PubMed)

-type reaction coordinates. Only the sudden onset of rotations at the very release of the ligand cannot be parameterized by a distance. They obviously require a particular treatment. Like a preliminary study on a peptide, the present case emphasizes the contribution of internal friction inside a protein, which can be computed from simulation data. The calculated equilibrium constant and the friction-corrected rates agree well with experimental data. (...) not to observe the process in real time, but to explore its pathway(s) through the energy landscape. From the profiles of free energy, equilibrium and kinetic quantities can be determined using transition-state theory. This study is dedicated to the pharmacologically relevant insulin-phenol complex. The distance of the center of mass chosen as a reaction coordinate allows a reasonable description over most of the pathway. The analysis is facilitated by analytical expressions we recently derived for distance

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2003 Biophysical journal

13338. Bounds on the minimum number of recombination events in a sample history. (PubMed)

are appropriate, since many recombination events in the history are typically undetectable, so the true number of historical recombinations is unobtainable. The statistics can be calculated quickly by computer and improve upon the earlier bound of Hudson and Kaplan 1985. A method is developed to combine bounds on local regions in the data to produce more powerful improved bounds. The method is flexible to different models of recombination occurrence. The approach gives recombination event bounds between all (...) pairs of sites, to help identify regions with more detectable recombinations, and these bounds can be viewed graphically. Under coalescent simulations, there is a substantial improvement over the earlier method (of up to a factor of 2) in the expected number of recombination events detected by one of the new minima, across a wide range of parameter values. The method is applied to data from a region within the lipoprotein lipase gene and the amount of detected recombination is substantially

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2003 Genetics

13339. Efficacy of elective lymph node dissection in patients with intermediate thickness primary melanoma. (PubMed)

Efficacy of elective lymph node dissection in patients with intermediate thickness primary melanoma. One of the most controversial areas in the management of malignant melanoma concerns the efficacy of prophylactic lymph node dissection. During a retrospective computer-aided data review of over 3000 melanoma patients referred to the Duke University Cancer Center, 613 patients with complete staging along with surgical and pathologic data, having trunk and extremity melanoma, were identified

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1983 Annals of Surgery

13340. Issues encountered in an attempt to implement a second-generation management information system. (PubMed)

be encountered in the application of computer-based technology to human services. An analysis of the center's existing information system and the development of the data forms and procedures necessary for a second-generation system to meet information needs revealed the unique data structure and analysis problems of human service delivery systems. These problems were complicated by regulatory agencies' imposition of external reporting requirements that frequently were unpredictable and inconsistent. Finally (...) Issues encountered in an attempt to implement a second-generation management information system. Human service organization are beset by internal and external requests for information. As the scale and complexity of such delivery systems has increased, the use of computer-based information systems has become a necessity. The evolution of a client information system in a large, decentralized mental health center is reviewed in this paper to illustrate several critical issues that can

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1981 Public Health Reports

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