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Coma Exam

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641. Randomized Controlled Trial for Vestibular Treatment in Concussion

discovered during the examination. The three types are: 1) gaze stabilization for vestibulo-ocular reflex dysfunction, 2) visual-vestibular habituation exercise for visual motion sensitivity, and 3) balance exercises for standing balance or gat dysfunction. Experimental: Low Intensity/ High Frequency Participants will be assigned T-REV with low intensity (30% of perceived effort) and high frequency (exercises performed 2x/day) Behavioral: T-REV For any intervention that involves physical exercise, four (...) parameters must be specified to complete the prescription; Type (mode), Intensity, Frequency, and Time. o The standard of care vestibular rehabilitation exercise program consists of three types of treatments that target the specific impairments and limitations discovered during the examination. The three types are: 1) gaze stabilization for vestibulo-ocular reflex dysfunction, 2) visual-vestibular habituation exercise for visual motion sensitivity, and 3) balance exercises for standing balance or gat

2018 Clinical Trials

642. Treating Severe Brain-injured Patients With Apomorphine

to receive a 4-weeks regimen of daily subcutaneous infusions of apomorphine hydrochloride. Patients will be monitored for four weeks before the initiation of the therapy, closely during treatment and they will undergo a 4-weeks inpatient follow-up after washout, as well as a two-year long-term remote follow-up. Shortly before and after the treatment regimen, the subjects will receive a multimodal assessment battery including neuroimaging exams. Primary outcome will be determined as behavioral response (...) to treatment as measured by changes of diagnosis using the Coma Recovery Scale - Revised (CRS-R), while secondary outcome measures will include the Nociception Coma Scale - Revised (NCS-R, circadian rhythm modifications using actimetry, core body temperature recording and night electroencephalography (EEG), positron emission tomography (PET), resting-state high-density EEG and functional magnetic resonance imaging (fMRI). The Glasgow Outcome Scale - Extended (GOS-E) and a phone-adapted version of the CRS-R

2018 Clinical Trials

643. The Difference of Two Year Recurrence Rate According to Anesthetic Method During Transurethral Resection of Bladder Mass in Patients With Non-muscle Invasive Bladder Cancer: Prospective, Randomized, Clinical Phase II Study

Information provided by (Responsible Party): Ja Hyeon Ku, Seoul National University Hospital Study Details Study Description Go to Brief Summary: The investigators compare the recurrence rate difference between two years after transurethral resection of the bladder tumor according to the method of anesthesia. Anesthetic methods are general anesthesia and spinal anesthesia. Assessment of recurrence is assessed by bladder endoscopy, CT, and pathological examination of surgical specimens. Condition (...) that there is a correlation with maintenance of immune cell function Research hypothesis and purpose The aim of this study was to evaluate the recurrence rate, recurrence - free survival rate, and recurrence - free survival rate of non - muscle invasive bladder carcinoma in patients undergoing bladder resection. Research Method Preoperative screening: Physical examination, Blood test, CT urography, Urine analysis, Urine culture, Urine cytology, Cystoscopy. Enforced Randomization on the day before surgery: 289 patients

2018 Clinical Trials

644. Efficacy of 3 Regimens of Chloroquine and Primaquine for Treatment of P. Vivax Malaria, Cruzeiro do Sul, Acre, Brazil

. Documented fever (axillary temperature ≥37.5o C) or history of fever during the previous 48 hours in the absence of another obvious cause of fever, such as pneumonia, otitis media, etc 4. Monoinfection with P. vivax with parasitemia between 100 and 200,000 asexual parasites/µl as determined by microscopic examination of thick and thin peripheral blood smears 5. Informed consent from the patient or parent/guardian (for those <18 years), assent from child (ages 7 to 17 years inclusive), patients 5 through (...) . Presence of signs of severe malaria (WHO criteria) Cerebral malaria (unarousable coma) Severe anemia (hematocrit <15% or clinical signs) hemoglobin <5 mg/ml) (Note: we will use hemoglobin less than 8 mg/ml as exclusion criteria) Renal failure (serum creatinine >3 mg/dL or clinical signs) Pulmonary edema Hypoglycemia (blood glucose <40mg/dL or clinical signs) Shock (systolic blood pressure <70 mm Hg in adults; 50 mm Hg in children) Spontaneous bleeding/disseminate intravascular coagulation Repeated

2018 Clinical Trials

645. Pre-emptive Scalp Infiltration With Dexamethasone Plus Ropivacaine for Postoperative Pain After Craniotomy

opioids administration is regarded as the first-line analgesic for post-craniotomy pain management, it may be associated with delayed awakening, respiratory depression, hypercarbia and it may interfere with the neurologic examination. For the avoidance of side-effects of systemic opioids, local anesthetics administered around the incision have been performed clinically. However, some studies revealed that the analgesic effect of local anesthetics was not unsatisfactory due to its short pain relief (...) or analgesic effects; Psychiatric disorders; Uncontrolled epilepsy; Chronic headache; Pregnant or breastfeeding; Symptomatic cardiopulmonary, renal, liver, diabetes or other systemic dysfunctions; Preoperative Glasgow Coma Scale less than 15; Intracranial hypertension; Peri-incisional infection; Undergoing emergency or awake craniotomy surgery; Delayed extubation; Expected or unexpected operative Intensive Care; Participates who cannot use patient-controlled analgesia device; Participates who cannot

2018 Clinical Trials

646. Evaluation of the Effectiveness of Thrombolytic Therapy in Acute Ischemic Stroke Patients Using NIRS

there will be no adverse effects on the examination nor treatment and it cannot interfere with routine approach of these therapy. In our study participants' vital parameters (blood pressure, heart rate, respiratory rate, sat O2), glasgow coma scale, NIRS values and NIHSS will be recorded during thrombolytic therapy at every 15 minutes (0.min, 15.min, 30min, 45min, 60min) and at 120 minutes. Furthermore NIRS values and imaging results will be recorded for investigation. In addition, if complications that may arise

2018 Clinical Trials

647. tDCS in Pediatric Disorders of Consciousness

. Collaborator: Johns Hopkins University Information provided by (Responsible Party): Hugo W. Moser Research Institute at Kennedy Krieger, Inc. Study Details Study Description Go to Brief Summary: In this preliminary study, we will examine the safety, tolerability, and feasibility of transcranial direct current stimulation (tDCS), in the setting of dosage escalation, as a candidate intervention for children with Disorders of Consciousness (DOC). We will also explore the use of electroencephalography (EEG (...) components from pre-stimulation to post-stimulation. Changes in Coma Recovery Scale Revised (CRS-R) total scores as a measure of consciousness [ Time Frame: Up to 4 months ] CRS-R Questionnaire: Assessment of change from baseline, post-sham stimulation, and pre-stimulations (1 mA, 2 mA) using the standardized scale to measure the level of consciousness. Comparisons in the level of consciousness will also be made between the enrolled and non-enrolled groups. The total score of CRS-R ranges from 0 to 23

2018 Clinical Trials

648. Clinical Trial to Evaluate the Drug Drug Interaction of CKD-501 and D308

is determined to be suitable at the time of screening such as laboratory tests(hematology, blood chemistry, urinalysis, virus/bacteriological test, etc.), sign of vitality, electrocardiogram Subject who signed the written consent of the Chonbuk National University Hospital IRB to participate in this study with full understanding of the purpose and contents of the examination prior to the clinical trial Subject who has will and ability to participate in clinical trials Exclusion Criteria: Subject who has (...) months of screening Those taking prescription or non-prescription drugs within 10days before the first administration of clinical trial medication Those who donated whole blood within 2 months or those who donated the components within 1 month before the first administration of the clinical trial drug Subject who has risk of serious or chronic medical, mental, or laboratory examinations that may increase the risk due to the administration of medicines for clinical trials and may interfere

2018 Clinical Trials

649. SKY vs. HEP in PTSD

or HEP interventions as an add-on to their existing treatment schedules. This study will examine if patients with PTSD experience a reduction in PTSD symptoms from baseline to 12-week follow-up, as measured by the PCL-5 after receiving either HEP or SKY. Condition or disease Intervention/treatment Phase PTSD Other: Sudarshan Kriya Yoga Other: Health Enhancement Program Phase 2 Detailed Description: STUDY DESIGN: Single-center, blinded (rater, investigator, and clinician), longitudinal, RCT comparing (...) diagnoses will be screened by the MINI (Mini International Neuropsychiatric Interview). The CAPS5 will also be used to rule out severe depersonalization and derealization as per exclusion criteria. If the participant is above the age of 65 years of age, they will complete a cognitive screening test using the Mini Mental State Examination, MMSE>24 to rule out significant cognitive impairment. Participants meeting all study criteria who wish to join the study will be enrolled and assigned a unique study

2018 Clinical Trials

650. Diaphragmatic Ultrasound as a Guide Tool During Weaning From Mechanical Ventilation

phase of disease for which patient was intubated Adequate cough Absence of excessive tracheobronchial secretions B) Objective criteria:- Adequate oxygenation:PaO2>60mmHg with PEEP<8,SaO2>90%,FIO2 <0.5,PaO2/FIO2>200 Respiratory rate <30 PH and PaCO2 appropriate for patients' baseline respiratory status Hemodynamically stable :minimal or no vasopressor/inotropes,no evidence of myocardial ischemia HR<140 beats/minute Patient is arousable or Glasgow coma scale (GCS)>13 Experimental: Group SD weaning (...) beats/minute Patient is arousable or Glasgow coma scale (GCS)>13 C) Ultrasound criteria:- DTF> 30% DE>11 mm Device: diaphragmatic ultrasound A) Diaphragmatic thickening fraction The diaphragm thickness will be measured from the middle of the pleural line to the middle of the peritoneal line. Then, the diaphragmatic fraction thickening (DTF) will be calculated. B) Diaphragmatic excursion Diaphragmatic movement will be measured with a 3.5-MHz US probe (Mindray machine, DC-N6). Outcome Measures Go

2018 Clinical Trials

651. VR-based EF Rehabilitation for Pediatric TBI

-intervention assessment. Aim 1. Refine clinically-appropriate paradigms for VR childhood TBI rehabilitation research. Aim 2. Explore feasibility, safety and preliminary efficacy of the VICT program. The feasibility and safety of the VICT program will be examined through both quantitative measures (adverse events, simulator sickness, and fatigability) and a semi-structured interview with children, families, and clinicians regarding perceived benefits and challenges. Preliminary efficacy data (...) or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Layout table for eligibility information Ages Eligible for Study: 7 Years to 17 Years (Child) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: diagnosed with TBI between 7 to 17 years old (inclusive) lowest post-resuscitation Glasgow Coma Scale (GCS)=13-15 combined with trauma

2018 Clinical Trials

652. China Obstetrics Alliance Cohort Study

: Preeclampsia (PE) is one of a common type of hypertensive disorder complicating pregnancy (HDCP). It is a class of clinical syndromes which shows relevant symptoms, hypertension and proteinuria after 20 weeks pregnant as main characteristic, and may accompany with fetal anomaly and systemic multi-system organs damage. Several complications, such as eclamptic seizures, coma, intracranial hemorrhage (ICH), cardiac failure, pneumonedema, hepatic failure, kidney failure, placental abruption and disseminated (...) of calcium ion, heterotrophia and so on. However, there are numbers of epidemiologic study have analyzed high risk factor of PE which provides significant medical evidence of prevention, early diagnosis and early treatment for PE, there is only little study focus on susceptibility gene and pathogenic genetic variation. Nowadays, there are numerous clinical phenotype are considered to exist, different phenotype gives different inheritance and epigenetics. Thus, the investigator's group will examine

2018 Clinical Trials

653. Ischemia Modified Albumin in Traumatic Brain Injury

) Detailed Description: Consecutive adult patients who were admitted with TBI, blood samples were taken once written informed consent obtained. Initial evaluation on admission was performed simultaneously by ICU physician and a neurosurgical resident by means of a detailed physical and neurological examination. Demographic characteristics and vascular risk factors (hypertension, diabetes mellitus, hyperlipidemia, and peripheral ischemic disease) were recorded in details. Also, Routine blood tests (...) , including full blood count, coagulation tests, glucose level, renal and hepatic function tests, total protein, and albumin levels; chest radiography were done. CT scan will be performed in all the cases for the confirmation of TBI. Glasgow coma scale (GCS) was assessed on admission and recorded and assessed daily to evaluate prognosis. Patients were monitored by BP, ECG, and Pulse oximetry. All patients received standard medical treatment which included anti-edema measures mannitol 20%, 0.25-0.5 g/kg

2018 Clinical Trials

654. Scalp Infiltration With Methylprednisolone Plus Ropivacaine for Post-Craniotomy Pain in Children

of craniotomy adds (such as consciousness obstacle, sleepiness, et al) disturbance to the pain assessment in children. Although opioids administration is regarded as the first-line analgesic for post-craniotomy pain management, it may be associated with delayed awakening, respiratory depression, hypercarbia and it may interfere with the neurologic examination. For the avoidance of side-effects of systemic opioids, local anesthetics administered around the incision have been performed clinically. However (...) was defined as any untoward medical occurrence. An SAE included death, immediately life-threatening conditions, coma, in-patient hospitalisation or prolongation of existing hospitalisation. Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff

2018 Clinical Trials

655. Estimating the Integrated Information Measure Phi from High-Density Electroencephalography during States of Consciousness in Humans Full Text available with Trip Pro

introduce a practical method to estimate Φ from high-density (128-channel) EEG and determine the contribution of each channel to Φ. We examine the correlation of power, frequency, functional connectivity, and modularity of EEG with regional Φ in various states of consciousness as modulated by diverse anesthetics. We find that our approximation of Φ alone is insufficient to discriminate certain states of anesthesia. However, a multi-dimensional parameter space extended by four parameters related to Φ (...) and EEG connectivity is able to differentiate all states of consciousness. The association of Φ with EEG connectivity during clinically defined anesthetic states represents a new practical approach to the application of IIT, which may be used to characterize various physiological (sleep), pharmacological (anesthesia), and pathological (coma) states of consciousness in the human brain.

2018 Frontiers in human neuroscience

656. Traumatismo craneoencefálico leve Full Text available with Trip Pro

correlated well with final outcomes. We investigated indications for skull radiography and computed tomography (CT), as well as for hospital admission for clinical observation.In this study, the presence of a neurological focus on clinical examination, the existence of a fracture on plain radiographs, advanced age and the presence of a coagulation disorder were associated with the increased likelihood of intracranial complications and a poor prognosis. The Glasgow Coma Scale was deficient predicting (...) Traumatismo craneoencefálico leve Mild traumatic brain injury (TBI) represents a major health concern, because a sizeable number of patients with mild TBI will develop potentially life-threatening complications. The target of this study was to describe a large series of adult patients suffering from mild TBI, treated at University Hospital of Getafe, between 2010 and 2015 (n = 2480). We examined the patients' epidemiological and baseline clinical profile, diagnosis, treatment and ultimate

2018 Surgical neurology international

657. Effect of trabeculectomy on ocular higher-order aberrations in patients with open angle glaucoma Full Text available with Trip Pro

mean square values. The measurements were repeated 1 month and 3 months after the procedure.A total of 20 eyes from 20 patients were examined. There was a significant decrease in intraocular pressure following surgery at 1 month and 3 months postoperatively. However, there was no statistically significant change in the spherical equivalent of the eyes. One month after surgery, a significant change in coma-like, spherical-like, and total higher-order aberrations of the eyes was observed. However (...) Effect of trabeculectomy on ocular higher-order aberrations in patients with open angle glaucoma The aim of this study was to evaluate the effect of trabeculectomy on ocular higher-order aberrations following surgery in a group of patients with open angle glaucoma.In this prospective study, patients with primary open angle glaucoma underwent wavefront aberrometry before trabeculectomy with mitomycin-C. Coma-like, spherical-like, and total ocular higher-order aberrations were measured as root

2018 Northern clinics of Istanbul

658. Reliability of Ocular Aberration Measurements in Children with Moderate and Low Myopia under Scotopic Conditions Full Text available with Trip Pro

Reliability of Ocular Aberration Measurements in Children with Moderate and Low Myopia under Scotopic Conditions To investigate the reliability of ocular aberration measurement in myopic children under scotopic conditions and to validate the mathematical Zernike pupil scaling-down technique.Ocular aberrations of 45 myopic children were examined under scotopic conditions via iTrace aberrometer. The intra- and intersession repeatability was evaluated for both the measured values with the true (...) with the corresponding measured one, the estimated values of defocus, coma, and the corresponding total aberrations were found significantly smaller than the measured values (all P < 0.01).The ocular aberration measurements in myopic children under the circumstances described are reliable. The scaling-down technique is a useful option for comparing the results obtained from different pupil sizes, but the estimated Zernike coefficients were not always comparable with the corresponding measured values.

2018 Journal of ophthalmology

659. Non-invasive Ventilation Versus High Flow Oxygen

, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Diagnosis of pneumonia based on at least two clinical/laboratory criteria and 1 radiologic criterion among the following: Clinical criteria: fever, cough, purulent sputum, pulmonary examination positive for signs consistent with pneumonia Laboratory criteria: leukocytosis (White blood cells >10000/mcL) or leukopenia (White blood cells < 4000/mcL), rise of the inflammatory markers Radiologic (...) respiratory failure - e.g. pulmonary embolism, acute respiratory distress syndrome (ARDS), pulmonary oedema Hemodynamic instability with necessity for use of inotropes and/or vasopressors Indication for endotracheal intubation (ETI): Glasgow Coma Scale (GCS) <8, agitation, device intolerance, respiratory arrest Immunosuppression (chronic immunosuppressive therapy, clinical history positive for any immunodeficiency - congenital or acquired) Do Not Resuscitate (DNR) and Do Not Intubate (DNI) indication

2018 Clinical Trials

660. Clinical Feature and Outcomes of Secondary Hydrocephalus Caused by Head Trauma Full Text available with Trip Pro

Clinical Feature and Outcomes of Secondary Hydrocephalus Caused by Head Trauma Post-traumatic hydrocephalus (PTH) is a frequent and serious complication following brain injury. The incidence of PTH varies greatly among studies. The purpose of this study was to investigate the incidence and treatment of PTH in patients with head trauma.We examined 956 patients with head trauma who visited our center from January 2012 to December 2015. The hydrocephalus diagnosis was based on radiologic findings (...) and clinical features, and patients were classified into the mild (Group 1, Glasgow Coma Scale score [GCS] 13-15), moderate (Group 2, GCS 9-12), or severe (Group 3, GCS 3-8) brain injury group according to their GCS at admission. To compare these groups, we used age, gender, radiologic findings, PTH developmental period, and postoperative results (Glasgow Outcome Scale).Of the 956 patients, 24 (2.5%) developed PTH. PTH occurred in 11 (1.4%), 3 (5.6%), and 10 (7.0%) patients in Groups 1, 2, and 3

2018 Korean Journal of Neurotrauma

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