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Clindamycin Topical

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41. Eradication of methicillin-resistant Staphylococcus aureus (MRSA) throat carriage: a randomised trial comparing topical treatment with rifampicin-based systemic therapy. (Abstract)

. A combination of rifampicin and either clindamycin or SXT was more effective in eliminating pharyngeal MRSA carriage compared with topical treatment with mupirocin only.Copyright © 2017 Elsevier B.V. and International Society of Chemotherapy. All rights reserved. (...) Eradication of methicillin-resistant Staphylococcus aureus (MRSA) throat carriage: a randomised trial comparing topical treatment with rifampicin-based systemic therapy. Eradication of methicillin-resistant Staphylococcus aureus (MRSA) colonisation may prevent transmission of strains between patients and reduces the risk of clinical infection. Colonisation of the throat is associated with prolonged carriage and is more difficult to eradicate. An open randomised study was conducted to evaluate

2018 International journal of antimicrobial agents Controlled trial quality: uncertain

42. Open-Label, Randomized Study Evaluating the Absorption and Systemic Pharmacokinetics of Topically Applied IDP-126 Gel in Comparison With Control Gel

and plasma PK of topically applied IDP-126 Gel compared to Control Gel. Condition or disease Intervention/treatment Phase Acne Vulgaris Drug: IDP-126 Gel Drug: Control Gel Phase 1 Detailed Description: To evaluate the safety and plasma pharmacokinetics (PK) of clindamycin and adapalene in IDP-126 Gel compared with that from Control Gel in subjects with moderate to severe acne vulgaris (acne) during once daily topical application of IDP-126 Gel for 28 days. Study Design Go to Layout table for study (...) Open-Label, Randomized Study Evaluating the Absorption and Systemic Pharmacokinetics of Topically Applied IDP-126 Gel in Comparison With Control Gel Open-Label, Randomized Study Evaluating the Absorption and Systemic Pharmacokinetics of Topically Applied IDP-126 Gel in Comparison With Control Gel - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved

2018 Clinical Trials

43. Comparison effect of azithromycin gel 2% with clindamycin gel 1% in patients with acne. Full Text available with Trip Pro

Comparison effect of azithromycin gel 2% with clindamycin gel 1% in patients with acne. Acne vulgaris is the most common skin disease. Local and systemic antimicrobial drugs are used for its treatment. But increasing resistance of Propionibacterium acnes to antibiotics has been reported.In a double-blind clinical trial, 40 patients with mild to moderate acne vulgaris were recruited. one side of the face was treated with Clindamycin Gel 1% and the other side with Azithromycin Topical Gel 2% BID (...) drugs on papules and pustules was 2-3 times greater than the effect on comedones. Average satisfaction score was not significant between the two groups (P = 0.6, repeated measurs ANOVA). finally, frequency distribution of complications was not significant between the two groups (P > 0.05, Fisher Exact test).Azithromycin gel has medical impact at least similar to Clindamycin Gel in treatment of mild to moderate acne vulgaris, and it may be consider as suitable drug for resistant acne to conventional

2016 Advanced biomedical research Controlled trial quality: uncertain

44. Study on the Genetic Determinants of Clindamycin/Rifampin Interaction

: Observational Estimated Enrollment : 100 participants Observational Model: Other Time Perspective: Prospective Study Start Date : January 2016 Estimated Primary Completion Date : February 2019 Estimated Study Completion Date : June 2019 Resource links provided by the National Library of Medicine related topics: Groups and Cohorts Go to Outcome Measures Go to Primary Outcome Measures : Genetic polymorphism of PXR, LXRalpha, CYP450 on clindamycin clearance with clindamycin/rifampin combination therapy [ Time (...) Study on the Genetic Determinants of Clindamycin/Rifampin Interaction Study on the Genetic Determinants of Clindamycin/Rifampin Interaction - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Study

2016 Clinical Trials

45. Pharmacological Interaction of Rifampicin on Clindamycin in Staphylococcic Osteoarticular Infections

: None (Open Label) Primary Purpose: Treatment Official Title: Pharmacological Interaction of Rifampicin on Clindamycin in Staphylococcic Osteoarticular Infections Actual Study Start Date : March 6, 2017 Estimated Primary Completion Date : April 2019 Estimated Study Completion Date : September 2019 Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Clindamycin and rifampicin dosages blood samples (...) Pharmacological Interaction of Rifampicin on Clindamycin in Staphylococcic Osteoarticular Infections Pharmacological Interaction of Rifampicin on Clindamycin in Staphylococcic Osteoarticular Infections - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please

2016 Clinical Trials

46. Adjunctive Clindamycin for Cellulitis: Clinical Trial Comparing Flucloxacillin With or Without Clindamycin for the Treatment of Limb Cellulitis (C4C Trial).

Title: A Double Blind Randomised Control Trial to Measure the Effect of the Addition of Clindamycin to Flucloxacillin for the Treatment of Limb Cellulitis Study Start Date : October 2013 Actual Primary Completion Date : December 2015 Estimated Study Completion Date : January 2016 Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Placebo Comparator: Flucloxacillin and placebo Intravenous or oral (...) Adjunctive Clindamycin for Cellulitis: Clinical Trial Comparing Flucloxacillin With or Without Clindamycin for the Treatment of Limb Cellulitis (C4C Trial). Adjunctive Clindamycin for Cellulitis: C4C Trial. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100

2013 Clinical Trials

47. Use of Topical Phenytoin in Bisphosphonate-related Osteonecrosis of the Mandible

, infection and pain were in 1,6 and 12 months after treatment. Condition or disease Intervention/treatment Phase Osteonecrosis Due to Drugs, Jaw Drug: Topical Phenytoin 5% Not Applicable Detailed Description: All patients undergo surgical necrotic bone debridement in combination with antibiotic therapy (clindamycin 300 mg q8h) for 4 weeks . Patients who had BRON of the mandible randomly allocated in 2 groups. Group 1 underwent debridement of necrotic bone and the involved area closed primary and in group (...) Use of Topical Phenytoin in Bisphosphonate-related Osteonecrosis of the Mandible Use of Topical Phenytoin in Bisphosphonate-related Osteonecrosis of the Mandible - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding

2017 Clinical Trials

48. Topical Treatment and Prevalence of P. Acnes

Details Study Description Go to Brief Summary: This study is about preventing surgical site infections of the shoulder. We hope to learn if clindamycin alone, benzoyl peroxide alone, or clindamycin and benzoyl peroxide together can affect growth of Propionibacterium acnes in the dermal layer. Condition or disease Intervention/treatment Phase Surgical Site Infection Drug: Clindamycin 1% Gel Drug: Benzoyl peroxide 5% gel Drug: BenzaClin 5%-1% Topical Gel Phase 2 Detailed Description: P. acnes are skin (...) in the dermal layer. 12 volunteers who are normal volunteers, students, or employees of USC will each receive 4 punch biopsies from their back above the scapular spine, with each biopsy taken from a region of the skin treated with a different topical (topical clindamycin alone, topical benzoyl peroxide alone, topical clindamycin and benzoyl peroxide together, and a control). A 3df overall test of the treatment indicators will test for any differences in positivity for P Acnes among the treatments; pairwise

2017 Clinical Trials

49. Compound Adapalene and Clindamycin Hydrochloride Gel in Treatment of Patients With Acne

Study Start Date : March 2015 Estimated Primary Completion Date : December 2015 Estimated Study Completion Date : March 2016 Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Experimental: Treat group 1 Group 1: 0.1% Adapalene + 1% Clindamycin Hydrochloride Drug: Adapalene + Clindamycin Hydrochloride 0.1% Adapalene + 1% Clindamycin Hydrochloride Experimental: Treatment group 2 Group 2: 0.1% Adapalene + 2 (...) Compound Adapalene and Clindamycin Hydrochloride Gel in Treatment of Patients With Acne Compound Adapalene and Clindamycin Hydrochloride Gel in Treatment of Patients With Acne - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies

2015 Clinical Trials

50. Double-blind Placebo-controlled Trial of Generic Clindamycin/Benzoyl Peroxide Gel Versus Onexton Gel in Acne Vulgaris

of a Generic Clindamycin 1.2% and Benzoyl Peroxide 3.75% Gel to Onexton® Gel in Subjects With Acne Vulgaris Study Start Date : May 2015 Actual Primary Completion Date : October 2015 Actual Study Completion Date : November 2015 Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Active Comparator: Onexton gel Clindamycin 1.2% and benzoyl peroxide 3.75% topical gel Applied a thin film of medication onto 6 areas (...) of the face (chin, left cheek, right cheek, nose, left forehead, and right forehead) once daily Drug: Onexton Topical gel for treating acne Other Name: Clindamycin/benzoyl peroxide gel Experimental: Clindamycin/benzoyl peroxide gel Generic clindamycin 1.2% and benzoyl peroxide 3.75% topical gel. Applied a thin film of medication onto 6 areas of the face (chin, left cheek, right cheek, nose, left forehead, and right forehead) once daily Drug: Clindamycin/benzoyl peroxide gel Generic Clindamycin/benzoyl

2015 Clinical Trials

51. Clindamycin-rifampin Drug Interaction in the Treatment of Bone and Joint Infections

-induction (Cytochrome P450 3A4/3A5) on Plasma Clindamycin Concentrations, With Clindamycin Given Intravenously and Orally to Treat Bone-and-joint Infections Actual Study Start Date : December 2015 Estimated Primary Completion Date : December 2019 Estimated Study Completion Date : December 2019 Resource links provided by the National Library of Medicine related topics: available for: Groups and Cohorts Go to Intervention Details: Drug: usual antibiotic treatment pharmacological studies in patients (...) Clindamycin-rifampin Drug Interaction in the Treatment of Bone and Joint Infections Clindamycin-rifampin Drug Interaction in the Treatment of Bone and Joint Infections - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before

2015 Clinical Trials

52. Clindamycin Phosphate 1.2%/Tretinoin 0.025% Gel for the Treatment of Acne Vulgaris: Which Patients are Most Likely to Benefit the Most? (Abstract)

Clindamycin Phosphate 1.2%/Tretinoin 0.025% Gel for the Treatment of Acne Vulgaris: Which Patients are Most Likely to Benefit the Most? Clindamycin phosphate 1.2%/tretinoin 0.025% gel is a topical combination formulation used once daily for the treatment of acne vulgaris, with approval in the United States for patients >12 years of age. Three 12-week, randomized, vehicle-controlled, pivotal trials included > 1,800 actively treated subjects. In addition, an open-label, 52-week study was also (...) completed with 442 subjects enrolled. The skin tolerability, safety, and efficacy of clindamycin phosphate 1.2%/tretinoin 0.025% gel applied once daily is well-established based on data from pivotal studies and analyses in other subsequent publications including from pooled analysis of results from 4,550 subjects. This article discusses results from the pivotal 12-week, Phase 3 studies of clindamycin phosphate 1.2%/tretinoin 0.025% gel applied once daily in 845 subjects with mild, moderate, or severe

2015 The Journal of clinical and aesthetic dermatology Controlled trial quality: uncertain

53. A Study Comparing Clindamycin and Benzoyl Peroxide Gel 1.2%/3.75% to Onextonâ„¢ Gel in the Treatment of Acne Vulgaris

provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Experimental: Clindamycin and BPO Gel 1.2%/3.75% Clindamycin and Benzoyl Peroxide Gel 1.2%/3.75% applied to the face once daily for 84 days. Drug: Clindamycin and Benzoyl Peroxide Gel 1.2%/3.75% Clindamycin and Benzoyl Peroxide Gel 1.2%/3.75% (Taro Pharmaceuticals Inc.) Other Name: Clindamycin, BPO Active Comparator: Onexton™ Gel Onexton™ Gel (Clindamycin and Benzoyl (...) A Study Comparing Clindamycin and Benzoyl Peroxide Gel 1.2%/3.75% to Onextonâ„¢ Gel in the Treatment of Acne Vulgaris A Study Comparing Clindamycin and Benzoyl Peroxide Gel 1.2%/3.75% to Onexton™ Gel in the Treatment of Acne Vulgaris - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number

2015 Clinical Trials

54. Efficacy and Tolerability of a Fixed Combination of Clindamycin Phosphate (1.2%) and Benzoyl Peroxide (3.75%) Aqueous Gel in Moderate and Severe Acne Vulgaris Subpopulations. (Abstract)

(55.1%) had at least a 2-grade reduction in evaluator's global severity score by week 12, and 30.6% of patients assessed their acne as 'clear' or 'almost clear'. Clindamycin-BP 3.75% was well tolerated, with no substantive differences from vehicle; and no patient discontinued due to AEs.Clindamycin-BP 3.75% aqueous gel is an effective and well-tolerated once-daily topical treatment for both moderate and severe acne. (...) Efficacy and Tolerability of a Fixed Combination of Clindamycin Phosphate (1.2%) and Benzoyl Peroxide (3.75%) Aqueous Gel in Moderate and Severe Acne Vulgaris Subpopulations. To evaluate the efficacy, safety, and tolerability of a fixed combination clindamycin phosphate 1.2% and benzoyl peroxide 3.75% (clindamycin-BP 3.75%) aqueous gel in the treatment of moderate and severe acne.Multicenter, double-blind study in 498 patients with moderate or severe acne randomized to clindamycin-BP 3.75

2015 Journal of drugs in dermatology : JDD Controlled trial quality: uncertain

55. Efficacy and safety of clindamycin-tretinoin gel versus clindamycin or tretinoin alone in acne vulgaris: a randomized, double-blind, vehicle-controlled study. (Abstract)

Efficacy and safety of clindamycin-tretinoin gel versus clindamycin or tretinoin alone in acne vulgaris: a randomized, double-blind, vehicle-controlled study. Topical combination therapy containing a retinoid and an antimicrobial is an effective treatment for acne vulgaris.To evaluate the efficacy and safety of a new topical formulation containing clindamycin phosphate 1.2% and tretinoin 0.025% solubilized in an aqueous-based gel (CT gel).1,649 participants were randomized 2:2:2:1 to 12 weeks (...) of double-blind treatment with CT gel, clindamycin, tretinoin, or vehicle gel administered once daily.Significantly more participants achieved 2-grade or greater improvement on the Investigator's Static Global Assessment score with CT gel versus clindamycin, tretinoin, or vehicle gel. CT gel produced a significantly greater reduction in absolute number of total lesions versus all other treatment groups, in total and noninflammatory lesions versus clindamycin, and in total and inflammatory lesions versus

2012 Journal of drugs in dermatology : JDD Controlled trial quality: uncertain

56. A Multi-center, Double-blind, Randomized Study, Comparing Clindamycin Phosphate Vaginal Cream 2% (Watson Laboratories, Inc.) to Clindesse® (Ther-Rx™, Clindamyin Phosphate Vaginal Cream 2%) and Both Active Treatments to a Placebo Control in the Treatmen

would confound the interpretation of clinical response. Subject will be under treatment during the study period for cervical intraepithelial neoplasia (CIN) or cervical carcinoma. History of hypersensitivity to clindamycin, lincomycin, or any of the components of the vaginal creams. Use within 2 weeks prior to baseline of 1) topical or systemic antibiotics or 2) topical or systemic antifungal. Use of spermicides, tampons, douches, diaphragms, condoms within 48 hours of the baseline visit. Concurrent (...) A Multi-center, Double-blind, Randomized Study, Comparing Clindamycin Phosphate Vaginal Cream 2% (Watson Laboratories, Inc.) to Clindesse® (Ther-Rxâ„¢, Clindamyin Phosphate Vaginal Cream 2%) and Both Active Treatments to a Placebo Control in the Treatmen A Multi-center, Double-blind, Randomized Study, Comparing Clindamycin Phosphate Vaginal Cream 2% (Watson Laboratories, Inc.) to Clindesse® (Ther-Rx™, Clindamyin Phosphate Vaginal Cream 2%) and Both Active Treatments to a Placebo Control

2014 Clinical Trials

57. Comparison of the Efficacy and Safety of Clindamycin + Benzoyl Peroxide Formulation With Azelaic Acid Formulation in the Treatment of Acne Vulgaris

of the Efficacy and Safety of Clindamycin 1% / Benzoyl Peroxide 3% and Azelaic Acid 20% in the Topical Treatment of Mild to Moderate Acne Vulgaris Actual Study Start Date : February 21, 2014 Actual Primary Completion Date : September 8, 2014 Actual Study Completion Date : September 8, 2014 Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Experimental: Arm 1 A total of 110 subjects will receive clindamycin + BPO (...) , salicylic acid, or alpha- or beta-hydroxy acids. Subjects who have a known hypersensitivity or previous allergic reaction to any of the active components (azaleic acid, lincomycin, clindamycin, BPO), or excipients of the study medication. Use of estrogens, including oral, implanted, and topical contraceptives, androgens, or anti-androgenic agents of less than 12 consecutive weeks prior to start of study dosing (change of the dose or drug is not permitted between 12 weeks prior study dosing until end

2014 Clinical Trials

58. Gentamicin Versus Clindamycin Versus Normal Saline Lavage in Axilla

Gentamicin Versus Clindamycin Versus Normal Saline Lavage in Axilla Gentamicin Versus Clindamycin Versus Normal Saline Lavage in Axilla - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Gentamicin Versus (...) Clindamycin Versus Normal Saline Lavage in Axilla The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02314806 Recruitment Status : Completed First Posted : December 11, 2014 Last Update Posted : December 11, 2014 Sponsor: Hospital General Universitario Elche Information provided by (Responsible Party): Jaime

2014 Clinical Trials

59. The phototoxic and photoallergy potential of clindamycin phosphate 1.2%/ tretinoin 0.025% gel for facial acne: results of two single-center, evaluator-blinded, randomized, vehicle-controlled phase 1 studies in healthy volunteers. (Abstract)

The phototoxic and photoallergy potential of clindamycin phosphate 1.2%/ tretinoin 0.025% gel for facial acne: results of two single-center, evaluator-blinded, randomized, vehicle-controlled phase 1 studies in healthy volunteers. A fixed-dose combination of clindamycin phosphate 1.2% and tretinoin 0.025% gel (VELTIN® (clindamycin phosphate and tretinoin) 1.2%/0.025% Gel [VELTIN]) (clindamycin/tretinoin gel) is currently available for the once-daily topical treatment of acne.Two-phase I studies (...) were conducted to evaluate the phototoxic and photoallergic potential of clindamycin/tretinoin gel.Study 1 (phototoxic) (n=37) and Study 2 (photoallergic) (n=58) were single-center, evaluator-blinded, randomized, vehicle-controlled, phase 1 studies conducted in healthy volunteers. In Study 1, clindamycin/tretinoin gel patches, vehicle gel patches and blank patches (no gel) were applied concurrently for 24 hours to naïve sites. After patch removal, sites were irradiated with 16 joules/cm2

2014 Journal of drugs in dermatology : JDD Controlled trial quality: uncertain

60. Clindamycin phosphate 1.2%-benzoyl peroxide 3% fixed-dose combination gel has an effective and acceptable safety and tolerability profile for the treatment of acne vulgaris in Japanese patients: a phase III, multicentre, randomised, single-blinded, active (Abstract)

Clindamycin phosphate 1.2%-benzoyl peroxide 3% fixed-dose combination gel has an effective and acceptable safety and tolerability profile for the treatment of acne vulgaris in Japanese patients: a phase III, multicentre, randomised, single-blinded, active A topical fixed-dose clindamycin phosphate 1·2% and benzoyl peroxide 3·0% combination gel (CLNP/BPO 3%) is known to be effective and safe in white people with acne.To evaluate the efficacy and safety of CLNP/BPO 3·0% topically applied once

2014 The British journal of dermatology Controlled trial quality: uncertain

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