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Clostridium perfringens

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181. Use of an online survey during an outbreak of clostridium perfringens in a retirement community-Arizona, 2012. (Abstract)

Use of an online survey during an outbreak of clostridium perfringens in a retirement community-Arizona, 2012. An outbreak of gastrointestinal (GI) illness among retirement community residents was reported to the Maricopa County Department of Public Health. Online surveys can be useful for rapid investigation of disease outbreaks, especially when local health departments lack time and resources to perform telephone interviews. Online survey utility among older populations, which may lack (...) the barbecue, 63 (95.5%) reported diarrhea, and 5 (7.6%) reported vomiting. Leftover beef from an attendee's refrigerator grew Clostridium perfringens. Of 552 residents contacted by telephone, 113 completed the telephone survey (mean age, 71.3 years; 63.3% women), 101 (89.4%) reported the ability to send e-mail, 82 (81.2%) checked e-mail daily, and 28 (27.7%) checked e-mail on a handheld device. The attack rate was 17.8% for online versus 2.7% for telephone respondents (P < .001).This outbreak demonstrated

2014 Journal of Public Health Management and Practice

182. Prevalence of C. Botulinum and C. Perfringens Spores in Food Products Available on Polish Market Full Text available with Trip Pro

Prevalence of C. Botulinum and C. Perfringens Spores in Food Products Available on Polish Market The aim of this study was to evaluate the prevalence of Clostridium botulinum and Clostridium perfringens in food samples purchased from Polish producers.The analyses were performed on 260 food samples collected in Lublin and Subcarpathian regions: 56 of smoked meat, 21 of pork meat, 20 of dairy products, 26 of vegetable and fruit preserves, 40 of ready-to-eat meals, 27 of fish preserves, and 70 (...) of honey collected directly from apiaries.C. botulinum strains were isolated from 2.3% (6/260) of samples and the isolates were classified as toxin types A (4/260) and B (2/260). C. perfringens strains were isolated from 14% (37/260) of samples. All the isolates were classified as toxin type A, 28 of them were able also to produce α toxin and 9 - β2 toxin.On the basis of the obtained results it could be suggested that risk assessment, especially regarding the entire honey harvesting process, should

2017 Journal of Veterinary Research

183. METABOLISM OF PENTOSES BY CLOSTRIDIA II. Clostridium perfringens, Clostridium beijerinckii, andClostridium butylicum: The Fermentation of C14-Labeled Pentoses by Full Text available with Trip Pro

METABOLISM OF PENTOSES BY CLOSTRIDIA II. Clostridium perfringens, Clostridium beijerinckii, andClostridium butylicum: The Fermentation of C14-Labeled Pentoses by 13513607 2000 07 01 2018 12 01 0021-9193 75 3 1958 Mar Journal of bacteriology J. Bacteriol. Metabolism of pentoses by clostridia. II. The fermentation of C14-labeled pentoses by Clostridium per fringens, Clostridium beijerinckii, and Clostridium butylicum. 335-8 CYNKIN M A MA GIBBS M M eng Journal Article United States J Bacteriol (...) 2985120R 0021-9193 0 Pentoses OM Carbohydrate Metabolism Clostridium metabolism Clostridium beijerinckii Fermentation Gram-Positive Bacteria Humans Pentoses metabolism 5834:5952:147:225:449 CLOSTRIDIUM/metabolism FERMENTATION PENTOSES/metabolism 1958 3 1 1958 3 1 0 1 1958 3 1 0 0 ppublish 13513607 PMC290086 Arch Biochem Biophys. 1951 Sep;33(2):173-8 14885997 J Biol Chem. 1951 Oct;192(2):769-805 14907672 J Biol Chem. 1951 Nov;193(1):411-23 14907729 J Bacteriol. 1950 Mar;59(3):387-400 15436409 Bacteriol

1958 Journal of bacteriology

184. Inhibition of Clostridium botulinum by Strains of Clostridium perfringens Isolated from Soil Full Text available with Trip Pro

Inhibition of Clostridium botulinum by Strains of Clostridium perfringens Isolated from Soil Thirty-one soil samples were examined for the presence of organisms capable of inhibiting growth and toxin production of strains of Clostridium botulinum type A. Such organisms were found in eight samples of soil. Inhibiting strains of C. perfringens were found in five samples, of C. sporogenes in three and of Bacillus cereus in three. Three of the C. perfringens strains produced an inhibitor effective (...) on all 11 strains of C. botulinum type A against which they were tested, seven of eight proteolytic type B strains, one nonproteolytic type B strain, five of nine type E strains and all seven type F strains, whether proteolytic or nonproteolytic. They did not inhibit any of 26 type C strains, 6 type D strains, 4 type E strains, or 24 C. sporogenes strains. In mixed culture, an inhibitor strain of C. perfringens repressed growth and toxin production by a C. botulinum type A strain even though

1975 Applied microbiology

185. Effect of Potassium Sorbate on Salmonellae, Staphylococcus aureus, Clostridium perfringens, and Clostridium botulinum in Cooked, Uncured Sausage Full Text available with Trip Pro

Effect of Potassium Sorbate on Salmonellae, Staphylococcus aureus, Clostridium perfringens, and Clostridium botulinum in Cooked, Uncured Sausage Skinless precooked, uncured sausage links with and without potassium sorbate (0.1% wt/wt) were inoculated with salmonellae, Staphylococcus aureus, Clostridium perfringens, and Clostridium botulinum and held at 27 C to represent temperature abuse of the product. Total counts of uninoculated product showed that the normal spoilage flora was delayed 1 day (...) when sorbate was present. Growth of salmonellae was markedly retarded by sorbate. Growth of S. aureus was delayed 1 day in the presence of sorbate, after which growth occurred to the same level as in product without sorbate. C. perfringens declined to below detectable levels within the first day in product with and without sorbate. Sorbate retarded the growth of C. botulinum. Botulinal toxin was detected in 4 days in product without sorbate but not until after 10 days in product with sorbate.

1974 Applied microbiology

186. SPORULATION OF CLOSTRIDIUM BOTULINUM TYPES A, B, AND E, CLOSTRIDIUM PERFRINGENS, AND PUTREFACTIVE ANAEROBE 3679 IN DIALYSIS SACS Full Text available with Trip Pro

SPORULATION OF CLOSTRIDIUM BOTULINUM TYPES A, B, AND E, CLOSTRIDIUM PERFRINGENS, AND PUTREFACTIVE ANAEROBE 3679 IN DIALYSIS SACS Schneider, Morris D. (Quartermaster Food and Container Institute for the Armed Forces, U.S. Army, Chicago, Ill.), Nicholas Grecz, and Abe Anellis. Sporulation of Clostridium botulinum types A, B, and E, Clostridium perfringens, and Putrefactive Anaerobe 3679 in dialysis sacs. J. Bacteriol. 85:126-133. 1963.-Concentrated cultures of spores of Clostridium botulinum type (...) A (33A, 37A), B (41B, 51B), and E (strain VH), C. perfringens (strain E), and Putrefactive Anaerobe 3679 were prepared in intussuscepted cellulose dialysis tubing. The apparatus consisted of a telescoped cellulose bag immersed into a suitable sporulation medium in a large Pyrex tube. The initial inoculum was a heavy suspension in physiological saline solution of either vegetative cells or heat-shocked spores. The seed material was introduced into the interior of the dialysis bag. Maximal spore

1963 Journal of bacteriology

187. The synergistic necrohemorrhagic action of Clostridium perfringens perfringolysin and alpha toxin in the bovine intestine and against bovine endothelial cells Full Text available with Trip Pro

The synergistic necrohemorrhagic action of Clostridium perfringens perfringolysin and alpha toxin in the bovine intestine and against bovine endothelial cells Bovine necrohemorrhagic enteritis is a major cause of mortality in veal calves. Clostridium perfringens is considered as the causative agent, but there has been controversy on the toxins responsible for the disease. Recently, it has been demonstrated that a variety of C. perfringens type A strains can induce necrohemorrhagic lesions (...) in a calf intestinal loop assay. These results put forward alpha toxin and perfringolysin as potential causative toxins, since both are produced by all C. perfringens type A strains. The importance of perfringolysin in the pathogenesis of bovine necrohemorrhagic enteritis has not been studied before. Therefore, the objective of the current study was to evaluate the role of perfringolysin in the development of necrohemorrhagic enteritis lesions in calves and its synergism with alpha toxin

2013 Veterinary Research

188. How do swine practitioners and veterinary pathologists arrive at a diagnosis of Clostridium perfringens type A enteritis in neonatal piglets? Full Text available with Trip Pro

How do swine practitioners and veterinary pathologists arrive at a diagnosis of Clostridium perfringens type A enteritis in neonatal piglets? A questionnaire was administered to 22 veterinary practitioners and 17 veterinary pathologists to investigate the methods used for diagnosis of Clostridium perfringens type A enteritis in neonatal pigs. Practitioners generally diagnosed C. perfringens type A associated enteritis by age of onset of diarrhea (between 1 to 7 days of age). Most practitioners (...) (95%) were moderately to very confident in their diagnosis. Pathologists generally diagnosed C. perfringens type A associated enteritis by combinations of isolation of the organism, genotyping or detecting the toxins of the organism, and ruling out other pathogens through histopathology. Almost half (41%) of the pathologists were not confident of their diagnosis. This study reports that the current diagnostic method for C. perfringens type A enteritis is not specific, and although many

2013 The Canadian Veterinary Journal

189. Acute Hemolysis in the Emergency Department: Think about Clostridium perfringens! Full Text available with Trip Pro

Acute Hemolysis in the Emergency Department: Think about Clostridium perfringens! Clostridium perfringens (CP) gives several clinical settings, from an asymptomatic to a massive intravascular hemolysis. We report a case of fatal intravascular hemolysis due to CP septicemia having a hepatic supposed starting point in the emergency department. Like in many cases, the diagnosis was made when patient had already gone into shock and died. The CP septicemia often complicated the course

2013 Case Reports in Emergency Medicine

190. An investigation into the association between cpb2-encoding Clostridium perfringens type A and diarrhea in neonatal piglets Full Text available with Trip Pro

An investigation into the association between cpb2-encoding Clostridium perfringens type A and diarrhea in neonatal piglets To investigate the possible role of cpb2-positive type A Clostridium perfringens in neonatal diarrheal illness in pigs, the jejunum and colon of matched normal and diarrheic piglets from 10 farms with a history of neonatal diarrhea were examined grossly and by histopathology, and tested for C. perfringens, for C. perfringens beta2 (CPB2) toxin, as well as for Clostridium (...) difficile toxins, Salmonella, enterotoxigenic Escherichia coli, rotavirus, transmissible gastroenteritis (TGE) virus, and coccidia. Clostridium perfringens isolates were tested using a multiplex real-time polymerase chain reaction (PCR) to determine the presence of cpa, consensus and atypical cpb2, and other virulence-associated genes. The numbers of C. perfringens in the intestinal contents were lower in diarrheic piglets (log₁₀ 5.4 CFU/g) compared with normal piglets (log₁₀ 6.5 CFU/g) (P < 0.05

2013 Canadian Journal of Veterinary Research

191. A novel watery diarrhoea caused by the co-infection of neonatal piglets with Clostridium perfringens type A and Escherichia coli (K88, 987P). (Abstract)

A novel watery diarrhoea caused by the co-infection of neonatal piglets with Clostridium perfringens type A and Escherichia coli (K88, 987P). In 2011, a novel watery diarrhoea in 1-7 day-old piglets occurred in Changchun, China, characterized by high pathogenicity and mortality. Investigation of clinical signs, examination for viruses, and isolation and identification of bacteria showed that co-infection by Clostridium perfringens type A and Escherichia coli (K88, 987P) was the most likely (...) cause of the disease. Newborn piglets challenged with a mixture of Clostridium perfringens type A and Escherichia coli (K88, 987P) died within 3 days with clinical signs and gross lesions similar to those in the piglets that died in the outbreak. A subsequent study showed that the use in sows of an inactivated vaccine against the two causal bacteria was effective at reducing the incidence of the watery diarrhoea in piglets. Piglets from sows given the inactivated vaccine had a incidence of watery

2013 Veterinary journal (London, England : 1997)

192. Effect of 3',5'-cyclic diguanylic acid in a broiler Clostridium perfringens infection model. Full Text available with Trip Pro

Effect of 3',5'-cyclic diguanylic acid in a broiler Clostridium perfringens infection model. In an effort to explore strategies to control Clostridium perfringens, we investigated the synergistic effect of a ubiquitous bacterial second messenger 3',5'-cyclic diguanylic acid (c-di-GMP) with penicillin G in a broiler challenge model. All chicks were inoculated in the crop by gavage on d 14, 15, and 16 with a mixture of 4 C. perfringens strains. Birds were treated with saline (control group) or 20 (...) . perfringens virulence genes showed a prevalence of 30% for the Clostridium perfringens alpha-toxin gene (cpa) from d 21 to 35 in the IM-treated group, whereas the occurrence of the cpa gene increased from 10 to 60% in the other 2 groups (control and gavage) from d 21 to 35. Detection of β-lactamase genes (blaCMY-2, blaSHV, and blaTEM) indicative of gram-negative bacteria in the same samples from d 21 to 35 did not show significant treatment effects. Amplified fragment-length polymorphism showed

2013 Poultry science Controlled trial quality: uncertain

193. Foodborne Disease Outbreaks caused by Bacillus cereus, Clostridium perfringens, and Staphylococcus aureus, United States, 1998-2008. Full Text available with Trip Pro

Foodborne Disease Outbreaks caused by Bacillus cereus, Clostridium perfringens, and Staphylococcus aureus, United States, 1998-2008. From 1998 to 2008, 1229 foodborne outbreaks caused by Bacillus cereus, Clostridium perfringens, and Staphylococcus aureus were reported in the United States; 39% were reported with a confirmed etiology. Vomiting was commonly reported in B. cereus (median, 75% of cases) and S. aureus outbreaks (median, 87%), but rarely in C. perfringens outbreaks (median, 9%). Meat (...) or poultry dishes were commonly implicated in C. perfringens (63%) and S. aureus (55%) outbreaks, and rice dishes were commonly implicated in B. cereus outbreaks (50%). Errors in food processing and preparation were commonly reported (93%), regardless of etiology; contamination by a food worker was only common in S. aureus outbreaks (55%). Public health interventions should focus on these commonly reported errors to reduce the occurrence of outbreaks caused by B. cereus, C. perfringens, and S. aureus

2013 Clinical Infectious Diseases

194. Human Claudin-8 and -14 Are Receptors Capable of Conveying the Cytotoxic Effects of Clostridium perfringens Enterotoxin Full Text available with Trip Pro

Human Claudin-8 and -14 Are Receptors Capable of Conveying the Cytotoxic Effects of Clostridium perfringens Enterotoxin Clostridium perfringens enterotoxin (CPE) contributes to several important human gastrointestinal (GI) diseases. This toxin and its derivatives are also being explored for translational applications, i.e., cancer therapy or drug delivery. Some, but not all, members of the 24-member claudin (Cldn) family of mammalian tight junction proteins can serve as CPE receptors. Among (...) in mammalian intestines, the current results support the possibility that these two hCldns contribute to natural CPE-mediated gastrointestinal disease and could be CPE-based therapeutic targets for cancers overexpressing those claudins. However, these results also suggest caution during therapeutic use of CPE, which might trigger toxic side effects in normal human tissues producing hCldn-8 or -14, as well as in those producing hCldn-3 or -4.Clostridium perfringens enterotoxin (CPE) is responsible

2013 mBio

195. Bacillus subtilis PB6 improves intestinal health of broiler chickens challenged with Clostridium perfringens-induced necrotic enteritis. Full Text available with Trip Pro

Bacillus subtilis PB6 improves intestinal health of broiler chickens challenged with Clostridium perfringens-induced necrotic enteritis. Necrotic enteritis (NE) is an enterotoxemic disease caused by Clostridium perfringens that results in significant economic losses, averaging damage of $0.05 per bird. The present study investigated the influence of a dietary supplement, Bacillus subtilis PB6, on performance, intestinal health, and gut integrity against C. perfringens-induced NE in broiler (...) birds. Bacillus subtilis PB6 (ATCC-PTA 6737) is a natural strain isolated from healthy chicken gut that has been shown in in vitro to produce antimicrobial substances with broad activity against various strains of Campylobacter and Clostridium species. The animal study was conducted on broiler chickens (Cobb 400) for the period of 35 d using a completely randomized design. The experimental design included 3 treatments groups. Each treatment group contained 6 replicates, 3 male and 3 female, with 12

2013 Poultry science Controlled trial quality: uncertain

196. Clostridium perfringens

Clostridium perfringens Clostridium perfringens Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Clostridium perfringens Clostridium (...) perfringens Aka: Clostridium perfringens , Gas Gangrene , Anaerobic Cellulitis , Clostridial Myonecrosis From Related Chapters II. Etiology: Clostridium Species Clostridium perfringens ( welchii) novyi septicum sordellii histolyticum III. Pathophysiology Tissue infection with gas-producing IV. Symptoms and Signs progression History of deep contaminated wound (Surgery, ) Onset Sudden pain at wound site Local swelling and edema of wound site Thin hemorrhagic exudate Toxemia Foul discharge from wound

2015 FP Notebook

197. The Binary Toxin CDT of Clostridium difficile as a Tool for Intracellular Delivery of Bacterial Glucosyltransferase Domains Full Text available with Trip Pro

The Binary Toxin CDT of Clostridium difficile as a Tool for Intracellular Delivery of Bacterial Glucosyltransferase Domains Binary toxins are produced by several pathogenic bacteria. Examples are the C2 toxin from Clostridium botulinum, the iota toxin from Clostridium perfringens, and the CDT from Clostridium difficile. All these binary toxins have ADP-ribosyltransferases (ADPRT) as their enzymatically active component that modify monomeric actin in their target cells. The binary C2 toxin

2018 Toxins

198. Clostridium paraputrificum septicemia and liver abscess Full Text available with Trip Pro

species are C. perfringens and C. septicum (64.9% and 17.5% respectively). C. perfringens cases carried a mortality of 67.6% with median survival of 11 h, and 70.2% of the C. perfringens cases experienced hemolysis. All C. septicum cases were found to have underlying liver malignancy at the time of the presentation with a mortality of only 30%. The remaining cases were caused by various Clostridium species, and this cohort's clinical course was significantly milder when compared to the above C (...) Clostridium paraputrificum septicemia and liver abscess We report the first case of a healthy 23-year-old female who underwent an interventional radiology-guided embolization of a hepatic adenoma, which resulted in a gas forming hepatic liver abscess and septicemia by Clostridium paraputrificum. A retrospective review of Clostridial liver abscesses was performed using a PubMed literature search, and we found 57 clostridial hepatic abscess cases. The two most commonly reported clostridial

2018 World journal of hepatology

199. Glycerol Monolaurate (GML) and a Nonaqueous Five-Percent GML Gel Kill Bacillus and Clostridium Spores Full Text available with Trip Pro

, B. subtilis, and B. cereus and anaerobic Clostridium perfringens and Clostridium (Clostridioides) difficile. Glycerol monolaurate alone was bactericidal for all five organisms tested. Glycerol monolaurate alone was effective in killing spores. When solubilized in a nonaqueous gel, the glycerol monolaurate gel was bactericidal for all spores tested. The data suggest that glycerol monolaurate nonaqueous gel could be effective in decontaminating environmental and body surfaces (...) Glycerol Monolaurate (GML) and a Nonaqueous Five-Percent GML Gel Kill Bacillus and Clostridium Spores Glycerol monolaurate is a broadly antimicrobial fatty acid monoester, killing bacteria, fungi, and enveloped viruses. The compound kills stationary-phase cultures of Bacillus anthracis, suggesting that the molecule may kill spores. In this study, we examined the ability of glycerol monolaurate alone or solubilized in a nonaqueous gel to kill vegetative cells and spores of aerobic B. anthracis

2018 mSphere

200. Clostridium sordellii Pathogenicity Locus Plasmid pCS1-1 Encodes a Novel Clostridial Conjugation Locus Full Text available with Trip Pro

evidence that genes within the cst locus are essential for the conjugative transfer of pCS1-1. The cst locus is present on all pCS1 subtypes, and homologous loci were identified on toxin-encoding plasmids from Clostridium perfringens and Clostridium botulinum and also carried within genomes of Clostridium difficile isolates, indicating that it is a widespread clostridial conjugation locus. The results of this study have broad implications for the dissemination of toxin genes and, potentially (...) Clostridium sordellii Pathogenicity Locus Plasmid pCS1-1 Encodes a Novel Clostridial Conjugation Locus A major virulence factor in Clostridium sordellii-mediated infection is the toxin TcsL, which is encoded within a region of the genome called the pathogenicity locus (PaLoc). C. sordellii isolates carry the PaLoc on the pCS1 family of plasmids, of which there are four characterized members. Here, we determined the potential mobility of pCS1 plasmids and characterized a fifth unique pCS1 member

2018 mBio

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