How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

3,322 results for

Coma Exam

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

1. European Academy of Neurology guideline on the diagnosis of coma and other disorders of consciousness Full Text available with Trip Pro

of consciousness and higher‐order cortical function than routine bedside examination alone, but this knowledge is not yet widely implemented in clinical practice. A comprehensive European guideline for the diagnosis of coma and other DoC based on the best available scientific and clinical data is therefore needed. Methods Objectives The aim is to provide the European neurological community with recommendations based on the best available evidence regarding diagnosis and classification of coma and other DoC (...) , including clinical bedside examination techniques and laboratory investigations based on functional neuroimaging (PET, fMRI) and EEG [including transcranial magnetic stimulation (TMS) and evoked potentials]. Definitions The term DoC includes patients in coma, VS/UWS and MCS. Coma may be defined as a state of profound unawareness from which the patient cannot be aroused. Crucially, eyes are closed, and a normal sleep–wake cycle is absent. This usually lasts only a few days or weeks following acute brain

2020 European Academy of Neurology

2. European Academy of Neurology guideline on the diagnosis of coma and other disorders of consciousness

October 2019 Accepted 9 January 2020 European Journal of Neurology 2020, 27: 741–756 doi:10.1111/ene.14151 Background and purpose: Patients with acquired brain injury and acute or prolonged disorders of consciousness (DoC) are challenging. Evidence to sup- port diagnostic decisions on coma and other DoC is limited but accumulating. This guideline provides the state-of-the-art evidence regarding the diagnosis of DoC, summarizing data from bedside examination techniques, functional neu- roimaging (...) and electroencephalography (EEG). Methods: Sixteen members of the European Academy of Neurology (EAN) Scienti?c Panel on Coma and Chronic Disorders of Consciousness, represent- ing 10 European countries, reviewed the scienti?c evidence for the evaluation of coma and other DoC using standard bibliographic measures. Recommenda- tions followed the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system. The guideline was endorsed by the EAN. Results: Besides a comprehensive neurological examination

2020 European Academy of Neurology

3. FOUR Score Coma Exam

Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "FOUR Score Coma Exam." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Related Topics in Examination About FPnotebook.com is a rapid access, point-of-care medical reference for primary care and emergency clinicians. Started in 1995, this collection now contains 6656 interlinked topic pages divided (...) FOUR Score Coma Exam FOUR Score Coma Exam Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 FOUR Score Coma Exam FOUR Score Coma Exam

2018 FP Notebook

4. Coma Exam

links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Coma Exam." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Related Topics in Examination About FPnotebook.com is a rapid access, point-of-care medical reference for primary care and emergency clinicians. Started in 1995, this collection now contains 6656 interlinked topic pages divided into a tree of 31 specialty books (...) Coma Exam Coma Exam Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Coma Exam Coma Exam Aka: Coma Exam II. Background: Key goal

2018 FP Notebook

5. Glasgow Coma Scale for Field Triage of Trauma: A Systematic Review

Glasgow Coma Scale for Field Triage of Trauma: A Systematic Review Comparative Effectiveness Review Number 182 Glasgow Coma S for Field Triage of Trauma: A Syste cale matic Review eComparative Effectiveness Review Number 182 Glasgow Coma Scale for Field Triage of Trauma: A Systematic Review Prepared for: Agency for Healthcare Research and Quality U.S. Department of Health and Human Services 5600 Fishers Lane Rockville, MD 20857 www.ahrq.gov Contract No. 290-2015-00009-I Prepared by: Pacific (...) Web site at www.effectivehealthcare.ahrq.gov. Search on the title of the report. Persons using assistive technology may not be able to fully access information in this report. For assistance contact EffectiveHealthCare@ahrq.hhs.gov. Suggested citation: Chou R, Totten AM, Pappas M, Carney N, Dandy S, Grusing S, Fu R, Wasson N, Newgard C. Glasgow Coma Scale for Field Triage of Trauma: A Systematic Review. Comparative Effectiveness Review No.182. (Prepared by the Pacific Northwest Evidence-based

2017 Effective Health Care Program (AHRQ)

6. FOUR Score Coma Exam

Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "FOUR Score Coma Exam." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Related Topics in Examination About FPnotebook.com is a rapid access, point-of-care medical reference for primary care and emergency clinicians. Started in 1995, this collection now contains 6656 interlinked topic pages divided (...) FOUR Score Coma Exam FOUR Score Coma Exam Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 FOUR Score Coma Exam FOUR Score Coma Exam

2017 FP Notebook

7. Routine intracranial pressure monitoring in acute coma. (Abstract)

Routine intracranial pressure monitoring in acute coma. We know that the brain damage resulting from traumatic and other insults is not due solely to the direct consequences of the primary injury. A significant and potentially preventable contribution to the overall morbidity arises from secondary hypoxic-ischaemic damage. Brain swelling accompanied by raised intracranial pressure (ICP) prevents adequate cerebral perfusion with well-oxygenated blood.Detection of raised ICP could be useful (...) in alerting clinicians to the need to improve cerebral perfusion, with consequent reductions in brain injury.To determine whether routine ICP monitoring in severe coma of any cause reduces the risk of all-cause mortality or severe disability at final follow-up.We searched the Cochrane Injuries Group Specialised Register, the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE (OvidSP), EMBASE (OvidSP), CINAHL Plus, ISI Web of Science (SCI-EXPANDED & CPCI-S), clinical trials registries

2015 Cochrane

8. Guidance for pathologists conducting post-mortem examinations on individuals with implanted electronic and medical devices

Guidance for pathologists conducting post-mortem examinations on individuals with implanted electronic and medical devices PUB 080615 1 V7 Final Guidance for pathologists conducting post-mortem examinations on individuals with implanted electronic medical devices June 2015 Authors: Dr Christopher Johnson, East Midlands Forensic Pathology Unit Professor James Lowe, Chair of the College’s Specialty Advisory Committee on Cellular Pathology, University of Nottingham Medical School Dr Mike Osborn (...) , Imperial College Healthcare NHS Trust Unique document number G139 Document name Guidance for pathologists conducting post-mortem examinations on individuals with implanted electronic medical devices Version number 1 Produced by Dr Christopher Johnson, Professor James Lowe and Dr Mike Osborn Date active June 2015 Date for review June 2018 Comments In accordance with the College’s pre-publications policy, this document wason The Royal College of Pathologists’ website for consultation from 6 October to 3

2015 Royal College of Pathologists

9. Whole-Body CT after Motor Vehicle Crash: No Benefit after High-Energy Impact and with Normal Physical Examination. (Abstract)

motor vehicle crash (MVC) meeting only kinetic elements of the Vittel criteria for the severity of trauma, with no evidence of trunk injury and a Glasgow Coma Scale score of 15. Materials and Methods This retrospective study included all consecutive adult patients who consulted an emergency department of a level 1 trauma center between August 2016 and July 2017 if they underwent whole-body CT for one or more kinetic elements of the Vittel criteria, had a normal examination of the trunk, and had (...) a Glasgow Coma Scale score of 15. Data of the MVC mechanism and physical and biologic examinations were collected, as well as patient treatment data after whole-body CT. Whole-body CT examinations were read by two double-blinded readers to help detect unsuspected injuries. Results Ninety-three patients were included; 72 were men with a mean age of 30.8 years ± 12.0 (standard deviation). Sixty-nine patients were occupants of a car. Seventeen patients were hit by a car while on motorbikes, three while

2019 Radiology

10. High on drugs: Multi-institutional pilot study examining the effects of substance use on acute pain management. (Abstract)

High on drugs: Multi-institutional pilot study examining the effects of substance use on acute pain management. Substance use and abuse may have the significant, but unanticipated, consequence of lessening the efficacy of opioid analgesics for acute pain management. We hypothesized that pre-injury substance use increases opioid analgesic consumption following traumatic injury.This retrospective multi-institutional pilot study included admitted patients to four level 1 trauma centers (...) with vehicular trauma over four months (n = 176). We examined the effect of positive urine drug screen (UDS; 7-drug panel, examined individually and combined, yes/no) and positive blood alcohol content (BAC, ≥80 mg/dL) on pain management with opioid analgesics over the hospital stay. Average daily opioid consumption was examined using a repeated measures mixed model, by positive UDS and BAC findings, adjusting for age, injury severity score, and non-opioid analgesia. Opioid analgesics were converted

2019 Injury

11. Outcome prediction in disorders of consciousness: the role of coma recovery scale revised. Full Text available with Trip Pro

Outcome prediction in disorders of consciousness: the role of coma recovery scale revised. To evaluate the utility of the revised coma remission scale (CRS-r), together with other clinical variables, in predicting emergence from disorders of consciousness (DoC) during intensive rehabilitation care.Data were retrospectively extracted from the medical records of patients enrolled in a specialized intensive rehabilitation unit. 123 patients in a vegetative state (VS) and 57 in a minimally (...) conscious state (MCS) were included and followed for a period of 8 weeks. Demographical and clinical factors were used as outcome measures. Univariate and multivariate Cox regression models were employed for examining potential predictors for clinical outcome along the time.VS and MCS groups were matched for demographical and clinical variables (i.e., age, aetiology, tracheostomy and route of feeding). Within 2 months after admission in intensive neurorehabilitation unit, 3.9% were dead, 35.5% had

2019 BMC Neurology

12. Electroencephalographic reactivity as predictor of neurological outcome in postanoxic coma: A multicenter prospective cohort study. Full Text available with Trip Pro

Electroencephalographic reactivity as predictor of neurological outcome in postanoxic coma: A multicenter prospective cohort study. Outcome prediction in patients after cardiac arrest (CA) is challenging. Electroencephalographic reactivity (EEG-R) might be a reliable predictor. We aimed to determine the prognostic value of EEG-R using a standardized assessment.In a prospective cohort study, a strictly defined EEG-R assessment protocol was executed twice per day in adult patients after CA. EEG-R (...) , neurological examination, and somatosensory evoked potentials (SSEPs).Of 160 patients enrolled, 149 were available for analyses. Absence of EEG-R for poor outcome prediction had a specificity of 82% and a sensitivity of 73%. For good outcome prediction, specificity was 73% and sensitivity 82%. Specificity for poor outcome prediction increased from 98% to 99% when EEG-R was added to a multimodal model. For good outcome prediction, specificity increased from 70% to 89%.EEG-R testing in itself

2019 Annals of Neurology

13. The Base Deficit, International Normalized Ratio, and Glasgow Coma Scale (BIG) Score, and Functional Outcome at Hospital Discharge in Children With Traumatic Brain Injury. (Abstract)

The Base Deficit, International Normalized Ratio, and Glasgow Coma Scale (BIG) Score, and Functional Outcome at Hospital Discharge in Children With Traumatic Brain Injury. To examine the association of the base deficit, international normalized ratio, and Glasgow Coma Scale (BIG) score on emergency department arrival with functional dependence at hospital discharge (Pediatric Cerebral Performance Category ≥ 4) in pediatric multiple trauma patients with traumatic brain injury.A retrospective (...) at the scene or referral hospital (odds ratio, 2.82; 95% CI, 1.35-5.87) and other postulated predictors of poor outcome. The area under the BIG receiver operating characteristic curve was 0.87 (0.84-0.90). Using an optimal BIG cutoff less than or equal to 8, sensitivity and negative predictive value for functional dependence at discharge were 93% and 96%, respectively, compared with a sensitivity of 79% and negative predictive value of 91% with Glasgow Coma Scale less than or equal to 8. In children

2019 Pediatric Critical Care Medicine

14. Duration of therapeutic coma and outcome of refractory status epilepticus. Full Text available with Trip Pro

Duration of therapeutic coma and outcome of refractory status epilepticus. Examine the association of duration of therapeutic coma (TC) with seizure recurrence, morbidity, and mortality in refractory status epilepticus (RSE). Define an optimal window for TC that provides sustained seizure control and minimizes complications.Retrospective, observational cohort study involving patients who presented with RSE to the University of Alabama at Birmingham or the University of California at San

2019 Epilepsia

15. A Method of Managing Severe Traumatic Brain Injury in the Absence of Intracranial Pressure Monitoring: The Imaging and Clinical Examination Protocol. Full Text available with Trip Pro

A Method of Managing Severe Traumatic Brain Injury in the Absence of Intracranial Pressure Monitoring: The Imaging and Clinical Examination Protocol. The imaging and clinical examination (ICE) algorithm used in the Benchmark Evidence from South American Trials: Treatment of Intracranial Pressure (BEST TRIP) randomized controlled trial is the only prospectively investigated clinical protocol for traumatic brain injury management without intracranial pressure (ICP) monitoring. As the default (...) literature standard, it warrants careful evaluation. We present the ICE protocol in detail and analyze the demographics, outcome, treatment intensity, frequency of intervention usage, and related adverse events in the ICE-protocol cohort. The 167 ICE protocol patients were young (median 29 years) with a median Glasgow Coma Scale motor score of 4 but with anisocoria or abnormal pupillary reactivity in 40%. This protocol produced outcomes not significantly different from those randomized to the monitor

2018 Journal of neurotrauma Controlled trial quality: uncertain

16. The essential neurological examination of the unconscious patient in the emergency room Full Text available with Trip Pro

The essential neurological examination of the unconscious patient in the emergency room To determine whether neurologists with long-term experience in the emergency room are in general agreement about the essential components of the neurological examination (NE) used on unconscious patients in whom an obvious cause for coma is lacking.We surveyed 31 board-certified practicing neurologists who regularly examine unconscious patients in the emergency room and asked them to list the specific (...) components of the NE that they would normally choose to apply in at least 80% of cases.Twenty-seven neurologists rated 24 of 38 items as essential steps of the neurological examination of the unconscious patient, with a high level of agreement amongst survey participants.There was a high degree of consensus amongst the neurologists surveyed about which steps are essential for the NE of the unconscious patient. These findings provide an important source of validation for teaching this particular NE

2018 Brain and behavior

17. Brain Network Disruptions Related to Traumatic Coma

and positron emission tomography (PET) scan (neuroinflammation ligands). Condition or disease Intervention/treatment Phase Traumatic Coma Radiation: PET examination with radiopharmaceutical drug [18F] DPA-714 Diagnostic Test: MRI examination Biological: Blood samples Not Applicable Detailed Description: So far, the gold standard for neuroprognostication of severe traumatic brain injury (TBI) or anoxic encephalopathy is the bedside behavioural evaluation. Nevertheless, the predictive value (...) Start Date : March 7, 2018 Estimated Primary Completion Date : November 7, 2019 Estimated Study Completion Date : February 7, 2020 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Arm Intervention/treatment Experimental: Comatose patient Subject with coma of traumatic or anoxic aetiology : PET examination with radiopharmaceutical drug [18F] DPA-714, MRI examination and Blood samples. Radiation: PET examination with radiopharmaceutical drug [18F

2018 Clinical Trials

18. Late Awakening in Survivors of Postanoxic Coma: Early Neurophysiologic Predictors and Association With ICU and Long-Term Neurologic Recovery. (Abstract)

Late Awakening in Survivors of Postanoxic Coma: Early Neurophysiologic Predictors and Association With ICU and Long-Term Neurologic Recovery. To examine neurophysiologic predictors and outcomes of patients with late awakening following cardiac arrest.Observational cohort study.Academic ICU.Adult comatose cardiac arrest patients treated with targeted temperature management and sedation.None.Time to awakening was calculated starting from initial sedation stop following targeted temperature

2018 Critical Care Medicine

19. Intranasal post-cardiac arrest treatment with orexin-A facilitates arousal from coma and ameliorates neuroinflammation. Full Text available with Trip Pro

Intranasal post-cardiac arrest treatment with orexin-A facilitates arousal from coma and ameliorates neuroinflammation. Cardiac arrest (CA) entails significant risks of coma resulting in poor neurological and behavioral outcomes after resuscitation. Significant subsequent morbidity and mortality in post-CA patients are largely due to the cerebral and cardiac dysfunction that accompanies prolonged whole-body ischemia post-CA syndrome (PCAS). PCAS results in strong inflammatory responses (...) curtail neuroinflammation is unknown. We hypothesize that targeting the orexinergic pathway via intranasal orexin-A (ORXA) treatment will enhance arousal from coma and decrease the production of proinflammatory cytokines resulting in improved functional outcome after resuscitation. We used a highly validated CA rat model to determine the effects of intranasal ORXA treatment 30-minute post resuscitation. At 4hrs post-CA, the mRNA levels of proinflammatory markers (IL1β, iNOS, TNF-α, GFAP, CD11b

2017 PLoS ONE

20. Glasgow Coma Scale Score Fluctuations are Inversely Associated With a NIRS-based Index of Cerebral Autoregulation in Acutely Comatose Patients. (Abstract)

Glasgow Coma Scale Score Fluctuations are Inversely Associated With a NIRS-based Index of Cerebral Autoregulation in Acutely Comatose Patients. The Glasgow Coma Scale (GCS) is an essential coma scale in critical care for determining the neurological status of patients and for estimating their long-term prognosis. Similarly, cerebral autoregulation (CA) monitoring has shown to be an accurate technique for predicting clinical outcomes. However, little is known about the relationship between CA (...) (impaired autoregulation), more severe neurological impairment is observed. However, the difference in COx between high and low GCS is small and warrants further studies investigating this association. CA multimodal monitoring with COx may have the potential to be used as a surrogate of neurological status when the neurological examination is not reliable (ie, sedation and paralytic drug administration).

2018 Journal of neurosurgical anesthesiology

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>