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Colposcopy

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1. Adjunctive colposcopy technologies for assessing suspected cervical abnormalities: the DYSIS colposcope with DYSISmap and the ZedScan I

Adjunctive colposcopy technologies for assessing suspected cervical abnormalities: the DYSIS colposcope with DYSISmap and the ZedScan I Adjunctiv Adjunctive colposcop e colposcopy technologies for y technologies for assessing suspected cervical assessing suspected cervical abnormalities: the D abnormalities: the DYSIS colposcope YSIS colposcope with D with DYSISmap and the Z YSISmap and the ZedScan I edScan I Diagnostics guidance Published: 25 April 2018 nice.org.uk/guidance/dg32 © NICE 2018 (...) and providers have a responsibility to promote an environmentally sustainable health and care system and should assess and reduce the environmental impact of implementing NICE recommendations wherever possible. Adjunctive colposcopy technologies for assessing suspected cervical abnormalities: the DYSIS colposcope with DYSISmap and the ZedScan I (DG32) © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 2 of 46Contents Contents

2018 National Institute for Health and Clinical Excellence - Diagnostics Guidance

2. Video Colposcopy for Reducing Patient Anxiety During Colposcopy: A Randomized Controlled Trial Full Text available with Trip Pro

Video Colposcopy for Reducing Patient Anxiety During Colposcopy: A Randomized Controlled Trial To test whether video colposcopy reduces anxiety among patients undergoing colposcopy.In a prospective, randomized multicenter trial, we compared video colposcopy and no video colposcopy in a one-to-one ratio. Situation-specific anxiety was measured before (S1) and after (S2) colposcopy using the State-Trait Anxiety Inventory. The primary endpoint was the reduction of the situation-specific anxiety (...) scores (ΔS=S2-S1). Secondary endpoints were pain during and 10 minutes after colposcopy, general unpleasantness, anxiety during colposcopy, satisfaction with the information about the procedure, and overall satisfaction (11-item visual analog scales). Analysis was by intention to treat. A sample size of 104 per group (n=208) was planned to achieve 80% power to detect a difference of 4.8 with a SD of 12.3 in the primary outcome.Between August 2016 and March 2017, 225 women were randomized. The mean ΔS

2017 EvidenceUpdates

3. The ZedScan as an adjunct to colposcopy in women with suspected cervical intra-epithelial neoplasia

The ZedScan as an adjunct to colposcopy in women with suspected cervical intra-epithelial neoplasia The ZedScan as an adjunct to colposcopy in women with suspected cervical intra‑epithelial neoplasia | Advice | NICE The ZedScan as an adjunct to colposcopy in women with suspected cervical intra‑epithelial neoplasia Medtech innovation briefing [MIB20] Published date: February 2015 Advice This advice has been updated and replaced by . Explore © NICE [year]. All rights reserved. Subject to .

2015 National Institute for Health and Clinical Excellence - Advice

4. Diagnostic accuracy of colposcopy with dynamic spectral imaging for cytology-negative/high-risk HPV positive (failed test of cure) after large loop excision of the transformation zone (LLETZ) of the cervix: Results of the DySIS colposcopy 1 study. Full Text available with Trip Pro

Diagnostic accuracy of colposcopy with dynamic spectral imaging for cytology-negative/high-risk HPV positive (failed test of cure) after large loop excision of the transformation zone (LLETZ) of the cervix: Results of the DySIS colposcopy 1 study. After treatment for cervical intraepithelial neoplasia (CIN), in the UK women who are cytology-negative, high-risk (HR) human papilloma virus (HPV) positive are referred to colposcopy. This pilot study assessed the incidence of residual/recurrent CIN (...) and the diagnostic accuracy of colposcopy with dynamic spectral imaging (DSI) mapping in their detection.This was a prospective service evaluation carried out in a UK National Health Service (NHS) colposcopy clinic. All women, referred with negative cytology/HR-HPV positive result following treatment for CIN from March 2013 until November 2014, who were examined with the DSI digital colposcope were included. We excluded 3 cases because of poor-quality imaging from user errors. Everyday clinical practice

2018 Medicine

5. Portable Pocket colposcopy performs comparably to standard-of-care clinical colposcopy using acetic acid and Lugol's iodine as contrast mediators - An investigational study in Perú. Full Text available with Trip Pro

Portable Pocket colposcopy performs comparably to standard-of-care clinical colposcopy using acetic acid and Lugol's iodine as contrast mediators - An investigational study in Perú. Our goal was to develop a tele-colposcopy platform for primary-care clinics to improve screening sensitivity and access. Specifically, we developed a low-cost, portable Pocket colposcope and evaluated its performance in a tertiary healthcare centre in Peru.Images of the cervix were captured with a standard-of-care (...) % and the sensitivity and specificity of physician interpretation compared with pathology by over 6.0 and 9.0%, respectively.The Pocket colposcope performance was similar to that of a standard-of-care colposcope when used to identify precancerous and cancerous lesions using acetic acid and Lugol's iodine during colposcopy examinations in Peru.The Pocket colposcope performance was similar to that of a standard-of-care colposcope when identifying cervical lesions.© 2018 Royal College of Obstetricians

2018 BJOG

6. Closer to a Uniform Language in Colposcopy: Study on the Potential Application of 2011 International Federation for Cervical Pathology and Colposcopy Terminology in Clinical Practice Full Text available with Trip Pro

Closer to a Uniform Language in Colposcopy: Study on the Potential Application of 2011 International Federation for Cervical Pathology and Colposcopy Terminology in Clinical Practice As the newest colposcopic terminology, the 2011 International Federation for Cervical Pathology and Colposcopy (IFCPC) classification provides standardized interpretation of colposcopic findings. In this study, we analyzed the colposcopic accuracy and the significance of individual findings according to the 2011

2017 BioMed research international

7. ASCCP Colposcopy Standards: Colposcopy Quality Improvement Recommendations for the United States Full Text available with Trip Pro

ASCCP Colposcopy Standards: Colposcopy Quality Improvement Recommendations for the United States The American Society for Colposcopy and Cervical Pathology (ASCCP) Colposcopy Standards recommendations address the role of and approach to colposcopy and biopsy for cervical cancer prevention in the United States. The recommendations were developed by an expert working group appointed by ASCCP's Board of Directors. The ASCCP Quality Improvement Working Group developed evidence-based guidelines (...) to promote best practices and reduce errors in colposcopy and recommended indicators to measure colposcopy quality.The working group performed a systematic review of existing major society and national guidelines and quality indicators. An initial list of potential quality indicators was developed and refined through successive iterative discussions, and draft quality indicators were proposed. The draft recommendations were then reviewed and commented on by the entire Colposcopy Standards Committee

2017 Journal of lower genital tract disease

8. ASCCP Colposcopy Standards: How do we perform colposcopy? Implications for establishing standards Full Text available with Trip Pro

ASCCP Colposcopy Standards: How do we perform colposcopy? Implications for establishing standards The American Society for Colposcopy and Cervical Pathology (ASCCP) Colposcopy Standards recommendations address the role of and approach to colposcopy and biopsy for cervical cancer prevention in the United States. The recommendations were developed by an expert working group appointed by ASCCP's Board of Directors. Working group 3 defined colposcopy procedure guidelines for minimum (...) and comprehensive colposcopy practice and evaluated the use of colposcopy adjuncts.The working group performed a systematic literature review to identify best practices in colposcopy methodology and to evaluate the use of available colposcopy adjuncts. The literature provided little evidence to support specific elements of the procedure. The working group, therefore, implemented a national survey of current and recent ASCCP members to evaluate common elements of the colposcopy examination. The findings

2017 Journal of lower genital tract disease

9. Mozart for Reducing Patient Anxiety During Colposcopy: A Randomized Controlled Trial (Abstract)

Mozart for Reducing Patient Anxiety During Colposcopy: A Randomized Controlled Trial To test whether music by Mozart reduces anxiety among patients undergoing colposcopy.In a randomized multicenter trial, we measured the reduction of the situation-specific anxiety of women hearing Mozart's Symphony No. 40 during colposcopy compared with women not hearing music using the State-Trait Anxiety Inventory. Secondary endpoints were reduction of heart rate (beats per minute), pain during and 10 minutes (...) after colposcopy, general unpleasantness, anxiety during colposcopy, and overall satisfaction (11-item visual analog scales). Analysis was by intention to treat. A sample size of 104 per group (N=208) was calculated to achieve 80% power to detect a difference of 4.8 with a SD of 12.3 in anxiety scores.Between February 2017 and May 2018, 212 women were randomized. The mean anxiety reduction was -9.4±10.8 SD in 103 women in the music group and -9.0±10.6 in 102 women in the control group (P=.40

2018 EvidenceUpdates

10. Adjunctive colposcopy technologies for examination of the uterine cervix - DySIS and the Niris Imaging System

Adjunctive colposcopy technologies for examination of the uterine cervix - DySIS and the Niris Imaging System Adjunctive colposcopy technologies for examination of the uterine cervix – DySIS and the Niris Imaging System | Guidance | NICE Adjunctive colposcopy technologies for examination of the uterine cervix – DySIS and the Niris Imaging System Diagnostics guidance [DG4] Published date: August 2012 Guidance This guidance has been updated and replaced by . Explore © NICE [year]. All rights

2012 National Institute for Health and Clinical Excellence - Diagnostics Guidance

11. Human papillomavirus vaccination: The ESGO-EFC position paper of the European society of Gynaecologic Oncology and the European Federation for colposcopy. Full Text available with Trip Pro

Human papillomavirus vaccination: The ESGO-EFC position paper of the European society of Gynaecologic Oncology and the European Federation for colposcopy. Vaccines against human papillomavirus (HPV) are available in Europe since 2006. They have been highly effective in preventing infection and disease caused by the vaccine types. Clinical efficacy data are available for cervical, vulvovaginal and anal precancer and invasive cervical cancer. Disease reduction is best with early vaccination (...) and depends on cost-effectiveness. The European Society of Gynaecologic Oncology and the European Federation for Colposcopy strongly support gender-neutral vaccination programs for children and young adolescents, with a catch-up program for young adults.Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.

2019 European Journal of Cancer

12. Development of the Patient's Experience and Attitude Colposcopy Eindhoven Questionnaire (PEACE-q). Full Text available with Trip Pro

Development of the Patient's Experience and Attitude Colposcopy Eindhoven Questionnaire (PEACE-q). No validated instruments for the evaluation of patient satisfaction in colposcopy do exist. Therefore, this study reports on the development of a Patient's Experience and Attitude to Colposcopy questionnaire.Patients who recently received colposcopy participated in a focus group. A panel of experts evaluated the transcriptions and agreed on a 15-item draft questionnaire. The draft questionnaire (...) was completed by 68 women who subsequently came for a colposcopy. For construct validation, Exploratory Factor Analysis (EFA) and Confirmatory Factor Analysis (CFA) were performed as well as reliability analysis. Concurrent validity was assessed with the 4-item Patient Health questionnaire (PHQ-4).Construct validation resulted in an 8-item patient perception scale with good psychometric properties (Cronbach's alpha: 0.76) and excellent model fit. Two subscales could be discriminated: patient procedure

2019 BMC health services research

13. The effect of an animation video on consultation time, anxiety and satisfaction in women with abnormal cervical cytology: Animation video reduces colposcopy time. Full Text available with Trip Pro

The effect of an animation video on consultation time, anxiety and satisfaction in women with abnormal cervical cytology: Animation video reduces colposcopy time. The objective was to assess whether supplementing hospital-dependent standard information with a hospital-independent animation video might reduce consultation time, pre-colposcopy anxiety levels and increase post-colposcopy satisfaction. Between November 2016 and May 2018, women were included if they were referred to the department (...) of Obstetrics and Gynaecology in one of the three participating hospitals in the Netherlands due to an abnormal cervical smear. Exclusion criteria were colposcopy in the medical history or inability to understand, speak or read Dutch. Two consecutive cohorts were created: a control group that received standard information and an intervention group that received the same plus the animation video. Outcome measures were consultation time, pre-colposcopy anxiety level and post-colposcopy satisfaction

2019 Preventive medicine reports Controlled trial quality: uncertain

14. Post-colposcopy Management of ASC-US and LSIL Pap Tests (PALS Trial): Pilot RCT. (Abstract)

Post-colposcopy Management of ASC-US and LSIL Pap Tests (PALS Trial): Pilot RCT. Evidence supporting optimal follow-up of women with atypical squamous cells of undetermined significance (ASC-US) or low-grade squamous intraepithelial lesion cytology found to have low-grade disease or normal findings at initial colposcopy is weak. Surveillance options include continued colposcopy, discharge with Pap testing, or HPV testing at 12 months. This study was a pilot RCT comparing these three follow-up (...) policies. The objectives were to determine the feasibility of an RCT and to compare the incidence of greater than or equal to high-grade squamous intraepithelial lesion (≥HSIL) in each of the follow-up policies.A total of 133 women referred with ASC-US or low-grade squamous intraepithelial lesion cytology between June and August 2012 underwent initial colposcopy where incident ≥HSIL histology was ruled out. Of these women, 125 were randomly assigned to colposcopic surveillance, Pap testing, or HPV

2019 Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC Controlled trial quality: uncertain

15. Mozart for Reducing Patient Anxiety During Colposcopy: A Randomized Controlled Trial. (Abstract)

Mozart for Reducing Patient Anxiety During Colposcopy: A Randomized Controlled Trial. 30575664 2018 12 21 1873-233X 133 1 2019 Jan Obstetrics and gynecology Obstet Gynecol Mozart for Reducing Patient Anxiety During Colposcopy: A Randomized Controlled Trial. 191 10.1097/AOG.0000000000003052 Quinlan Maura Parker MP Department of Obstetrics and Gynecology, Northwestern University School of Medicine, Chicago, Illinois La Grange Park, Illinois. Quinlan John J JJ eng Journal Article United States

2019 Obstetrics and Gynecology Controlled trial quality: predicted high

16. Prospective cohort study examining cervical cancer screening methods in HIV-positive and HIV-negative Cambodian Women: a comparison of human papilloma virus testing, visualization with acetic acid and digital colposcopy. Full Text available with Trip Pro

Prospective cohort study examining cervical cancer screening methods in HIV-positive and HIV-negative Cambodian Women: a comparison of human papilloma virus testing, visualization with acetic acid and digital colposcopy. Logistical and economic issues make traditional cytology-based cervical cancer screening challenging in developing countries. Alternative, cost-effective, screening strategies must be developed to screen millions of women in resource-poor countries such as Cambodia.A (...) prospective cohort study during which all women underwent four cervical cancer screening methods: (1) self-sampled human papilloma virus (HPV) testing (careHPV system), (2) clinician-collected HPV testing, (3) visualization with acetic acid (VIA) and (4) digital colposcopy (DC) with the Enhanced Visual Assessment System (EVA).A referral hospital in Phnom Penh, Cambodia.Two hundred and fifty Cambodian women (129 HIV+, 121 HIV-). Subjects were recruited from the National Center for HIV/AIDS Dermatology

2019 BMJ open

17. MiRNA detection in cervical exfoliated cells for missed high-grade lesions in women with LSIL/CIN1 diagnosis after colposcopy-guided biopsy. Full Text available with Trip Pro

MiRNA detection in cervical exfoliated cells for missed high-grade lesions in women with LSIL/CIN1 diagnosis after colposcopy-guided biopsy. Low-grade squamous intraepithelial lesion/cervical intraepithelial neoplasia grade 1 (LSIL/CIN1) preceded by colposcopy guided biopsy is recommended conservative follow-up, although some of these lesions are actually high-grade lesions, which are missed on an initial colposcopy. Therefore, in this work, we evaluate the potential role of miRNA detection (...) in cervical exfoliated cells in a clinic-based population for predicting missed high-grade lesions in women diagnosed with LSIL/CIN1 after colposcopy-guided biopsy.A total number of 177 women with a diagnosis of LSIL/CIN1 obtained by colposcopy-guided biopsy were grouped into two categories according to the histology of the conization specimens: consistent LSIL/CIN1 group (surgical pathology consistent with colposcopic diagnosis) and missed high-grade lesion group (surgical pathology found high-grade

2019 BMC Cancer

18. Management and treatment of cervical intraepithelial neoplasia in the Netherlands after referral for colposcopy. Full Text available with Trip Pro

Management and treatment of cervical intraepithelial neoplasia in the Netherlands after referral for colposcopy. The aim of this study was to describe trends in the diagnosis and treatment of women referred from the national screening program with cervical intraepithelial neoplasia (CIN) in the Netherlands, and to compare these trends with national guidelines and identify potential areas for improvement for the new primary high-risk HPV screening program.We conducted a population-based cohort (...) study using data from the Dutch pathology archive. Women aged 29-63 years who took part in the Dutch cervical screening program between 1 January 2005 and 31 December 2014 were selected. Three referral groups were identified: direct referrals and those referred after either one (first indirect referrals) or two (second indirect referrals) repeat cytology tests, totaling 85 239 referrals for colposcopy. The most invasive management technique and the most severe diagnosis of each screening episode

2019 Acta Obstetricia et Gynecologica Scandinavica

19. The impact of decentralising colposcopy services from tertiary-level to primary-level care in inner-city Johannesburg, South Africa: a before and after study. Full Text available with Trip Pro

The impact of decentralising colposcopy services from tertiary-level to primary-level care in inner-city Johannesburg, South Africa: a before and after study. To assess whether decentralising colposcopy services to a primary care facility in inner-city Johannesburg, South Africa raises access to colposcopy.Before-after study comparing 2 years before and 2 years after decentralisation, using clinical records and laboratory data on cervical cytology and histology.The proportion of all women (...) attending Hillbrow Community Health Centre (HCHC) with an abnormal Papanikolaou (Pap) smear who had a colposcopy post-decentralisation.Charlotte Maxeke Johannesburg Academic Hospital (CMJAH) has provided colposcopy services for several decades. HCHC, located about 3 km away, began colposcopy services in 2014.Women, aged above 18 years, who had a colposcopy for diagnosis and treatment of precancerous cervical lesions following a Pap smear, from 2012 to 2016 at CMJAH or HCHC.Pre-decentralisation at CMJAH

2019 BMJ open

20. Cross-sectional study of HPV testing in self-sampled urine and comparison with matched vaginal and cervical samples in women attending colposcopy for the management of abnormal cervical screening. Full Text available with Trip Pro

Cross-sectional study of HPV testing in self-sampled urine and comparison with matched vaginal and cervical samples in women attending colposcopy for the management of abnormal cervical screening. Human papillomavirus (HPV) testing in cervical screening offers the potential for self-sampling to improve uptake among non-attenders. High-risk (HR) HPV detection in urine shows promise, but few studies have examined its sensitivity for cervical intraepithelial neoplasia (CIN2+) detection compared (...) with standard cervical samples. The aims of this cross-sectional study were to optimise conditions for urine testing for HPV detection; to determine concordance for HR-HPV detection in matched urine, vaginal and cervical samples; to compare the sensitivity of HR-HPV testing for the detection of CIN2+ in matched samples; and to determine the acceptability of urine testing for cervical screening.Cross-sectional study.Secondary care colposcopy clinic in North West England.Women aged 25 years of age or older

2019 BMJ open

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