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Coma Exam

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441. Azithromycin Plus Chloroquine Versus Mefloquine for the Treatment of Uncomplicated Malaria in Africa

a negative urine gonadotropin prior to entry into the study and must agree to use adequate contraception during the entire study Exclusion Criteria: Severe or complicated malaria including subjects with any of the following: a.) Impaired consciousness (e.g. obtundation, unarousable coma), seizures (any seizure within 24 hours prior to enrollment) or abnormal neurologic exam suggestive of severe or complicated malaria b.) Hemoglobinuria c.) Jaundice d.) Respiratory distress (respiratory rate >= 30/min) e

2004 Clinical Trials

442. Natural History of West Nile Virus Infection

Description Go to Brief Summary: This study will examine how West Nile virus (WNV) infection affects the body. Some people infected with WNV have no symptoms. In others, symptoms may vary from fever and headache to a polio-like syndrome with paralysis, to coma and brain changes like those of a stroke. Many patients recover with no lasting effects, while a few can have long-lasting neurological damage or may die. This study will collect clinical, laboratory, diagnostic, and radiographic information (...) on people thought to have WNV to better understand the disease. Patients 18 years of age and older diagnosed with or suspected of having West Nile virus infection may be eligible for this study. Patients will be hospitalized until they are well enough to go home and will undergo the following tests and procedures: Medical history and physical examination: A thorough history and physical examination will be done on the first day of the study. Then, brief physical exams, including measures of blood

2003 Clinical Trials

443. Trial of Azithromycin Plus Chloroquine Versus Sulfadoxine-Pyrimethamine Plus Chloroquine for the Treatment of Uncomplicated Malaria in India

agree to use adequate contraception during the entire study EXCLUSION CRITERIA: Severe or complicated malaria including subjects with any of the following: a.) Impaired consciousness (e.g. obtundation, unarousable coma), seizures or abnormal neurologic exam suggestive of severe or complicated malaria; b.) Hemoglobinuria; c.) Jaundice; d.) Respiratory distress (respiratory rate >=30/min); e.) Persistent vomiting; f.) Hematuria, as reported by the patient Pregnant or breast-feeding women History

2003 Clinical Trials

444. Chloroquine Alone or in Combination for Malaria in Children in Malawi

of severe malaria included one or more of the following: Hemoglobin ≤5 g/dL; prostration; respiratory distress; bleeding; recent seizures, coma or obtundation (Blantyre coma score < 5); inability to drink, or persistent vomiting. All cases were then adjudicated by a panel of investigators prior to analysis. Mean Hemoglobin at the Last Study Visit in Each Treatment Arm for the Age Group of Participants 3 Years of Age or Younger. [ Time Frame: 1 year ] Hemoglobin values were assessed from blood collected (...) at Days 112 and 224, and at 1 year. Subjects were were counted as a "change from 'normal' to 'abnormal' " if they had the 'normal' (or not-applicable) response for the initial day 28 exam and an 'abnormal' response at their last exam. If a subject did not have an exam at 1 year then the last available exam that was not associated with an illness episode (either Day 112 or 224) was used. Number of Participants Infected With Parasites With the Mutation Pfcrt 76T on Day 0 of the Initial Episode

2006 Clinical Trials

445. Mechanical Retrieval and Recanalization of Stroke Clots Using Embolectomy

mechanical embolectomy procedure with either device will take approximately 1 to 2 hours. Participants will have brief neurological exams several times during this time to monitor changes in their neurological condition. Participants will have follow-up visits, including neurological exams, at 30 days and at 90 days. This study is part of the Specialized Program of Translational Research in Acute Stroke (SPOTRIAS), which allows researchers to enhance and initiate translational research that ultimately (...) of 0-2 Allowed but not required: patients treated with IV tPA (tissue plasminogen activator) up to 4.5 hours from symptom onset with persistent target occlusion on post-treatment MR RESCUE MR or CT protocol performed at the completion of drug infusion (Note: Rapidly improving neurological signs prior to randomization is an exclusion) Exclusion Criteria: NIHSS >/= 30 Contraindication to MRI (pacemaker etc) Acute intracranial hemorrhage Coma Rapidly improving neurological signs prior to randomization

2006 Clinical Trials

446. Loss of consciousness: when to perform computed tomography? (PubMed)

Loss of consciousness: when to perform computed tomography? To determine the diagnostic value of physical examination (including neurologic exam) for positive computed tomography scan findings in children with closed head injury, Glasgow Coma Scale score 13-15 in the emergency department, and loss of consciousness or amnesia.Prospective descriptive study.A large, tertiary, pediatric trauma center in San Diego County.Children ages 2-16 with an isolated closed head injury, history of loss (...) of consciousness or amnesia, and Glasgow Coma Scale 13-15 who were referred for pediatric trauma evaluation and received a head computed tomography as part of this evaluation.A standardized physical examination including skull/scalp exam, pupils, tympanic membrane, and brief neurologic exam was documented on each patient.Subjects age 2-16 being evaluated by the pediatric trauma team for closed head injury with loss of consciousness or amnesia and Glasgow Coma Scale 13-15 received a standardized physical exam

2004 Pediatric Critical Care Medicine

447. Methylprednisolone Given by 24-Hour or 48-Hour Infusion Versus Tirilazad for Acute Spinal Cord Injury

, Layout table for eligibility information Ages Eligible for Study: 14 Years and older (Child, Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria PROTOCOL ENTRY CRITERIA: --Disease Characteristics-- Acute spinal cord injury; diagnosis confirmed by study physician using National Acute Spinal Cord Injury Study neurologic exam Glasgow Coma Score greater than 9 Randomization within 6 hours of injury required; treatment must begin within 8 hours of injury No root

2000 Clinical Trials

448. Magnesium Sulfate For Brain Injury

changed in order to keep the Magnesium blood level at approximately 4meq/L. If the person does not receive magnesium sulfate, he receives a placebo which looks just like magnesium sulfate but contains no active medication. If the person leaves the hospital before the five days are over, the magnesium or placebo is stopped. Patients on the study will receive a brief exam in person or over the phone at one and three months after the injury to determine whether they have had any seizures and to evaluate (...) information Ages Eligible for Study: 14 Years and older (Child, Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Traumatic brain injury with post-resuscitation Glasgow Coma Scale of 3-12 or, if intubated, motor score of 1-5, or who require emergent neurosurgical intervention precluding the accurate assessment of Glasgow Coma Scale. Exclusion Criteria: Injury greater than 8 hours old Age under 14 years Compromised renal function (creatinine

2000 Clinical Trials

449. PET Scanning in Parkinson s Disease

in order to aid in their phenotypic classification as will at risk individuals who show no neurological signs. Individuals with sporadic Parkinson's disease will also be scanned. These will be over the age of 50 years and will have no known family history of Parkinson's disease or any other movement disorder. PD patients will have an admission physical exam and medical history as well as laboratory tests deemed necessary on the basis of history and physical exam. SCHIZOPHRENIA: - Members (...) substance dependence). Cumulative lifetime history of any (excepting nicotine-related) DSM5-defined mild substance use disorder (or any DSM-IV-defined substance abuse),either in excess of 5 years total or not in remission for at least 6 months, Inability to stay caffeine- and nicotine-free for 4 hours Current suicidality or assaultiveness History of movement disorder History of head injury requiring hospitalization History of coma Inability to meet general safety criteria for MRI study (as determined

2001 Clinical Trials

450. Comparison of Two Methods in the Treatment of Cytomegalovirus of the Eyes in Patients With AIDS

detachment (although old retinal detachments unrelated to HIV infection which have been repaired are permitted). Corneal, lens, or vitreous opacification that precludes funduscopic exam. Clinically significant pulmonary or neurologic impairment, such as intubation or coma. (Patients with a CNS mass or history of seizure disorder may enroll.) Tuberculous, diabetic, or hypertensive retinopathy, or other retinal lesions that would interfere with measurements of response or progression. Known

1999 Clinical Trials

451. Defibrotide in Treating Patients With Liver Damage Following Peripheral Stem Cell Transplantation

documentation by physical exam or imaging that liver size is increased over baseline at admission Patients who do not meet the criteria in Section 3.1.1 (ie. have two of the major criteria but not three) and have biopsy proven VOD are eligible in the presence of characteristics consistent with severe disease (see below). Patients with concurrent, confounding causes of liver dysfunction clinically evident or evident on ultrasound or other radiographic imaging (such as evidence of biliary ductal dilatation (...) patients with Grade B skin only are eligible. Patients intubated for documented intrinsic lung disease --- Patients intubated secondary to a mechanical barrier to ventilation, e.g.pulmonary edema or ascites, will be eligible as long as the PaO2/FiO2 ratio is ≥ 300 and/or the oxygen index (OI={MAP x FiO2}÷ PaO2 x 100) is ≤ 25% at the time of enrollment Patients who meet Grade IV common toxicity criteria for neurotoxicity (other than Grade IV confusion and/or delirium), i.e. coma, seizures, toxic

1999 Clinical Trials

452. Text-interpreter language for flexible generation of patient notes and instructions. (PubMed)

with specific protocols, the clinician can be prompted with problem-specific items of history, exam, and lab data to be gathered and documented. The language implements a number of text-related commands as well as branching logic and arithmetic commands. In addition to generating text, it is simple to implement arithmetic calculations such as weight-specific drug dosages; multiple branching decision-support protocols for paramedical personnel (or physicians); and calculation of clinical scores (e.g., coma

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1992 Proceedings of the Annual Symposium on Computer Application in Medical Care

453. Reasons to omit digital rectal exam in trauma patients: no fingers, no rectum, no useful additional information. (PubMed)

Reasons to omit digital rectal exam in trauma patients: no fingers, no rectum, no useful additional information. Performance of digital rectal examination (DRE) on all trauma patients during the secondary survey has been advocated by the Advanced Trauma Life Support course. However, there is no clear evidence of its efficacy as a diagnostic test for traumatic injury. The purpose of this study is to analyze the value of a policy mandating DRE on all trauma patients as part of the initial (...) evaluation process and to discern whether it can routinely be omitted.Prospective study of patients treated at a Level I trauma center. Clinical indicators other than DRE (OCI) denoting gastrointestinal bleeding (GIB), urethral disruption (UD), or spinal cord injury (SCI) were sought and correlated with DRE findings suggesting the same. Impression of the examining physician as to the need and value of DRE was also studied. Patients with a Glasgow Coma Scale Score (GCS) of 3 and pharmacologically

2005 Journal of Trauma

454. Thoracolumbar fracture in blunt trauma: is clinical exam enough for awake patients? (PubMed)

Thoracolumbar fracture in blunt trauma: is clinical exam enough for awake patients? Physical examination is widely used to screen trauma patients for thoracolumbar fracture (TLFx). Retrospective data suggests that patients with altered sensorium may not manifest symptoms after TLFx. This study was designed to prospectively test the sensitivity of physical examination for detection of TLFx in patients with altered mentation.Prospective data collection in a large urban Level I trauma center from (...) April 2002 to December 2003. During the study period, thoracolumbar radiography was performed on patients with signs or symptoms of TLFx, and also on patients with significant blunt trauma and any alteration in mentation, including drowsiness or apparent intoxication. All patients were classified as reliable if Glasgow coma score was >13 and the treating physician judged them capable of accurately reporting pain, and those who did not met both these conditions were deemed unreliable. Patients

2006 Journal of Trauma

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