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Comedolytic

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21. Acne Vulgaris (Follow-up)

treatments, alone or in combination, is most appropriate. Current consensus recommends a combination of topical retinoid and antimicrobial therapy as first-line therapy for almost all patients with acne. [ ] The superior efficacy of this combination, compared with either monotherapy, results from complementary mechanisms of action targeting different pathogenic factors. Retinoids reduce abnormal desquamation, are comedolytic, and have some anti-inflammatory effects, whereas benzoyl peroxide (...) is antimicrobial with some keratolytic effects and antibiotics have anti-inflammatory and antimicrobial effects. [ ] Note the images below. Acne with reactive hyperpigmentation; before treatment. Acne with reactive hyperpigmentation; after treatment. Topical treatments Retinoids Topical retinoids are comedolytic and anti-inflammatory. They normalize follicular hyperproliferation and hyperkeratinization. Topical retinoids reduce the numbers of microcomedones, comedones, and inflammatory lesions. [ ] Topical

2014 eMedicine.com

22. Acne Vulgaris (Treatment)

treatments, alone or in combination, is most appropriate. Current consensus recommends a combination of topical retinoid and antimicrobial therapy as first-line therapy for almost all patients with acne. [ ] The superior efficacy of this combination, compared with either monotherapy, results from complementary mechanisms of action targeting different pathogenic factors. Retinoids reduce abnormal desquamation, are comedolytic, and have some anti-inflammatory effects, whereas benzoyl peroxide (...) is antimicrobial with some keratolytic effects and antibiotics have anti-inflammatory and antimicrobial effects. [ ] Note the images below. Acne with reactive hyperpigmentation; before treatment. Acne with reactive hyperpigmentation; after treatment. Topical treatments Retinoids Topical retinoids are comedolytic and anti-inflammatory. They normalize follicular hyperproliferation and hyperkeratinization. Topical retinoids reduce the numbers of microcomedones, comedones, and inflammatory lesions. [ ] Topical

2014 eMedicine.com

23. Adapalene suppresses sebum accumulation via the inhibition of triacylglycerol biosynthesis and perilipin expression in differentiated hamster sebocytes in vitro. (PubMed)

Adapalene suppresses sebum accumulation via the inhibition of triacylglycerol biosynthesis and perilipin expression in differentiated hamster sebocytes in vitro. Acne is a chronic inflammatory disease in sebaceous glands and pilosebaceous units where excess sebum production and follicular hyperkeratinization are observed. Adapalene, which exerts comedolytic and anti-inflammatory effects, is used for the topical treatment of mild to moderate acne.We examined the effect of adapalene on sebum

2013 Journal of dermatological science

24. Efficacy of the addition of salicylic acid to clindamycin and benzoyl peroxide combination for acne vulgaris. (PubMed)

Efficacy of the addition of salicylic acid to clindamycin and benzoyl peroxide combination for acne vulgaris. Clindamycin phosphate (CDP), benzoyl peroxide (BPO) and salicylic acid (SA) are known to be effective acne therapy agents depending on their anti-inflammatory and comedolytic properties. The purpose of this study was to investigate the efficacy and tolerability of the addition of SA treatment to CDP and BPO (SA and CDP + BPO) and compare it with CDP + BPO in patients with mild

2012 The Journal of dermatology

25. Salicylic Acid Peels Versus Jessner's Solution for Acne Vulgaris: A Comparative Study. (PubMed)

Salicylic Acid Peels Versus Jessner's Solution for Acne Vulgaris: A Comparative Study. Salicylic acid was recently formulated in a hydroethanolic vehicle at a concentration of 20% to 30%. Salicylic acid has strong comedolytic effects because of its lipophilic nature.To compare the therapeutic efficacy and tolerability of salicylic acid peels with those of Jessner's solution peels in patients with acne vulgaris.Thirteen patients (13 men; mean age 22.6, range 20-28) with facial acne were enrolled

2012 Dermatologic Surgery

26. Benzoyl Peroxide

and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See for financial assistance information. Ontology: Benzoyl Peroxide (C0005088) Definition (NCI) A peroxide with antibacterial, irritant, keratolytic, comedolytic, and anti-inflammatory activity. Upon topical application, benzoyl peroxide decomposes to release oxygen which is lethal to the bacteria Proprionibacterium acnes. Due to its irritant effect

2015 FP Notebook

27. Keratolytic Agents

: Keratolytic Agents , Keratolytic From Related Chapters II. Preparations: Acne (Comedolytic) (0.1% cream, .025% gel) ( ) 0.1% gel 5-10% III. Preparations: Wart See -HP ( ) ( ) ( ) ( , ) IV. Preparations: Actininc Keratosis ( ) Diclofenac (Solaraze) to (ingenol mebutate) Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Keratolytic Agents." Click on the image (or right click) to open the source website in a new browser window. Related

2015 FP Notebook

28. Moderate Acne Vulgaris Management

is much less irritating than 5-10% is effective against P. acnes Continue with each step of acne management Follow-up Return in 6 weeks IV. Management: Step 2 - Comedolytics Indications Comedones Mild inflammatory s and s Preparations Continue topical in morning (from step 1) Add at night First-line options Topical ( ) Start with 0.025% cream at bedtime Also available as microsphere gel ( ) Start with 0.1% gel at bedtime Also available with as gel (0.1%/2.5%) Best tolerated topical retinoid Warn

2015 FP Notebook

29. Tretinoin: A Review of Its Anti-inflammatory Properties in the Treatment of Acne (PubMed)

Tretinoin: A Review of Its Anti-inflammatory Properties in the Treatment of Acne Tretinoin has been primarily used for the early stages of acne because of its proven comedolytic end benefits. This article reviews and updates the collective body of evidence of tretinoin in the treatment of acne, which suggests that this drug also possesses a broad range of acne-related immunomodulating properties that are capable of disrupting and hindering the various stages of the inflammatory cascade

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2011 The Journal of clinical and aesthetic dermatology

30. Comparison of tretinoin 0.05% cream and 3% alcohol-based salicylic acid preparation in the treatment of acne vulgaris. (PubMed)

Comparison of tretinoin 0.05% cream and 3% alcohol-based salicylic acid preparation in the treatment of acne vulgaris. No single effective topical treatment is available for treating all pathogenic factors causing acne vulgaris (AV). Salicylic acid (SA), tretinoin (all-TRA) and clindamycin phosphate (CDP) are known to to be effective agents depending on their comedolytic and anti-inflammatory properties.To compare the efficacy and tolerability of SA and CDP combination (SA+CDP) with all-TRA

2011 Journal of the European Academy of Dermatology and Venereology : JEADV

31. Efficacy and safety of topical nadifloxacin and benzoyl peroxide versus clindamycin and benzoyl peroxide in acne vulgaris: A randomized controlled trial. (PubMed)

Efficacy and safety of topical nadifloxacin and benzoyl peroxide versus clindamycin and benzoyl peroxide in acne vulgaris: A randomized controlled trial. Topical therapy with comedolytics and antibiotics are often advocated for mild and moderate severity acne vulgaris. Nadifloxacin, a new fluoroquinolone with anti-Propionibacterium acnes activity and additional anti-inflammatory activity, is approved for use in acne. This randomized controlled assessor blind trial compared the clinical

Full Text available with Trip Pro

2011 Indian journal of pharmacology

32. Randomized trial comparing a chemical peel containing a lipophilic hydroxy acid derivative of salicylic acid with a salicylic acid peel in subjects with comedonal acne. (PubMed)

Randomized trial comparing a chemical peel containing a lipophilic hydroxy acid derivative of salicylic acid with a salicylic acid peel in subjects with comedonal acne. Lipohydroxyacid is a lipophilic derivative of salicylic acid with comedolytic properties.To compare lipohydroxyacid and salicylic acid peels in subjects with comedonal acne.In this split face, randomized study, 20 subjects with comedonal acne received lipohydroxyacid peels on one side of the face, while the other side

2011 Journal of cosmetic dermatology

33. A 10% glycolic acid containing oil-in-water emulsion improves mild acne: a randomized double-blind placebo-controlled trial. (PubMed)

A 10% glycolic acid containing oil-in-water emulsion improves mild acne: a randomized double-blind placebo-controlled trial. Acne is characterized by hyperseborrhea, follicular hyperkeratosis, and growth of propionibacteria. Alpha hydroxy acids depending on the pH of the finished product exhibit comedolytic as well as antimicrobial properties.The aim of this study was to investigate an oil-in-water emulsion-containing 10% glycolic acid (pH 4; Dr. August Wolff GmbH & Co. KG Arzneimittel

2011 Journal of cosmetic dermatology

34. Study for Long-term Treatment of Acne Vulgaris With Skinoren Versus Differin

-term treatment period. Condition or disease Intervention/treatment Phase Acne Vulgaris Drug: skinoren Drug: differin Phase 4 Detailed Description: Differin gel, containing adapalene 0.1%, has been used now for several years in the topical treatment of mild to moderate acne. It has comedolytic and anti-inflammatory activities,and is equally effective and less irritant than other topical retinoids. Adapalene has been shown to maintain therapeutic effect achieved after three months of monotherapy

2011 Clinical Trials

35. Acne Vulgaris

-up. Consultation with a specialist may be necessary. How various drugs work in treating acne. Table Drugs Used to Treat Acne Drug Adverse Effects Comments Topical antibacterials Benzoyl peroxide 2.5%, 5%, and 10% gel, lotion, or wash Dry skin Possible bleaching of clothing and hair Allergic reactions (rarely) Comedolytic and antibacterial with very low to no development of resistance Should be used in all patients if tolerated Gel product usually preferred Benzoyl peroxide / erythromycin gel Dry (...) skin Possible bleaching of clothing and hair Allergic reactions (rarely) Some forms must be kept refrigerated Benzoyl peroxide / clindamycin gel Dry skin Possible bleaching of clothing and hair Allergic reactions (rarely) — Clindamycin 1% gel or lotion Diarrhea (rarely) Should be avoided in patients with inflammatory bowel disease Erythromycin 1.5 to 2% (multiple vehicles) Local irritation (rarely) Well-tolerated, but frequent development of bacterial resistance Topical comedolytics and exfoliants

2013 Merck Manual (19th Edition)

36. Efficacy and Tolerance of a Derivative of Salicylic Acid and 5% Benzoyl Peroxide in Facial Acne Vulgaris

. These treatments can be associated with local tolerance problems and/or antibiotic resistance. Salicylic acid has been shown to be an effective treatment for acne. LHA is a lipophilic hydroxy acid derivative of salicylic acid that has comedolytic and antibacterial properties. The objective of this trial was to compare the efficacy and tolerance of a cream formulation containing 0.3% LHA (LHA formulation) to a 5% benzoyl peroxide gel. Condition or disease Intervention/treatment Phase Acne Vulgaris Drug: Lipo

2008 Clinical Trials

37. A Clinical Study to Evaluate the Safety and Effectiveness of an Investigational Product Called CT Gel

or disease Intervention/treatment Phase Acne Vulgaris Acne Drug: CT Gel Drug: Clindamycin Gel (clindamycin ) Drug: Tretinoin Gel (tretinoin) Drug: Vehicle Gel Phase 3 Detailed Description: CT Gel is a fixed-combination product that addresses the multifactorial factors of acne vulgaris pathogenesis. Based on numerous nonclinical pharmacology studies of each active ingredient, it is expected that this new product will have three biological actions: 1) comedolytic, 2) antimicrobial, and 3) anti-inflammatory

2008 Clinical Trials

38. Effective over-the-counter acne treatments. (PubMed)

antibacterial agent, and salicylic acid, a mild comedolytic and antiinflammatory medication. Other, less-common OTC ingredients include sulfur, sodium sulfacetamide, and alpha hydroxy acids. Zinc, vitamin A, tea tree oil, and ayurvedic therapies also are available OTC for acne. Additional and better studies are needed to clarify the benefit of these latter medications.

2008 Seminars in Cutaneous Medicine and Surgery

39. Comedolysis by a lipohydroxyacid formulation in acne-prone subjects. (PubMed)

formulation twice daily for 2 weeks. Ten of 14 other women who presented the same skin condition remained untreated as controls. The comedolytic effect was assessed using non-invasive ultraviolet-light video recording combined with computerized image analysis. The cornified follicular plugs were progressively cleared in 10/12 LHA-treated women and in 3/10 untreated volunteers. Analytical assessments showed a significant decrease in both the number and total size of microcomedones in the LHA-treated women (...) . By contrast, no quantitative change was disclosed in the untreated group. It is concluded that the tested LHA formulation exerts comedolytic properties that might help in preventing post-summertime acne exacerbations.

2003 European journal of dermatology : EJD

40. Microdermabrasion for Acne

: microdermabrasion Phase 2 Detailed Description: Acne vulgaris remains among the most common cutaneous disorders, impacting the vast majority of people at some point during their lives. It is associated with significant psychosocial morbidity, and there remains the need for efficacious and low risk therapeutic options. Microdermabrasion is a technique combining abrasion and negative pressure used primarily in the treatment of aging skin. It has also been proposed to improve acne presumably through a comedolytic

2006 Clinical Trials

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