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Clindamycin Topical

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121. Topical clindamycin in post-adenotonsillectomy analgesia in children: a double-blind, randomized clinical trial. (PubMed)

Topical clindamycin in post-adenotonsillectomy analgesia in children: a double-blind, randomized clinical trial. Tonsillectomy, with or without adenoidectomy, is one of the most common surgical procedures in pediatric otolaryngology. Pain is the main cause of morbidity in the postoperative period, where it is serious in some cases, leading to odynophagia and resultant complications such as dehydration. We evaluated the effect of topical clindamycin in the reduction of oropharyngeal pain (...) in children who underwent adenotonsillectomy. Secondary outcomes were otalgia, analgesic use, oral bacterial count, type of diet, secondary bleeding, vomiting, fever, and weight loss.Double-blind, randomized clinical trial.Tertiary hospital.Eighty-two children of both sexes between four and 12 years of age who underwent adenotonsillectomy were allocated to receive topical clindamycin or placebo in the immediate preoperative, intraoperative, and eight-to-12-hours postoperative periods. Pain was measured

2009 Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

122. Recommendations for good practice in Ultrasound: Oocyte retrieval

literature search was conducted. Databases (PUBMED/Medline and the Cochrane Library) were searched from inception to 17 July 2018. Search terms focussed on ultrasound, oocyte retrieval, Doppler, sedation, anaesthesia, infection, antibiotics, hydrosalpinx and flushing, and included extended key words and MESH terms. References were divided according to topic, and full texts were assessed (see Supplementary Figure 1, available as Supplementary data at ESHRE online). Where possible, references of papers

2019 European Society of Human Reproduction and Embryology

123. Should a patient with impetigo have a nasal swab taken or be prescribed a topical nasal ointment in addition to oral antibiotics?

Should a patient with impetigo have a nasal swab taken or be prescribed a topical nasal ointment in addition to oral antibiotics? Should a patient with impetigo have a nasal swab taken or be prescribed a topical nasal ointment in addition to oral antibiotics? - Trip Database or use your Google+ account Find evidence fast ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING (...) . As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news. For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com Should a patient with impetigo have a nasal swab taken or be prescribed a topical nasal ointment in addition to oral antibiotics? CKS

2009 TRIP Answers

124. Proposals for a more effective antibiotic policy in Belgium

? The ultimate objective of the study is to formulate proposals and recommendations to promote the prudent use of antibiotics in the human and veterinary sector, to effectively reduce antibacterial resistance. Although infection prevention and control, hospital hygiene and prevention (e.g. vaccination) play a key role in the overall aim to reduce antibiotic resistance, these topics were considered out of scope for the present study. The focus of the present study is limited to antibiotics (ATC c group J01 (...) ), i.e. antimicrobials with activity against bacteria; other antimicrobials like antifungals, antivirals and antiparasitics were not considered. Although infection control such as hospital hygiene and vaccination against non- susceptible pathogens play an important role in the overall reduction of antibiotic resistance, these topics were not included in the scope of the present study. Likewise, the development of new antibiotics, clinical trials and the research and development aspects, were

2019 Belgian Health Care Knowledge Centre

125. There?s Pus About, So Are Antibiotics In or Out? Adding antibiotics for abscess management

25% of patients will experience adverse effects, with gastrointestinal adverse effects occurring for an additional one in 11 on clindamycin and one in 50 on trimethoprim-sulfamethoxazole, compared to placebo. Evidence: • Two recent systematic reviews, including four and 14 randomized controlled trials (RCTs), 2,406 and 4,198 patients, respectively. 1,2 Results statistically significant unless mentioned. o Both relied heavily on two new high-quality RCTs (2,051 patients) of clindamycin (...) with antibiotics that cover MRSA, but not those without (example: cephalexin). 2 o Total adverse effects: 1 25% versus 22% (placebo), Number Needed to Harm (NNH)=38. ? Gastrointestinal adverse effects: 2 • Clindamycin: ~10% more than placebo, NNH=11. • Trimethoprim-sulfamethoxazole: 2% more than placebo, NNH=47. o Limitations: One systematic review only included studies of antibiotics that have activity against MRSA; 1 only two studies included patients with diabetes (2.4% and 11% of study populations

2019 Tools for Practice

126. Antibiotic Prophylaxis in Gynaecologic Procedures

user or . Click to view the full text on ScienceDirect. Abstract Objective To review the evidence and provide recommendations on antibiotic prophylaxis for gynaecologic procedures. Outcomes Outcomes evaluated include need and effectiveness of antibiotics to prevent infections in gynaecologic procedures. Evidence Medline and The Cochrane Library were searched for articles published between January 1978 and January 2011 on the topic of antibiotic prophylaxis in gynaecologic procedures. Results were (...) antibiotic prophylaxis (I-A). 2 All women undergoing laparoscopic hysterectomy or laparoscopically assisted vaginal hysterectomy should receive prophylactic antibiotics (III-B). 3 The choice of antibiotic for hysterectomy should be a single dose of a first-generation cephalosporin. If patients are allergic to cephalosporin, then clindamycin, erythromycin, or metronidazole should be used (I-A). 4 Prophylactic antibiotics should be administered 15 to 60 minutes prior to skin incision. No additional doses

2018 Society of Obstetricians and Gynaecologists of Canada

127. United Kingdom National Guideline for the Management of Pelvic Inflammatory Disease (2019 Interim Update)

the potential to induce macrolide resistance in M. genitalium and, if possible, use should be restricted to women who are known to be M. genitalium negative. PID guideline V4 page 12 Inpatient Regimens i.v. ceftriaxone 2g daily plus i.v. doxycycline 100mg twice daily (oral doxycycline may be used if tolerated) followed by oral doxycycline 100mg twice daily plus oral metronidazole 400mg twice daily for a total of 14 days Grade 1A 36,37 i.v. clindamycin 900mg 3 times daily plus i.v. gentamicin (2mg/kg loading (...) dose) followed by 1.5mg/kg 3 times daily [a single daily dose of 7mg/kg may be substituted]) followed by either oral clindamycin 450mg 4 times daily or oral doxycycline 100mg twice daily plus oral metronidazole 400mg twice daily to complete 14 days Grade 1A 36 Gentamicin levels should be monitored if this regimen is used. Intravenous therapy should be continued until 24 hours after clinical improvement and then switched to oral (Grade 2D). Intravenous doxycycline is not currently licensed in the UK

2019 British Association for Sexual Health and HIV

128. Nystatin

the latest trusted evidence on nystatin or other clinical topics then use Trip today. This page lists the very latest high quality evidence on nystatin and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months. What is Trip? Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care. Trip has been online (...) of Oropharyngeal Candidiasis This study has been completed. Sponsor: AIDS Clinical Trials Group (...) Collaborator: National Institute of Allergy and Infectious Diseases (NIAID) Information provided by (Responsible Party): AIDS Clinical Trials Group ClinicalTrials.gov Identifier: NCT01427738 First received: November 3, 2010 Last updated: February 12, 2015 Last verified: February 2015 Full Text View Purpose The purpose of this study was to see which one of two medicines (topical gentian violet [GV] or nystatin

2018 Trip Latest and Greatest

129. Antibiotics

wanted the latest trusted evidence on antibiotics or other clinical topics then use Trip today. This page lists the very latest high quality evidence on antibiotics and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months. What is Trip? Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care. Trip has (...) (...) for children's oral health Visit the Ad Council's children's oral health website Evidence Education About * Associated Topics Short-term oral antibiotics may be as effective as the standard course of penicillin for children with acute streptococcal pharyngitis Shukan Kanuga, DDS, MSD . Overview Systematic Review Conclusion Three to 6 days of short-term late-generation antibiotics have comparable treatment efficacy as a 10-day course of oral penicillin in children with acute group A β-hemolytic streptococcus

2018 Trip Latest and Greatest

130. Amoxicillin

. If you wanted the latest trusted evidence on amoxicillin or other clinical topics then use Trip today. This page lists the very latest high quality evidence on amoxicillin and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months. What is Trip? Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care (...) of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com Top results for amoxicillin 1. Effect of Postoperative Amoxicillin on Dental Implant Failure Rates Remains Unknown UTCAT3276, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Effect of Postoperative Amoxicillin on Dental Implant Failure Rates Remains Unknown Clinical Question For patients receiving dental implants, does the use

2018 Trip Latest and Greatest

131. Acne

in that it is less dependent on the presence of fat in the gut for absorption. Evaluate the safety profiles of isotretinoin-Lidose and food-dependent generic isotretinoin in the largest clinical study with isotretinoin-925 randomized patients from 49 study sites. Determine if the efficacy of this new formulation is noninferior 2014 20. Clindamycin 1% / tretinoin 0.025% gel (Treclin) - for the topical treatment of acne vulgaris 2014 Follow us: © 2019 Trip Database Ltd. company number 04316414. Trip is proud (...) trusted evidence on acne or other clinical topics then use Trip today. This page lists the very latest high quality evidence on acne and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months. What is Trip? Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care. Trip has been online since 1997

2018 Trip Latest and Greatest

132. Cephalexin

wanted the latest trusted evidence on cephalexin or other clinical topics then use Trip today. This page lists the very latest high quality evidence on cephalexin and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months. What is Trip? Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care. Trip has (...) and medical record confirmation at 1 month. We enrolled 153 participants, and 146 had outcome data for intent-to-treat analysis 2013 6. Randomized controlled trial of cephalexin versus clindamycin for uncomplicated pediatric skin infections 21339275 2011 03 02 2011 05 10 2016 12 15 1098-4275 127 3 2011 Mar Pediatrics Pediatrics Randomized controlled trial of cephalexin versus clindamycin for uncomplicated pediatric skin infections. e573-80 10.1542/peds.2010-2053 To compare clindamycin and cephalexin

2018 Trip Latest and Greatest

133. Systemic Antibiotics for the Treatment of Skin and Soft Tissue Abscesses: A Systematic Review and Meta-Analysis

Annals of Emergency Medicine Volume 73, no. 1 : January 2019 INFECTIOUS DISEASE/SYSTEMATIC REVIEW/META-ANALYSISEditor’s Capsule Summary What is already known on this topic Skin abscesses in many parts of the world are predominantly caused by methicillin-resistant Staphylococcus aureus. The primary treatment of a skin abscess is incision and drainage. What question this study addressed Do methicillin-resistant S aureus–active antibiotics improve clinical outcomes among patients with a drained skin (...) articles forpotentialmissedarticles.We also consultedwith topic experts to help identify any further relevant studies. Inclusioncriteriaconsistedofallrandomizedcontrolled trialscomparingsystemicantibioticswithactivityagainst MRSAversusplacebointhetreatmentofskinandsofttissue abscessesafterincisionanddrainage.Theprimaryoutcome wastreatmentfailure,asde?nedbytheoriginalstudy,which musthaveincludedaspeci?cassessmentofthewoundwithin 21days.Secondaryoutcomesincludedrecurrenceratefornew abscesses

2018 Annals of Emergency Medicine Systematic Review Snapshots

134. Diagnosis and Prevention of Periprosthetic Joint Infections

practice guideline methodology please visit www.aaos.org/cpg. This clinical practice guideline evaluates the effectiveness of diagnostic modalities and prevention strategies for periprosthetic joint infections in hip and knee arthroplasty. The AAOS approach incorporates practicing physicians (clinical experts) and methodologists who are free of potential conflicts of interest relevant to the topic under study, as recommended by clinical practice guideline development experts (Institute of Medicine (...) The primary purpose of the present document is to provide interested readers with full documentation of the best available evidence for various procedures associated with the topic of this review. Publication of most clinical practice guidelines is announced by an Academy press release, articles authored by the clinical practice guideline development group and published in the Journal of the American Academy of Orthopaedic Surgeons, and articles published in AAOS Now. Most clinical practice guidelines

2019 American Academy of Orthopaedic Surgeons

135. Prevention of Early-Onset Group B Streptococcal Disease in Newborns

penicillin remains the agent of choice for intrapartum prophylaxis, with intravenous ampicillin as an acceptable alternative. First-generation cephalosporins (ie, cefazolin) are recommended for women whose reported penicillin allergy indicates a low risk of anaphylaxis or is of uncertain severity. For women with a high risk of anaphylaxis, clindamycin is the recommended alternative to penicillin only if the GBS isolate is known to be susceptible to clindamycin. Alternatively, penicillin allergy skin (...) to ensure that the need to test GBS isolates for clindamycin susceptibility is recognized and performed by laboratory personnel, and that the health care provider understands the importance of reviewing such a test result. Intravenous vancomycin remains the only pharmacokinetically and microbiologically validated option for intrapartum antibiotic prophylaxis in women who report a high-risk penicillin allergy and whose GBS isolate is not susceptible to clindamycin. The vancomycin dosage for intrapartum

2019 American College of Obstetricians and Gynecologists

136. Bacterial vaginosis in pregnancy and risk of spontaneous preterm delivery

bones). No significant levels of clindamycin are attained in the cerebrospinal fluid, even in the presence of inflamed meninges. The average biological half-life is 2.4 hours. Approximately 10% of the bioactivity is excreted in the urine and 3.6% in the feces; the remainder is excreted as bioinactive metabolites (70). Both the oral and topical use of clindamycin has been associated with severe colitis with the higher doses (70). This side effect does not appear to be more common nor does (...) -pregnant and even more often in pregnant women. Topical vs. systemic use of clindamycin If clindamycin is to be used for treating bacterial vaginosis, topical rather than systemic clindamycin should be preferred, since BV is a local condition is in the vaginal mucosa, and because systemic clindamycin causes more harmful ecological effects. Be noted that in some cases topical vaginal use of clindamycin can lead to significant systemic absorption. Metronidazol - microbiology Writer: Claus Østergaard

2019 Nordic Federation of Societies of Obstetrics and Gynecology

137. Management of Rhinosinusitis in Adolescents and Adults

be nasal obstruction or purulent/greenish nasal discharge ± facial pain, headache ± smell disturbance Examination: anterior rhinoscopy Symptoms increasing after 5 days or persistent after 10 days Common cold Treat accordingly Mild* ARS VAS = 0 to 3 Moderate* ARS VAS >3 to 7 Symptomatic relief medication** + topical steroid Severe* ARS VAS >7 to 10 Symptomatic relief medication** + topical steroid + consider antibiotic*** Symptomatic relief medication** Topical steroid No improvement after 14 days (...) of symptoms within 3 days ARS with orbital or intracranial complications 1. Nasal endoscopy 2. Culture and sensitivity 3. Symptomatic relief 4. Topical corticosteroids 5. Oral antibiotics 1. Hospital admission 2. Nasal endoscopy 3. CT and/or MRI scan 4. Culture and sensitivity 5. Symptomatic relief 6. Topical corticosteroids 7. Intravenous antibiotics 8. Consider surgery if medical therapy fails after 48 hours 1. Hospital admission 2. Nasal endoscopy 3. CT and/or MRI scan 4. Culture and sensitivity 5

2019 Ministry of Health, Malaysia

139. Prevention and Control of Methecillin-Resistant Staphylcoccus Aureus (MRSA)

obtained, and when they are obtained. It is generally accepted that instituting CP is appropriate for those patients known to be colonised with MRSA in the acute setting (5) although there is conflicting evidence on this particular topic (6). What follows in this section largely relates to the acute healthcare setting. However, screening may be a component of the prevention and control of CA- MRSA as outlined in section 2.1.5. Recommendations 2.09 A National Clinical Guideline Prevention and Control

2019 National Clinical Guidelines (Ireland)

140. Surveillance, Diagnosis and Management of Clostridium Difficile Infection in Ireland

a significant reduction in CDI incidence, which was associated with the intervention under investigation and one demonstrated a non-significant reduction of CDI. The interventions that led to a reduction in CDI were all aimed at the curtailment of the use of cephalosporins and clindamycin. Four additional studies were identified by the Agency for Healthcare Research and Quality.(55) These studies reported that changes in antimicrobial education and policies which result in a reduction in ‘high-risk

2019 National Clinical Guidelines (Ireland)

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