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Clindamycin Topical

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101. Safety and efficacy of clindamycin phosphate 1.2%-benzoyl peroxide 3% fixed-dose combination gel for the treatment of acne vulgaris: a phase 3, multicenter, randomized, double-blind, active- and vehicle-controlled study. (Abstract)

Safety and efficacy of clindamycin phosphate 1.2%-benzoyl peroxide 3% fixed-dose combination gel for the treatment of acne vulgaris: a phase 3, multicenter, randomized, double-blind, active- and vehicle-controlled study. Topical fixed-combination therapy containing 1% clindamycin as 1.2% clindamycin phosphate (CLNP) and 3% benzoyl peroxide (BPO) is an effective treatment for acne vulgaris (acne).To demonstrate that the combination of 1.2% CLNP with lower strength BPO (CLNP 1.2%-BPO 3%) in a gel

2011 Journal of drugs in dermatology : JDD Controlled trial quality: uncertain

102. Evaluation of Fosmidomycin and Clindamycin in the Treatment of Acute Uncomplicated Plasmodium Falciparum Malaria

Completion Date : December 2011 Resource links provided by the National Library of Medicine related topics: available for: resources: Arms and Interventions Go to Arm Intervention/treatment Experimental: Fosmidomycin and clindamycin treatment All the subject will be given fosmidomycin 30mg/kg/dose + clindamycin 10mg/kg/dose twice daily for three days (total daily dose fosmidomycin 60mg/kg, clindamycin 20mg/kg). Drug: Fosmidomycin and clindamycin The study drugs will be co-administered under supervision (...) Evaluation of Fosmidomycin and Clindamycin in the Treatment of Acute Uncomplicated Plasmodium Falciparum Malaria Evaluation of Fosmidomycin and Clindamycin in the Treatment of Acute Uncomplicated Plasmodium Falciparum Malaria - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved

2011 Clinical Trials

103. Combination of azelaic acid 5% and clindamycin 2% for the treatment of acne vulgaris. (Abstract)

Combination of azelaic acid 5% and clindamycin 2% for the treatment of acne vulgaris. Acne vulgaris, an inflammatory skin disease with different clinical appearances, is a common problem in most adolescents. It seems that using combinations of topical agents can decrease resistance to the treatment and improve the efficacy. Therefore, we evaluated the effects of azelaic acid (AA) 5% and clindamycin (Clin) 2% combination (AA-Clin) on mild-to-moderate acne vulgaris.The efficacy and safety of 12

2011 Cutaneous and ocular toxicology Controlled trial quality: uncertain

104. Principles of Topical Dermatologic Therapy

. Antimicrobials Topical antimicrobials include Antibiotics Antifungals Insecticides Nonspecific antiseptic agents Antibiotics have few indications. Topical clindamycin and erythromycin are used as primary or adjunctive treatment for in patients who do not warrant or tolerate oral antibiotics. Topical metronidazole and occasionally topical sulfacetamide , clindamycin , or erythromycin are used for . Mupirocin has excellent gram-positive (mainly Staphylococcus aureus and streptococci) coverage and can be used (...) Principles of Topical Dermatologic Therapy Principles of Topical Dermatologic Therapy - Dermatologic Disorders - MSD Manual Professional Edition Brought to you by The trusted provider of medical information since 1899 SEARCH SEARCH MEDICAL TOPICS Common Health Topics Resources QUIZZES & CASES Quizzes Cases The trusted provider of medical information since 1899 SEARCH SEARCH MEDICAL TOPICS Common Health Topics Resources QUIZZES & CASES Quizzes Cases / / / / IN THIS TOPIC Test your knowledge

2013 Merck Manual (19th Edition)

105. A randomized, investigator-blinded trial to assess the antimicrobial efficacy of a benzoyl peroxide 5%/ clindamycin phosphate 1% gel compared with a clindamycin phosphate 1.2%/tretinoin 0.025% gel in the topical treatment of acne vulgaris. (Abstract)

A randomized, investigator-blinded trial to assess the antimicrobial efficacy of a benzoyl peroxide 5%/ clindamycin phosphate 1% gel compared with a clindamycin phosphate 1.2%/tretinoin 0.025% gel in the topical treatment of acne vulgaris. Combination products in which the individual components have different mechanisms of antimicrobial action have been shown in many disease states to provide the most effective therapy.This 16-week, two-center, investigator-blinded, randomized, parallel-group (...) study evaluated the antimicrobial efficacy of clindamycin phosphate 1%/benzoyl peroxide 5% gel (BPO/C) as compared to a clindamycin phosphate 1.2%/tretinoin 0.025% gel (T/C) over 16 weeks in the treatment of moderate to moderately severe acne.While subjects in both arms experienced reductions in total Propionibacterium acnes (P. acnes) counts, the BPO/C arm produced greater reductions throughout the study. Furthermore, overall reductions in the number of clindamycin-resistant and erythromycin

2010 Journal of drugs in dermatology : JDD Controlled trial quality: uncertain

106. Adherence to Study Medication Compared to Generic Topical Clindamycin Plus Generic Topical Tretinoin in Subjects With Mild to Moderate Acne Vulgaris

Adherence to Study Medication Compared to Generic Topical Clindamycin Plus Generic Topical Tretinoin in Subjects With Mild to Moderate Acne Vulgaris Adherence to Study Medication Compared to Generic Topical Clindamycin Plus Generic Topical Tretinoin in Subjects With Mild to Moderate Acne Vulgaris - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved (...) Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Adherence to Study Medication Compared to Generic Topical Clindamycin Plus Generic Topical Tretinoin in Subjects With Mild to Moderate Acne Vulgaris The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our

2010 Clinical Trials

107. Recommendations for good practice in Ultrasound: Oocyte retrieval Full Text available with Trip Pro

-guided transvaginal OPU is a widely performed procedure, but standards for best practice are not available. STUDY DESIGN, SIZE, DURATION A working group (WG) collaborated on writing recommendations on the practical aspects of transvaginal OPU. A literature search for evidence of the key aspects of the procedure was carried out. Selected papers ( n = 190) relevant to the topic were analyzed by the WG. PARTICIPANTS/MATERIALS, SETTING, METHODS The WG members considered the following key points (...) technique. The document presents general recommendations for transvaginal OPU, and specific recommendations for its different stages, including prior to, during and after the procedure. Most evidence focussed on comparing different equipment (needles) and on complications and risks, including the risk of infection. For these topics, the recommendations were largely based on the results of the studies. Recommendations are provided on equipment and materials, possible risks and complications, audit

2020 European Society of Human Reproduction and Embryology

108. Efficacy of combined topical treatment of acne vulgaris with adapalene and nadifloxacin: a randomized study. (Abstract)

Efficacy of combined topical treatment of acne vulgaris with adapalene and nadifloxacin: a randomized study. Topical retinoid and antibiotic combination therapy is an integral part of acne treatment and is considered the appropriate first-line therapy according to the Japanese guideline for moderate and severe acne. In this combination, clindamycin or doxycycline are mostly used as antibiotics, but there have been no reports on the effectiveness of nadifloxacin, a widely used antibiotic (...) in Japan and European countries for acne, in combination with topical retinoid. To confirm the efficacy and safety of adapalene gel and nadifloxacin cream in the treatment of Japanese patients with acne vulgaris, a total of 50 patients were randomized to the two groups, the combination therapy and the adapalene monotherapy, and each therapy was tested for 8 weeks. The percentage reduction in the number of inflammatory acne lesions was evaluated and the safety was monitored through adverse events

2011 The Journal of dermatology Controlled trial quality: uncertain

109. Clinical Study Between Two Clindamycin 1%/Benzoyl Peroxide 5% Topical Gels

Clinical Study Between Two Clindamycin 1%/Benzoyl Peroxide 5% Topical Gels Clinical Study Between Two Clindamycin 1%/Benzoyl Peroxide 5% Topical Gels - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Clinical (...) Study Between Two Clindamycin 1%/Benzoyl Peroxide 5% Topical Gels The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01138514 Recruitment Status : Completed First Posted : June 7, 2010 Results First Posted : March 29, 2016 Last Update Posted : March 29, 2016 Sponsor: Perrigo Company Information provided

2010 Clinical Trials

110. Bioequivalence Study Comparing Clindamycin Phosphate (1.2%) and Tretinoin (0.025%) Topical Gel to Ziana and Placebo

Bioequivalence Study Comparing Clindamycin Phosphate (1.2%) and Tretinoin (0.025%) Topical Gel to Ziana and Placebo Bioequivalence Study Comparing Clindamycin Phosphate (1.2%) and Tretinoin (0.025%) Topical Gel to Ziana and Placebo - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number (...) of saved studies (100). Please remove one or more studies before adding more. Bioequivalence Study Comparing Clindamycin Phosphate (1.2%) and Tretinoin (0.025%) Topical Gel to Ziana and Placebo The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01257906 Recruitment Status : Completed First Posted

2010 Clinical Trials

111. Clinical Study Between Two 1% Clindamycin/5% Benzoyl Peroxide Topical Gel Formulations

Clinical Study Between Two 1% Clindamycin/5% Benzoyl Peroxide Topical Gel Formulations Clinical Study Between Two 1% Clindamycin/5% Benzoyl Peroxide Topical Gel Formulations - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies (...) before adding more. Clinical Study Between Two 1% Clindamycin/5% Benzoyl Peroxide Topical Gel Formulations The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01044264 Recruitment Status : Completed First Posted : January 7, 2010 Results First Posted : December 17, 2012 Last Update Posted : January 24

2010 Clinical Trials

112. Antibiotics for trachoma. (Abstract)

, and clindamycin in communities treated with azithromycin, with approximately 5-fold risk ratios at 12 months. The evidence did not support increased resistance to penicillin or trimethoprim-sulfamethoxazole. None of the studies measured resistance to C trachomatis. No serious adverse events were reported. The main adverse effect noted for azithromycin (˜10%) was abdominal pain, vomiting, and nausea.Oral azithromycin versus topical tetracycline (communities)Three cluster-randomised studies compared oral (...) , antibiotic resistance, and adverse effects (secondary objectives).We searched relevant electronic databases and trials registers. The date of the last search was 4 January 2019.We included randomised controlled trials (RCTs) that satisfied either of two criteria: (a) trials in which topical or oral administration of an antibiotic was compared to placebo or no treatment in people or communities with trachoma, (b) trials in which a topical antibiotic was compared with an oral antibiotic in people

2019 Cochrane

113. Polyvalent immunoglobulins – Part 1: A rapid review

in Health), Wim Penninckx (FAGG – AFMPS – Federaal agentschap voor geneesmiddelen en gezondheidsproducten – Agence fédérale des medicaments et des produits de santé) Acknowledgements: We Would like to thank Luc Hourlay (KCE), Irina Cleemput (KCE) and Jutte van der Werff (UZ Brussel, ZNA Paola kinderziekenhuis) for their input in this study. Reported interests: ‘All experts and stakeholders consulted within this report were selected because of their involvement in the topic of Immunoglobulines. Therefore (...) , by definition, each of them might have a certain degree of conflict of interest to the main topic of this report’ Participation in scientific or experimental research as an initiator, principal investigator or researcher: Michel Delforge (Comparative study administration IV Immunoglobulins) Payments to speak, training remuneration, subsidised travel or payment for participation at a conference: Rik Schrijvers (Travel support CSL Behring CIS meeting 2019) Layout: Ine Verhulst Disclaimer: • The external

2020 Belgian Health Care Knowledge Centre

114. [SHINSA]English Translation of Review Report: Zagallo

delamanid July 2014 Diquas diquafosol sodium April 2010 Duac clindamycin phosphate hydrate/benzoyl peroxide March 2015 E Name Active Ingredient Approved In PDF EN PDF JP Efient prasugrel hydrochloride March 2014 Eliquis apixaban December 2012 * Emulsion-adjuvanted Cell-culture Derived Influenza HA Vaccine (Prototype) for Intramuscular Injection "KAKETSUKEN" emulsion-adjuvanted cell-culture derived influenza HA vaccine (prototype) March 2015 Epoprostenol ACT Partial Change Approval epoprostenol sodium (...) ) July 2016 * Prizbind idarucizumab (genetical recombination) September 2016 Proemend fosaprepitant meglumine March 2016 * Errata sheet. The English translation has been corrected accordingly. Q Name Active Ingredient Approved In PDF EN PDF JP Quattrovac adsorbed diphtheria-purified pertussis-tetanus-inactivated polio (Sabin strain) combined vaccine July 2012 R Name Active Ingredient Approved In PDF EN PDF JP Radicut edaravone June 2015 Rapalimus (tablet) sirolimus July 2014 Rapalimus (topical gel

2019 Pharmaceuticals and Medical Devices Agency, Japan

115. Antibiotics after incision and drainage for uncomplicated skin abscesses Full Text available with Trip Pro

recurrence, Clostridium difficile infection, and MRSA resistance to TMP-SMX or clindamycin? Is a shorter course of antibiotics (such as 5 days) as effective as a longer course (10 days)? Is topical therapy (such as iodine, honey, silver, other antimicrobials) effective for treating uncomplicated skin abscesses compared with systemic therapy? Do other adjunctive measures, such as nasal decontamination or antisepsis for the body, reduce the risk that skin abscesses will recur? Updates to this article shows (...) Incision and drainage plus trimethoprim and sulfamethoxazole or clindamycin Incision and drainage alone No antibiotics Antibiotics + or CLI TMP SMX We suggest TMP-SMX or clindamycin plus incision and drainage rather than incision and drainage alone. Discuss both options with each patient. All Applies to Click for details Strong Benefits outweigh harms for almost everyone. All or nearly all informed patients would likely want this option. Weak Benefits outweigh harms for the majority

2018 BMJ Rapid Recommendations

116. Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children Full Text available with Trip Pro

and resuscitation, 3) ventilation, 4) endocrine and metabolic therapies, and 5) adjunctive therapies. A sixth subgroup was added to review research priorities in pediatric sepsis . The co-chairs, co-vice chairs, and group heads made initial selections of the topics. We included topics addressed in the 2016 SSC adult guidelines that were relevant to children, as well as other key pediatric topics discussed in previously published guidelines ( ). The PICO format, which describes the population (P), intervention (...) ., head-of-bed positioning during invasive mechanical ventilation) and have been addressed in other guidelines (e.g., Pediatric Acute Lung Injury Consensus Conference [PALICC]) ( ). However, topics with particular relevance to children with septic shock or other sepsis -associated acute organ dysfunction were included in this guideline, even if there was evaluation of similar or overlapping topics in previous publications. The final decision regarding PICO question inclusion was reached by discussion

2020 Society of Critical Care Medicine

117. Clinical Practice Guideline on the Diagnosis and Prevention of Periprosthetic Joint Infections

clinical practice guideline methodology please visit www.aaos.org/cpg. This clinical practice guideline evaluates the effectiveness of diagnostic modalities and prevention strategies for periprosthetic joint infections in hip and knee arthroplasty. The AAOS approach incorporates practicing physicians (clinical experts) and methodologists who are free of potential conflicts of interest relevant to the topic under study, as recommended by clinical practice guideline development experts (Institute (...) documentation of the best available evidence for various procedures associated with the topic of this review. Publication of most clinical practice guidelines is announced by an Academy press release, articles authored by the clinical practice guideline development group and published in the Journal of the American Academy of Orthopaedic Surgeons, and articles published in AAOS Now. Most clinical practice guidelines are also distributed at the AAOS Annual Meeting in various venues such as on Academy Row

2020 American Academy of Orthopaedic Surgeons

118. Clostridioides difficile Infection in Adults and Children

to treat condition other than CDI, age 65 or older, and use of proton pump inhibitors. 3 Special Populations Extra-colonic CDI Small bowel enteritis secondary to C. difficile is rare, but usually occurs in patients with a partial or total colectomy. The literature on this topic consists primarily of case reports, 45 making it difficult to recommend specific treatment strategies. However, outcomes in small bowel enteritis from CDI can be poor and, these patients warrant aggressive therapy in most cases (...) to overclassify pediatric disease as severe, hence the need for 2 or more abnormal lab criteria required to make a severe diagnosis (or the presence of a high-risk condition). The frequency of pediatric CDI patients meeting criteria for severe disease is low (~8%), with similar proportions of severe disease noted across all pediatric age groups. 63 Prevention Antibiotics and Prevention Nearly all antimicrobial classes have been associated with CDI. However, clindamycin and cephalosporins (especially third

2020 University of Michigan Health System

119. Prevention of Early-Onset Group B Streptococcal Disease in Newborns

the option of empiric in- trapartum antibiotic prophylaxis as a shared decision-making process in this clinical scenario. c Intravenous penicillin remains the agent of choice for intrapartumprophylaxis,withintravenousampicillinas an acceptable alternative. First-generation cepha- losporins (i.e., cefazolin) are recommended for women whose reported penicillin allergy indicates a low risk of anaphylaxisorisofuncertainseverity.Forwomenwith a high risk of anaphylaxis, clindamycin is the recom- mended (...) alternative to penicillin only if the GBS isolate is known to be susceptible to clindamycin. c Alternatively, penicillin allergy testing, if available, is safe during pregnancy and can be beneficial for all women who report a penicillin allergy, particularly those that are suggestive of being IgE mediated, or of unknown severity, or both. Ascertaining the absence of a type I hypersensitivity reaction will eliminate the need to use alternatives to penicillin for GBS EOD prophylaxis and provide long-term

2020 American College of Obstetricians and Gynecologists

120. Antibiotic Use for the Urgent Management of Dental Pain and Intra-oral Swelling Clinical Practice Guideline Full Text available with Trip Pro

effective against various gram-negative anaerobes and is associated with lower incidence of gastrointestinal adverse effects. # Bacterial resistance rates for azithromycin are higher than for other antibiotics, and clindamycin substantially increases the risk of developing Clostridioides difficile infection even after a single dose. Owing to concerns about antibiotic resistance, patients who receive azithromycin should be instructed to closely monitor their symptoms and call a dentist or primary care (...) provider if their infection worsens while receiving therapy. Similarly, clindamycin has a US Food and Drug Administration black box warning for Clostridioides difficile infection, which can be fatal. x 26 US Food and Drug Administration. CLEOCIN HCl. Available at: . Accessed October 4, 2019. Patients should be instructed to call their primary care provider if they develop fever, abdominal cramping, or ≥ 3 loose bowel movements/d. If the patient currently is taking an antibiotic within the same spectrum

2020 American Dental Association Guidelines

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