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Comedolytic

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1. Comedolytic

Comedolytic Comedolytic Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Comedolytic Comedolytic Aka: Comedolytic From Related Chapters (...) II. Indication III. Approach Comedolytics result in similar effect after 90 days Start with less irritating agents (see below) Apply skin products in layers First, apply Comedolytic Next, apply (skin ) Last, apply sun screen (2017) Presc Lett 24(1): 3 IV. Preparations: Standard Comedolytics (Ambi 10, Dermoxyl, Vanoxide and other OTC) Salicylic acid (Buf-Puf and other OTC) ( ) ( , 0.1% gel is OTC as of 2017) V. Preparations: Less Irritating Comedolytics Creams are less irritating than gels 2.5

2018 FP Notebook

2. Comedolytic

Comedolytic Comedolytic Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Comedolytic Comedolytic Aka: Comedolytic From Related Chapters (...) II. Indication III. Approach Comedolytics result in similar effect after 90 days Start with less irritating agents (see below) Apply skin products in layers First, apply Comedolytic Next, apply (skin ) Last, apply sun screen (2017) Presc Lett 24(1): 3 IV. Preparations: Standard Comedolytics (Ambi 10, Dermoxyl, Vanoxide and other OTC) Salicylic acid (Buf-Puf and other OTC) ( ) ( , 0.1% gel is OTC as of 2017) V. Preparations: Less Irritating Comedolytics Creams are less irritating than gels 2.5

2015 FP Notebook

3. Identification of a Unique Subset of 2-Methylene-19-Nor Analogs of Vitamin D with Comedolytic Activity in the Rhino Mouse. (PubMed)

Identification of a Unique Subset of 2-Methylene-19-Nor Analogs of Vitamin D with Comedolytic Activity in the Rhino Mouse. The active metabolite of vitamin D, 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)), and a series of 2-methylene-19-nor analogs of 1,25(OH)(2)D(3) were evaluated for their ability to reduce the size of utricles (comedolytic activity) in a rhino mouse model of acne. All analogs tested, as well as the native hormone, increased the skin epidermal thickness. In contrast, only (...) a subset of analogs that lacked a full side chain and 25-hydroxyl group were found to possess comedolytic activity. A reduction in comedone area could be achieved without adversely affecting serum calcium levels. Although all compounds that contained a side chain ranging from 2 to 5 carbons in length had similar potency as comedolytic agents, increasing the length of the side chain resulted in a progressive increase in calcemic liability. Dose-response studies of the comedolytic analogs showed

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2010 Journal of Investigative Dermatology

4. Acne - Guidelines for Prescribing Topical Treatment

%. (prescription required for > 5% strengths) Mildly comedolytic and antibacterial. First line therapy for mild to moderate acne. 5% formulations as effective as 10% prescription formulations with less skin irritation. Water-based formulations are less drying than alcohol-based products. Directions: Apply to entire affected area once daily at bedtime or twice daily Start with lower strength (2.5%-5%) or less frequent nighttime application (i.e. every other night) Increase strength or frequency as tolerated

2018 medSask

6. Microcomedones in non-lesional acne prone skin New orientations on comedogenesis and its prevention. (PubMed)

in MC were screened by proteomics, immunohistochemistry and Western blotting. The in vitro effects of a comedolytic Silybum marianum fruit extract (SMFE) were studied in sebocyte cultures by RNA-Seq and modulation of CYP1A1 by qPCR and enzymatic activity. MC severity was correlated to lesions counts and keratin expression during 48 weeks in 23 acne patients using a topical comedolytic formulation containing SMFE.Two infundibular keratins, K75 and K79, co-localized in MC with the sebocyte progenitor

2019 Journal of the European Academy of Dermatology and Venereology

7. Comparative Trial of Silver Nanoparticle Gel and 1% Clindamycin Gel when Use in Combination with 2.5% Benzoyl Peroxide in Patients with Moderate Acne Vulgaris. (PubMed)

Comparative Trial of Silver Nanoparticle Gel and 1% Clindamycin Gel when Use in Combination with 2.5% Benzoyl Peroxide in Patients with Moderate Acne Vulgaris. Treatments of acne vulgaris commonly use antimicrobials and comedolytic agents. Considering bacterial resistance to topical antibiotics, the alternative treatment such as silver manufactured into nanoparticle receives an attention. Silver nanoparticle has an antibacterial effect against Propionibacterium acnes and anti-inflammation

2018 Journal of the Medical Association of Thailand = Chotmaihet thangphaet

8. Nonclinical and human pharmacology of the potent and selective topical retinoic acid receptor-γ agonist trifarotene. (PubMed)

as the activity on the expression of retinoid target genes in human keratinocytes and ex vivo cultured skin. In vivo studies investigated topical comedolytic, anti-inflammatory and depigmenting properties. The trifarotene-induced gene expression profile was investigated in nonlesional skin of patients with acne and compared with ex vivo and in vivo models. Finally, the metabolic stability in human keratinocytes and hepatic microsomes was established.Trifarotene is a selective RARγ agonist with > 20-fold (...) selectivity over RARα and RARβ. Trifarotene is active and stable in keratinocytes but rapidly metabolized by human hepatic microsomes, predicting improved safety. In vivo, trifarotene 0·01% applied topically is highly comedolytic and has anti-inflammatory and antipigmenting properties. Gene expression studies indicated potent activation of known retinoid-modulated processes (epidermal differentiation, proliferation, stress response, retinoic acid metabolism) and novel pathways (proteolysis, transport/skin

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2018 British Journal of Dermatology

9. Mechanistic Insight into the Activity of a Sulfone Compound Dapsone on Propionibacterium (Newly Reclassified as Cutibacterium) Acnes-Mediated Cytokine Production. (PubMed)

Mechanistic Insight into the Activity of a Sulfone Compound Dapsone on Propionibacterium (Newly Reclassified as Cutibacterium) Acnes-Mediated Cytokine Production. Acne remains as the most common skin disease in the United States even despite multiple approved topical and systemic medications available. These treatments available over the counter and by prescription can be classified based on comedolytic, antibacterial and anti-inflammatory activities and are often used in combination. Therefore

2018 Experimental Dermatology

10. Why Topical Retinoids Are Mainstay of Therapy for Acne (PubMed)

Academy of Dermatology (AAD) and the European Dermatology Forum (EDF), have agreed that retinoids have an essential role in this widespread disease. The AAD states "retinoids are the core of topical therapy for acne because they are comedolytic, resolve the precursor microcomedone lesion, and are anti-inflammatory;" further, they "allow for maintenance of clearance." Despite uniform recommendation for use of topical retinoids, a recent study of prescribing practices from 2012 to 2014 indicated

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2017 Dermatology and therapy

11. New developments in acne treatment: role of combination adapalene–benzoylperoxide (PubMed)

New developments in acne treatment: role of combination adapalene–benzoylperoxide The fixed-dose combination adapalene 0.1%/benzoylperoxide 2.5% (A/BPO) was introduced as an acne vulgaris therapeutic in 2007. It combines anti-inflammatory, keratolytic, comedolytic, and antibacterial properties. Thus, it addresses several pathophysiological factors involved in the pathophysiology of acne. This review highlights the rationale for the use of this fixed-dose combination product, its therapeutic

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2016 Therapeutics and clinical risk management

12. Moderate Acne Vulgaris Management

is much less irritating than 5-10% is effective against P. acnes Continue with each step of acne management Follow-up Return in 6 weeks IV. Management: Step 2 - Comedolytics Indications Comedones Mild inflammatory s and s Preparations Continue topical in morning (from step 1) Add at night First-line options Topical ( ) Start with 0.025% cream at bedtime Also available as microsphere gel ( ) Start with 0.1% gel at bedtime Also available with as gel (0.1%/2.5%) Best tolerated topical retinoid Warn

2018 FP Notebook

13. Keratolytic Agents

: Keratolytic Agents , Keratolytic From Related Chapters II. Preparations: Acne (Comedolytic) (0.1% cream, .025% gel) ( ) 0.1% gel 5-10% III. Preparations: Wart See -HP ( ) ( ) ( ) ( , ) IV. Preparations: Actininc Keratosis ( ) Diclofenac (Solaraze) to (ingenol mebutate) Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Keratolytic Agents." Click on the image (or right click) to open the source website in a new browser window. Related

2018 FP Notebook

14. Benzoyl Peroxide

and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See for financial assistance information. Ontology: Benzoyl Peroxide (C0005088) Definition (NCI) A peroxide with antibacterial, irritant, keratolytic, comedolytic, and anti-inflammatory activity. Upon topical application, benzoyl peroxide decomposes to release oxygen which is lethal to the bacteria Proprionibacterium acnes. Due to its irritant effect

2018 FP Notebook

15. The Use of Lipohydroxy Acid in Skin Care and Acne Treatment (PubMed)

to induce dermal thickening by stimulating glycosaminoglycans, collagen, and elastin production. Finally, lipohydroxy acid has been demonstrated to possess comedolytic properties. This article reviews the available data on the use of lipohydroxy acid in treating aging skin and acne.

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2016 The Journal of clinical and aesthetic dermatology

16. Acne vulgaris

the use of topical agents including benzoyl peroxide, topical retinoids and topical antibiotics for mild to moderate acne. Benzoyl peroxide is antibacterial and mildly comedolytic — it is effective in mild to moderate acne and both comedones and inflamed lesions respond well [ ; ]. Addition of benzoyl peroxide to topical antibiotic therapies is recommended to reduce the risk of antibiotic resistance [ ; ; ; ; ]. Topical retinoids are comedolytic, anti-comedogenic, anti-inflammatory and inhibit (...) -bacterial effects [ ]. Topical monotherapy with antibiotics is not recommended because of the risk of antibiotic resistance [ ; ; ; ; ]. The American Academy of Dermatology [ ] recommend Clindamycin 1% solution or gel as the preferred topical antibiotic for acne. Azelaic acid Azelaic acid is mildly effective as a comedolytic, antibacterial, and anti-inflammatory agent [ ]. It is recommended as second-line treatment in several guidelines [ ; ; ]. Some people may prefer azelaic acid to benzoyl peroxide

2014 NICE Clinical Knowledge Summaries

17. 8 Week Study to Evaluate and Compare the Efficacy and Tolerability of MAXCLARITY II and MURAD To Treat Acne

and is often considered an important component of acne treatment. Salicylic acid has comedolytic properties and is often used when other topical therapies are not tolerated. Benzoyl peroxide and SA are frequently the first products that adolescents will use for acne because both can be purchased without a prescription in several different concentrations and formulations. One of the main success factors in acne therapy is user compliance with treatment, product cost, availability and ease of use. Poor

2015 Clinical Trials

18. Treatment of Acne Vulgaris With Salicylic Acid Chemical Peel and Pulsed Dye Laser: A Split Face, Rater-Blinded, Randomized Controlled Trial. (PubMed)

Treatment of Acne Vulgaris With Salicylic Acid Chemical Peel and Pulsed Dye Laser: A Split Face, Rater-Blinded, Randomized Controlled Trial. Pulsed dye laser (PDL) has been used to treat acne lesions and scar erythema by interrupting superficial vasculature. Salicylic acid chemical peels are employed chiefly due to their lipophilic, comedolytic, and anti-inflammatory properties. Although studies have looked at peels and laser therapy independently in acne management, we examined

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2015 Journal of lasers in medical sciences

19. An Efficiency of a Moisturizer Containing Licochalcone A, L-carnitine and 1,2-decanediol With Adapalene Gel in Acne

property could reduce irritant effects, emergent from using topical treatment and also reduce severity of acne. Research teams chose an adapalene gel to act as topical treatment for curing acne. It has anti-inflammatory and comedolytic effects and has fewer side effects than other groups of topical retinoic acids. However, peeling skin, redness skin, tingling sensation or itching sensation may occur if they are continually used for a long period. Thus, for the purpose of studying the efficacy

2014 Clinical Trials

20. Efficacy of 0.1% adapalene in a non-inflammatory Kyoto Rhino Rat acne model. (PubMed)

-inflammatory acne, and to investigate the comedolytic effects of adapalene in krh/krh rats.Krh/krh rats at 12weeks of age were topically treated with adapalene or a vehicle 6 times a week, for 12weeks. Skin lesions were clinically investigated and skin samples were obtained from treated skins from each animal after 6 and 12weeks of treatments.Comedone was clinically enlarged in the control group compared with the adapalene group. The adapalene group showed significantly increased epidermal thickness

2014 Journal of dermatological science

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