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181. Evaluation of the diagnostic accuracy of Computer-Aided Detection of tuberculosis on Chest radiography among private sector patients in Pakistan (PubMed)

retrospective data from CAD4TB and Xpert MTB/RIF testing carried out at two private TB treatment and diagnostic centers in Karachi. Sensitivity, specificity, potential Xperts saved, were computed and the receiver operator characteristic curves were constructed for four different models of CAD4TB. A total of 6,845 individuals with presumptive TB were enrolled in the study, 15.2% of which had MTB + ve result on Xpert. A high sensitivity (range 65.8-97.3%) and NPV (range 93.1-98.4%) were recorded for CAD4TB (...) Evaluation of the diagnostic accuracy of Computer-Aided Detection of tuberculosis on Chest radiography among private sector patients in Pakistan The introduction of digital CXR with automated computer-aided interpretation, has given impetus to the role of CXR in TB screening, particularly in low resource, high-burden settings. The aim of this study was to evaluate the diagnostic accuracy of CAD4TB as a screening tool, implemented in the private sector in Karachi, Pakistan. This study analyzed

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2018 Scientific reports

182. Geographic Availability of Low-Dose Computed Tomography for Lung Cancer Screening in the United States, 2017 (PubMed)

JC Lung Cancer Alliance, Washington, DC. eng T32 GM081740 GM NIGMS NIH HHS United States Journal Article Research Support, N.I.H., Extramural 2018 10 04 United States Prev Chronic Dis 101205018 1545-1151 IM Aged Early Detection of Cancer Female Healthcare Disparities statistics & numerical data Humans Lung Neoplasms diagnosis mortality Male Mass Screening standards statistics & numerical data Middle Aged Radiation Dosage Tomography, X-Ray Computed statistics & numerical data United States 2018 10 (...) Geographic Availability of Low-Dose Computed Tomography for Lung Cancer Screening in the United States, 2017 30289107 2019 02 21 2019 02 21 1545-1151 15 2018 10 04 Preventing chronic disease Prev Chronic Dis Geographic Availability of Low-Dose Computed Tomography for Lung Cancer Screening in the United States, 2017. E119 10.5888/pcd15.180241 Eberth Jan M JM Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, 29208. Email

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2018 Preventing chronic disease

183. Privacy-preserving record linkage in large databases using secure multiparty computation (PubMed)

Privacy-preserving record linkage in large databases using secure multiparty computation Practical applications for data analysis may require combining multiple databases belonging to different owners, such as health centers. The analysis should be performed without violating privacy of neither the centers themselves, nor the patients whose records these centers store. To avoid biased analysis results, it may be important to remove duplicate records among the centers, so that each patient's (...) data would be taken into account only once. This task is very closely related to privacy-preserving record linkage.This paper presents a solution to privacy-preserving deduplication among records of several databases using secure multiparty computation. It is build upon one of the fastest practical secure multiparty computation platforms, called Sharemind.The tests on ca 10 million records of simulated databases with 1000 health centers of 10000 records each show that the computation is feasible

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2018 BMC medical genomics

184. qCon: QoS-Aware Network Resource Management for Fog Computing (PubMed)

qCon: QoS-Aware Network Resource Management for Fog Computing Fog computing is a new computing paradigm that employs computation and network resources at the edge of a network to build small clouds, which perform as small data centers. In fog computing, lightweight virtualization (e.g., containers) has been widely used to achieve low overhead for performance-limited fog devices such as WiFi access points (APs) and set-top boxes. Unfortunately, containers have a weakness in the control (...) of network bandwidth for outbound traffic, which poses a challenge to fog computing. Existing solutions for containers fail to achieve desirable network bandwidth control, which causes bandwidth-sensitive applications to suffer unacceptable network performance. In this paper, we propose qCon, which is a QoS-aware network resource management framework for containers to limit the rate of outbound traffic in fog computing. qCon aims to provide both proportional share scheduling and bandwidth shaping

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2018 Sensors (Basel, Switzerland)

185. Sonographically estimated risks of malignancy for thyroid nodules computed with five standard classification systems: changes over time and their relation to malignancy. (PubMed)

systems (e.g., Thyroid Image Reporting and Data Systems [TIRADS]). We conducted a longitudinal study to evaluate the temporal stability of the initial risk estimates computed with five widely used systems and to determine whether risk class increases during follow-up are indeed predictive of malignancy.We re-analyzed data prospectively collected at a single academic referral center on 232 patients (age: 54.1 ± 13.7 years) with 432 asymptomatic, sonographically or cytologically benign thyroid nodules (...) Sonographically estimated risks of malignancy for thyroid nodules computed with five standard classification systems: changes over time and their relation to malignancy. Over 50% of newly diagnosed thyroid nodules are either cytologically benign or presumed to be benign on the basis of low-suspicion sonographic findings. The strategies used for their long-term surveillance are based mainly on the estimated residual risk of malignancy calculated with various ultrasonographic classification

2018 Thyroid

186. Assessment of Visual Function With a Portable Brain-computer Interface

Assessment of Visual Function With a Portable Brain-computer Interface Assessment of Visual Function With a Portable Brain-computer Interface - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Assessment (...) of Visual Function With a Portable Brain-computer Interface The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03760055 Recruitment Status : Enrolling by invitation First Posted : November 30, 2018 Last Update Posted : February 12, 2019 Sponsor: NGoggle Collaborators: Duke University National Eye Institute

2018 Clinical Trials

187. Prognostic Value of Cardiovascular Magnetic Resonance and Single-Photon Emission Computed Tomography in Suspected Coronary Heart Disease: Long-Term Follow-up of a Prospective, Diagnostic Accuracy Cohort Study. (PubMed)

Prognostic Value of Cardiovascular Magnetic Resonance and Single-Photon Emission Computed Tomography in Suspected Coronary Heart Disease: Long-Term Follow-up of a Prospective, Diagnostic Accuracy Cohort Study. There are no prospective, prognostic data comparing cardiovascular magnetic resonance (CMR) and single-photon emission computed tomography (SPECT) in the same population of patients with suspected coronary heart disease (CHD).To establish the ability of CMR and SPECT to predict major (...) of MACE. Only CMR remained a significant predictor after adjustment for other cardiovascular risk factors, angiography result, or stratification for initial patient treatment.Data are from a single-center observational study (albeit conducted in a high-volume institution for both CMR and SPECT).Five-year follow-up of the CE-MARC study indicates that compared with SPECT, CMR is a stronger predictor of risk for MACEs, independent of cardiovascular risk factors, angiography result, or initial patient

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2016 Annals of Internal Medicine

188. The effect of augmenting OPTN data with external death data on calculating patient survival rates after organ transplantation. (PubMed)

; P = 0.8587) versus OPTN only, or OPTN + verified (HR, 1.05; 95% CI, 1.00-1.10; P = 0.0511), and OPTN + all (HR, 1.05; 95% CI, 1.00-1.10; P = 0.0353) versus OPTN + all (Assumed Alive).Patient survival rates varied minimally with augmented data sources, although using external death data without extending the survival time of recipients not identified in these sources results in a biased estimate. It remains important for transplant centers to maintain contact with transplant recipients and obtain (...) The effect of augmenting OPTN data with external death data on calculating patient survival rates after organ transplantation. Although the Organ Procurement and Transplantation Network (OPTN) database contains a rich set of data on United States transplant recipients, follow-up data may be incomplete. It was of interest to determine if augmenting OPTN data with external death data altered patient survival estimates.Solitary kidney, liver, heart, and lung transplants performed between January 1

2016 Transplantation

189. Single-Cell Gene Expression Profiling and Cell State Dynamics: Collecting Data, Correlating Data Points and Connecting the Dots (PubMed)

Single-Cell Gene Expression Profiling and Cell State Dynamics: Collecting Data, Correlating Data Points and Connecting the Dots Single-cell analyses of transcript and protein expression profiles-more precisely, single-cell resolution analysis of molecular profiles of cell populations-have now entered the center stage with widespread applications of single-cell qPCR, single-cell RNA-Seq and CyTOF. These high-dimensional population snapshot techniques are complemented by low-dimensional time (...) -resolved, microscopy-based monitoring methods. Both fronts of advance have exposed a rich heterogeneity of cell states within uniform cell populations in many biological contexts, producing a new kind of data that has triggered computational analysis methods for data visualization, dimensionality reduction, and cluster (subpopulation) identification. The next step is now to go beyond collecting data and correlating data points: to connect the dots, that is, to understand what actually underlies

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2016 Current opinion in biotechnology

190. Randomized controlled single center study comparing a polyhexanide containing bio-cellulose dressing with silver sulfadiazine cream in partial-thickness dermal burns

Randomized controlled single center study comparing a polyhexanide containing bio-cellulose dressing with silver sulfadiazine cream in partial-thickness dermal burns Randomized controlled single center study comparing a polyhexanide containing bio-cellulose dressing with silver sulfadiazine cream in partial-thickness dermal burns Randomized controlled single center study comparing a polyhexanide containing bio-cellulose dressing with silver sulfadiazine cream in partial-thickness dermal burns (...) epithelialisation (skin covering). The authors did not state the perspective. Effectiveness data: The primary measures of effectiveness were time to wound healing, and pain during and between dressing changes. Wound healing was assessed, using digital photographs, by two experienced wound specialists. Pain was measured on a 10-point visual analogue scale, immediately after dressing change, for pain during dressing change, and immediately before dressing change, for pain in between dressing changes. Wounds were

2011 NHS Economic Evaluation Database.

191. Mechanical Thrombectomy in Acute Ischemic Stroke: Initial Single-Center Experience and Comparison with Randomized Controlled Trials. (PubMed)

Mechanical Thrombectomy in Acute Ischemic Stroke: Initial Single-Center Experience and Comparison with Randomized Controlled Trials. Until recently, intravenous thrombolysis was the only reperfusion therapy with proven efficacy in patients with acute ischemic stroke. However, this treatment option has low recanalization rates in large-vessel occlusions. The search for additional treatments continued until 5 randomized trials (MR CLEAN, ESCAPE, EXTEND-IA, SWIFT PRIME, and REVASCAT) revealed (...) the superiority of mechanical thrombectomy for anterior circulation large-vessel occlusion. After 1 year of performing thrombectomy with stent retrievers in our tertiary hospital, we intended to answer the question: is it possible to achieve similar results in a "real-world" setting?We analyzed data from our prospective observational registry, compared it with the trials aforementioned, and concluded that the answer is affirmative.Our study population of 77 patients, with a mean age of 68,2 years and 48,1

2017 Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

192. An Interactive Patient-Centered Consent for Research Using Medical Records

, including the issues of the appropriate content and duration of informed consent and patient preferences about research use of clinical information. This study will design an electronic consent application intended to improve patients' satisfaction with and understanding of consent for research using their EHR data. The electronic application will provide interactive functionality that creates a virtual, patient-centered discussion with patients about research that uses EHR data. Also, to correct (...) of family medicine practices. Primary outcomes will be satisfaction with the consent decision and understanding of the consent content. This application will allow patients to learn more about clinical research and make informed choices about whether or not they want their health records and data to be used for research. This first phase of this project (IRB#:201500678) was innovative because it created a virtual, patient-centered discussion about research using EHR data. Moreover, this project produced

2017 Clinical Trials

193. Prevention of Substance Use in At-Risk Students: A Family-Centered Web Program

Prevention of Substance Use in At-Risk Students: A Family-Centered Web Program Prevention of Substance Use in At-Risk Students: A Family-Centered Web Program - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Prevention of Substance Use in At-Risk Students: A Family-Centered Web Program The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03060291 Recruitment Status : Active, not recruiting First Posted : February 23, 2017 Last Update Posted : October 15, 2018 Sponsor: University of Oregon Collaborator: National

2017 Clinical Trials

194. Health Coaching & Technology in a Weight Loss Center

staff, and clinicians in the development and implementation of new therapeutic modalities. The study aims to evaluate a telehealth-based health coaching program that is embedded in the Dartmouth-Hitchcock Weight and Wellness Center that integrates novel remote monitoring technology in effecting behavioral change using Amulet, a Dartmouth Computer Science developed mHealth device over a 16-week period. First, the feasibility and accessibility of an eHealth-delivered health coaching obesity (...) A Batsis, MD Dartmouth-Hitchcock Medical Center More Information Go to Layout table for additonal information Responsible Party: John A. Batsis, MD, Associate Professor of Medicine and The Dartmouth Institute for Health Policy & Clinical Practice, Dartmouth-Hitchcock Medical Center ClinicalTrials.gov Identifier: Other Study ID Numbers: D17123 First Posted: October 16, 2017 Last Update Posted: January 8, 2019 Last Verified: January 2019 Individual Participant Data (IPD) Sharing Statement: Plan to Share

2017 Clinical Trials

195. A Multi-center Study of VAL-083 in Patients With Recurrent Platinum Resistant Ovarian Cancer

. Joseph's Hospital and Medical Center - Phoenix, Arizona More Information Go to Layout table for additonal information Responsible Party: DelMar Pharmaceuticals, Inc. ClinicalTrials.gov Identifier: Other Study ID Numbers: DLM-17-001 First Posted: September 13, 2017 Last Update Posted: February 21, 2019 Last Verified: February 2019 Individual Participant Data (IPD) Sharing Statement: Plan to Share IPD: No Plan Description: The Clinical Study Report for this trial will be prepared and provided to the U.S (...) A Multi-center Study of VAL-083 in Patients With Recurrent Platinum Resistant Ovarian Cancer A Multi-center Study of VAL-083 in Patients With Recurrent Platinum Resistant Ovarian Cancer - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more

2017 Clinical Trials

196. Implementation-effectiveness trial of an ecological intervention for physical activity in ethnically diverse low income senior centers. (PubMed)

Implementation-effectiveness trial of an ecological intervention for physical activity in ethnically diverse low income senior centers. As the US population ages, there is an increasing need for evidence based, peer-led physical activity programs, particularly in ethnically diverse, low income senior centers where access is limited.The Peer Empowerment Program 4 Physical Activity' (PEP4PA) is a hybrid Type II implementation-effectiveness trial that is a peer-led physical activity (PA (...) ) intervention based on the ecological model of behavior change. The initial phase is a cluster randomized control trial randomized to either a peer-led PA intervention or usual center programming. After 18 months, the intervention sites are further randomized to continued support or no support for another 6 months. This study will be conducted at twelve senior centers in San Diego County in low income, diverse communities. In the intervention sites, 24 peer health coaches and 408 adults, aged 50 years

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2017 BMC Public Health

197. Geographical Information System Evaluation and Trends of Nonaccidental Trauma at a Level I Trauma Center, Pilot Study. (PubMed)

Geographical Information System Evaluation and Trends of Nonaccidental Trauma at a Level I Trauma Center, Pilot Study. Although trauma may be considered a random act, geographical patterns of trauma potentially emerge. Our institution is unique in that it rests at an intersection of two of the highest areas of poverty and assault in New York City and has adequate data to analyze these patterns.We review the incident reports logged by emergency medical services (EMS) technicians arriving (...) with intentionally injured trauma patients from January 1 to December 31, 2013 at a single institution. After acquisition of this data, it was placed into a computer file using an individual identifying numbers for each incident along with latitude and longitude coordinates determined by global positioning software for each event. The data were separated into blunt and penetrating categories. Penetrating trauma was further separated into the type of instrument used: edged weapon or firearm. Kernel density

2017 Annals of Surgery

198. pSCANNER: patient-centered Scalable National Network for Effectiveness Research. (PubMed)

to integrate data from three existing networks covering over 21 million patients in all 50 states: (1) VA Informatics and Computing Infrastructure (VINCI), with data from Veteran Health Administration's 151 inpatient and 909 ambulatory care and community-based outpatient clinics; (2) the University of California Research exchange (UC-ReX) network, with data from UC Davis, Irvine, Los Angeles, San Francisco, and San Diego; and (3) SCANNER, a consortium of UCSD, Tennessee VA, and three federally qualified (...) health systems in the Los Angeles area supplemented with claims and health information exchange data, led by the University of Southern California. Initial use cases will focus on three conditions: (1) congestive heart failure; (2) Kawasaki disease; (3) obesity. Stakeholders, such as patients, clinicians, and health service researchers, will be engaged to prioritize research questions to be answered through the network. We will use a privacy-preserving distributed computation model with synchronous

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2017 Journal of the American Medical Informatics Association

199. Using Discrete-Event Simulation to Promote Quality Improvement and Efficiency in a Radiation Oncology Treatment Center. (PubMed)

Using Discrete-Event Simulation to Promote Quality Improvement and Efficiency in a Radiation Oncology Treatment Center. To meet demand for radiation oncology services and ensure patient-centered safe care, management in an academic radiation oncology department initiated quality improvement efforts using discrete-event simulation (DES). Although the long-term goal was testing and deploying solutions, the primary aim at the outset was characterizing and validating a computer simulation model (...) of existing operations to identify targets for improvement.The adoption and validation of a DES model of processes and procedures affecting patient flow and satisfaction, employee experience, and efficiency were undertaken in 2012-2013. Multiple sources were tapped for data, including direct observation, equipment logs, timekeeping, and electronic health records.During their treatment visits, patients averaged 50.4 minutes in the treatment center, of which 38% was spent in the treatment room. Patients

2017 Quality Management in Health Care

200. Visual Shape Perception as Bayesian Inference of 3D Object-Centered Shape Representations. (PubMed)

similarity task, and present an extensive evaluation of existing models' abilities to account for the experimental data. We find that our shape inference model captures subjects' behaviors better than competing models. Taken as a whole, our experimental and computational results illustrate the promise of our approach and suggest that people's shape representations of unfamiliar objects are probabilistic, 3D, and object-centered. (PsycINFO Database Record(c) 2017 APA, all rights reserved). (...) of unfamiliar objects can be characterized as statistical inference of 3D shape in an object-centered coordinate system. We describe a computational model based on our theoretical framework, and provide evidence for the model along two lines. First, we show that, counterintuitively, the model accounts for viewpoint-dependency of object recognition, traditionally regarded as evidence against people's use of 3D object-centered shape representations. Second, we report the results of an experiment using a shape

2017 Psychological Review

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