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Clinical Index of Stable Febrile Neutropenia

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21. Metastatic Non-Small-Cell Lung Cancer: ESMO Clinical Practice Guidelines

comparing monthly car- boplatin plus weekly paclitaxel versus single-agent vinorelbine or gemcitabine in patients aged 70–89 years with PS 0–2 has reportedasurvivaladvantageforcombinationtherapy[35]. Bene?t was observed across all subgroups, but increased tox- icity (notably febrile neutropenia and sepsis-related deaths) was observed. Platinum-based chemotherapy is the preferred option for elderly patients with PS 0-1—as well as selected PS2—and adequate organ function, while a single-agent approach (...) Metastatic Non-Small-Cell Lung Cancer: ESMO Clinical Practice Guidelines Metastaticnon-small-celllungcancer(NSCLC):ESMO ClinicalPracticeGuidelinesfordiagnosis,treatment andfollow-up † M.Reck 1,2 ,S.Popat 3,4 ,N.Reinmuth 1,2 ,D.DeRuysscher 5 ,K.M.Kerr 6 ,S.Peters 7 & onbehalfof theESMOGuidelinesWorkingGroup * 1 DepartmentofThoracicOncology,LungenClinic,Grosshansdorf; 2 MemberoftheGermanCenterforLungResearch(DZL),Germany; 3 RoyalMarsdenHospitalNHS FoundationTrust,London; 4

2014 European Society for Medical Oncology

22. Clinical Practice Guideline for the Use of Antimicrobial Agents in Neutropenic Patients with Cancer Full Text available with Trip Pro

trials [ ]. Most clinicians (including Panel members) use and understand this clinically relevant categorization of “high-risk” in the context of fever and neutropenia. Low-risk patients are clinically defined by neutropenia anticipated to last ≤7 days, are clinically stable, and have no medical comorbid conditions. In addition to this clinical definition, the MASCC has developed a risk assessment scheme and a well-validated scoring method that can identify subgroups of febrile neutropenic patients (...) of the infection risks, diagnostic methods, and antimicrobial therapies required for management of febrile patients through the neutropenic period. Accordingly, algorithmic approaches to fever and neutropenia, infection prophylaxis, diagnosis, and treatment have been established during the past 40 years, guided and modified by clinical evidence and experience over time. The Infectious Diseases Society of America Fever and Neutropenia Guideline aims to provide a rational summation of these evolving algorithms

2010 Infectious Diseases Society of America

23. To Find a Safe Dose and Show Early Clinical Activity of Weekly Nab-paclitaxel in Pediatric Patients With Recurrent/ Refractory Solid Tumors

discontinuation or met one of the following criteria: - Common Terminology Criteria for Adverse Events (CTCAE) Grade (Gr) 3 or 4 nonhematologic toxicity (excluding transient transaminitis) - CTCAE Gr 3 or 4 nausea or vomiting that persisted > 5 days despite maximal anti-emetic treatment - CTCAE Gr 4 thrombocytopenia or anemia that persisted > 7 days or required transfusion > 7 days - CTCAE Gr 3 thrombocytopenia with bleeding - CTCAE Gr 4 uncomplicated neutropenia lasting > 7 days - Febrile neutropenia (...) To Find a Safe Dose and Show Early Clinical Activity of Weekly Nab-paclitaxel in Pediatric Patients With Recurrent/ Refractory Solid Tumors Study to Find a Safe Dose and Show Early Clinical Activity of Weekly Nab-paclitaxel in Pediatric Patients With Recurrent/ Refractory Solid Tumors - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save

2013 Clinical Trials

24. Prostate cancer: diagnosis and management

to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 22 of 51What are the risks associated with docetaxel treatment? A large UK randomised trial found that: 15 out of 100 people who took docetaxel developed febrile neutropenia (that is, they got a fever because the chemotherapy had reduced their white blood cells' ability to fight infection). 1 out of 100 people who took docetaxel died because of infections that, in the opinion of the investigators, they might (...) , consider a remote follow-up strategy for people with a stable PSA who have had no significant treatment complications, unless they are taking part in a clinical trial that needs formal clinic-based follow-up. [2019] [2019] 1.3.47 Follow up people with prostate cancer who have chosen a watchful waiting regimen with no curative intent in primary care only if protocols for this have been agreed between the local urological cancer MDT and the relevant primary care organisation(s). Measure their PSA

2019 National Institute for Health and Clinical Excellence - Clinical Guidelines

25. Crohn’s disease: management

health and one or more symptoms such as weight loss, fever, severe abdominal pain and usually frequent (3 to 4 or more) diarrhoeal stools daily. People with severe active Crohn's disease may or may not develop new fistulae or have extra-intestinal manifestations of the disease. This clinical definition normally, but not exclusively, corresponds to a Crohn's Disease Activity Index (CDAI) score of 300 or more, or a Harvey-Bradshaw score of 8 to 9 or above. [2010] [2010] 1.2.19 When using the CDAI (...) appropriate. [2010] [2010] 1.2.16 Treatment with infliximab or adalimumab (see recommendations 1.2.12 and 1.2.15) should only be continued if there is clear evidence of ongoing active disease as determined by clinical symptoms, biological markers and investigation, including endoscopy if necessary. Specialists should discuss the risks and benefits of continued treatment with patients and consider a trial withdrawal from treatment for all patients who are in stable clinical remission. People who continue

2019 National Institute for Health and Clinical Excellence - Clinical Guidelines

26. Niraparib (ovarian cancer) - Benefit assessment according to §35a Social Code Book V

treatment Allowed: ? corticosteroids for symptom control in brain metastases as well as bisphosphonates or denosumab in bone disorders, each in a stable dose at the start of the administration at least 4 weeks before start of the study ? palliative radiotherapy for pain treatment of bone metastases already existing at the start of the study as long as there is no evidence of disease progression ? antiemetics, antidiarrhoeal drugs ? G-CSF in febrile neutropenia ? Warfarin, subcutaneous heparin (...) . d. Complete or partial response and either a CA-125 level within the normal range or at least 90 percent reduction in CA-125 level, stable for at least 7 days. e. Cohorts initially planned for the study. Not relevant for the indirect comparison. f. Determined by CT/MRI according to RECIST 1.1 and/or by additional diagnostic tests (e.g. histological/cytological, ultrasound, endoscopy, PET) and/or by clear clinical signs and symptoms independent of non-malignant or iatrogenic causes. g. Outcome

2020 Institute for Quality and Efficiency in Healthcare (IQWiG)

27. Cell-Free Circulating Tumour DNA Blood Testing to Detect EGFR T790M Mutation in People With Advanced Non–Small Cell Lung Cancer

Clinical Evidence March 2020 Ontario Health Technology Assessment Series; Vol. 20: No. 5, pp. 1–176, March 2020 17 Exclusion Criteria • Animal and in vitro studies • Editorials, case reports, conference abstracts, or commentaries Participants Inclusion Criteria • Patients with NSCLC who have an EGFR-sensitizing mutation who have progressed while using first- or second-generation EGFR-tyrosine kinase inhibitor (TKI) therapy Exclusion Criteria • Patients with other types of cancer Index Test (...) : No. 5, pp. 1–176, March 2020 2 ACKNOWLEDGMENTS This report was developed by a multidisciplinary team from the Quality business unit at Ontario Health. The clinical epidemiologist was Anna Lambrinos, the primary health economist was Lindsey Falk, the secondary health economist was Olga Gajic-Veljanoski, the health economics associate was Lucia Cheng, the patient and public partnership analyst was Ammara Shafique, and the medical librarian was Corinne Holubowich. The medical editors were Elizabeth

2020 Health Quality Ontario

28. Bariatric surgery in Belgium: organisation and payment of care before and after surgery

be structured depending on its location (a) if in primary or community care it is separate from the surgical MDT and refers in as a hub and spoke and (b) if in secondary care most team members are likely shared between the clinics. Welbourn 2018 41 166 KCE Report 329 Bariatric surgery in Belgium 7 LIST OF TABLES Table 1 – Billing codes for medical fees (Bariatric surgery) 20 Table 2 – Evolution of bariatric surgery in Belgium (2009 - 2017): number of first surgeries since the start of the specific (...) about the English bariatric surgery registry 192 Table 26 – Summary table of volume-outcome relationship literature 206 KCE Report 329 Bariatric surgery in Belgium 9 LIST OF ABBREVIATIONS ABBREVIATION DEFINITION BASO Belgian Association for the Study of Obesity BBAHS Belgian Bariatric Allied Health Society BCS Body contouring surgery BMI Body Mass Index BESOMS Belgian Section of Obesity and Metabolic Surgery BOMSS British Obesity and Metabolic Surgery Society BPD-DS Biliopancreatic diversion

2020 Belgian Health Care Knowledge Centre

29. Canadian Cardiovascular Society/Canadian Cardiac Transplant Network Position Statement on Heart Transplantation: Patient Eligibility, Selection, and Post-Transplantation Care Full Text available with Trip Pro

Guidelines Committee. J Card Fail. 2015; 21 : 519-534 have been used to define frailty. Mehra M.R. Canter C.E. Hannan M.M. et al. The 2016 International Society for Heart Lung Transplantation listing criteria for heart transplantation: a 10-year update. J Heart Lung Transplant. 2016; 35 : 1-23 Several tools for assessing frailty have been used for patients who undergo HTx and left ventricular assist device (LVAD) placement including the Fried Frailty Phenotype score (≥ 3 of 5 measures), the Deficit Index (...) usefulness in heart transplantation. Transplant Rev (Orlando). 2017; 31 : 218-224 3. We recommend an assessment of frailty using the Fried Frailty Phenotype score, Deficit Index, or Edmonton Frailty Scale, for example, for all patients being considered for HTx (Strong Recommendation, Moderate-Quality Evidence). Values and preferences. LVAD placement in selected patients might be considered to improve frailty before HTx. Table 1 Frailty assessment tools Model Domain Assessment Calculation Fried Frailty

2020 Canadian Cardiovascular Society

30. A palliative approach to care in the last 12 months of life

of Life Greetings from Doris Grinspun, Chief Executive Officer, Registered Nurses’ Association of Ontario The Registered Nurses’ Association of Ontario (RNAO) is delighted to present the clinical best practice guideline (BPG) A Palliative Approach to Care in the Last 12 Months of Life. Evidence-based practice supports the excellence in service that health providers are committed to delivering every day. We offer our heartfelt thanks to the many stakeholders who make our vision for BPGs a reality (...) documents that include recommendations on specific clinical, healthy work environment and health system topics. They are intended for nurses and members of the interprofessional health team in direct care positions, and for educators, administrators and executives, policy- makers, researchers, and persons G and families with lived experience. BPGs promote consistency and excellence in clinical care, administrative practices, policies, and education, with the aim of achieving optimal health outcomes

2020 Registered Nurses' Association of Ontario

31. Management of Poisoning

hyperthermia. Anecdotal case reports have shown improved clinical symptoms with its use (pg 135). Grade D, Level 3 D In the absence of an established toxic dose, the presence of more than mild clinical effects (vomiting, somnolence, mydriasis, diaphoresis, including those consistent with serotonin syndrome) should be used as an indication for emergency department referral, regardless of the dose reportedly ingested. 23 Patients who have unintentional SSRI ingestions and are asymptomatic may stay at home (...) ; olanzapine 10 mg; quetiapine 100 mg; risperidone 25 1 mg; or ziprasidone 80mg) (pg 141). Grade C, Level 3 C Clinical manifestations of typical antipsychotics poisoning generally include neuroleptic malignant syndrome, rigidity, dystonia, fever and widened QRS interval (pg 141). Grade C, Level 2+ D The primary treatment of cardiotoxicity is plasma alkalinisation with sodium bicarbonate and hyperventilation (pg 141). Grade D, Level 4 GPP Patients with altered mental state or persistent tachycardia despite

2020 Ministry of Health, Singapore

32. Autologous hematopoietic cell transplantation for autoimmune diseases

transplantation for MS, SSc, and CD Study Population Treatment Follow- up/outcomes Multiple Sclerosis Burt, 2019 [9] Multiple Sclerosis International Stem Cell Transplant (MIST) Phase III, multi-centre Population: Patients with stable DMT with >2 relapses within the prior 12 mo. and an EDSS score of 2.0 to 6.0 enrolled between 2009 and January 2018 Med. age yrs. (SD) 36 (8.6) Inclusion: relapse-remitting MS according to McDonald criteria, age 18 to 55 years, 2 or more clinical relapses or 1 relapse and MRI (...) events) 0 (-1 to 1), p=0.53 -5.9 (-31.4 to 20.4), p=0.66 Disease flares 5 (7 events) 7 (10 events) Nonflare symptoms 4 (11 events) 1 (2 events) Hematologic 3 (8 events) 0 (0 events) 0 (0 to 0), p=0.27 13.0 (-4.1 to 32.1), p>0.99 Anemia 1 (5 events) 0 (0 events) Neutropenia 2 (2 events) 0 (0 events) Pancytopenia 1 (1 events) 0 (0 events) Fever SAEs 4 (4 events) 1 (1 events) Renal SAEs 2 (2 events) 2 (2 events) Repsiratory SAEs 4 (4 events) 0 (0 events) Other 8 (14 events) 8 (11 events) CYC

2019 Cancer Care Ontario

33. Istradefylline (Nourianz) - Parkinson's disease

8.4.3. Electrocardiograms (ECGs) 58 8.4.4. QT 59 8.4.5. Immunogenicity 59 8.5. Analysis of Submission-Specific Safety Issues 59 8.5.1. Impulse Control Disorder 59 8.5.2. Dizziness, Hypotension, Orthostatic Hypotension 61 8.5.3. Falls 62 8.5.4. Effects on Ability to Drive 62 8.5.5. Cardiac Safety 63 8.5.6. Suicide 64 8.5.7. Neutropenia and Neutropenic Sepsis 66 8.5.8. Drug-Drug interactions 67 8.6. Safety Analyses by Demographic Subgroups 67 CDER Clinical Review Template Version date: September 6 (...) Istradefylline (Nourianz) - Parkinson's disease CENTER FOR DRUG EVALUATION AND RESEARCH APPLICATION NUMBER: 022075Orig1s000 CLINICAL REVIEW(S) (b) (4) Clinical Review Natalie Branagan, MD NDA 022075 Nourianz/istradefylline CLINICAL REVIEW Application Type NDA Application Number(s) 022075 Priority or Standard Class 2 Resubmission Submit Date(s) February 27, 2019 Received Date(s) February 27, 2019 PDUFA Goal Date August 27, 2019 Division/Office DNP Reviewer Name(s) Natalie Branagan, MD Review

2019 FDA - Drug Approval Package

34. PARP Inhibitors in the Management of Ovarian Cancer

. Patients with progressive anemia may be offered growth factor per ASCO guidelines and physician and patient comfort. (Type: informal consensus, benefits outweigh harms; Evidence quality: insufficient; Strength of recommendation: moderate). Recommendation 5.1 Neutropenia: Growth factor is not indicated for use in patients receiving daily PARPi. Neutropenia (grade 4 lasting at least 5-7 days or associated with fever) should result in dose hold until recovery of infection and granulocyte count, followed (...) PARP Inhibitors in the Management of Ovarian Cancer PARP Inhibitors in the Management of Ovarian Cancer: ASCO Guideline | Journal of Clinical Oncology Search in: Menu > > > > Article Tools RAPID COMMUNICATIONS Gynecological Cancer Article Tools OPTIONS & TOOLS COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.20.01924 Journal of Clinical Oncology - published online before print August 13, 2020 PMID: PARP Inhibitors in the Management of Ovarian Cancer: ASCO Guideline

2020 American Society of Clinical Oncology Guidelines

35. Advanced Prostate Cancer: AUA/ASTRO/SUO Guideline

and predicted life expectancy Performance status and predicted life expectancy are both critical elements to incorporate into individualized clinical decision-making in men with advanced prostate cancer. Performance status remains a key factor in treatment decision-making, particularly among men with advanced prostate cancer. Indeed, performance status has been found to be strongly associated with survival among men with mCRPC, 35-38 and has been used to define index patients in prior versions (...) are challenged to remain up-to-date and informed with respect to a multitude of treatment options for patients with advanced prostate cancer. To assist in clinical decision-making, evidence-based guideline statements were developed to provide a rational basis for evidence-based treatment. This guideline covers advanced prostate cancer, including disease stages that range from prostate-specific antigen (PSA) recurrence after exhaustion of local treatment options to widespread metastatic disease. Methodology

2020 American Urological Association

36. Joint AAD-NPF Guidelines of care for the management and treatment of psoriasis with topical therapy and alternative medicine modalities for psoriasis severity measures

California, Los Angeles, CA h University of California, San Francisco School of Medicine, Department of Dermatology, San Francisco, CA i Mayo Clinic, Rochester, MN j University of Pennsylvania Perelman School of Medicine, Philadelphia, PA k Medical College of Wisconsin, Milwaukee, WI l Department of Dermatology, Icahn School of Medicine at Mt. Sinai, New York, NY m University of Pittsburgh, Pittsburgh, PA n UC San Diego, San Diego, CA o Patient Advocate, National Psoriasis Foundation, Portland, OR p (...) 16 The American Academy of Dermatology (AAD) strives to produce clinical guidelines that 17 reflect the best available evidence supplemented with the judgment of expert clinicians. 18 Significant efforts are taken to minimize the potential for conflicts of interest to influence 19 guideline content. The management of conflict of interest for this guideline complies with the 20 Council of Medical Specialty Societies’ Code of Interactions with Companies. Funding of 21 guideline production

2020 American Academy of Dermatology

37. Nonopioid Pharmacologic Treatments for Chronic Pain

of healthcare services. This report is not intended to be a substitute for the application of clinical judgment. Anyone who makes decisions concerning the provision of clinical care should consider this report in the same way as any medical reference and in conjunction with all other pertinent information, i.e., in the context of available resources and circumstances presented by individual patients. This report is made available to the public under the terms of a licensing agreement between the author (...) and the Agency for Healthcare Research and Quality. This report may be used and reprinted without permission except those copyrighted materials that are clearly noted in the report. Further reproduction of those copyrighted materials is prohibited without the express permission of copyright holders. AHRQ or U.S. Department of Health and Human Services endorsement of any derivative products that may be developed from this report, such as clinical practice guidelines, other quality enhancement tools

2020 Effective Health Care Program (AHRQ)

38. Treatment of Patients with Schizophrenia

index BPRS Brief Psychiatric Rating Scale CATIE Clinical Antipsychotic Trials for Intervention Effectiveness CBT Cognitive-behavioral therapy CBTp Cognitive-behavioral therapy for individuals with psychosis CDC Centers for Disease Control and Prevention CGI Clinical Global Impression CI Confidence interval CrI Credible interval CSC Coordinated specialty care CSG Canadian Schizophrenia Guidelines CYP Cytochrome P450 DISCUS Dyskinesia Identification System - Condensed User Scale DSM Diagnostic (...) to Enhance Quality of Care 11 External Review 13 8 Funding and Approval 13 Glossary of Terms 13 References 18 Disclosures 102 Individuals and Organizations That Submitted Comments 104 Appendices: Review of Research Evidence 107 Appendix A. Clinical Questions 107 Clinical Questions 107 Appendix B. Search Strategies, Study Selection, and Search Results 107 AHRQ Review 107 Treatment of Neurological Side Effects of Antipsychotic Medications 109 Appendix C. Review of Research Evidence Supporting Guideline

2020 American Psychiatric Association

39. Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children Full Text available with Trip Pro

and Sepsis Investigators (PALISI) and Shock Society. Dr. Peters participates in the UK PICS study group (vice-chair) and has testified as an expert witness in cases of clinical negligence, causation of injuries. Dr. Agus participates in the American Academy of Pediatrics (AAP), Pediatric Academic Societies (PAS), American Pediatric Society, Society for Pediatric Research, and The American Society for Clinical Investigation, and he has testified as an expert witness in cases related to ICU (...) , and a contributor to Up-to-Date. Dr. Cies received funding from Allergan, Merck, Thermo Fisher Scientific, and Atlantic Diagnostic Laboratories (consultant), and he participates in Pediatric Pharmacy Advocacy Group (multiple positions), Society of Infectious Diseases Pharmacists (Vice-Chair of the Inter-organizations Liaison Committee), and the American College of Clinical Pharmacists (member and fellow). Dr. Cruz has testified as an expert witness in cases of children with tuberculosis-related meningitis

2020 Society of Critical Care Medicine

40. Polatuzumab vedotin in combination with bendamustine and rituximab for the treatment of relapsed/refractory diffuse large B-cell lymphoma (DLBCL) who are not candidates for haematopoietic stem cell transplant

of the lymphoma, and impact on surrounding tissue. In addition to staging classifications, the International Prognostic Index (IPI) is used for determining initial prognosis in patients with DLBCL at the time of diagnosis. The IPI consists of five clinical predictors that are used to assign patients to one of four different risk categories (low, low-intermediate, high-intermediate and high risk). It is estimated that two-thirds of patients are cured with this first-line therapy. Disease stage (based (...) on the IPI score) and patient age are significant factors affecting survival. Although most DLBCL patients are cured by standard immunochemotherapy, 10-15% of DLBCL are primary refractory and 20-30% relapse (4). Relapsed DLBCL is characterised by the appearance of any new lesion after a documented history of response, while refractory DLBCL is characterised as progressive disease or no response (stable disease) from the start of previous treatment. 1.2 Current clinical practice The recommended first-line

2020 EUnetHTA

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