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81. Noncaseating granulomatous diseases in germ cell cancer patients-A single-center experience. (PubMed)

Noncaseating granulomatous diseases in germ cell cancer patients-A single-center experience. In patients with testicular Germ Cell Tumors (GCT) noncaseating granulomatous diseases such as Sarcoid Like Lesions (SLL) or Sarcoidosis can mimic metastasis due to hilar or mediastinal lymphadenopathy. Due to the clinical and prognostic impact, exclusion of malignant diseases is mandatory.Retrospectively, data from 636 GCT patients, who were seen in the course of tumor surveillance/follow-up were (...) -nine patients suffered from suspected tumor relapse. Whereas thoracic relapses were suspected in 15 patients on chest computed tomography, thoracic relapse was confirmed in 5 cases by open surgery. In 2 cases open surgery yielded reactive lymphadenitis, and in 8 cases SLL was diagnosed either via EBUS-TBNA (n = 7) or thoracoscopic wedge resection plus lymphadenectomy (n = 1). With focus on overall survival, no relevant difference was found between all tested subgroups (P = 0.265; logrank test

2019 Urologic oncology

82. Experience of the management of coronary artery bypass graft only on moderate ischemic mitral regurgitation: A single-center retrospective study. (PubMed)

surgery. The statistical data were processed by SPSS 19 software with computer; statistical significant difference with P < .05.Overall in-hospital mortality was 2.75% (3 patients). Patients had lower mean LVEF in the postoperative compared with the preoperative period, but all the patients had higher LVEF since 6 months than preoperative period (P < .001). Compared with the preoperative dates, postoperative valvular regurgitation, left ventricular and atrial size and LVEDV postoperative 10 days (...) Experience of the management of coronary artery bypass graft only on moderate ischemic mitral regurgitation: A single-center retrospective study. To summary the impact of off-pump coronary artery bypass grafting (CABG) only on patients with moderate ischemic mitral regurgitation and survival.We retrospectively analyzed 109 patients with coronary artery disease (CAD) complicated by moderate mitral regurgitation, from January, 2008 to December, 2014, in the Department of Cardiovascular Surgery

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2019 Medicine

83. TCGA Expedition: A Data Acquisition and Management System for TCGA Data. (PubMed)

accessible TCGA data are released through public portals, but many challenges exist in navigating and using data obtained from these sites. We developed TCGA Expedition to support the research community focused on computational methods for cancer research. Data obtained, versioned, and archived using TCGA Expedition supports command line access at high-performance computing facilities as well as some functionality with third party tools. For a subset of TCGA data collected at University of Pittsburgh, we (...) , participant- and sample-centered, local TCGA data directory with metadata structures that directly reference the local data files as well as the original data files. The software supports flexible searches of the data via a web portal, user-centric data tracking tools, and data provenance tools. Using this software, we created a collaborative repository, the Pittsburgh Genome Resource Repository (PGRR) that enabled investigators at our institution to work with all TCGA data formats, and to interrogate

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2016 PLoS ONE

84. The center for expanded data annotation and retrieval. (PubMed)

The center for expanded data annotation and retrieval. The Center for Expanded Data Annotation and Retrieval is studying the creation of comprehensive and expressive metadata for biomedical datasets to facilitate data discovery, data interpretation, and data reuse. We take advantage of emerging community-based standard templates for describing different kinds of biomedical datasets, and we investigate the use of computational techniques to help investigators to assemble templates and to fill (...) in their values. We are creating a repository of metadata from which we plan to identify metadata patterns that will drive predictive data entry when filling in metadata templates. The metadata repository not only will capture annotations specified when experimental datasets are initially created, but also will incorporate links to the published literature, including secondary analyses and possible refinements or retractions of experimental interpretations. By working initially with the Human Immunology

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2015 Journal of the American Medical Informatics Association

85. The NIH BD2K center for big data in translational genomics. (PubMed)

The NIH BD2K center for big data in translational genomics. The world's genomics data will never be stored in a single repository - rather, it will be distributed among many sites in many countries. No one site will have enough data to explain genotype to phenotype relationships in rare diseases; therefore, sites must share data. To accomplish this, the genetics community must forge common standards and protocols to make sharing and computing data among many sites a seamless activity. Through (...) the Global Alliance for Genomics and Health, we are pioneering the development of shared application programming interfaces (APIs) to connect the world's genome repositories. In parallel, we are developing an open source software stack (ADAM) that uses these APIs. This combination will create a cohesive genome informatics ecosystem. Using containers, we are facilitating the deployment of this software in a diverse array of environments. Through benchmarking efforts and big data driver projects, we

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2015 Journal of the American Medical Informatics Association

86. Magnetic resonance imaging (MRI) compared with computed tomography (CT) for interobserver agreement of gross tumor volume delineation in pancreatic cancer: a multi-institutional contouring study on behalf of the AIRO group for gastrointestinal cancers. (PubMed)

-observer agreement in gross tumor volume (GTV) and duodenum delineation for pancreatic cancer compared with computer tomography (CT).Two clinical cases of borderline resectable (Case 1) and unresectable (Case 2) pancreatic cancer were selected. In two sequential steps, diagnostic contrast-enhanced CT scan and MRI sequences were sent to the participating centers. CT-GTVs were contoured while blinded to MRI data sets. DICE index was used to evaluate the spatial overlap accuracy.Thirty-one radiation (...) Magnetic resonance imaging (MRI) compared with computed tomography (CT) for interobserver agreement of gross tumor volume delineation in pancreatic cancer: a multi-institutional contouring study on behalf of the AIRO group for gastrointestinal cancers. Due to the high soft tissue resolution, magnetic resonance imaging (MRI) could improve the accuracy of pancreatic tumor delineation in radiation treatment planning. A multi-institutional study was proposed to evaluate the impact of MRI on inter

2019 Acta Oncologica

87. Machine Learning in Health and Biomedicine: A PLOS Medicine, PLOS Computational Biology, and PLOS ONE Call for Papers

research with direct clinical and health policy implications, studies that elucidate biological processes underlying health and disease, innovations in machine learning methodology and data provision, and other advances in the field. Research accepted for publication in PLOS Medicine will appear in a Special Issue to be published in late Fall 2018, along with commentary from leading experts in the field. The broader Collection, comprising all articles published in PLOS Computational Biology , PLOS ONE (...) and PLOS Medicine, will launch in late Fall and continue into 2019. Articles must be submitted by May 25, 2018. Scope The PLOS Computational Biology Guest Editor will be , Associate Professor of Molecular Genetics, Computer Science, and Electrical and Computer Engineering at the University of Toronto. PLOS Computational Biology seeks machine learning papers providing new insight into living systems, focusing on New machine learning methods for analyzing new types of genomic and proteomic data

2018 PLOS Blogs Network

88. Correlations between Computational Fluid Dynamics and clinical evaluation of nasal airway obstruction due to septal deviation: an observational study. (PubMed)

Correlations between Computational Fluid Dynamics and clinical evaluation of nasal airway obstruction due to septal deviation: an observational study. The primary objective of this study was to determine how Computational Fluid Dynamics (CFD) could be correlated to clinical evaluation of Nasal Airway Obstruction (NAO) in a population of patients with symptomatic septal deviation (SD). The secondary objective was to determine whether CFD could define which side was the more obstructed.This (...) was an observational study.Few publications have attempted to correlate CFD with clinical evaluation of NAO. This correlation would permit validation and improved interpretation. This study was performed in a university research laboratory specialized in fluid mechanics.We included patients referred for septal surgery at our center. Age range was 19 to 58 years. Preoperative CT scans were performed. All patients with non-structural causes of NAO such as rhinitis, sinusitis or tumoral / autoimmune processes (i.e

2019 Clinical Otolaryngology

89. Characterizing electronic health record usage patterns of inpatient medicine residents using event log data. (PubMed)

review) as information entry (note and order entry).Analysis of EHR event log data can enable medical educators and programs to develop more targeted interventions to improve physician-computer-patient interactions, centered on specific EHR actions. (...) Characterizing electronic health record usage patterns of inpatient medicine residents using event log data. Amid growing rates of burnout, physicians report increasing electronic health record (EHR) usage alongside decreasing clinical facetime with patients. There exists a pressing need to improve physician-computer-patient interactions by streamlining EHR workflow. To identify interventions to improve EHR design and usage, we systematically characterize EHR activity among internal medicine

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2019 PLoS ONE

90. The Cardiovascular Trial of the Testosterone Trials: rationale, design, and baseline data of a clinical trial using computed tomographic imaging to assess the progression of coronary atherosclerosis. (PubMed)

The Cardiovascular Trial of the Testosterone Trials: rationale, design, and baseline data of a clinical trial using computed tomographic imaging to assess the progression of coronary atherosclerosis. Data from prior studies have yielded inconsistent results on the association of serum testosterone levels with the risk for cardiovascular disease. There are no clinical trial data on the effects of testosterone replacement therapy on plaque progression.We designed a study to investigate the effect (...) of testosterone therapy on coronary artery plaque progression using serial coronary computed tomographic angiography (CCTA). In this paper, we describe the study design, methods, and characteristics of the study population.The Cardiovascular Trial of the Testosterone Trials (TTrials; NCT00799617) is a double-blind, placebo-controlled trial of 1 year of testosterone therapy in men 65 years or older with clinical manifestations of androgen deficiency and unequivocally low serum testosterone concentrations (<275

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2015 Coronary artery disease

91. Minimizing Thermal Stress for Data Center Servers through Thermal-Aware Relocation (PubMed)

Minimizing Thermal Stress for Data Center Servers through Thermal-Aware Relocation A rise in inlet air temperature may lower the rate of heat dissipation from air cooled computing servers. This introduces a thermal stress to these servers. As a result, the poorly cooled active servers will start conducting heat to the neighboring servers and giving rise to hotspot regions of thermal stress, inside the data center. As a result, the physical hardware of these servers may fail, thus causing (...) performance loss, monetary loss, and higher energy consumption for cooling mechanism. In order to minimize these situations, this paper performs the profiling of inlet temperature sensitivity (ITS) and defines the optimum location for each server to minimize the chances of creating a thermal hotspot and thermal stress. Based upon novel ITS analysis, a thermal state monitoring and server relocation algorithm for data centers is being proposed. The contribution of this paper is bringing the peak outlet

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2014 The Scientific World Journal

92. MD Anderson Cancer Center’s IBM Watson project fails, and so did the journalism related to it

technology is another healthcare arena where uncritical media narratives can cause harm by raising false hopes and allowing costly and unproven investments to proceed without scrutiny. A case in point is the recent collapse of M.D. Anderson Cancer Center’s ambitious venture to use IBM’s Watson cognitive computing system to expedite clinical decision-making around the globe and match patients to clinical trials. Launched in 2013, the project initially received glowing mainstream media coverage (...) MD Anderson Cancer Center’s IBM Watson project fails, and so did the journalism related to it MD Anderson Cancer Center's IBM Watson project fails, and so did the journalism related to it - HealthNewsReview.org Note to our followers: Our nearly 13-year run of daily publication of new content on HealthNewsReview.org came to a close at the end of 2018. Publisher Gary Schwitzer and other contributors may post new articles periodically. But all of the 6,000+ articles we have published contain

2017 HealthNewsReview

93. High Adherence to Iron/Folic Acid Supplementation during Pregnancy Time among Antenatal and Postnatal Care Attendant Mothers in Governmental Health Centers in Akaki Kality Sub City, Addis Ababa, Ethiopia: Hierarchical Negative Binomial Poisson Regression. (PubMed)

and the collected data was cleaned and entered into Epi Info 3.5.1 and analyzed by R version 3.2.0. Hierarchical Negative Binomial Poisson Regression Model was fitted to identify the factors associated with a number of Iron/Folic Acid uptake. Adjusted Incidence rate ratio (IRR) with 95% confidence interval (CI) was computed to assess the strength and significance of the association.More than 90% of the mothers were supplemented with at least one Iron/Folic Acid supplement from pill per week during (...) High Adherence to Iron/Folic Acid Supplementation during Pregnancy Time among Antenatal and Postnatal Care Attendant Mothers in Governmental Health Centers in Akaki Kality Sub City, Addis Ababa, Ethiopia: Hierarchical Negative Binomial Poisson Regression. Iron deficiency during pregnancy is a risk factor for anemia, preterm delivery, and low birth weight. Iron/Folic Acid supplementation with optimal adherence can effectively prevent anemia in pregnancy. However, studies that address this area

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2017 PLoS ONE

94. Biomedical Informatics and Computational Biology for High-Throughput Data Analysis (PubMed)

Biomedical Informatics and Computational Biology for High-Throughput Data Analysis 24688384 2015 11 16 2015 11 19 1537-744X 2014 2014 TheScientificWorldJournal ScientificWorldJournal Biomedical informatics and computational biology for high-throughput data analysis. 398181 10.1155/2014/398181 Shen Bairong B Center for Systems Biology, Soochow University, P.O. Box 206, Suzhou 215006, China. Ma Jian J Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA (...) . Wang Jiajun J School of Electronics and Information Engineering, Soochow University, Suzhou 215006, China. Wang Junbai J Department of Pathology, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, 0310 Oslo, Norway. eng Editorial 2014 02 12 United States ScientificWorldJournal 101131163 1537-744X 0 Adaptor Proteins, Signal Transducing 0 NCK2 protein, human 0 Oncogene Proteins 0 Proteins 0 Tumor Necrosis Factor-alpha IM Adaptor Proteins, Signal Transducing genetics Computational

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2014 The Scientific World Journal

95. 2012 ACCF/AHA/ACR/SCAI/SIR/STS/SVM/SVN/SVS Key Data Elements and Definitions for Peripheral Atherosclerotic Vascular DiseaseA Report of the American College of Cardiology Foundation/American Heart Association Task Force on Clinical Data Standards (Writing

, magnetic resonance angiography, computed tomographic angiography, and catheter-based radiocontrast angiography, such as the artery imaged and the location and severity of stenoses. Data elements relevant to treatment include pharmacotherapy and exercise rehabilitation for claudication. also includes detailed data elements for both endovascular and open surgical revascularization such as the target vessel, the specific procedure, outcomes, and complications. 3.3 AAA Table of Data Elements provides (...) assessment of AAA. The table comprises detailed elements of diagnostic imaging tests, including ultrasonography, magnetic resonance imaging, and computed tomography, such as aneurysm type, size, location, and other characteristics. Additional elements relate to endovascular and open surgical repair and include details of the procedures, outcomes, and complications. 3.4 Renal and Mesenteric Artery Disease Table of Data Elements In the context of this document, renal artery disease is defined

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2012 Society of Interventional Radiology

96. Tablet computer enhanced training improves internal medicine exam performance. (PubMed)

Tablet computer enhanced training improves internal medicine exam performance. Traditional teaching concepts in medical education do not take full advantage of current information technology. We aimed to objectively determine the impact of Tablet PC enhanced training on learning experience and MKSAP® (medical knowledge self-assessment program) exam performance.In this single center, prospective, controlled study final year medical students and medical residents doing an inpatient service (...) rotation were alternatingly assigned to either the active test (Tablet PC with custom multimedia education software package) or traditional education (control) group, respectively. All completed an extensive questionnaire to collect their socio-demographic data, evaluate educational status, computer affinity and skills, problem solving, eLearning knowledge and self-rated medical knowledge. Both groups were MKSAP® tested at the beginning and the end of their rotation. The MKSAP® score at the final exam

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2017 PLoS ONE

97. Dynamic Voltage Frequency Scaling Simulator for Real Workflows Energy-Aware Management in Green Cloud Computing. (PubMed)

Dynamic Voltage Frequency Scaling Simulator for Real Workflows Energy-Aware Management in Green Cloud Computing. Nowadays, the growing computational capabilities of Cloud systems rely on the reduction of the consumed power of their data centers to make them sustainable and economically profitable. The efficient management of computing resources is at the heart of any energy-aware data center and of special relevance is the adaptation of its performance to workload. Intensive computing (...) and time saving are presented. Also, results achieved by the intra-host DVFS strategy with different governors are compared to those of the data center using a recent and successful DVFS-based inter-host scheduling strategy as overlapped mechanism to the DVFS intra-host technique.

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2017 PLoS ONE

98. I saw this on the computer. Most physicians, at first glance, get this wrong. What is it?

I saw this on the computer. Most physicians, at first glance, get this wrong. What is it? Dr. Smith's ECG Blog: I saw this on the computer. Most physicians, at first glance, get this wrong. What is it? Thursday, November 3, 2016 I was reading ECGs on the system, and saw this: I immediately recognized it like I recognize a friend's face. (OK, I'm unusual, I'll admit it) What is it? When I showed this to residents, they uniformly thought it was Left Bundle Branch Block (LBBB). Look again. What (...) and a wider QRS 3. 4-16 comprise a 1) regular , 2) wide complex rhythm at 3) a rate of 96 4) without P-waves . A paced rhythm has this appearance on precordial leads, as the right ventricular pacing lead is usually in the RV apex and depolarization then proceeds from the apex to the base (from leads II and V6 towards the right shoulder). The computer does a good job of finding pacing spikes, even when they are invisible to the human eye. The computer did not detect pacing spikes here. This patient's heart

2016 Dr Smith's ECG Blog

99. Thrombus aspiration in late presenters with ST-elevation myocardial infarction: A single-center randomized trial. (PubMed)

Thrombus aspiration in late presenters with ST-elevation myocardial infarction: A single-center randomized trial. To examine whether routine thrombus aspiration (TA) is associated with improved myocardial salvage in patients with ST-elevation myocardial infarction (STEMI) presenting ≥12 h after onset of symptoms.TA is a recognized treatment option in patients with STEMI undergoing primary percutaneous coronary intervention (PPCI) especially in the setting of heavy thrombus burden. However, data (...) on the role of TA in STEMI patients presenting late after onset of symptoms are limited.In this single-center prospective randomized study, patients with subacute STEMI presenting ≥12 and ≤48 h after symptom onset were randomized to primary PCI with or without manual TA in a 1:1 ratio. The primary endpoint was the myocardial salvage index assessed with Single Photon Emission Computed Tomography (SPECT) on admission and 4 days later.A total of 60 patients underwent randomization. Baseline characteristics

2018 Journal of interventional cardiology

100. [Group preventive consultation of the population concerning nutrition. Experience of School of the balanced nutrition founded on the basis of the Health center]. (PubMed)

women (27–72 years old) who passed group preventive consultation in the Center of health at «School of a balanced nutrition » were carried out. Anthropometrical data and the actual nutrition with use of the computer program «Analysis of the Person Nutrition» were studied. The study of nutritional status of 242 women with different body mass revealed an excess consumption of fats and carbohydrates, dietary energy supply in obese. Basing on the structural features of patient’s nutrition the School (...) [Group preventive consultation of the population concerning nutrition. Experience of School of the balanced nutrition founded on the basis of the Health center]. The development of the program of group preventive consultation of visitors of the centers of health concerning nutrition and assessment of its efficiency was the purpose of the work. The analysis of the results of inspection of 2569 visitors of the Health сenter at the age of 18–78 years and randomized, open, cross research of 242

2018 Voprosy pitaniia

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