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21. Outcome Predictors of Non Traumatic Coma in Children

: Prospective Official Title: Outcome Predictors of Non Traumatic Coma in Children Estimated Study Start Date : September 1, 2018 Estimated Primary Completion Date : September 1, 2019 Estimated Study Completion Date : December 1, 2019 Resource links provided by the National Library of Medicine related topics: Groups and Cohorts Go to Intervention Details: Device: CT brain noninvasive medical examination or procedure that uses specialized X-ray equipment to produce cross-sectional images of the body. Outcome (...) Outcome Predictors of Non Traumatic Coma in Children Outcome Predictors of Non Traumatic Coma in Children - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Outcome Predictors of Non Traumatic Coma in Children

2018 Clinical Trials

22. Heat Coma Temperature and Supercooling Point in Oceanic Sea Skaters (Heteroptera, Gerridae) Full Text available with Trip Pro

Heat Coma Temperature and Supercooling Point in Oceanic Sea Skaters (Heteroptera, Gerridae) Heat coma temperatures (HCTs) and super cooling points (SCPs) were examined for nearly 1000 oceanic sea skaters collected from in the Pacific and Indian Oceans representing four Halobates species; H. germanus, H. micans, H. sericeus, and H. sp. Analysis was conducted using the entire dataset because a negative correlation was seen between the HCTs and SCPs in all four species. A weak negative correlation

2018 Insects

23. Effect of Memantine on Serum Levels of Neuron-Specific Enolase and on the Glasgow Coma Scale in Patients With Moderate Traumatic Brain Injury. (Abstract)

Effect of Memantine on Serum Levels of Neuron-Specific Enolase and on the Glasgow Coma Scale in Patients With Moderate Traumatic Brain Injury. Traumatic brain injury (TBI) is a major cause of disability and death globally. Despite significant progress in neuromonitoring and neuroprotection, pharmacological interventions have failed to generate favorable results. We examined the effect of memantine on serum levels of neuron-specific enolase (NSE), a marker of neuronal damage, and the Glasgow (...) Coma Scale (GCS) in patients with moderate TBI. Patients were randomly assigned to the control group (who received standard TBI management) and the treatment group (who, alongside their standard management, received enteral memantine 30 mg twice daily for 7 days). Patients' clinical data, GCS, findings of head computed tomography, and serum NSE levels were collected during the study. Forty-one patients were randomized into the control and treatment groups, 19 and 22 patients respectively. Baseline

2018 Journal of clinical pharmacology Controlled trial quality: uncertain

24. Aetiology and outcome of non-traumatic coma in African children: a systematic review

Aetiology and outcome of non-traumatic coma in African children: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites (...) characteristics (e.g. species, sex or drug class or dose) and effect size. They should be considered hypothesis-generating. Ideally, a threshold describing the number of studies per subgroup required for analysis should be specified. For further guidance please refer to the and to pre-clinical meta-analysis. Example: The following study characteristics will be examined as potential source of heterogeneity: species (stratified per species); sex (stratified per sex); duration of index ischemia (linear); stem

2020 PROSPERO

25. Validation of Korean Version of Coma Recovery Scale-Revised (K-CRSR) Full Text available with Trip Pro

Validation of Korean Version of Coma Recovery Scale-Revised (K-CRSR) To determine the validity and reliability of the Korean version of the Coma Recovery Scale-Revised (K-CRSR) for evaluation of patients with a severe brain lesion.With permission from Giacino, the developer of the Coma Recovery Scale Revised (CRSR), the scale was translated into Korean and back-translated into English by a Korean physiatrist highly proficient in English, and then verified by the original developer. Adult (...) patients with a severe brain lesion following traumatic brain injury, stroke, or hypoxic brain injury were examined. To assess the inter-rater reliability, all patients were tested with K-CRSR by two physiatrists individually. To determine intra-rater reliability, the same test was re-administered by the same physiatrists after three days.Inter-rater reliability (k=0.929, p<0.01) and intra-rater reliability (k=0.938, p<0.01) were both high for total K-CRSR scores. Inter- and intra-rater agreement rates

2018 Annals of rehabilitation medicine

26. A meta-analysis of Deep brain stimulation versus Spinal cord stimulation for the treatment in patients in coma , minimally conscious state or vegetative state.

A meta-analysis of Deep brain stimulation versus Spinal cord stimulation for the treatment in patients in coma , minimally conscious state or vegetative state. Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content (...) heterogeneity and can provide insight into the relationship between study characteristics (e.g. species, sex or drug class or dose) and effect size. They should be considered hypothesis-generating. Ideally, a threshold describing the number of studies per subgroup required for analysis should be specified. For further guidance please refer to the and to pre-clinical meta-analysis. Example: The following study characteristics will be examined as potential source of heterogeneity: species (stratified per

2020 PROSPERO

27. Prolonged duration of apnea test during brain death examination in a case of intraparenchymal hemorrhage Full Text available with Trip Pro

Prolonged duration of apnea test during brain death examination in a case of intraparenchymal hemorrhage Apnea test is required as part of the brain death examination. The duration of the apnea test is variable but typically requires 8-10 min. Prolonged apnea tests have been reported in the setting of hypothermia. Here, we describe a case of prolonged duration of apnea test secondary to a phenomenon called cardiac ventilation.The patient presented in coma with brainstem areflexia after having

2017 SAGE Open Medical Case Reports

28. A NETWORK APPROACH TO EXAMINING INJURY SEVERITY IN PEDIATRIC TBI Full Text available with Trip Pro

in structural network connectivity in pediatric patients who had sustained a moderate-severe TBI (msTBI). We compared those who experienced early post-traumatic seizures to those who did not; we found network differences months after seizure activity stopped. We also examined correlations between network measures and a common measure of injury severity, the Glasgow Coma Scale (GCS). The global GCS score did not have a detectable relationship to brain integrity, but sub-scores of the GCS (eyes, motor, verbal (...) A NETWORK APPROACH TO EXAMINING INJURY SEVERITY IN PEDIATRIC TBI Traumatic brain injury (TBI) is the leading cause of death and disability in children, and can lead to long lasting functional impairment. Many factors influence outcome, but imaging studies examining effects of individual variables are limited by sample size. Roughly 20-40% of hospitalized TBI patients experience seizures, but not all of these patients go on to develop a recurrent seizure disorder. Here we examined differences

2017 Proceedings. IEEE International Symposium on Biomedical Imaging

29. Neurophysiological Examination in Patients With Brain Death

Neurophysiological Examination in Patients With Brain Death Neurophysiological Examination in Patients With Brain Death - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Neurophysiological Examination (...) Yıl University Study Details Study Description Go to Brief Summary: This study examines muscle movements of elecromyography in adults with brain death. Half of the participants will have brain death, the other half will be healthy volunteers. Condition or disease Brain Death Detailed Description: In some of the patients who have brain death diagnosis, some movements may be seen. Because of these movements, the doctors sometimes avoid to make brain death diagnosis. So making brain death diagnosis

2017 Clinical Trials

30. Is Anesthetic Loss of Consciousness a Top Down or Bottom up Phenomenon. What Does the Neurologic Examination Say?.

Intervention/treatment Phase Anesthesia; Functional Diagnostic Test: FOUR coma scale and frontal espectrograpy evaluation Not Applicable Detailed Description: Clinical experimental randomized study, approved by the Ethic Committee, with informed consent, included ASA I- II adults, without neurological illness and normal physical exam. The patient randomized in two groups, rapid induction (GR) with propofol in target controlled infusion (TCI) effect site mode using the phamacokinetic (PK) model from Marsh (...) Is Anesthetic Loss of Consciousness a Top Down or Bottom up Phenomenon. What Does the Neurologic Examination Say?. Is Anesthetic Loss of Consciousness a Top Down or Bottom up Phenomenon. What Does the Neurologic Examination Say?. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number

2017 Clinical Trials

31. Pitfall in Pupillometry: Exaggerated Ciliospinal Reflex in a Patient in Barbiturate Coma Mimicking a Nonreactive Pupil Full Text available with Trip Pro

Pitfall in Pupillometry: Exaggerated Ciliospinal Reflex in a Patient in Barbiturate Coma Mimicking a Nonreactive Pupil Although a neurological examination is fundamental to the evaluation of comatose patients, it is less reliable in a medically induced coma. A commonly misinterpreted finding in patients in a pentobarbital coma is altered pupillary reactivity secondary to an exaggerated ciliospinal reflex. Recognizing an exaggerated ciliospinal reflex in patients in a pentobarbital coma (...) is important and may prevent unnecessary intervention. We present a patient induced in a pentobarbital coma for the treatment of status epilepticus who exhibited a nonreactive pupil secondary to an exaggerated ciliospinal reflex confirmed by pupillometry. We also discuss the anatomy of the ciliospinal reflex and literature regarding its clinical relevance.

2017 Cureus

32. Cracking Coma: Towards EEG and MRI Based Precision Medicine After Cardiac Arrest

Cracking Coma: Towards EEG and MRI Based Precision Medicine After Cardiac Arrest Cracking Coma: Towards EEG and MRI Based Precision Medicine After Cardiac Arrest - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding (...) more. Cracking Coma: Towards EEG and MRI Based Precision Medicine After Cardiac Arrest The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03308305 Recruitment Status : Recruiting First Posted : October 12, 2017 Last Update

2017 Clinical Trials

33. Recovery from Coma Post-Cardiac Arrest Is Dependent on the Orexin Pathway Full Text available with Trip Pro

Recovery from Coma Post-Cardiac Arrest Is Dependent on the Orexin Pathway Cardiac arrest (CA) affects >550,000 people annually in the United States whereas 80-90% of survivors suffer from a comatose state. Arousal from coma is critical for recovery, but mechanisms of arousal are undefined. Orexin-A, a hypothalamic excitatory neuropeptide, has been linked to arousal deficits in various brain injuries. We investigated the orexinergic system's role in recovery from CA-related neurological (...) impairments, including arousal deficits. Using an asphyxial CA and resuscitation model in rats, we examine neurological recovery post-resuscitation in conjunction with changes in orexin-A levels in cerebrospinal fluid (CSF) and orexin-expressing neurons. We also conduct pharmacological inhibition of orexin post-resuscitation. We show that recovery from neurological deficits begins between 4 and 24 h post-resuscitation, with additional recovery by 72 h post-resuscitation. Orexin-A levels in the CSF

2017 Journal of neurotrauma

34. Reliability of Robotic Telemedicine for Assessing Critically Ill Patients with the Full Outline of UnResponsiveness Score and Glasgow Coma Scale Full Text available with Trip Pro

Reliability of Robotic Telemedicine for Assessing Critically Ill Patients with the Full Outline of UnResponsiveness Score and Glasgow Coma Scale Telemedicine is increasingly utilized in the evaluation of critically ill patients, including those with decreased level of consciousness (LOC) or coma. Improving access to providers with neurologic expertise affords earlier triage and directed patient management. However, objective data regarding the reliability of using standardized coma scales (...) , traditionally employed at the bedside for remote assessment, are largely lacking.Bedside and remote assessments of patients with decreased LOC, using either the Glasgow Coma Scale (GCS) or Full scale Of UnResponsiveness (FOUR), score are equivalent.Prospective trial comparing the reliability of bedside and remote coma assessments using GCS or FOUR score clinical evaluation tools utilizing robotic telepresence technology. Total scores of the GCS and FOUR score were compared between bedside and remote

2017 Telemedicine Journal and e-Health

35. Effect of Age on Glasgow Coma Scale in Patients with Moderate and Severe Traumatic Brain Injury: An Approach with Propensity Score-Matched Population Full Text available with Trip Pro

Effect of Age on Glasgow Coma Scale in Patients with Moderate and Severe Traumatic Brain Injury: An Approach with Propensity Score-Matched Population Background: The most widely used methods of describing traumatic brain injury (TBI) are the Glasgow Coma Scale (GCS) and the Abbreviated Injury Scale (AIS). Recent evidence suggests that presenting GCS in older patients may be higher than that in younger patients for an equivalent anatomical severity of TBI. This study aimed to assess (...) these observations with a propensity-score matching approach using the data from Trauma Registry System in a Level I trauma center. Methods: We included all adult patients (aged ≥20 years old) with moderate to severe TBI from 1 January 2009 to 31 December 2016. Patients were categorized into elderly (aged ≥65 years) and young adults (aged 20-64 years). The severity of TBI was defined by an AIS score in the head (AIS 3‒4 and 5 indicate moderate and severe TBI, respectively). We examined the differences in the GCS

2017 International journal of environmental research and public health

36. The prognostic value of MRI for coma post cardiac arrest : a systematic review and meta-analysis

The prognostic value of MRI for coma post cardiac arrest : a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external (...) characteristics (e.g. species, sex or drug class or dose) and effect size. They should be considered hypothesis-generating. Ideally, a threshold describing the number of studies per subgroup required for analysis should be specified. For further guidance please refer to the and to pre-clinical meta-analysis. Example: The following study characteristics will be examined as potential source of heterogeneity: species (stratified per species); sex (stratified per sex); duration of index ischemia (linear); stem

2019 PROSPERO

37. Validation of the Russian Version of Coma Recovery Scale-Revised (CRS-R)

): Research Center of Neurology, Russia Study Details Study Description Go to Brief Summary: The purpose of this study is to validate Russian version of Coma Recovery Scale - Revised and to assess its psychometric properties. Condition or disease Intervention/treatment Consciousness Disorders Behavioral: Examination with neurological scales. Detailed Description: There is a need of validated scale for correct assessment for patients with disorders of consciousness (DOC) in Russia. One of the most detailed (...) adults with disorders of consciousness of different etiology on different period of recovery after coma. It is planned to include patients with various states of consciousness (e.g., vegetative state, minimally conscious state "minus" and minimally conscious state "plus") in balanced proportions. Every patient will be examined by two independent researchers on the same day. The patients will be examined twice with a week interval between examinations for evaluation of sensitivity of CRS-r. Test

2017 Clinical Trials

38. Post-anoxic quantitative MRI changes may predict emergence from coma and functional outcomes at discharge. Full Text available with Trip Pro

days of arrest and used a semi-automated algorithm to perform quantitative volumetric analysis of apparent diffusion coefficient (ADC) sequences at various thresholds. Area under receiver operating characteristic curves (ROC-AUC) were estimated to compare predictive values of quantitative MRI with pupillary exam at days 3, 5 and 7 post-arrest, for persistence of coma and functional outcomes at discharge. Cerebral Performance Category scores of 3-4 were considered poor outcome.Excluding patients (...) Post-anoxic quantitative MRI changes may predict emergence from coma and functional outcomes at discharge. Traditional predictors of neurological prognosis after cardiac arrest are unreliable after targeted temperature management. Absence of pupillary reflexes remains a reliable predictor of poor outcome. Diffusion-weighted imaging has emerged as a potential predictor of recovery, and here we compare imaging characteristics to pupillary exam.We identified 69 patients who had MRIs within seven

2017 Resuscitation

39. Early prediction of coma recovery after cardiac arrest with blinded pupillometry. (Abstract)

Early prediction of coma recovery after cardiac arrest with blinded pupillometry. Prognostication studies on comatose cardiac arrest (CA) patients are limited by lack of blinding, potentially causing overestimation of outcome predictors and self-fulfilling prophecy. Using a blinded approach, we analyzed the value of quantitative automated pupillometry to predict neurological recovery after CA.We examined a prospective cohort of 103 comatose adult patients who were unconscious 48 hours after CA (...) and underwent repeated measurements of quantitative pupillary light reflex (PLR) using the Neurolight-Algiscan device. Clinical examination, electroencephalography (EEG), somatosensory evoked potentials (SSEP), and serum neuron-specific enolase were performed in parallel, as part of standard multimodal assessment. Automated pupillometry results were blinded to clinicians involved in patient care. Cerebral Performance Categories (CPC) at 1 year was the outcome endpoint.Survivors (n = 50 patients; 32 CPC 1

2017 Annals of Neurology

40. Coma Exam

links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Coma Exam." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Related Topics in Examination About FPnotebook.com is a rapid access, point-of-care medical reference for primary care and emergency clinicians. Started in 1995, this collection now contains 6656 interlinked topic pages divided into a tree of 31 specialty books (...) Coma Exam Coma Exam Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Coma Exam Coma Exam Aka: Coma Exam II. Background: Key goal

2015 FP Notebook

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