How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

1,186 results for

Clindamycin Topical

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

141. Antibiotic Prophylaxis in Obstetric Procedures

text on ScienceDirect. Abstract Objective To review the evidence and provide recommendations on antibiotic prophylaxis for obstetrical procedures. Outcomes Outcomes evaluated include need and effectiveness of antibiotics to prevent infections in obstetrical procedures. Evidence Published literature was retrieved through searches of Medline and The Cochrane Library on the topic of antibiotic prophylaxis in obstetrical procedures. Results were restricted to systematic reviews, randomized controlled (...) for Caesarean section should be a single dose of a first-generation cephalosporin. If the patient has a penicillin allergy, clindamycin or erythromycin can be used (I-A). 3. The timing of prophylactic antibiotics for Caesarean section should be 15 to 60 minutes prior to skin incision. No additional doses are recommended (I-A). 4. If an open abdominal procedure is lengthy (>3 hours) or estimated blood loss is greater than 1500 mL, an additional dose of the prophylactic antibiotic may be given 3 to 4 hours

2017 Society of Obstetricians and Gynaecologists of Canada

142. Screening and Management of Bacterial Vaginosis in Pregnancy

is undertaken, it should be with metronidazole 500 mg orally twice daily for seven days or clindamycin 300 mg orally twice daily for seven days. Topical (vaginal) therapy is not recommended for this indication (I-B). 6. Testing should be repeated one month after treatment to ensure that cure was achieved (III-L). Key Words: , , , To access this article, please choose from the options below Log In Register Purchase access to this article Claim Access If you are a current subscriber with Society Membership (...) in formulating the guideline. Outcomes Outcomes evaluated include antibiotic treatment efficacy and cure rates, and the influence of the treatment of bacterial vaginosis on the rates of adverse pregnancy outcomes such as preterm labour and delivery and preterm premature rupture of membranes. Evidence Medline, EMBASE, CINAHL, and Cochrane databases were searched for articles, published in English before the end of June 2007 on the topic of bacterial vaginosis in pregnancy. Values The evidence obtained

2017 Society of Obstetricians and Gynaecologists of Canada

143. Dental Management of Pediatric Patients Receiving Chemotherapy, Hematopoietic Cell Transplantation, and/or Radiation Therapy

Fluoride: Preventive measures include the use of fluoridated toothpaste, fluoride supplements if indicated, neutral fluoride gels/rinses, or applications of fluoride varnish for patients at risk for caries and/or xerostomia. 6,8 A brush-on technique is convenient and may increase the likelihood of patient com- pliance with topical fluoride therapy. 8 Lip care: Lanolin-based creams and ointments are more effective in moisturizing and protecting against damage than petrolatum-based products. 8 Trismus (...) ., microfibrillar col- lagen, topical thrombin) and additional medications as recommended by the hematologist/oncologist (e.g., aminocaproic acid, tranexamic acid) may help control bleeding. 1 • Other coagulation tests may be in order for individual patients. Dental procedures: • Ideally, all dental care should be completed before im- munosuppressive therapy is initiated. When that is not feasible, temporary restorations may be placed and non- acute dental treatment may be delayed until the patient’s

2018 American Academy of Pediatric Dentistry

144. Surveillance of healthcare-associated infections and prevention indicators in European intensive care units: HAI-Net ICU protocol, version 2.2

two weeks, depending on the size of the ICU. The following priority topics and indicators were selected for the HAI-Net ICU protocol. Methods and data sources differ according to the indicator. ? Hand hygiene: alcohol hand rub consumption during the previous year in the ICU. The consumption of alcohol-based hand rubs in intensive care units is collected from the hospital pharmacy records for the year prior to the surveillance year. ? ICU staffing: registered nurse-to-patient ratio and nursing

2017 European Centre for Disease Prevention and Control - Technical Guidance

145. Outpatient Management of Fever and Neutropenia in Adults Treated for Malignancy

and logistic considerations are outlined within the guideline. The panel continued to endorse consensus recommendations from the previous version of this guideline that patients with febrile neutropenia receive initial doses of empirical antibacterial therapy within 1 hour of triage and be monitored for ≥ 4 hours before discharge. An oral fluoroquinolone plus amoxicillin/clavulanate (or clindamycin, if penicillin allergic) is recommended as empirical outpatient therapy, unless fluoroquinolone prophylaxis (...) as clinical judgment, were recommended. , This update includes new evidence on risk stratification of patients who are seemingly stable and at lower risk for FN, a population that has been difficult to assess accurately in the past. Antimicrobial prophylaxis recommendations are not included in this guideline update; they will be updated in a forthcoming separate ASCO/IDSA guidance document. The decision to address these two topics in separate guidelines was made to make the recommendations clearer

2018 American Society of Clinical Oncology Guidelines

146. CRACKCast E171 – Pediatric Cardiac Disorders

potentially save the lives of more young athletes who suddenly collapse secondary to hypertrophic cardiomyopathy, prolonged QT syndromes, and commotio cordis. Rosen’s in Perspective We hope you’re listening to this podcast while you’re well rested, caffeinated, or have time to listen to it at ½ speed. It’s a big one. There is more content in this episode then we can cover in the podcast, so there will be a few questions that are in the shownotes only. Today we’re hoping to cover these topics in less than (...) %), changing murmur (21%), dental caries (14%), and hepatosplenomegaly (14%). Less common signs are CHF (9%), splinter hemorrhages (5%), Roth’s spots (5%), and Osler’s nodes (4%). [12] Describe 2 potential prophylaxis regimens Single dose 30-60 minutes before procedure Children PO Amoxicillin 50mg/kg Cephalexin 50mg/kg (Pen-allergic) Clindamycin 20mg/kg (Pen-allergic Azithromycin 15mg/kg (Pen-allergic) Unable to take PO Cefazolin or Ceftriaxone 50mg/kg IM/IV Clindomycin 20mg/kg IM/IV See Table 170.7

2018 CandiEM

147. Outpatient Management of Fever and Neutropenia in Adults Treated for Malignancy

and logistic considerations are outlined within the guideline. The panel continued to endorse consensus recommendations from the previous version of this guideline that patients with febrile neutropenia receive initial doses of empirical antibacterial therapy within 1 hour of triage and be monitored for ≥ 4 hours before discharge. An oral fluoroquinolone plus amoxicillin/clavulanate (or clindamycin, if penicillin allergic) is recommended as empirical outpatient therapy, unless fluoroquinolone prophylaxis (...) as clinical judgment, were recommended. , This update includes new evidence on risk stratification of patients who are seemingly stable and at lower risk for FN, a population that has been difficult to assess accurately in the past. Antimicrobial prophylaxis recommendations are not included in this guideline update; they will be updated in a forthcoming separate ASCO/IDSA guidance document. The decision to address these two topics in separate guidelines was made to make the recommendations clearer

2018 Infectious Diseases Society of America

149. 2018 United Kingdom National Guideline for the Management of Pelvic Inflammatory Disease

and, if possible, use should be restricted to women who are known to be M. genitalium negative. Inpatient Regimens i.v. ceftriaxone 2g daily plus i.v. doxycycline 100mg twice daily (oral doxycycline may be used if tolerated) followed by oral doxycycline 100mg twice daily plus oral metronidazole 400mg twice daily for a total of 14 days Grade 1A 37,38 i.v. clindamycin 900mg 3 times daily plus i.v. gentamicin (2mg/kg loading dose) followed by 1.5mg/kg 3 times daily [a single daily dose of 7mg/kg may (...) be substituted]) followed by either oral clindamycin 450mg 4 times daily or oral doxycycline 100mg twice daily plus oral metronidazole 400mg twice daily to complete 14 days Grade 1A 37 Gentamicin levels should be monitored if this regimen is used. Intravenous therapy should be continued until 24 hours after clinical improvement and then switched to oral (Grade 2D). Intravenous doxycycline is not currently licensed in the UK but is available from IDIS world medicines (tel. 01932 824100). 14 Alternative

2018 British Association for Sexual Health and HIV

150. Perioperative Pathways: Enhanced Recovery After Surgery

a combination of clindamycin and gentamycin or a quinolone such as ciprofloxacin (23). Health care providers should consult their institutional antibiograms to confirm local susceptibility rates to the chosen coverage regimen. For lengthy procedures, additional intraoperative doses of the chosen antibiotic, given at intervals of two times the half-life of the drug (measured from the initiation of the preoperative dose, not from the onset of surgery), are recommended to maintain adequate levels throughout (...) , recommended scrub time can be as long as 5 minutes ( ). The solution should then be removed with a towel and the surgical site painted with a topical povidone-iodine solution, which should be allowed to dry for 2 minutes before draping (47). Vaginal cleansing with either 4% chlorhexidine gluconate or povidone-iodine should be performed before hysterectomy or vaginal surgery (44). Although currently only povidone-iodine preparations are U.S. Food and Drug Administration-approved for vaginal surgical-site

2018 American College of Obstetricians and Gynecologists

151. CRACKCast E177 – Acute Complications of Pregnancy

with a hydatidiform mole and usually resolves with evacuation of the mole. Patients may present with signs of thyroid storm, including altered mental status, severe tachycardia, and signs of high-output heart failure (eg, edema, dyspnea, orthopnea). Rosen’s in Perspective Topics to be covered: Ectopic pregnancy Bleeding in late pregnancy Hypertension in pregnancy AFE Rh immunization Abd pain in pregnancy N/V in pregnancy VTE in pregnancy Vaginal and UTIs Thyroid disease (shownotes) 1) List 6 causes of first (...) oral tocolytic therapy with beta adrenergic agonists 8) How are BV, vaginal yeast infections and trichomonas infections managed during pregnancy? BV: BV associated with morbidity – so treat! 7-day course of metronidazole or 7-day course of clindamycin. Intravaginal treatment is not recommended in pregnant patients. Vaginal yeast infections: There is no association of Candida colonization with adverse pregnancy outcomes, and treatment is for relief of symptoms only. Oral azoles are contraindicated

2018 CandiEM

152. Management of Diabetic Foot

(Second Edition) smaller number demonstrating efficacy against gram-negative bacteria (e.g. neomycin, silver sulphadiazine). Some antibiotics that are used systemically (e.g. gentamicin, metronidazole, clindamycin) have also been formulated for topical use. 47, level I In a Cochrane systematic review, topical antimicrobial dressing was more effective than non-antimicrobial dressing in wound healing of diabetic foot (RR=1.28, 95% CI 1.12 to 1.45). However, there was no significant difference in adverse (...) be considered in moderate pain. Strong opioids (e.g. morphine) should be offered to patients with moderate to severe pain. 44 In neuropathic pain, adjuvants are used at all steps of the analgesic ladder. 44 Examples of the adjuvants are antidepressant (e.g. amitriptyline or duloxetine) and anticonvulsant (e.g. gabapentin or pregabalin). 45 Refer to Appendix 8 on T reatment of Neuropathic Pain in Diabetic Foot. b. Topical antimicrobial Wound treatments aim to alleviate symptoms, promote healing and avoid

2018 Ministry of Health, Malaysia

154. Light therapies for acne. (PubMed)

Light therapies for acne. Acne vulgaris is a very common skin problem that presents with blackheads, whiteheads, and inflamed spots. It frequently results in physical scarring and may cause psychological distress. The use of oral and topical treatments can be limited in some people due to ineffectiveness, inconvenience, poor tolerability or side-effects. Some studies have suggested promising results for light therapies.To explore the effects of light treatment of different wavelengths (...) greatly in wavelength, dose, active substances used in photodynamic therapy (PDT), and comparator interventions (most commonly no treatment, placebo, another light intervention, or various topical treatments). Numbers of light sessions varied from one to 112 (most commonly two to four). Frequency of application varied from twice daily to once monthly.Selection and performance bias were unclear in the majority of studies. Detection bias was unclear for participant-assessed outcomes and low

Full Text available with Trip Pro

2016 Cochrane

155. CRACKCast E120 – Dermatologic presentations

soft tissue infections, drug eruptions, or immune disorders. Patients with Stevens-Johnson syndrome (<10% TBSA) and toxic epidermal necrolysis require inpatient treatment, preferably in a burn unit. Cutaneous signs of systemic disease may include pruritus, urticaria, erythema multiforme, erythema nodosum, pyoderma gangrenosum, and others. Physicians should be familiar with one or two topical steroid preparations of low, medium, and high potency and their appropriate therapeutic use. Hydrocortisone (...) dermatophytic infection of the skin, hair, and/or nails, usually by the Trichophyton organism. Infections of the body, groin, and extremities usually respond to topical antifungal agents. A number of effective topical antifungal agents are available, including clotrimazole, haloprogin, miconazole, tolnaftate, terbinafine, naftifine, and others. Two or three daily applications of the cream form of any of these preparations result in healing of most superficial lesions in 1 to 3 weeks. Tinea Capitis Tinea

2017 CandiEM

156. CRACKCast E058 – Ankle and Foot

Malleolar Fracture Bi mall eolar fractures: *unstable Caused by an oblique shearing force May still be non-operative if stable. May need a CT scan to figure the subtle #’s Tri malleolar fractures: Medial, lateral AND posterior malleoli All need ORIF Open fractures: Irrigation, reduction ABx, tetanus Ancef, Gentamycin Add Clindamycin or Penicillin G for soil contamination (for Clostridium) Pilon fractures Distal tibial metaphysis (falls) Look for calcaneus, tibial plateau, femoral neck, acetabulum (...) ://orthoinfo.aaos.org/topic.cfm?topic=A00632 Tillaux fractures are Salter-Harris III fractures through the anterolateral aspect of the distal tibial epiphysis, with variable amounts of displacement Pathophysiology: occurs because the epiphyseal plate closes in a medial→lateral fashion Occurs in an abduction-external rotation mechanism, requires an open epiphysis. Kids usually 12-15 yrs old. May require ORIF depending on degree of displacement Wisecracks 1. Discuss soft tissue injuries of the ankle Soft tissue

2017 CandiEM

157. CRACKCast E137 – Skin Infections

that extends through the epidermis into the dermis. It is manifested as ulcers with a punched-out appearance, with raised reddened margins covered with thick crust. It has a predilection for the lower extremities. Unlike impetigo, ecthyma can result in cutaneous scarring. Treatment: Mild-moderate non-bullous impetigo = topical mupirocin TID for 5 days Severe impetigo, bullous impetigo, ulcerative impetigo = Staph and MRSA coverage: Clindamycin AND Septra Cephalexin AND Septra [2] What is the eagle effect (...) ). Also: Penicillins work on the cell wall, but if bacteria are not in the growth phase, its ineffective. Clindamycin works on the ribosomes, so gets around this issue. [3] What is the difference b/n a furuncle and carbuncle? Folliculitis, furuncles, and carbuncles are purulent infections originating in the hair follicle. They are more likely to occur after damage to the hair follicle, such as from shaving. Folliculitis usually resolves on its own but can be treated with warm compresses or topical

2017 CandiEM

158. CRACKCast E126 – Diabetes Mellitus and Disorders of Glucose Homeostasis

complications is essential in Emergency Medicine, as we often encounter patients afflicted with diabetes and related disorders of glucose homeostasis on shift. Shownotes – Also check out EMCases Rapid Review video on DKA and Rosen’s In Perspective : This is an important topic – the complications of diabetes lead to immense morbidity and mortality. Our body (specifically the brain) needs a tight control on serum glucose for optimal functioning – this podcast is all about what happens when the balance is off (...) outlining the antimicrobial therapies for serious infections in diabetics. A summarized table is provided below. Infectious Condition Antimicrobial Therapy Diabetic Foot Infection Mild: Consider TMP-SMX, 800/160 BID or Clindamycin 300 mg q6h Moderate to Severe: Clindamycin 600 mg IV q6h +/- Piptazo 3.375 g IV q6h and Vancomycin 15 mg/kg IV q12h Malignant Otitis Externa Oral: Ciprofloxacin 500 mg PO BID for 10-14 days IV: Ceftazidime 2 g IV q8h +/- Gentamicin 2 mg/kg IV q8h Mucormycosis Amphoteracin B 1

2017 CandiEM

159. CRACKCast E098 – Sexually Transmitted Infections

% KOH solution to wet mount slide (whiff test). Metronidazole 500 mg PO BID x 7 days. Metronidazole gel 0.75% 5 g intravaginally once daily x 5 days. Clindamycin cream 2% 5 g intravaginally qhs x 7 days. Vulvovaginal candidiasis Common nonspecific findings of pruritus, abnormal discharge, dyspareunia, and external dysuria. Vulvar erythema and edema with satellite lesions, erythema of the vaginal mucosa, and a thick curdy whitish vaginal discharge. Fluconazole 150 mg PO single dose. Topical OTC (...) as outpatient – parenteral if systemic complications. Daily antiviral therapy will decrease the frequency while being taken but does not affect frequency or severity once discontinued. Topical antiviral therapy not recommended. Example regimens: Primary : Acyclovir 400 mg PO TID x 7-10 days OR Valacyclovir 1000 mg PO BID x 7-10 days Secondary : Acyclovir 400 mg PO TID x 5 days OR Valacyclovir 1000 mg PO daily daily x 5 days Question 5) List 3 complications of herpes infection Meningoencephalitis Hepatitis

2017 CandiEM

160. CRACKCast E071 – Ophthalmology Part B

and oxidizing material needs removal Need eye shielding Need IV ceftazidime Need topical erythromycin 3) List 4 options for treatment of corneal abrasions Mechanical Corneal Abrasions FB sensation, photophobia, decreased VA Pain relief with topical anesthetics diagnose the problem as corneal injury Watch for a positive Seidel’s sign – which suggests a corneal perforation Treatment Full lid eversion and examination! Contact lenses shouldn’t be worn until the abrasion is healed (3-5 days) Eye patches aren’t (...) needed! Cycloplegic prn g. Tropicamide Topical antibiotics – probably only needed for people who wear contact lenses Pseudomonal coverage if contact lens wearer (tobramycin 0.5% 1-2 drops q 4hrs) Topical analgesics: Ketorolac 0.5% QID Diclofenac 0.1% QID Tetanus immunization only needed for any “tetanus-prone” injury with dirt and organic matter NO cases of tetanus have been documented from simple corneal abrasions Symptoms should resolve by 24-72 hrs Corneal Foreign Bodies High risk features

2017 CandiEM

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>