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Cluster Headache

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2. Cluster headache

Cluster headache Cluster headache - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Cluster headache Last reviewed: February 2019 Last updated: July 2018 Summary Attack of severe pain localised to the unilateral orbital, supra-orbital, and/or temporal areas; lasts from 15 minutes to 3 hours. Occurs from once every other day to 8 times per day. Attacks occur at the same time period for several weeks (the cluster period (...) ); accompanied by ipsilateral autonomic signs. Most patients are restless or agitated during attacks compared to people with migraine who often report motion sensitivity during attacks. Pathophysiology is thought to result from hypothalamic activation with secondary trigeminal and autonomic activation. Cluster period attacks can be precipitated by alcohol, volatile smells, warm temperatures, and sleep. Diagnosis is based on International Headache Society 3-beta (IHS-3b) criteria. Medications for acute

2018 BMJ Best Practice

3. Effectiveness of Oxygen and Other Acute Treatments for Cluster Headache: Results From the Cluster Headache Questionnaire, an International Survey. (PubMed)

Effectiveness of Oxygen and Other Acute Treatments for Cluster Headache: Results From the Cluster Headache Questionnaire, an International Survey. To assess the effectiveness and adverse effects of acute cluster headache medications in a large international sample, including recommended treatments such as oxygen, commonly used medications such as opioids, and emerging medications such as intranasal ketamine. Particular focus is paid to a large subset of respondents 65 years of age (...) or older.Large international surveys of cluster headache are rare, as are examinations of treatments and side effects in older cluster headache patients. This article presents data from the Cluster Headache Questionnaire, with respondents from over 50 countries and with the vast majority from the United States, the United Kingdom, and Canada.This internet-based survey included questions on cluster headache diagnostic criteria, which were used as part of the inclusion/exclusion criteria for the study, as well

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2019 Headache

4. Protocol for a comparison of therapies for cluster headache systematic review, updated meta-analysis, and network meta-analysis of medication effect by class (acute and preventative) and by headache subtype (episodic and chronic)

Protocol for a comparison of therapies for cluster headache systematic review, updated meta-analysis, and network meta-analysis of medication effect by class (acute and preventative) and by headache subtype (episodic and chronic) Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate

2019 PROSPERO

5. Cluster Headache Clinical Phenotypes: Tobacco Nonexposed (Never Smoker and No Parental Secondary Smoke Exposure as a Child) versus Tobacco-Exposed: Results from the United States Cluster Headache Survey. (PubMed)

Cluster Headache Clinical Phenotypes: Tobacco Nonexposed (Never Smoker and No Parental Secondary Smoke Exposure as a Child) versus Tobacco-Exposed: Results from the United States Cluster Headache Survey. To present results from the United States Cluster Headache Survey comparing the clinical presentation of tobacco nonexposed and tobacco-exposed cluster headache patients.Cluster headache is uniquely tied to a personal history of tobacco usage/cigarette smoking and, if the individual cluster (...) headache sufferer did not smoke, it has been shown that their parent(s) typically did and that individual had significant secondary smoke exposure as a child. The true nontobacco exposed (no personal or secondary exposure) cluster headache sufferer has never been fully studied.The United States Cluster Headache Survey consisted of 187 multiple choice questions related to cluster headache including: patient demographics, clinical headache characteristics, family history, triggers, smoking history

2018 Headache

6. Carotid dissection presenting as a prolonged cluster-like headache in a patient with episodic cluster headache (PubMed)

Carotid dissection presenting as a prolonged cluster-like headache in a patient with episodic cluster headache We present a patient with known episodic cluster headache, who presented with cluster-like headache in the course of internal carotid artery dissection (ICAD) and discuss possible pathophysiological links between the two diseases. It is well known that cluster-like headache could be the presenting symptom of ICAD. However, ICAD occurring in a patient with a known episodic cluster (...) headache was only once previously described. In the end of the manuscript, we propose red flags to help clinicians differentiate between primary cluster headache and cluster-like attacks masking underlying ICAD. Finally, we raise the question whether at least some proportion of those patients with cluster headache and Horner syndrome previously classified as a primary headache disorder might have been secondary cases to ICAD.© BMJ Publishing Group Ltd (unless otherwise stated in the text of the article

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2017 BMJ case reports

7. gammaCore for cluster headache

gammaCore for cluster headache gammaCore for cluster headache gammaCore for cluster headache Medtech innovation briefing Published: 22 October 2018 nice.org.uk/guidance/mib162 pathways Summary Summary The technology technology described in this briefing is gammaCore. It is used as a daily preventative measure for cluster headache and can be used to treat pain during a headache. The inno innovativ vative aspects e aspects compared with other vagus nerve stimulators is that gammaCore is applied (...) to the surface of the neck rather than surgically implanted. The intended place in ther place in therap apy y would be as well as standard care, most likely where standard treatments for cluster headache are ineffective, not tolerated or contraindicated. It would be prescribed by neurologists who provide specialist headache services. The main points from the e main points from the evidence vidence summarised in this briefing are from 5 studies: 3 randomised controlled trials, 1 open-label randomised trial

2018 National Institute for Health and Clinical Excellence - Advice

8. Normobaric and hyperbaric oxygen therapy for the treatment and prevention of migraine and cluster headache. (PubMed)

Normobaric and hyperbaric oxygen therapy for the treatment and prevention of migraine and cluster headache. Migraine and cluster headaches are severe and disabling. Migraine affects up to 18% of women, while cluster headaches are much less common (0.2% of the population). A number of acute and prophylactic therapies are available. Hyperbaric oxygen therapy (HBOT) is the therapeutic administration of 100% oxygen at environmental pressures greater than one atmosphere, while normobaric oxygen (...) therapy (NBOT) is oxygen administered at one atmosphere. This is an updated version of the original Cochrane review published in Issue 3, 2008 under the title 'Normobaric and hyperbaric oxygen for migraine and cluster headache'.To examine the efficacy and safety of normobaric oxygen therapy (NBOT) and hyperbaric oxygen therapy (HBOT) in the treatment and prevention of migraine and cluster headache.We updated searches of the following databases up to 15 June 2015: CENTRAL (the Cochrane Library

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2015 Cochrane

9. Is melatonin effective for preventing cluster headache?

Is melatonin effective for preventing cluster headache? Is melatonin effective for preventing cluster headache? – SPS - Specialist Pharmacy Service – The first stop for professional medicines advice Menu · · Published 8th February 2016, updated 26th March 2019 · Southampton Medicines Advice Service, UKMi This Medicines Q&A evaluates the limited available published evidence investigating the role of melatonin in the prevention of cluster headaches Attachments · PDF · 128 KB Principal Pharmacist

2016 Specialist Pharmacy Services

10. Transcutaneous stimulation of the cervical branch of the vagus nerve for cluster headache and migraine

Transcutaneous stimulation of the cervical branch of the vagus nerve for cluster headache and migraine T T r ranscutaneous stimulation of the cervical anscutaneous stimulation of the cervical br branch of the vagus nerv anch of the vagus nerve for cluster headache e for cluster headache and migr and migraine aine Interventional procedures guidance Published: 23 March 2016 nice.org.uk/guidance/ipg552 Y Y our responsibility our responsibility This guidance represents the view of NICE, arrived (...) . 1 1 Recommendations Recommendations 1.1 Current evidence on the safety of transcutaneous stimulation of the cervical branch of the vagus nerve for cluster headache and migraine raises no major concerns. The evidence on efficacy is limited in quantity and quality. Therefore, © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 1 of 9this procedure should only be used with special arrangements for clinical governance

2016 National Institute for Health and Clinical Excellence - Interventional Procedures

11. Cluster headache attack remission with sphenopalatine ganglion stimulation: experiences in chronic cluster headache patients through 24 months. (PubMed)

Cluster headache attack remission with sphenopalatine ganglion stimulation: experiences in chronic cluster headache patients through 24 months. Cluster headache (CH) is a debilitating headache disorder with severe consequences for patient quality of life. On-demand neuromodulation targeting the sphenopalatine ganglion (SPG) is effective in treating the acute pain and a subgroup of patients experience a decreased frequency of CH attacks.We monitored self-reported attack frequency, headache (...) ).In this population of 33 refractory CCH patients, in addition to providing the ability to treat acute attacks, neuromodulation of the SPG induced periods of remission from cluster attacks in a subset of these. Some patients experiencing remission were also able to reduce or stop their preventive medication and remissions were accompanied by an improvement in headache disability.

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2016 The journal of headache and pain

12. What is cluster headache? Fact sheet for patients and their families. A publication to mark Cluster Headache Day 2016 (PubMed)

What is cluster headache? Fact sheet for patients and their families. A publication to mark Cluster Headache Day 2016 27678213 2017 02 03 2017 02 03 1971-3274 31 3 2016 Jul-Sep Functional neurology Funct. Neurol. What is cluster headache? Fact sheet for patients and their families. A publication to mark Cluster Headache Day 2016. 181-3 Rossi Paolo P Whelan J J Craven A A Ruiz De La Torre E E eng Journal Article Italy Funct Neurol 8707746 0393-5264 IM Cluster Headache epidemiology genetics

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2016 Functional Neurology

13. Real-world health plan claims analysis of differences in healthcare utilization and total cost in patients suffering from cluster headaches and those without headache-related conditions. (PubMed)

Real-world health plan claims analysis of differences in healthcare utilization and total cost in patients suffering from cluster headaches and those without headache-related conditions. According to the World Health Organization, headache disorders are underappreciated by many health systems. These disorders have a substantial impact on quality of life, yet the true correlation between headache conditions and increased total healthcare utilization is not well understood. This study further (...) explores the impact of headache conditions on healthcare utilization.To assess differences in healthcare utilization and total cost in patients suffering from cluster headaches (CH) compared with patients without headache-related conditions.Medical and pharmacy claims data from 4 regional health plans were used to evaluate differences in healthcare utilization and cost in patients with a diagnosis code for CH (chronic, episodic, or unspecified) from International Classification of Diseases, Ninth

2017 American Journal Of Managed Care

14. Cranial parasympathetic activation induces autonomic symptoms but no cluster headache attacks. (PubMed)

Cranial parasympathetic activation induces autonomic symptoms but no cluster headache attacks. Background Low frequency (LF) stimulation of the sphenopalatine ganglion (SPG) may increase parasympathetic outflow and provoke cluster headache (CH) attacks in CH patients implanted with an SPG neurostimulator. Methods In a double-blind randomized sham-controlled crossover study, 20 CH patients received LF or sham stimulation for 30 min on two separate days. We recorded headache characteristics (...) , cephalic autonomic symptoms (CAS), plasma levels of parasympathetic markers such as pituitary adenylate cyclase-activating polypeptide-38 (PACAP38) and vasoactive intestinal peptide (VIP), and mechanical detection and pain thresholds as a marker of sensory modulation. Results In the immediate phase (0-60 min), 16 (80%) patients experienced CAS after LF stimulation, while nine patients (45%) reported CAS after sham ( p = 0.046). We found no difference in induction of cluster-like attacks between LF

2019 Cephalalgia : an international journal of headache

15. Deep brain stimulation modulates hypothalamic-brainstem fibers in cluster headache: case report. (PubMed)

Deep brain stimulation modulates hypothalamic-brainstem fibers in cluster headache: case report. Hypothalamic deep brain stimulation (DBS) has been used for more than a decade to treat cluster headache (CH) but its mechanisms remain poorly understood. The authors have successfully treated a patient with CH using hypothalamic DBS and found that the contact used for chronic stimulation was located in a white matter region posterior to the mammillary bodies. Fiber tracts crossing that region were

2019 Journal of Neurosurgery

16. Non-invasive neuromodulation for migraine and cluster headache: a systematic review of clinical trials. (PubMed)

Non-invasive neuromodulation for migraine and cluster headache: a systematic review of clinical trials. Non-invasive neuromodulation therapies for migraine and cluster headache are a practical and safe alternative to pharmacologics. Comparisons of these therapies are difficult because of the heterogeneity in study designs. In this systematic review of clinical trials, the scientific rigour and clinical relevance of the available data were assessed to inform clinical decisions about non-invasive (...) neuromodulation. PubMed, Cochrane Library and ClinicalTrials.gov databases and the WHO's International Clinical Trials Registry Platform were searched for relevant clinical studies of non-invasive neuromodulation devices for migraine and cluster headache (1 January 1990 to 31 January 2018), and 71 were identified. This analysis compared study designs using recommendations of the International Headache Society for pharmacological clinical trials, the only available guidelines for migraine and cluster headache

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2019 Neurosurgery and Psychiatry

17. Analysis of HCRTR2 Gene Variants and Cluster Headache in Sweden. (PubMed)

Analysis of HCRTR2 Gene Variants and Cluster Headache in Sweden. The purpose of this study was to investigate the HCRTR2 gene variants rs3122156, rs2653342, and rs2653349 in a large homogenous Swedish case-control cohort in order to further evaluate the possible contribution of HCRTR2 to cluster headache.Cluster headache is a severe neurovascular disorder and the pathophysiology is not yet fully understood. Due to striking circadian and circannual patterns of this disease, the hypothalamus has (...) been a research focus in cluster headache. Several studies with many different cohorts from Europe have investigated the hypocretin receptor 2 (HCRTR2) gene, which is expressed in the hypothalamus. In particular, one HCRTR2 single nucleotide polymorphism, rs2653349, has been subject to a number of genetic association studies on cluster headache, with conflicting results. Two other HCRTR2 gene variants, rs2653342 and rs2653349, have been reported to be linked to cluster headache in an Italian

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2019 Headache

18. Multicentre, prospective, randomised, controlled, blinded-endpoint study to evaluate the efficacy and safety of pterygopalatine ganglion pulsed radiofrequency treatment for cluster headache: study protocol. (PubMed)

Multicentre, prospective, randomised, controlled, blinded-endpoint study to evaluate the efficacy and safety of pterygopalatine ganglion pulsed radiofrequency treatment for cluster headache: study protocol. Single-centre reports on small groups of patients have shown that pterygopalatine ganglion pulsed radiofrequency treatment in patients with refractory cluster headache (CH) can quickly relieve pain without significant side effects. However, a randomised controlled trial is still necessary (...) ganglion puncture. A mixture containing steroids and local anaesthetics will be slowly injected into the patients in the NB group. The patients in the PRF group will be treated with PRF at 42°C for 360 s. After treatment, the duration of cluster periods; degree of pain during headache attacks; frequency of headache attacks; duration of each headache attack; dose of auxiliary analgesic drugs; duration of remission; degree of patient satisfaction; effectiveness rates at 1 day, 3 days, 1 week, 2 weeks, 1

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2019 BMJ open

19. Zonisamide for Cluster Headache Prophylaxis: A Case Series. (PubMed)

Zonisamide for Cluster Headache Prophylaxis: A Case Series. There is very little literature surrounding the prophylactic use of zonisamide in cluster headaches. The study aims to evaluate the effectiveness of zonisamide for prophylaxis of cluster headache in patients with chronic or episodic cluster headache.Both chronic and episodic cluster headaches are debilitating disorders which are often refractory to multiple prophylactic medication regimens. There is a scarcity of research in this area (...) , and current prophylactic options for patients are fairly limited, which is troublesome for affected patients. Zonisamide is an established antiepileptic with a multifactorial mechanism of action which has shown to be useful in other headache disorders such as migraine.Twenty cluster headache patients, both episodic (n = 12; ICHD 3.1.1) and chronic (n = 8; ICHD 3.1.2), who had been or currently were treated with zonisamide, were retrospectively evaluated. Effectiveness of the medication was assessed

2019 Headache

20. Cluster Headache in Subjects With Substance Use Disorder: A Case Series and a Review of the Literature. (PubMed)

Cluster Headache in Subjects With Substance Use Disorder: A Case Series and a Review of the Literature. To describe a case series of 7 patients presenting cluster headache (CH) criteria and a substance use disorder, reported to a French Addictovigilance center. Then, to assess clinical, pharmacological, and neurobiological linkages between substance use and CH onset.CH patients are presenting a higher prevalence of comorbidities, among which the use of psychoactive substances, licit or illicit (...) the subjects and precedes the beginning of attacks for 5/7 subjects.We have found a CH prevalence of 0.9% in our studied population, while it is estimated at 0.1% in the general population. The coexistence of cluster headache and addiction behaviors reflects possible common neurobiological pathways, which would include the hypothalamus. Research could be conducted on the potential of hypothalamic therapeutic targets.© 2019 American Headache Society.

2019 Headache

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