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Clindamycin Topical

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161. CRACKCast E070 – Oral Medicine

paralysis If presence of trismus, may need surgical airway as not always responsive to paralysis (internal pterygoid or masseter muscle spasm) Broad antibiotics to cover hemolytic strep, mixed strep-staph and bacteroides species. Usually recommended High-dose antibiotic therapy, such as 24 million units penicillin daily Q 4hrs IV plus metronidazole 1 g IV load, with 500 mg IV q6h, Clindamycin 900 mg q6h also is effective but as always, if very ill consider going broader (eg Mero + Vanco + Clinda) CT (...) Ulcerative Gingivitis ANUG (also known as trench mouth) is a bacterial invasion of non-necrotic tissue! Think cellulitis of the gingiva, except with a gray pseudomembranous layer forming in the mouth (usually ant incisor or molar region) Mainstays of treatment are: Analgesia In order to start brushing and eating again, need to tx pain. Systemic Tylenol / NSAIDS combined with topical viscous lidocaine Antibiotics Penicillin or tetracycline (avoid in children with primary teeth due to staining) Improved

2017 CandiEM

162. CRACKCast E071 – Ophthalmology Part A

need topical anesthetics Irrigate until pH is NORMAL Remove particulate matter from the fornices After irrigation Cycloplegic 5% erythromycin ointment QID Pain management Check IOP Severity of injury judged by corneal cloudiness Long term: scarring, symblepharon, glaucoma, cataracts Irritants, solvents, detergent, super glue, mace exposures are treated just like chemical burns Superglue: only need referral if eyelids are inverted and lashes scratching the eyeball 2) What is the treatment of UV (...) keratitis? Radiation burns Ultraviolet keratitis (tanning booths, sunlamps, high altitude, welder’s arc) Latent period of 6-10 hrs then: Foreign body sensation, tearing, intense pain photophobia, blepharospasm Signs Decreased VA, conjunctival injection Treatment Cycloplegic Topical broad spectrum abx (weak evidence for this) PO analgesics Symptoms should resolve in 24 hrs 3) What is ophthalmia neonatorum? In which time-frame are each bacteria expected to be causative? What is the treatment? Ophthalmia

2017 CandiEM

167. Clinical Practice Guidelines for Clostridium difficile Infection in Adults and Children

and the C. difficile strains present. Restriction of fluoroquinolones, clindamycin, and cephalosporins (except for surgical antibiotic prophylaxis) should be considered (strong recommendation, moderate quality of evidence) . XXVI. What is the role of proton pump inhibitor restriction in controlling CDI rates? Although there is an epidemiologic association between proton pump inhibitor (PPI) use and CDI, and unnecessary PPIs should always be discontinued, there is insufficient evidence (...) (BOD). The guideline was endorsed by ASHP, SIDP, and PIDS. Guidelines and Conflicts of Interest All members of the expert panel complied with the IDSA policy on conflicts of interest, which requires disclosure of any financial, intellectual, or other interest that might be construed as constituting an actual, potential, or apparent conflict. To provide thorough transparency, IDSA requires full disclosure of all relationships, regardless of relevancy to the guideline topic [14]. Evaluation

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2017 Infectious Diseases Society of America

168. Antibacterial-coated sutures versus non-antibacterial-coated sutures for the prevention of abdominal, superficial and deep, surgical site infection (SSI)

undergoing assessment, and thus has a conflict of interest according to the EUnetHTA guidelines for handling conflict of interest. Professor Kriwanek has attended symposia related to and gave lectures on the topic of antibacterial-coated sutures which were sponsored by the company Johnson & Johnson. This sponsoring included the refunding of accommodation, travel costs and congress fees. He has no other conflicts of interest related to the topic of antibacterial-coated sutures to declare. According

2017 EUnetHTA

169. Comparative Efficacy and Safety of Benzoyl Peroxide Used in Combination With Clindamycin vs. Benzoyl Peroxide Used in Combination With Clindamycin and Doxycycline in the Treatment of Moderate Acne

in Combination With Clindamycin and Doxycycline in the Treatment of Moderate Acne Study Start Date : August 2007 Actual Primary Completion Date : August 2008 Actual Study Completion Date : August 2008 Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Active Comparator: BPO with clindamycin foam Benzoyl peroxide (BPO) wash with clindamycin foam Drug: Benzoyl peroxide with clindamycin Benzoyl peroxide wash (...) Comparative Efficacy and Safety of Benzoyl Peroxide Used in Combination With Clindamycin vs. Benzoyl Peroxide Used in Combination With Clindamycin and Doxycycline in the Treatment of Moderate Acne Comparative Efficacy and Safety of Benzoyl Peroxide Used in Combination With Clindamycin vs. Benzoyl Peroxide Used in Combination With Clindamycin and Doxycycline in the Treatment of Moderate Acne - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer

2009 Clinical Trials

170. Fosmidomycin With Clindamycin or With Clindamycin Plus Artesunate

Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment Official Title: Evaluation of Fosmidomycin and Clindamycin When Administered Concurrently to Adult Subjects With Acute Uncomplicated Plasmodium Falciparum Malaria Resource links provided by the National Library of Medicine related topics: available for: resources: Arms and Interventions Go to Arm Intervention/treatment No Intervention: single arm Fos-clin/Arte Drug: Fosmidomycin 450 mg capsules, every 12 hrs for 3 (...) Fosmidomycin With Clindamycin or With Clindamycin Plus Artesunate Fosmidomycin With Clindamycin or With Clindamycin Plus Artesunate - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Fosmidomycin

2009 Clinical Trials

174. Guidelines for Laparoscopic Ventral Hernia Repair

articles that may have been missed during the original search. Additional relevant articles were obtained and included in the review for grading. To facilitate the review by multiple reviewers, the guideline was divided into the following topics: 1. Laparoscopic vs. Open Repair 2. Preoperative Considerations 3. Operative Technique 4. Postoperative Management: Avoiding and Treating Problems Additional articles pertaining to specific subsections of the above topics were reviewed and graded, providing (...) . Vancomycin or Clindamycin should be given to patients allergic to cephalosporins. (Moderate quality, Strong recommendation) The guidelines recently published jointly by the American Society of Health-System Pharmacists (ASHP), the Infectious Diseases Society of America (IDSA), the Surgical Infection Society (SIS), and the Society for Healthcare Epidemiology of America (SHEA) recommend that a single dose of a first-generation cephalosporin (cefazolin) be administered within 60 minutes prior to incisional

2016 Society of American Gastrointestinal and Endoscopic Surgeons

175. Management of Intra-Abdominal Infection : guidelines by the Surgical Infection Society

Abstract Background: Previous evidence-based guidelines on the management of intra-abdominal infection (IAI) were published by the Surgical Infection Society (SIS) in 1992, 2002, and 2010. At the time the most recent guideline was released, the plan was to update the guideline every five years to ensure the timeliness and appropriateness of the recommendations. Methods: Based on the previous guidelines, the task force outlined a number of topics related to the treatment of patients with IAI (...) and then developed key questions on these various topics. All questions were approached using general and specific literature searches, focusing on articles and other information published since 2008. These publications and additional materials published before 2008 were reviewed by the task force as a whole or by individual subgroups as to relevance to individual questions. Recommendations were developed by a process of iterative consensus, with all task force members voting to accept or reject each

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2016 Surgical Infection Society

176. WHO guidelines for the treatment of Chlamydia trachomatis

of key end-users of the STI guidelines will be conducted after the release of the guidelines. The results of the survey will be used to identify challenges and barriers to the uptake of the guidelines, to evaluate their usefulness for improving service delivery, and to identify topics or gaps in treatment that need to be addressed in future editions. 3.3 IMPLEMENTATION OF THE WHO GUIDELINES FOR THE TREATMENT OF C. TRACHOMATIS ADAPTATION, IMPLEMENTATION AND MONITORING These guidelines provide (...) , and Web annex D for details of the evidence reviewed, L Q F O X G L Q JH Y L G H Q F HS UR ? O H VD Q GH Y L G H Q F H W R G H F LVL R Q I U D P HZ R U N V S S 5 ( & 2 0 0 (1 ' $ 7 , 2 1 For all neonates, the WHO STI guideline recommends topical ocular prophylaxis for the prevention of gonococcal and chlamydial ophthalmia neonatorum. Strong recommendation, low quality evidence RECOMMENDATION 7 For ocular prophylaxis, the WHO STI guideline suggests one of the following options for topical

2016 World Health Organisation Guidelines

177. Acne clinical guideline

%, and 10% benzoyl peroxide on inflammatory acne vulgaris. Int J Dermatol . 1986 ; 25 : 664–667 | | , x 59 Schutte, H., Cunliffe, W.J., and Forster, R.A. The short-term effects of benzoyl peroxide lotion on the resolution of inflamed acne lesions. Br J Dermatol . 1982 ; 106 : 91–94 | | Topical antibiotics (eg, clindamycin and erythromycin) A I, II x 60 Mills, O. Jr., Thornsberry, C., Cardin, C.W., Smiles, K.A., and Leyden, J.J. Bacterial resistance and therapeutic outcome following three months (...) of topical acne therapy with 2% erythromycin gel versus its vehicle. Acta Derm Venereol . 2002 ; 82 : 260–265 | | | , x 61 Bernstein, J.E. and Shalita, A.R. Topically applied erythromycin in inflammatory acne vulgaris. J Am Acad Dermatol . 1980 ; 2 : 318–321 | | | , x 62 Jones, E.L. and Crumley, A.F. Topical erythromycin vs blank vehicle in a multiclinic acne study. Arch Dermatol . 1981 ; 117 : 551–553 | | , x 63 Shalita, A.R., Smith, E.B., and Bauer, E. Topical erythromycin v clindamycin therapy

2016 American Academy of Dermatology

178. Systemic antibiotics for treating diabetic foot infections. (PubMed)

antibiotics, topical foot care or placebo.In April 2015 we searched the Cochrane Wounds Group Specialised Register; The Cochrane Central Register of Controlled Trials (CENTRAL; The Cochrane Library); Ovid MEDLINE, Ovid MEDLINE (In-Process & Other Non-Indexed Citations); Ovid EMBASE, and EBSCO CINAHL. We also searched in the Database of Abstracts of Reviews of Effects (DARE; The Cochrane Library), the Health Technology Assessment database (HTA; The Cochrane Library), the National Health Service Economic (...) ) clindamycin and cephalexin (one trial).Carbapenems combined with anti-pseudomonal agents produced fewer adverse effects than anti-pseudomonal penicillins (RR 0.27, 95% CI 0.09 to 0.84; 1 trial). An additional trial did not find significant differences in the rate of adverse events between a carbapenem alone and an anti-pseudomonal penicillin, but the rate of diarrhoea was lower for participants treated with a carbapenem (RR 0.58, 95% CI 0.36 to 0.93; 1 trial). Daptomycin produced fewer adverse effects

2015 Cochrane

179. Interventions for hidradenitis suppurativa. (PubMed)

: risk ratio (RR) 0.78, 95% CI 0.58 to 1.05, moderate quality evidence) or risk of recurrence (after three months: RR 0.96, 95% CI 0.68 to 1.34, moderate quality evidence) in those randomised to receive a gentamicin-collagen sponge prior to primary closure compared with primary closure alone.RCTs of other interventions, including topical clindamycin 1% solution; oral tetracycline; oral ethinylestradiol 50 mcg with either cyproterone acetate 50 mg or norgestrel 500 mcg; intense pulsed light; neodymium

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2015 Cochrane

180. Management of acne

contraceptives¶ Systemic antibiotics OR BPO OR topical retinoids† OR both OR Fixed-dose combinations: BPO/clinda OR BPO/adapalene OR, after failure of above, clinda/tretinoin‡ Figure 2: Clinical treatment algorithm for acne. A complete list of recommendations is available in the full guideline (Appendix 4, available at www.cmaj.ca/lookup/suppl/doi:10.1503/cmaj.140665/-/DC1). BPO = benzoyl peroxide, clinda = clindamycin, dashed line = optional path. *Blue light and oral zinc may be considered for mild (...) -to-moderate papulopustular acne (low strength of recommendation). †Best evidence is for adapalene and tazarotene. ‡Lower-quality evidence available for clindamycin–tretinoin gel. §Evaluate after 2–3 months. ¶For women only. **Evaluate monthly for isotretinoin. Guidelines CMAJ 5 ple applications. Many acne medications may not be covered by provincial plans; in these cases, it may be particularly important to consider cost. For comedonal acne, we recommend topical reti noids or benzoyl peroxide (medium

2015 CPG Infobase

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