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101. Oscillatory, Computational, and Behavioral Evidence for Impaired GABAergic Inhibition in Schizophrenia. (PubMed)

Oscillatory, Computational, and Behavioral Evidence for Impaired GABAergic Inhibition in Schizophrenia. The dysconnection hypothesis of schizophrenia (SZ) proposes that psychosis is best understood in terms of aberrant connectivity. Specifically, it suggests that dysconnectivity arises through aberrant synaptic modulation associated with deficits in GABAergic inhibition, excitation-inhibition balance and disturbances of high-frequency oscillations. Using a computational model combined (...) a neurophysiologically informed model, we quantified group differences in GABA, gamma measures, and the predictive validity of model parameters for orientation discrimination in the SZ group. MEG visual gamma frequency was reduced in SZ, with lower peak frequency associated with more severe negative symptoms. Orientation discrimination performance was impaired in SZ. Dynamic causal modeling of the MEG data showed that local synaptic connections were reduced in SZ and local inhibition correlated negatively

2019 Schizophrenia bulletin

102. Efficacy of Short-term Treatment of Internet and Computer Game Addiction: A Randomized Clinical Trial. (PubMed)

functioning, and d = 0.67 for depression. Fourteen adverse events and 8 serious adverse events occurred. A causal relationship with treatment was considered likely in 2 AEs, one in each group.Short-term treatment for internet and computer game addiction is a promising, manualized, short-term CBT for a broad range of internet addictions in multiple treatment centers. Further trials investigating the long-term efficacy of STICA and addressing specific groups and subgroups compared with active control (...) Efficacy of Short-term Treatment of Internet and Computer Game Addiction: A Randomized Clinical Trial. Internet and computer game addiction represent a growing mental health concern, acknowledged by the World Health Organization.To determine whether manualized cognitive behavioral therapy (CBT), using short-term treatment for internet and computer game addiction (STICA), is efficient in individuals experiencing internet and computer game addiction.A multicenter randomized clinical trial

2019 JAMA psychiatry (Chicago, Ill.)

103. Detecting hospital behaviors of up-coding on DRGs using Rasch model of continuous variables and online cloud computing in Taiwan. (PubMed)

Detecting hospital behaviors of up-coding on DRGs using Rasch model of continuous variables and online cloud computing in Taiwan. This work aims to apply data-detection algorithms to predict the possible deductions of reimbursement from Taiwan's Bureau of National Health Insurance (BNHI), and to design an online dashboard to send alerts and reminders to physicians after completing their patient discharge summaries.Reimbursement data for discharged patients were extracted from a Taiwan medical (...) center in 2016. Using the Rasch model of continuous variables, we applied standardized residual analyses to 20 sets of norm-referenced diagnosis-related group (DRGs), each with 300 cases, and compared these to 194 cases with deducted records from the BNHI. We then examine whether the results of prediction using the Rasch model have a high probability associated with the deducted cases. Furthermore, an online dashboard was designed for use in the online monitoring of possible deductions on fee items

2019 BMC health services research

104. Standardized reporting systems for computed tomography coronary angiography and calcium scoring: A real-world validation of CAD-RADS and CAC-DRS in patients with stable chest pain. (PubMed)

Standardized reporting systems for computed tomography coronary angiography and calcium scoring: A real-world validation of CAD-RADS and CAC-DRS in patients with stable chest pain. To assess the prognostic implications of standardized reporting systems for coronary computed tomography angiography (CCTA) and coronary artery calcium scores (CACS) in patients with stable chest pain.The Coronary Artery Disease Reporting And Data System (CAD-RADS) and Coronary Artery Calcium - Data and Reporting (...) System (CAC-DRS) aim to improve communication of CACS and CCTA results, but its influence on prognostication is unknown.Images from 1769 patients who underwent CCTA as part of the Scottish Computed Tomography of the HEART (SCOT-HEART) multi-center randomized controlled trial were assessed. CACS were classified as CAC-DRS 0 to 3 based on Agatston scores. CCTA were classified as CAD-RADS 0 to 5 based on the most clinically relevant finding per patient. The primary outcome was the five-year events

2019 Journal of cardiovascular computed tomography

105. Cervical Computed Tomography Dependent Diagnosis of Crowned Dens Syndrome in Calcium Pyrophosphate Dihydrate Crystal Deposition Disease. (PubMed)

Cervical Computed Tomography Dependent Diagnosis of Crowned Dens Syndrome in Calcium Pyrophosphate Dihydrate Crystal Deposition Disease. The purpose of this study is to assess the presence of Crowned Dens Syndrome (CDS) in patients with Calcium pyrophosphate disease (CPPD). We report 34 patients with Crowned Dens Syndrome in one of the largest series from a single tertiary medical center in North America.A retrospective chart review was conducted at the University of Kansas Medical Center from (...) is an under-recognized entity which should be considered in elderly patients with neck pain in the setting of Calcium pyrophosphate disease. Our data demonstrates a high percentage (about 60%) of patients with Calcium pyrophosphate disease who had cervical computed tomography findings consistent with Crowned Dens Syndrome. This underscores the importance of performing cervical computed tomography when evaluating patients with neck pain and Calcium pyrophosphate disease.Copyright © 2019. Published

2019 American Journal of Medicine

106. Virtual Mechanical Testing Based on Low-Dose Computed Tomography Scans for Tibial Fracture: A Pilot Study of Prediction of Time to Union and Comparison with Subjective Outcomes Scoring. (PubMed)

their validity for measuring structural bone formation or biomechanical integrity.In this pilot study, a sequential cohort of patients with a tibial shaft fracture were prospectively recruited for observation following standard reamed intramedullary nailing in a level-I trauma center. Follow-up at 6, 12, 18, and 24 weeks included radiographs and completion of PROMs (EuroQol 5-Dimension [EQ-5D] and pain scores). Low-dose computed tomography (CT) scans were also performed at 12 weeks. Scans were reconstructed (...) Virtual Mechanical Testing Based on Low-Dose Computed Tomography Scans for Tibial Fracture: A Pilot Study of Prediction of Time to Union and Comparison with Subjective Outcomes Scoring. Quantitative outcomes assessment remains a persistent challenge in orthopaedic trauma. Although patient-reported outcome measures (PROMs) and radiographic assessments such as Radiographic Union Scale for Tibial Fractures (RUST) scores are frequently used, very little evidence has been presented to support

2019 The Journal of Bone and Joint Surgery. American Volume

107. Characterizing electronic health record usage patterns of inpatient medicine residents using event log data. (Full text)

review) as information entry (note and order entry).Analysis of EHR event log data can enable medical educators and programs to develop more targeted interventions to improve physician-computer-patient interactions, centered on specific EHR actions. (...) Characterizing electronic health record usage patterns of inpatient medicine residents using event log data. Amid growing rates of burnout, physicians report increasing electronic health record (EHR) usage alongside decreasing clinical facetime with patients. There exists a pressing need to improve physician-computer-patient interactions by streamlining EHR workflow. To identify interventions to improve EHR design and usage, we systematically characterize EHR activity among internal medicine

2019 PLoS ONE PubMed

108. The Cardiovascular Trial of the Testosterone Trials: rationale, design, and baseline data of a clinical trial using computed tomographic imaging to assess the progression of coronary atherosclerosis. (Full text)

The Cardiovascular Trial of the Testosterone Trials: rationale, design, and baseline data of a clinical trial using computed tomographic imaging to assess the progression of coronary atherosclerosis. Data from prior studies have yielded inconsistent results on the association of serum testosterone levels with the risk for cardiovascular disease. There are no clinical trial data on the effects of testosterone replacement therapy on plaque progression.We designed a study to investigate the effect (...) of testosterone therapy on coronary artery plaque progression using serial coronary computed tomographic angiography (CCTA). In this paper, we describe the study design, methods, and characteristics of the study population.The Cardiovascular Trial of the Testosterone Trials (TTrials; NCT00799617) is a double-blind, placebo-controlled trial of 1 year of testosterone therapy in men 65 years or older with clinical manifestations of androgen deficiency and unequivocally low serum testosterone concentrations (<275

2015 Coronary artery disease PubMed

109. Minimizing Thermal Stress for Data Center Servers through Thermal-Aware Relocation (Full text)

Minimizing Thermal Stress for Data Center Servers through Thermal-Aware Relocation A rise in inlet air temperature may lower the rate of heat dissipation from air cooled computing servers. This introduces a thermal stress to these servers. As a result, the poorly cooled active servers will start conducting heat to the neighboring servers and giving rise to hotspot regions of thermal stress, inside the data center. As a result, the physical hardware of these servers may fail, thus causing (...) performance loss, monetary loss, and higher energy consumption for cooling mechanism. In order to minimize these situations, this paper performs the profiling of inlet temperature sensitivity (ITS) and defines the optimum location for each server to minimize the chances of creating a thermal hotspot and thermal stress. Based upon novel ITS analysis, a thermal state monitoring and server relocation algorithm for data centers is being proposed. The contribution of this paper is bringing the peak outlet

2014 The Scientific World Journal PubMed

110. MD Anderson Cancer Center’s IBM Watson project fails, and so did the journalism related to it

technology is another healthcare arena where uncritical media narratives can cause harm by raising false hopes and allowing costly and unproven investments to proceed without scrutiny. A case in point is the recent collapse of M.D. Anderson Cancer Center’s ambitious venture to use IBM’s Watson cognitive computing system to expedite clinical decision-making around the globe and match patients to clinical trials. Launched in 2013, the project initially received glowing mainstream media coverage (...) MD Anderson Cancer Center’s IBM Watson project fails, and so did the journalism related to it MD Anderson Cancer Center's IBM Watson project fails, and so did the journalism related to it - HealthNewsReview.org Note to our followers: Our nearly 13-year run of daily publication of new content on HealthNewsReview.org came to a close at the end of 2018. Publisher Gary Schwitzer and other contributors may post new articles periodically. But all of the 6,000+ articles we have published contain

2017 HealthNewsReview

111. High Adherence to Iron/Folic Acid Supplementation during Pregnancy Time among Antenatal and Postnatal Care Attendant Mothers in Governmental Health Centers in Akaki Kality Sub City, Addis Ababa, Ethiopia: Hierarchical Negative Binomial Poisson Regression. (Full text)

and the collected data was cleaned and entered into Epi Info 3.5.1 and analyzed by R version 3.2.0. Hierarchical Negative Binomial Poisson Regression Model was fitted to identify the factors associated with a number of Iron/Folic Acid uptake. Adjusted Incidence rate ratio (IRR) with 95% confidence interval (CI) was computed to assess the strength and significance of the association.More than 90% of the mothers were supplemented with at least one Iron/Folic Acid supplement from pill per week during (...) High Adherence to Iron/Folic Acid Supplementation during Pregnancy Time among Antenatal and Postnatal Care Attendant Mothers in Governmental Health Centers in Akaki Kality Sub City, Addis Ababa, Ethiopia: Hierarchical Negative Binomial Poisson Regression. Iron deficiency during pregnancy is a risk factor for anemia, preterm delivery, and low birth weight. Iron/Folic Acid supplementation with optimal adherence can effectively prevent anemia in pregnancy. However, studies that address this area

2017 PLoS ONE PubMed

112. Biomedical Informatics and Computational Biology for High-Throughput Data Analysis (Full text)

Biomedical Informatics and Computational Biology for High-Throughput Data Analysis 24688384 2015 11 16 2015 11 19 1537-744X 2014 2014 TheScientificWorldJournal ScientificWorldJournal Biomedical informatics and computational biology for high-throughput data analysis. 398181 10.1155/2014/398181 Shen Bairong B Center for Systems Biology, Soochow University, P.O. Box 206, Suzhou 215006, China. Ma Jian J Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA (...) . Wang Jiajun J School of Electronics and Information Engineering, Soochow University, Suzhou 215006, China. Wang Junbai J Department of Pathology, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, 0310 Oslo, Norway. eng Editorial 2014 02 12 United States ScientificWorldJournal 101131163 1537-744X 0 Adaptor Proteins, Signal Transducing 0 NCK2 protein, human 0 Oncogene Proteins 0 Proteins 0 Tumor Necrosis Factor-alpha IM Adaptor Proteins, Signal Transducing genetics Computational

2014 The Scientific World Journal PubMed

113. 2012 ACCF/AHA/ACR/SCAI/SIR/STS/SVM/SVN/SVS Key Data Elements and Definitions for Peripheral Atherosclerotic Vascular DiseaseA Report of the American College of Cardiology Foundation/American Heart Association Task Force on Clinical Data Standards (Writing (Full text)

, magnetic resonance angiography, computed tomographic angiography, and catheter-based radiocontrast angiography, such as the artery imaged and the location and severity of stenoses. Data elements relevant to treatment include pharmacotherapy and exercise rehabilitation for claudication. also includes detailed data elements for both endovascular and open surgical revascularization such as the target vessel, the specific procedure, outcomes, and complications. 3.3 AAA Table of Data Elements provides (...) assessment of AAA. The table comprises detailed elements of diagnostic imaging tests, including ultrasonography, magnetic resonance imaging, and computed tomography, such as aneurysm type, size, location, and other characteristics. Additional elements relate to endovascular and open surgical repair and include details of the procedures, outcomes, and complications. 3.4 Renal and Mesenteric Artery Disease Table of Data Elements In the context of this document, renal artery disease is defined

2012 Society of Interventional Radiology PubMed

114. Tablet computer enhanced training improves internal medicine exam performance. (Full text)

Tablet computer enhanced training improves internal medicine exam performance. Traditional teaching concepts in medical education do not take full advantage of current information technology. We aimed to objectively determine the impact of Tablet PC enhanced training on learning experience and MKSAP® (medical knowledge self-assessment program) exam performance.In this single center, prospective, controlled study final year medical students and medical residents doing an inpatient service (...) rotation were alternatingly assigned to either the active test (Tablet PC with custom multimedia education software package) or traditional education (control) group, respectively. All completed an extensive questionnaire to collect their socio-demographic data, evaluate educational status, computer affinity and skills, problem solving, eLearning knowledge and self-rated medical knowledge. Both groups were MKSAP® tested at the beginning and the end of their rotation. The MKSAP® score at the final exam

2017 PLoS ONE PubMed

115. Dynamic Voltage Frequency Scaling Simulator for Real Workflows Energy-Aware Management in Green Cloud Computing. (Full text)

Dynamic Voltage Frequency Scaling Simulator for Real Workflows Energy-Aware Management in Green Cloud Computing. Nowadays, the growing computational capabilities of Cloud systems rely on the reduction of the consumed power of their data centers to make them sustainable and economically profitable. The efficient management of computing resources is at the heart of any energy-aware data center and of special relevance is the adaptation of its performance to workload. Intensive computing (...) and time saving are presented. Also, results achieved by the intra-host DVFS strategy with different governors are compared to those of the data center using a recent and successful DVFS-based inter-host scheduling strategy as overlapped mechanism to the DVFS intra-host technique.

2017 PLoS ONE PubMed

116. I saw this on the computer. Most physicians, at first glance, get this wrong. What is it?

I saw this on the computer. Most physicians, at first glance, get this wrong. What is it? Dr. Smith's ECG Blog: I saw this on the computer. Most physicians, at first glance, get this wrong. What is it? Thursday, November 3, 2016 I was reading ECGs on the system, and saw this: I immediately recognized it like I recognize a friend's face. (OK, I'm unusual, I'll admit it) What is it? When I showed this to residents, they uniformly thought it was Left Bundle Branch Block (LBBB). Look again. What (...) and a wider QRS 3. 4-16 comprise a 1) regular , 2) wide complex rhythm at 3) a rate of 96 4) without P-waves . A paced rhythm has this appearance on precordial leads, as the right ventricular pacing lead is usually in the RV apex and depolarization then proceeds from the apex to the base (from leads II and V6 towards the right shoulder). The computer does a good job of finding pacing spikes, even when they are invisible to the human eye. The computer did not detect pacing spikes here. This patient's heart

2016 Dr Smith's ECG Blog

117. Thrombus aspiration in late presenters with ST-elevation myocardial infarction: A single-center randomized trial. (PubMed)

Thrombus aspiration in late presenters with ST-elevation myocardial infarction: A single-center randomized trial. To examine whether routine thrombus aspiration (TA) is associated with improved myocardial salvage in patients with ST-elevation myocardial infarction (STEMI) presenting ≥12 h after onset of symptoms.TA is a recognized treatment option in patients with STEMI undergoing primary percutaneous coronary intervention (PPCI) especially in the setting of heavy thrombus burden. However, data (...) on the role of TA in STEMI patients presenting late after onset of symptoms are limited.In this single-center prospective randomized study, patients with subacute STEMI presenting ≥12 and ≤48 h after symptom onset were randomized to primary PCI with or without manual TA in a 1:1 ratio. The primary endpoint was the myocardial salvage index assessed with Single Photon Emission Computed Tomography (SPECT) on admission and 4 days later.A total of 60 patients underwent randomization. Baseline characteristics

2018 Journal of interventional cardiology

118. [Group preventive consultation of the population concerning nutrition. Experience of School of the balanced nutrition founded on the basis of the Health center]. (PubMed)

women (27–72 years old) who passed group preventive consultation in the Center of health at «School of a balanced nutrition » were carried out. Anthropometrical data and the actual nutrition with use of the computer program «Analysis of the Person Nutrition» were studied. The study of nutritional status of 242 women with different body mass revealed an excess consumption of fats and carbohydrates, dietary energy supply in obese. Basing on the structural features of patient’s nutrition the School (...) [Group preventive consultation of the population concerning nutrition. Experience of School of the balanced nutrition founded on the basis of the Health center]. The development of the program of group preventive consultation of visitors of the centers of health concerning nutrition and assessment of its efficiency was the purpose of the work. The analysis of the results of inspection of 2569 visitors of the Health сenter at the age of 18–78 years and randomized, open, cross research of 242

2018 Voprosy pitaniia

119. Canal Transportation and Centering Ability of ProTaper and SafeSider in Preparation of Curved Root Canals: A CBCT Evaluation. (Full text)

scans were then obtained. The distance between the external root surface and internal canal wall was measured at the mesial and distal at 1, 3 and 7 mm from the apex. The values measured on primary and secondary CBCT scans were compared to assess possible changes in original central canal path and canal transportation. Data were compared using the t-test and repeated measure ANOVA.ProTaper and SafeSider were significantly different in terms of canal transportation and centering ability, and ProTaper (...) Canal Transportation and Centering Ability of ProTaper and SafeSider in Preparation of Curved Root Canals: A CBCT Evaluation. Maintaining the original central canal path is an important parameter in efficient root canal preparation. Instruments causing minimal changes in original canal path are preferred for this purpose. This study sought to compare canal transportation and centering ability of ProTaper and SafeSider instruments in curved mesiobuccal root canals of mandibular first molars

2018 Iranian endodontic journal PubMed

120. Demand management and optimization of clinical laboratory services in a tertiary referral center in Saudi Arabia (Full text)

lock-out frequencies identified in a literature review. Data was captured on test numbers before and after initiating computer-based lock-outs along with the reference laboratory cost of these tests for the first 6 months of 2016 and 2017.Alterations in testing patterns (mimimum retest intervals) and frequencies for tests.The number of tests ordered during the 6-month period in 2017 were reduced by an average of 6.6% versus the same period for 2016, saving 2.03 million Saudi Arabian Riyals (SAR (...) Demand management and optimization of clinical laboratory services in a tertiary referral center in Saudi Arabia Demand for clinical laboratory services in our insti.tution has increased by 7% each year in the past 5 years, while the amount budgeted for services has remained fixed. To address the issue, we conducted a pilot study to curb inappropriate demand by implementing a minimum retest interval (time-based restrictions on the ordering certain tests) and thus reduce costs.Explore the impact

2018 Annals of Saudi Medicine PubMed

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