How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

858 results for

Common Clotting Pathway

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

161. Cladribine (Mavenclad) - multiple sclerosis

in neurological impairment and severe disability. The present application seeks approval of cladribine for the treatment of adult patients with highly active relapsing remitting multiple sclerosis (RRMS) as defined by clinical or imaging features. During the course of the procedure the target population was revised to adult patients with highly active relapsing MS (RMS). 2.1.2. Epidemiology MS is the most common cause of serious neurological disability in young adults. It is estimated that more than 2.3 (...) concentrations found with therapeutic doses (22 –29 ng/ml in human plasma). As part of general pharmacology studies the effects of cladribine on blood coagulation system (prothrombin time, activated partial thromboplastin, fibrinogen concentration), blood clotting time, ADP-induced platelet aggregation and haemolytic effects were studied using blood of rabbits and in vivo studies in dogs. At concentrations between 0.1 – 100 µM no effect was observed. Safety pharmacology programme The tests included

2017 European Medicines Agency - EPARs

162. Social Determinants of Risk and Outcomes for Cardiovascular Disease

on cardiovascular outcomes. Such interventions might be directed at individual’s underlying abilities to develop and maintain relationships or might be directed at a social milieu rather than at individuals. Finally, the possibility remains that low social support does not lie in the causal pathway. Further investigation of the mechanisms linking low support and CVD may be helpful. The degree to which low social support interacts with other social determinants of cardiovascular health remains somewhat unclear (...) of beliefs and behaviors characteristic of a definable group that is transmitted without biological inheritance. Despite the difficulties, the concept is useful for understanding some differences in prevalence and treatment of illness. Poor control of type 2 diabetes mellitus is particularly common among Mexican American farm workers. Researchers from Stanford University interviewed adult patients with diabetes mellitus at 2 farm worker clinics, 1 in California and 1 in Oregon, and found that many

2015 American Heart Association

163. Guidelines for the Management of Spontaneous Intracerebral Hemorrhage

/seizure management, and other medical complications; procedures, including management of intracranial pressure (ICP), intra- ventricular hemorrhage, and the role of surgical clot removal; outcome prediction; prevention of recurrent ICH; rehabilita- tion; and future considerations. Each subcategory was led by a primary author, with 1 or 2 additional authors making contri- butions. Full PubMed searches were conducted of all English language articles regarding relevant human disease treatment from 2009 (...) of patients with ICH is crucial, because early deterioration is common in the first few hours after ICH onset. More than 20% of patients will experience a decrease in the Glasgow Coma Scale (GCS) of 2 or more points between the prehospital emergency medical services (EMS) assessment and the initial evaluation in the emergency department (ED). 6 Furthermore, another 15% to 23% of patients demonstrate continued deterioration within the first hours after hospital arrival. 7,8 The risk for early neurological

Full Text available with Trip Pro

2015 American Heart Association

164. State-of-the-Art Methods for Evaluation of Angiogenesis and Tissue Vascularization

. , These tunnel spaces represent matrix conduits for EC motility, tube remodeling, and recruitment of mural cells to the abluminal surface of developing vessels to enable processes such as vessel remodeling and vascular basement membrane matrix assembly. In vitro models have been used as a primary discovery tool to identify critical regulators of the EC lumen and tube formation pathway, which were later confirmed with in vivo models. They have also have been extensively used to confirm in vivo findings (...) into a collagen or fibrin matrix. A common strategy to focally seed ECs into a matrix is to coat beads with ECs and then embed these EC-coated beads into a 3D matrix. Alternatively, ECs can be allowed to form 3D spheroidal aggregates that can similarly be delivered as focal starting points into a 3D matrix. Spheroidal aggregates of human ECs have also been transplanted in a 3D matrix into immunocompromised mice to generate a 3D capillary network that anastomoses with the mouse vasculature and is perfused

Full Text available with Trip Pro

2015 American Heart Association

165. Basic Concepts and Potential Applications of Genetics and Genomics for Cardiovascular and Stroke Clinicians

of this article. Previous versions: Introduction Although genetics and genomics play an increasingly large role in the practice of medicine, the clinical care of patients suffering from cardiovascular disease or stroke has not been significantly affected. This is despite the tremendous strides being made to understand the genetic basis of both rare and common cardiovascular and stroke disorders through techniques such as genome-wide association studies (GWASs) and next-generation sequencing studies. Much (...) is that their DNA variants affect the function of genes. There are rare variants that have a large effect on the function of a gene by either significantly increasing or decreasing the activity of the gene; these are the kind of variants that cause disease in many members of a single family and are known as mutations. Classic examples include hypertrophic cardiomyopathy and Marfan syndrome. There are common variants (>1% of the general population) that have a small effect on the function of a gene

Full Text available with Trip Pro

2015 American Heart Association

166. Adult Sinusitis

topical or systemic antifungal agents Introduction Sinusitis affects about 1 in 8 adults in the United States, resulting in over 30 million annual diagnoses. , The direct cost of managing acute and chronic sinusitis exceeds $11 billion per year, , with additional expense from lost productivity, reduced job effectiveness, and impaired quality of life. - More than 1 in 5 antibiotics prescribed in adults are for sinusitis, making it the fifth most common diagnosis responsible for antibiotic therapy (...) %), and the individuals surveyed were almost as likely to receive a diagnosis of rhinosinusitis as they were of asthma (13%). The broad category of rhinosinusitis in the preceding paragraph includes ARS and CRS. Most ARS begins when a viral upper respiratory infection (URI) extends into the paranasal sinuses, which may be followed by bacterial infection. About 20 million cases of presumed bacterial ARS (ABRS) occur annually in the United States, rendering it one of the most common conditions encountered by clinicians

2015 American Academy of Otolaryngology - Head and Neck Surgery

167. Practice Guidelines for Perioperative Blood Management

. Observational studies and case reports indicate that certain congenital or acquired conditions ( e.g. , sickle-cell anemia, clotting factor deficiency, hemophilia, and liver disease) may be associated with blood transfusion complications (Category B3/B4-H evidence ) In addition, observational studies indicate that findings from pertinent preoperative laboratory tests ( e.g. , hemoglobin, hematocrit, coagulation tests) may be predictive of perioperative blood loss, the risk of transfusion, or other adverse (...) or “pathways” during a procedure whereby certain interventions should be employed. Literature Findings: RCTs comparing multimodal protocols or algorithms using coagulation tests or hemoglobin concentrations with routine blood management practices report variable findings regarding blood and blood product transfusions when such protocols are implemented (Category A2-E evidence ). RCTs demonstrate reduced blood transfusions and percentage of patients transfused when thromboelastrography (TEG)-guided

2015 American Society of Anesthesiologists

168. Scientific Rationale for the Inclusion and Exclusion Criteria for Intravenous Alteplase in Acute Ischemic Stroke

, arteriovenous malformation; CT, computed tomography; ECT, ecarin clotting time; FDA, US Food and Drug Administration; INR, international normalized ratio; OAC, oral anticoagulant; PT, partial thromboplastin time; rtPA, recombinant tissue-type plasminogen activator; SAH, subarachnoid hemorrhage; and TT, thrombin time. Reprinted from Jauch et al. Copyright © 2013, American Heart Association, Inc. Some of these exclusions are much more common than others, and some are potentially treatable, modifiable (...) have already undergone extensive scientific study such as the clear benefit of alteplase treatment in elderly stroke patients, those with severe stroke, those with diabetes mellitus and hyperglycemia, and those with minor early ischemic changes evident on computed tomography. Some exclusions such as recent intracranial surgery are likely based on common sense and sound judgment and are unlikely to ever be subjected to a randomized, clinical trial to evaluate safety. Most other contraindications

Full Text available with Trip Pro

2015 American Heart Association

169. Guidelines for the management of spontaneous intracerebral hemorrhage

compression stockings did not reduce DVT, pulmonary embolism (PE), or death. CLOTS 2 found that DVT was more common in patients who had below-knee graduated compression stockings than in those with thigh-high graduated compression stockings. Finally, CLOTS 3 enrolled 2876 patients (376 with ICH) and found that intermittent pneumatic compression begun as early as the day of hospital admission reduced the occurrence of proximal DVT, with the effect being particularly prominent in patients with hemorrhagic (...) and assessment of ICH and its causes; hemostasis and coagulopathy; blood pressure (BP) management; inpatient management, including general monitoring and nursing care, glucose/temperature/seizure management, and other medical complications; procedures, including management of intracranial pressure (ICP), intraventricular hemorrhage, and the role of surgical clot removal; outcome prediction; prevention of recurrent ICH; rehabilitation; and future considerations. Each subcategory was led by a primary author

Full Text available with Trip Pro

2015 American Academy of Neurology

170. Guidelines for the Management of Spontaneous Intracerebral Hemorrhage

/seizure management, and other medical complications; procedures, including management of intracranial pressure (ICP), intra- ventricular hemorrhage, and the role of surgical clot removal; outcome prediction; prevention of recurrent ICH; rehabilita- tion; and future considerations. Each subcategory was led by a primary author, with 1 or 2 additional authors making contri- butions. Full PubMed searches were conducted of all English language articles regarding relevant human disease treatment from 2009 (...) of patients with ICH is crucial, because early deterioration is common in the first few hours after ICH onset. More than 20% of patients will experience a decrease in the Glasgow Coma Scale (GCS) of 2 or more points between the prehospital emergency medical services (EMS) assessment and the initial evaluation in the emergency department (ED). 6 Furthermore, another 15% to 23% of patients demonstrate continued deterioration within the first hours after hospital arrival. 7,8 The risk for early neurological

2015 Congress of Neurological Surgeons

171. Secondary Prevention After Coronary Artery Bypass Graft Surgery

hemostasis by averting the activation and consumption of clotting factors and platelets associated with bypass. However, the clotting disorders and platelet dysfunction induced by cardiopulmonary bypass may actually have desirable effects by protecting anastomosis patency and preventing graft thrombosis. Several reports have documented the existence of a relative hypercoagulable state after off-pump surgery, associated with higher levels of postoperative platelet activity and a decrease in platelet

Full Text available with Trip Pro

2015 American Heart Association

172. Interventional Spine and Pain Procedures in Patients on Antiplatelet and Anticoagulant Medications

are mainly found in anterior and lateral aspects of the epidural space. Furthermore, the fragility of these vessels increases with age. Igarashi et al demonstrated blood vessel trauma in 28% of patients who underwent an epidural puncture at L2 to L3. The size of the venous plexus changes with the segmental localization of the anastomoses. Large diameter anastomoses exist at the C6 to C7, superior thoracic, and entire lumbar regions. These vessels are often located at sites of common interventional pain (...) effects, including dose-dependent inhibition of platelet function, suppression of plasma coagulation, and enhancement of fibrinolysis. Secondary hemostasis and thrombus stability is also impaired, due to aspirin’s acetylation of fibrinogen and its enhancement of fibrinolysis. Aspirin, unlike non–aspirin NSAIDs, decreases thrombin formation in clotting blood. Aspirin at higher doses prevents endothelial cell prostacyclin production by inhibiting COX-2. Prostacyclin inhibits platelet coagulation

2015 American Society of Regional Anesthesia and Pain Medicine

173. Use of Biomarkers to Guide Decisions on Systemic Therapy for Women With Metastatic Breast Cancer

skeletal tissue, so that at least some of the tumor can be processed without having to undergo decalcification, would be clearly advantageous, but may not be practical on small-needle biopsy specimens. For needle biopsies of metastatic breast cancer to bone, submitting the accompanying blood clot in the specimen container separately from the fragments of bony tissue may yield viable tumor that would not have to undergo decalcification and could be used for the analysis of HER2 in breast cancer (...) sequencing of the tumor to initiate systemic therapy or direct selection of a new systemic therapy regimen outside of a research setting. However, the Panel notes that therapeutic clinical trials investigating specific pathways are ongoing, and study eligibility may require documentation of a specific genetic profile. This scenario is considered investigational and warrants detailed discussion with the patient about the lack of clinical utility of next-generation sequencing. Clinical Interpretation

Full Text available with Trip Pro

2015 American Society of Clinical Oncology Guidelines

174. ACS/ASCO Breast Cancer Survivorship Care Guideline

and Journal of Clinical Oncology . Copyright © 2015 American Cancer Society and American Society of Clinical Oncology. All rights reserved. No part of this document may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without written permission by the American Cancer Society or the American Society of Clinical Oncology. INTRODUCTION Section: Breast cancer is the most common noncutaneous (...) malignancy among women, representing 4 in 10 female cancer survivors in the United States. Long-term survival is common after breast cancer treatment, with a 5-year survival rate of almost 90% ; thus, addressing survivors' unique post-treatment needs is critical to providing quality health care. Nearly a decade ago, two landmark publications from the Institute of Medicine highlighted the importance of surveillance, health promotion, and assessing and managing the myriad of physical, psychological

2015 American Society of Clinical Oncology Guidelines

175. Surgical Management of Osteoarthritis of the Knee

), and the burden is increasing both as the prevalence of OA increases and also as patient expectations for treatment rise. Twenty seven million adults (more than 10 percent) of the US adult population had clinical osteoarthritis (OA) in 2005, and in 2009 OA was the fourth most common cause of hospitalization (Murphy & Helmick, 2012). OA is the leading indication for joint replacement surgery; 905,000 knee and hip replacements were performed in 2009 at a cost of 42.3 billion dollars (Murphy & Helmick, 2012 (...) genetic factors, trauma, prior meniscectomy, overuse, and infection. INCIDENCE AND PREVALENCE Twenty seven million adults (more than 10 percent) of the US adult population had clinical osteoarthritis (OA) in 2005, and in 2009 OA was the fourth most common cause of hospitalization (Murphy & Helmick, 2012). The incidence of knee osteoarthritis is estimated to affect 240 persons per 100,000/year. It is estimated that 9.9 million adults had symptomatic osteoarthritis of the knee in 2010. 29 With rising

2015 American Academy of Orthopaedic Surgeons

176. Radiologic Management of Thoracic Nodules and Masses

; Tan-Lucien H. Mohammed, MD 10 ; Jason W. Pinchot, MD 11 ; Anthony G. Saleh, MD 12 ; Henning Willers, MD 13 ; Eric J. Hohenwalter, MD. 14 Summary of Literature Review Introduction/Background Lung cancer causes more deaths than the next 3 most common cancers combined (colon, breast, and prostate). An estimated 162,460 deaths from lung cancer occur in the United States each year, and the incidence of the disease is rising [1]. The diagnosis of lung cancer carries a very poor prognosis; the expected 5 (...) complication rates compared to solid organ biopsy. The Society of Interventional Radiology has published guidelines stating that an overall complication rate of 10% is acceptable for lung biopsies, compared to 2% for all other organ systems [10]. The most common complication of percutaneous lung biopsy is bleeding (hemoptysis, chest wall, parenchymal); however, the most common complication requiring intervention is pneumothorax (10%–30%). Chest tube insertion is needed in approximately ACR Appropriateness

2015 American College of Radiology

177. Guidelines for the treatment of malaria. Third edition

2014; 6:CD008152. doi: 10.1002/14651858.CD008152.pub3. White NJ, Qiao LG, Qi G, Luzzatto L. Rationale for recommending a lower dose of primaquine as a Plasmodium falciparum gametocytocide in populations where G6PD deficiency is common. Malar J 2012;11:418. 4 | Treatment of uncomplicated Plasmodium falciparum malaria 42 Guidelines for the treatment of malaria 3 RD EDITIONThe population benefits of reducing malaria transmission with gametocytocidal drugs such as primaquine require that a very high (...) Vomiting is common in acute malaria and may be severe. Parenteral antimalarial treatment may therefore be required until oral administration is tolerated. Then a full 3-day course of ACT should be given. Anti-emetics are potentially sedative and may have neuropsychiatric adverse effects, which could mask or confound the diagnosis of severe malaria. They should therefore be used with caution. 4.7.4 | MANAGEMENT OF SEIZURES Generalized seizures are more common in children with P. falciparum malaria than

2015 World Health Organisation Guidelines

178. Hormone Therapy for the Menopause after Endometriosis Surgery – Friend or Foe?

of the condition is reserved to keyhole surgery and laboratory analysis of biopsies as ultrasound scans have limited accuracy. The pathway to get referred to a hospital specialist and then get referred for keyhole surgery results in an average waiting time of 10 years between first symptoms and diagnosis. Endometriosis – what can be done about it? The Mirena progesterone-releasing coil can reduce pain but prevents conception The disease is believed to be dependent on oestrogen which is a hormone produced from (...) a woman’s ovaries. Common treatments aim to prevent cyclical fluctuation in these hormones by inhibiting ovulation and the most readily used treatment is the combined contraceptive pill. A found that the progesterone releasing coil, Mirena, has beneficial effects on pain, but like other coils prevents conception. Surgically treating these cells via keyhole surgery with techniques to burn or cut out the lesions of endometriosis has a beneficial effect on pain and fertility. However, the recurrence rate

2015 Evidently Cochrane

179. HTA of Atrial Fibrillation Screening

Authority iii Foreword Atrial fibrillation (AF), the most common arrhythmia seen in general practice, is a major cause of morbidity and mortality in Ireland. Not only is it associated with a fivefold increase in the risk of stroke, but these strokes are more likely to be fatal compared with non-AF strokes, and a greater proportion of survivors are left with significant functional impairment. The overall burden of AF is increasing as our population ages, making it ever more important that the arrhythmia (...) by routine practice. Increasing the start age of screening or the screening interval may improve the cost-effectiveness of a prospective screening programme. HTA of a national screening programme for atrial fibrillation in primary care Health Information and Quality Authority xiii Executive Summary 1. Background Atrial fibrillation (AF) is the most common arrhythmia seen in general practice and is associated with a five-fold increase in the risk of stroke. Strokes related to atrial fibrillation are also

2015 Health Information and Quality Authority

180. Diagnosis and investigation of AL amyloidosis

is uncommon unless amyloidosis is associated with myeloma, bleeding or chronic kidney disease. An abnormal clotting screen is relatively common; a prolonged thrombin time is the most frequent abnormality, but is of no clinical consequence. A prolonged prothrombin time is the only coagulation abnormality associated with bleeding (Mumford et al. ). Elevation of NT–proBNP and cardiac troponin T (TnT) concentrations are seen in a wide variety of cardiac conditions and in chronic kidney disease. However (...) . , Bartram, C.R. , Ho, A.D. , Goldschmidt, H. , Jauch, A. & Schonland, S.O. ( 2008 ) Evaluation of the cytogenetic aberration pattern in amyloid light chain amyloidosis as compared with monoclonal gammopathy of undetermined significance reveals common pathways of karyotypic instability . Blood , 111 , 4700 – 4705 . Bochtler, T. , Hegenbart, U. , Heiss, C. , Benner, A. , Moos, M. , Seckinger, A. , Pschowski‐Zuck, S. , Kirn, D. , Neben, K. , Bartram, C.R. , Ho, A.D. , Goldschmidt, H. , Hose, D. , Jauch

2014 British Committee for Standards in Haematology

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>