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61. Improving Door-to-Needle Times for Acute Ischemic Stroke: Effect of Rapid Patient Registration, Moving Directly to Computed Tomography, and Giving Alteplase at the Computed Tomography Scanner. Full Text available with Trip Pro

was implemented in 3 phases at a single academic medical center. In HASTE I (June 6, 2012 to June 5, 2013), baseline performance was analyzed. In HASTE II (June 6, 2013 to January 24, 2015), 3 changes were implemented: (1) a STAT stroke protocol to prenotify the stroke team about incoming stroke patients; (2) administering alteplase at the computed tomography (CT) scanner; and (3) registering the patient as unknown to allow immediate order entry. In HASTE III (January 25, 2015 to June 29, 2015), we (...) Improving Door-to-Needle Times for Acute Ischemic Stroke: Effect of Rapid Patient Registration, Moving Directly to Computed Tomography, and Giving Alteplase at the Computed Tomography Scanner. The effectiveness of specific systems changes to reduce DTN (door-to-needle) time has not been fully evaluated. We analyzed the impact of 4 specific DTN time reduction strategies implemented prospectively in a staggered fashion.The HASTE (Hurry Acute Stroke Treatment and Evaluation) project

2017 Circulation. Cardiovascular quality and outcomes

62. The use of whole body computed tomography scans in pediatric trauma patients: Are there differences among adults and pediatric centers? (Abstract)

The use of whole body computed tomography scans in pediatric trauma patients: Are there differences among adults and pediatric centers? Whole body CT (WBCT) scan is known to be associated with significant radiation risk especially in pediatric trauma patients. The aim of this study was to assess the use WBCT scan across trauma centers for the management of pediatric trauma patients.We performed a two year (2011-2012) retrospective analysis of the National Trauma Data Bank. Pediatric (age (...) ≤18years) trauma patients managed in level I or II adult or pediatric trauma centers with a head, neck, thoracic, or abdominal CT scan were included. WBCT scan was defined as CT scan of the head, neck, thorax, and abdomen. Patients were stratified into two groups: patients managed in adult centers and patients managed in designated pediatric centers. Outcome measure was use of WBCT. Multivariate logistic regression analysis was performed.A total of 30,667 pediatric trauma patients were included

2015 Journal of Pediatric Surgery

63. Comparative Analysis of Canal Centering Ability of Different Single File Systems Using Cone Beam Computed Tomography- An In-Vitro Study Full Text available with Trip Pro

Comparative Analysis of Canal Centering Ability of Different Single File Systems Using Cone Beam Computed Tomography- An In-Vitro Study The ability of an endodontic instrument to remain centered in the root canal system is one of the most important characteristic influencing the clinical performance of a particular file system. Thus, it is important to assess the canal centering ability of newly introduced single file systems before they can be considered a viable replacement of full-sequence (...) rotary file systems.The aim of the study was to compare the canal transportation, centering ability, and time taken for preparation of curved root canals after instrumentation with single file systems One Shape and Wave One, using cone-beam computed tomography (CBCT).Sixty mesiobuccal canals of mandibular molars with an angle of curvature ranging from 20(o) to 35(o) were divided into three groups of 20 samples each: ProTaper PT (group I) - full-sequence rotary control group, OneShape OS (group II

2015 Journal of clinical and diagnostic research : JCDR

64. The Future of Cardiovascular Computed Tomography: Advanced Analytics and Clinical Insights. (Abstract)

that will potentially see an increasingly core role for CCT at the center of clinical cardiovascular practice. In coronary artery disease assessment this may be via improved hemodynamic adjudication, and shear stress analysis using computational flow dynamics, more accurate and robust plaque characterization with spectral or photon-counting CT, or advanced quantification of CT data via artificial intelligence, machine learning, and radiomics. In structural heart disease, CCT is already pivotal to procedural (...) The Future of Cardiovascular Computed Tomography: Advanced Analytics and Clinical Insights. Cardiovascular computed tomography (CCT) has undergone rapid maturation over the last decade and is now of proven clinical utility in the diagnosis and management of coronary artery disease, in guiding structural heart disease intervention, and in the diagnosis and treatment of congenital heart disease. The next decade will undoubtedly witness further advances in hardware and advanced analytics

2019 JACC. Cardiovascular imaging

65. Oscillatory, Computational, and Behavioral Evidence for Impaired GABAergic Inhibition in Schizophrenia. Full Text available with Trip Pro

Oscillatory, Computational, and Behavioral Evidence for Impaired GABAergic Inhibition in Schizophrenia. The dysconnection hypothesis of schizophrenia (SZ) proposes that psychosis is best understood in terms of aberrant connectivity. Specifically, it suggests that dysconnectivity arises through aberrant synaptic modulation associated with deficits in GABAergic inhibition, excitation-inhibition balance and disturbances of high-frequency oscillations. Using a computational model combined (...) a neurophysiologically informed model, we quantified group differences in GABA, gamma measures, and the predictive validity of model parameters for orientation discrimination in the SZ group. MEG visual gamma frequency was reduced in SZ, with lower peak frequency associated with more severe negative symptoms. Orientation discrimination performance was impaired in SZ. Dynamic causal modeling of the MEG data showed that local synaptic connections were reduced in SZ and local inhibition correlated negatively

2019 Schizophrenia bulletin

66. Early Versus Late Computed Tomography and Nasal Endoscopy in the Diagnosis of Nasopharyngeal and Paranasal Sinus Malignancy. (Abstract)

Early Versus Late Computed Tomography and Nasal Endoscopy in the Diagnosis of Nasopharyngeal and Paranasal Sinus Malignancy. 30900468 2020 01 06 2020 01 06 1945-8932 33 4 2019 Jul American journal of rhinology & allergy Am J Rhinol Allergy Early Versus Late Computed Tomography and Nasal Endoscopy in the Diagnosis of Nasopharyngeal and Paranasal Sinus Malignancy. 388-394 10.1177/1945892419838106 Marino Michael J MJ https://orcid.org/0000-0002-8672-0310 1 Department of Otorhinolaryngology, Mayo (...) Clinic, Phoenix, Arizona. Hsieh Mei-Chin MC 2 Louisiana Tumor Registry, Louisiana State University Health Sciences Center, School of Public Health, New Orleans, Louisiana. Wu Eric L EL 3 Department of Otolaryngology-Head and Neck Surgery, Tulane University School of Medicine, New Orleans, Louisiana. Riley Charles A CA https://orcid.org/0000-0002-1993-7018 4 Division of Otolaryngology, Fort Belvoir Community Hospital, Fort Belvoir, Virginia. Wu Xiao-Cheng XC 2 Louisiana Tumor Registry, Louisiana State

2019 American journal of rhinology & allergy

67. Standardized reporting systems for computed tomography coronary angiography and calcium scoring: A real-world validation of CAD-RADS and CAC-DRS in patients with stable chest pain. Full Text available with Trip Pro

Standardized reporting systems for computed tomography coronary angiography and calcium scoring: A real-world validation of CAD-RADS and CAC-DRS in patients with stable chest pain. To assess the prognostic implications of standardized reporting systems for coronary computed tomography angiography (CCTA) and coronary artery calcium scores (CACS) in patients with stable chest pain.The Coronary Artery Disease Reporting And Data System (CAD-RADS) and Coronary Artery Calcium - Data and Reporting (...) System (CAC-DRS) aim to improve communication of CACS and CCTA results, but its influence on prognostication is unknown.Images from 1769 patients who underwent CCTA as part of the Scottish Computed Tomography of the HEART (SCOT-HEART) multi-center randomized controlled trial were assessed. CACS were classified as CAC-DRS 0 to 3 based on Agatston scores. CCTA were classified as CAD-RADS 0 to 5 based on the most clinically relevant finding per patient. The primary outcome was the five-year events

2019 Journal of cardiovascular computed tomography Controlled trial quality: predicted high

68. Detecting hospital behaviors of up-coding on DRGs using Rasch model of continuous variables and online cloud computing in Taiwan. Full Text available with Trip Pro

Detecting hospital behaviors of up-coding on DRGs using Rasch model of continuous variables and online cloud computing in Taiwan. This work aims to apply data-detection algorithms to predict the possible deductions of reimbursement from Taiwan's Bureau of National Health Insurance (BNHI), and to design an online dashboard to send alerts and reminders to physicians after completing their patient discharge summaries.Reimbursement data for discharged patients were extracted from a Taiwan medical (...) center in 2016. Using the Rasch model of continuous variables, we applied standardized residual analyses to 20 sets of norm-referenced diagnosis-related group (DRGs), each with 300 cases, and compared these to 194 cases with deducted records from the BNHI. We then examine whether the results of prediction using the Rasch model have a high probability associated with the deducted cases. Furthermore, an online dashboard was designed for use in the online monitoring of possible deductions on fee items

2019 BMC health services research

69. Efficacy of Short-term Treatment of Internet and Computer Game Addiction: A Randomized Clinical Trial. (Abstract)

functioning, and d = 0.67 for depression. Fourteen adverse events and 8 serious adverse events occurred. A causal relationship with treatment was considered likely in 2 AEs, one in each group.Short-term treatment for internet and computer game addiction is a promising, manualized, short-term CBT for a broad range of internet addictions in multiple treatment centers. Further trials investigating the long-term efficacy of STICA and addressing specific groups and subgroups compared with active control (...) Efficacy of Short-term Treatment of Internet and Computer Game Addiction: A Randomized Clinical Trial. Internet and computer game addiction represent a growing mental health concern, acknowledged by the World Health Organization.To determine whether manualized cognitive behavioral therapy (CBT), using short-term treatment for internet and computer game addiction (STICA), is efficient in individuals experiencing internet and computer game addiction.A multicenter randomized clinical trial

2019 JAMA psychiatry (Chicago, Ill.) Controlled trial quality: predicted high

70. Virtual Mechanical Testing Based on Low-Dose Computed Tomography Scans for Tibial Fracture: A Pilot Study of Prediction of Time to Union and Comparison with Subjective Outcomes Scoring. (Abstract)

their validity for measuring structural bone formation or biomechanical integrity.In this pilot study, a sequential cohort of patients with a tibial shaft fracture were prospectively recruited for observation following standard reamed intramedullary nailing in a level-I trauma center. Follow-up at 6, 12, 18, and 24 weeks included radiographs and completion of PROMs (EuroQol 5-Dimension [EQ-5D] and pain scores). Low-dose computed tomography (CT) scans were also performed at 12 weeks. Scans were reconstructed (...) Virtual Mechanical Testing Based on Low-Dose Computed Tomography Scans for Tibial Fracture: A Pilot Study of Prediction of Time to Union and Comparison with Subjective Outcomes Scoring. Quantitative outcomes assessment remains a persistent challenge in orthopaedic trauma. Although patient-reported outcome measures (PROMs) and radiographic assessments such as Radiographic Union Scale for Tibial Fractures (RUST) scores are frequently used, very little evidence has been presented to support

2019 The Journal of Bone and Joint Surgery. American Volume

71. Cervical Computed Tomography Dependent Diagnosis of Crowned Dens Syndrome in Calcium Pyrophosphate Dihydrate Crystal Deposition Disease. (Abstract)

Cervical Computed Tomography Dependent Diagnosis of Crowned Dens Syndrome in Calcium Pyrophosphate Dihydrate Crystal Deposition Disease. The purpose of this study is to assess the presence of Crowned Dens Syndrome (CDS) in patients with Calcium pyrophosphate disease (CPPD). We report 34 patients with Crowned Dens Syndrome in one of the largest series from a single tertiary medical center in North America.A retrospective chart review was conducted at the University of Kansas Medical Center from (...) is an under-recognized entity which should be considered in elderly patients with neck pain in the setting of Calcium pyrophosphate disease. Our data demonstrates a high percentage (about 60%) of patients with Calcium pyrophosphate disease who had cervical computed tomography findings consistent with Crowned Dens Syndrome. This underscores the importance of performing cervical computed tomography when evaluating patients with neck pain and Calcium pyrophosphate disease.Copyright © 2019. Published

2019 American Journal of Medicine

72. Magnetic resonance imaging (MRI) compared with computed tomography (CT) for interobserver agreement of gross tumor volume delineation in pancreatic cancer: a multi-institutional contouring study on behalf of the AIRO group for gastrointestinal cancers. Full Text available with Trip Pro

-observer agreement in gross tumor volume (GTV) and duodenum delineation for pancreatic cancer compared with computer tomography (CT).Two clinical cases of borderline resectable (Case 1) and unresectable (Case 2) pancreatic cancer were selected. In two sequential steps, diagnostic contrast-enhanced CT scan and MRI sequences were sent to the participating centers. CT-GTVs were contoured while blinded to MRI data sets. DICE index was used to evaluate the spatial overlap accuracy.Thirty-one radiation (...) Magnetic resonance imaging (MRI) compared with computed tomography (CT) for interobserver agreement of gross tumor volume delineation in pancreatic cancer: a multi-institutional contouring study on behalf of the AIRO group for gastrointestinal cancers. Due to the high soft tissue resolution, magnetic resonance imaging (MRI) could improve the accuracy of pancreatic tumor delineation in radiation treatment planning. A multi-institutional study was proposed to evaluate the impact of MRI on inter

2019 Acta Oncologica

73. Correlations between Computational Fluid Dynamics and clinical evaluation of nasal airway obstruction due to septal deviation: an observational study. (Abstract)

Correlations between Computational Fluid Dynamics and clinical evaluation of nasal airway obstruction due to septal deviation: an observational study. The primary objective of this study was to determine how Computational Fluid Dynamics (CFD) could be correlated to clinical evaluation of Nasal Airway Obstruction (NAO) in a population of patients with symptomatic septal deviation (SD). The secondary objective was to determine whether CFD could define which side was the more obstructed.This (...) was an observational study.Few publications have attempted to correlate CFD with clinical evaluation of NAO. This correlation would permit validation and improved interpretation. This study was performed in a university research laboratory specialized in fluid mechanics.We included patients referred for septal surgery at our center. Age range was 19 to 58 years. Preoperative CT scans were performed. All patients with non-structural causes of NAO such as rhinitis, sinusitis or tumoral / autoimmune processes (i.e

2019 Clinical Otolaryngology

74. Magnetic Resonance Imaging With Extracellular Contrast Detects Hepatocellular Carcinoma With Greater Accuracy Than With Gadoxetic Acid or Computed Tomography. (Abstract)

reporting and data system (LI-RADS).We studied 125 participants (102 men; mean age, 55.3 years) with chronic liver disease who underwent CT, ECA-MRI, or HBA-MRI (with gadoxetic acid) before surgery for a nodule initially detected by ultrasound at a tertiary center in Korea, from November 2016 through February 2019. We collected data on major features and assigned LI-RADS categories (v2018) from CT and MRI examinations. We then compared the diagnostic performance for LR-5 for each modality alone (...) Magnetic Resonance Imaging With Extracellular Contrast Detects Hepatocellular Carcinoma With Greater Accuracy Than With Gadoxetic Acid or Computed Tomography. Computed tomography (CT) and magnetic resonance imaging (MRI) are used to detect hepatocellular carcinoma (HCC). We performed a prospective study to compare the diagnostic performance of CT, MRI with extracellular contrast agents (ECA-MRI), and MRI with hepatobiliary agents (HBA-MRI) in the detection of HCC using the liver imaging

2019 Clinical Gastroenterology and Hepatology

75. Improving Access to and Usability of Systematic Review Data for Health Systems Guidelines Development

www.ahrq.gov Contract No. 290-2015-00009-I Prepared by: Pacific Northwest Evidence-based Practice Center Portland, OR Investigators: Annette M. Totten, Ph.D. Connor Smith, B.S. Kenneth Dunham, B.A. Rebecca M. Jungbauer, Dr.P.H., M.P.H. Elaine Graham, M.L.S. AHRQ Publication No. 19-EHC010-EF February 2019ii Key Messages Purpose of Project Identify and test interactive methods to make the large amount of data in an Evidence-based Practice Center (EPC) systematic review more accessible for decision makers (...) report data to guideline committees in learning health systems. • The recommended pilot extension could confirm usefulness of prototypes and resources needed. iii This report is based on research conducted by the Pacific Northwest Evidence-based Practice Center (EPC) under contract to the Agency for Healthcare Research and Quality (AHRQ), Rockville, MD (Contract No. 290-2015-00009-I). The findings and conclusions in this document are those of the authors, who are responsible for its contents

2019 Effective Health Care Program (AHRQ)

76. A computational method for genotype calling in family-based sequencing data Full Text available with Trip Pro

A computational method for genotype calling in family-based sequencing data As sequencing technologies can help researchers detect common and rare variants across the human genome in many individuals, it is known that jointly calling genotypes across multiple individuals based on linkage disequilibrium (LD) can facilitate the analysis of low to modest coverage sequence data. However, genotype-calling methods for family-based sequence data, particularly for complex families beyond parent (...) -offspring trios, are still lacking.In this study, first, we proposed an algorithm that considers both linkage disequilibrium (LD) patterns and familial transmission in nuclear and multi-generational families while retaining the computational efficiency. Second, we extended our method to incorporate external reference panels to analyze family-based sequence data with a small sample size. In simulation studies, we show that modeling multiple offspring can dramatically increase genotype calling accuracy

2016 BMC bioinformatics

77. A collection of non-human primate computed tomography scans housed in MorphoSource, a repository for 3D data Full Text available with Trip Pro

A collection of non-human primate computed tomography scans housed in MorphoSource, a repository for 3D data A dataset of high-resolution microCT scans of primate skulls (crania and mandibles) and certain postcranial elements was collected to address questions about primate skull morphology. The sample consists of 489 scans taken from 431 specimens, representing 59 species of most Primate families. These data have transformative reuse potential as such datasets are necessary for conducting high (...) power research into primate evolution, but require significant time and funding to collect. Similar datasets were previously only available to select research groups across the world. The physical specimens are vouchered at Harvard's Museum of Comparative Zoology. The data collection took place at the Center for Nanoscale Systems at Harvard. The dataset is archived on MorphoSource.org. Though this is the largest high fidelity comparative dataset yet available, its provisioning on a web archive

2016 Scientific data

78. Does Immediate Total-Body Computed Tomography Reduce Mortality and Time in the Emergency Department for Trauma Patients?

Society. Effect of whole-body CT during trauma resuscitation on survival: a retrospective, multicentre study. Lancet. 2009;373:1455-1461. 2. Weninger P, Mauritz W, Fridrich P, et al. Emergency room management of patients with blunt major trauma: evaluation of the multislice computed tomography protocol exempli?ed by an urban trauma center. J Trauma. 2007;62:584-591. 3. Wurmb TE, Frühwald P, Hopfner W, et al. Whole-body multislice computed tomography as the ?rst line diagnostic tool in patients (...) Does Immediate Total-Body Computed Tomography Reduce Mortality and Time in the Emergency Department for Trauma Patients? Systematic Review Snapshot TAKE-HOME MESSAGE Based only on retrospective observational cohort studies, immediate total-body computedtomography(CT)reducestimeintheemergencydepartment(ED)andto theoperatingroombutdoesnotreducemortalitycomparedwithselectiveimaging. Does Immediate Total-Body Computed Tomography Reduce Mortality and Time in the Emergency Department for Trauma

2013 Annals of Emergency Medicine Systematic Review Snapshots

79. Guidelines for Family-Centered Care in the Neonatal, Pediatric, and Adult ICU

Guidelines for Family-Centered Care in the Neonatal, Pediatric, and Adult ICU Guidelines for Family-Centered Care in the Neonatal, Pediatr... : Critical Care Medicine You may be trying to access this site from a secured browser on the server. Please enable scripts and reload this page. Login No user account? Lippincott Journals Subscribers , use your username or email along with your password to log in. Remember me on this computer Register for a free account Registered users can save articles (...) ( ). There are no randomized trials addressing the effect of open or flexible family presence on family -centered outcomes. Data from existing observational studies addressed family satisfaction with variable ICU accessibility. One study examined open versus restricted family presence and demonstrated no differences in information or comfort for the families ( ). Another study exposed families to open family presence with one group also receiving an information booklet ( ). When comparing unrestricted with open family

2017 Society of Critical Care Medicine

80. Surgical Perspective: Centers for Disease Control and Prevention Guideline for the Prevention of Surgical Site Infection 2017

Surgical Perspective: Centers for Disease Control and Prevention Guideline for the Prevention of Surgical Site Infection 2017 Surgical Perspective: Centers for Disease Control and Prevention Guideline for the Prevention of Surgical Site Infection 2017 | Surgical Infections

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