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181. Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock

. Topic selection was the responsibility of the co-chairs and group heads, with input from the guideline panel in each group. Prioritization of the topics was completed by discussion through e-mails, teleconferences, and face-to-face meetings. All guideline questions were structured in PICO format, which described the population, intervention, control, and outcomes. Questions from the last version of the SSC guidelines were reviewed; those that were considered important and clinically relevant were (...) discussion or voting at any committee meetings during which content germane to their COI was discussed. Five were judged as having conflicts that were managed through reassignment to another group as well as the described restrictions on voting on recommendations in areas of potential COI. One individual was asked to step down from the committee. All panelists with COI were required to work within their group with full disclosure when a topic for which they had relevant COI was discussed, and they were

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2016 European Respiratory Society

182. Guidelines on Prevention, Diagnosis and Treatment of Infective Endocarditis

of the ESC on a given topic and are regularly updated. Members of this Task Force were selected by the ESC to represent professionals involved with the medical care of patients with this pathology. Selected experts in the field undertook a comprehensive review of the published evidence for management (including diagnosis, treatment, prevention and rehabilitation) of a given condition according to ESC Committee for Practice Guidelines (CPG) policy. A critical evaluation of diagnostic and therapeutic

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2015 European Society of Cardiology

183. Peritoneal dialysis catheter-related infection: exit site and tunnel

enterococcus (VRE), if prolonged use of vancomycin is planned. Plum et al in a prospective randomised study, showed the greater efficacy of the intraperitoneal (IP) application of clindamycin as a first-line antibiotic compared with the oral route for the treatment of tunnel infections. [9] The results showed no significant difference in the pericatheter fluid along the catheter at study entry, with 4 mm (median; range: 2-6 mm) in the oral group and 4 mm (range: 2-4 mm) in the IP group. The IP treatment (...) intraperitoneal vancomycin plus oral rifampin or oral trimethoprim/sulfamethoxazole for Gram-positive catheter infections. There was no difference with either treatment on catheter infection cure rate. The second study showed that there is greater efficacy with the intraperitoneal application of clindamycin as a first-line antibiotic compared with the oral route, for the treatment of tunnel infections. The KHA-CARI Guidelines – Caring for Australasians with Renal Impairment

2014 KHA-CARI Guidelines

184. Antibiotic susceptibility of <i>Propionibacterium acnes</i> isolated from patients with acne in a public hospital in Southwest China: prospective cross-sectional study. (PubMed)

%) were susceptible to tetracycline, followed by clindamycin and clarithromycin in 101 (44.5%) and 102 (44.93%) isolates, respectively. Susceptibility of P. acnes was detected for erythromycin in 96 (42.3%) patients, followed by azithromycin in 94 (41.4%). Subjects who received antibiotics (topical and oral) had higher frequencies of antibiotic-resistant P. acnes as well as increased antibiotic minimum inhibitory concentrations compared with patients without antibiotic treatment.P. acnes was highly (...) in Southwest China.This was a prospective cross-sectional study. Cutaneous samples were obtained from acne lesions on the face of 375 patients. Samples were cultured in anaerobic medium to identify the presence of P. acnes. Susceptibility tests of isolated P. acnes were performed for tetracycline, doxycycline, clindamycin, erythromycin, azithromycin and clarithromycin using the Epsilometer test.P. acnes was isolated from 227 patients; 224 isolates (98.7%) were susceptible to doxycycline and 220 (96.9

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2019 BMJ open

185. Bacteroides Spp. Blebitis, Keratitis, and Endophthalmitis Following Uncomplicated Trabeculectomy. (PubMed)

to endophthalmitis despite hourly topical fortified antibiotic therapy. Although gram stain and culture of the bleb surface, a conjunctival suture, the aqueous humor, and the vitreous were negative, topical real-time quantitative polymerase chain reaction (qRT-PCR) testing disclosed the presence of Bacteroides spp. Following treatment with topical and intravitreal clindamycin and intravenous meropenem, all clinical evidence of infection resolved. Best spectacle corrected visual acuity improved to 20/25 (0.8

2019 Journal of Glaucoma

186. Morphological characteristics of ocular toxoplasmosis and its regression pattern on swept-source optical coherence tomography angiography: a case report. (PubMed)

near the foveal center. Spectral-domain optical coherence tomography (SD-OCT) revealed disorganization of the retinal structure with markedly thickened choroid beneath the active lesion. Highly elevated serum titers of IgG antibodies against Toxoplasma gondii were observed. Topical and systemic steroids with oral Bactrim were administered after a diagnosis of ocular toxoplasmosis was made. After improvement in the severity of vitritis, structural en face swept-source optical coherence tomography (...) (SS-OCT) imaging demonstrated diffuse choroidal dilation with many collateral vascular branches surrounding the active lesion. Eight intravitreal injections of clindamycin (1 mg/0.1 ml) were administered at 1- to 2-week intervals along with systemic antibiotics and steroids. After the treatment, the toxoplasmic lesion resolved to an atrophic chorioretinal scar. Dilated choroidal vessel size was normalized and collateral vascular branches were markedly constricted on structural en face SS-OCT

2019 BMC Ophthalmology

187. Antibiotic Prophylaxis for Dental Patients at Risk for Infection

oral medication Ampicillin OR Cefazolin or ceftriaxone 2 g IM or IV 1 g IM or IV 50 mg/kg IM or IV 50 mg/kg IM or IV Allergic to penicillins or ampicillin—oral Cephalexin* † OR Clindamycin OR Azithromycin or clarithromycin 2 g 600 mg 500 mg 50 mg/kg 20 mg/kg 15 mg/kg Allergic to penicillin or ampicillin and unable to take oral medication Cefazolin or ceftriaxone † OR Clindamycin 1 g IM or IV 600 mg IM or IV 50 mg/kg IM or IV 20 mg/kg IM or IV AMERICAN ACADEMY OF PEDIATRIC DENTISTRY RECOMMENDATIONS (...) We are unable to recommend for or against the use of topical oral antimicrobials in patients with prosthetic joint implants or other ortho- paedic implants undergoing dental procedures. Grade of Recommendation: Inconclusive An Inconclusive recommendation means that there is a lack of compelling evidence resulting in an unclear balance between potential benefits and potential harm. Practitioners should feel little constraint in deciding whether to follow a recommendation labeled as Inconclusive

2014 American Academy of Pediatric Dentistry

188. Top 10 Most Read in March: Caesarean section and for-profit status of hospitals, mental health links to diet, and weight discrimination

variety in topics and study types. In the top spot this month is a systematic review and meta-analysis by Hoxha et al discussing the association of for-profit status of a hospital and the odds of a woman having a caesarean section. Nguyen et al , at number four, undertake a cross-sectional study to investigate the association between fruit and vegetable consumption and the prevalence of psychological distress in middle-ages and older Australians, finding that there is potential for increased fruit (...) and vegetable consumption in helping to reduce psychological distress. Reaching number seven this month is a study looking at the association between perceived weight discrimination and physical activity, by Jackson and Steptoe of UCL. At number eight this month we see a clinical trial comparing flucloxacillin with clindamycin to flucloxacillin alone for the treatment of limb cellulitis, while at number ten we have a pilot study carried out to inform the design of a future trial to determine

2017 BMJ Open Blog

190. Adult Sinusitis

to confirm diagnosis and guide management, and promote judicious use of systemic and topical therapy, which includes radiography, nasal endoscopy, computed tomography, and testing for allergy and immune function. Emphasis was also placed on identifying multiple chronic conditions that would modify management of rhinosinusitis, including asthma, cystic fibrosis, immunocompromised state, and ciliary dyskinesia. Action statements The update group made strong recommendations that clinicians (1) should (...) and other causes of sinonasal symptoms; (5) should assess the patient with CRS or recurrent ARS for multiple chronic conditions that would modify management, such as asthma, cystic fibrosis, immunocompromised state, and ciliary dyskinesia; (6) should confirm the presence or absence of nasal polyps in a patient with CRS; and (7) should recommend saline nasal irrigation, topical intranasal corticosteroids, or both for symptom relief of CRS. The update group stated as options that clinicians may (1

2015 American Academy of Otolaryngology - Head and Neck Surgery

191. Antibiotic prophylaxis for GI endoscopy

Antibiotic prophylaxis for GI endoscopy GUIDELINE Antibiotic prophylaxis for GI endoscopy Thisisoneofaseriesofstatementsdiscussingtheuseof GI endoscopy in common clinical situations. The Stan- dards of Practice Committee of the American Society for Gastrointestinal Endoscopy (ASGE) prepared this docu- ment, and it updates a previously issued document on this topic. 1 In preparing this guideline, MEDLINE and PubMed databases were used to search for publications between January 1975 and December (...) 2013 pertaining to this topic. The search was supplemented by accessing the “related articles” feature of PubMed, with articles identi?ed on MEDLINE and PubMed as the references. Additional references were obtained from the bibliogra- phies of the identi?ed articles and from recommenda- tions of expert consultants. When few or no data were available from well-designed prospective trials, emphasis was given to results from large series and reports from recognized experts. Weaker recommendations

2015 American Society for Gastrointestinal Endoscopy

192. WHO recommendations for prevention and treatment of maternal peripartum infections

should be used in preference to other classes of antibiotics. Conditional recommendation based on very low-quality evidence Treatment of peripartum infections 19. A simple regimen such as ampicillin and once-daily gentamicin is recommended as first-line antibiotics for the treatment of chorioamnionitis. Conditional recommendation based on very low-quality evidence 20. A combination of clindamycin and gentamicin is recommended as first-line antibiotics for the treatment of postpartum endometritis (...) of care for leading causes of maternal death, especially those clustered around the time of childbirth, in the post-MDG era. The guideline is evidence-informed and covers topics related to interventions selected and prioritized by an international, multidisciplinary group of health care professionals, consumer representatives and other stakeholders. Specifically, it presents evidence-based recommendations for preventing and treating genital tract infections during labour, childbirth or puerperium

2015 World Health Organisation Guidelines

193. Practice Parameters for the Management of Clostridium Difficile Infection

, and anus by developing Clinical Practice Guidelines based on the best available evidence. t hese guidelines are inclusive, not pre- scriptive, and are intended for the use of all practitioners, health care workers, and patients who desire information about the management of the conditions addressed by the topics covered in these guidelines. t heir purpose is to pro- vide information on which decisions can be made, rather than dictate a specific form of treatment. it should be recognized (...) of antimicrobial therapy. 1 t he major risk factor for CDi is recent antibiotic use, with 1 report finding that 96% of symptomatic patients received antibiotics within 14 days of infection, and all af- fected patients were exposed to antibiotics within 3 months of CDi symptoms. 15 a lthough any antibiotic can result in a change in bacterial milieu, certain drugs such as penicil- lins, clindamycin, fluoroquinolones, and third-generation cephalosporins are more commonly associated with its development. 16 o ther

2015 American Society of Colon and Rectal Surgeons

194. Antibiotic Prophylaxis with Bone Grafting Procedures Reduces Risk of Postoperative Complications

Antibiotic Prophylaxis with Bone Grafting Procedures Reduces Risk of Postoperative Complications UTCAT2804, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Antibiotic Prophylaxis with Bone Grafting Procedures Reduces Risk of Postoperative Complications Clinical Question In patients indicated for bone grafting, does oral antibiotic prophylaxis decrease risk of postoperative complications, including infections? Clinical (...) to dental implant and bone grafting procedures reduces post-operative complications but various clinical and patient factors must be taken into special consideration. Amoxicillin is suggested to be considered first due to its cost and antimicrobial activity towards the oral flora. Cephalexin and clindamycin should be considered as alternatives. #2) Lindeboom/2003 Adults (N=20) indicated for bone grafting prior to implant placement Randomized Controlled Trial Key results No infections were seen

2015 UTHSCSA Dental School CAT Library

196. Solithromycin Triskel - community-acquired pneumonia, anthrax and tularaemia

are considered acceptable alternatives where macrolide resistance rates are low. A combination of a ß-lactam and a macrolide is recommended for moderate or severe CAP or in cases of failure to respond to the first line treatment. The guidelines do not recommend empiric treatment for atypical pathogens (L. pneumophila and M. pneumoniae) for all patients with CAP, although this position remains a topic of intense debate. The prevalence of penicillin-resistant S. pneumoniae (PRSP), macrolide-resistant S (...) , clindamycin, vancomycin or rifampicin are suggested as supplementary antibiotics for inhalational anthrax Currently in the EU, ciprofloxacin, levofloxacin and penicillin VK are approved in some countries for treatment of anthrax. Assessment Report EMA/CHMP/226929/2017 Page 7/93 2.2 About the product Solithromycin is a fluoroketolide. In vitro, it shows activity against macrolide-resistant S. pneumoniae and M. pneumoniae and against some macrolide-resistant S. aureus. Replacement of the cladinose sugar

2017 European Medicines Agency - EPARs

197. Adalimumab for treating moderate to severe hidradenitis suppurativa

been diagnosed with moderate to severe hidradenitis suppurativa at least 1 year earlier and who were intolerant to, or whose disease had not responded to, oral antibiotics. Moderate to severe disease was defined as people with Hurley stage II or III hidradenitis suppurativa in at least 1 affected anatomic region, and a total abscess and inflammatory nodule (AN) count greater than 3. Neither of the trials recruited people from the UK. Treatment with oral or topical antibiotics during the trial (...) that there is no standard of care and no NICE guidance; there were no medical treatments specifically licensed for hidradenitis suppurativa until adalimumab received its marketing authorisation. The committee noted the results of a survey of the UK Dermatology Trials Network and British Association of Dermatologists, presented in the company submission, which showed that the most commonly used treatments in the UK – after topical antibiotics – are oral antibiotics; first tetracycline, and then a combination

2016 National Institute for Health and Clinical Excellence - Technology Appraisals

198. Urological Infections

in this text are graded according to their level of evidence (LE) and Guidelines are given a grade of recommendation (GR), according to a classification system modified from the Oxford Centre for Evidence-Based Medicine Levels of Evidence [22]. The aim of grading recommendations is to provide transparency between the underlying evidence and the recommendation given. In this 2015 EAU Guidelines compilation, all standard information on LE and GR has been taken out of the individual Guidelines topics

2015 European Association of Urology

199. Management of Venous Leg Ulcers: Clinical Practice Guidelines of the Society for Vascular Surgery and the American Venous Forum

provider choose from a number of débridement methods, including sharp, enzymatic, mechanical, biologic, and autolytic. More than one débridement method may be appropriate. [GRADE - 2; LEVEL OF EVIDENCE - B] Guideline 4.3: Anesthesia for Surgical Débridement We recommend that local anesthesia (topical or local injection) be administered to minimize discomfort associated with surgical venous leg ulcer débridement. In selected cases, regional block or general anesthesia may be required. [GRADE - 1; LEVEL (...) OF EVIDENCE - C] Oral antibiotics are preferred initially, and the duration of antibiotic therapy should be limited to 2 weeks unless persistent evidence of wound infection is present. [GRADE - 1; LEVEL OF EVIDENCE - C] Guideline 4.13: Topical Antibiotics for Infected Wounds We suggest against use of topical antimicrobial agents for the treatment of infected venous leg ulcers. [GRADE - 2; LEVEL OF EVIDENCE - C] Guideline 4.14: Topical Dressing Selection We suggest applying a topical dressing

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2014 American Venous Forum

200. Management of Chronic Kidney Disease (CKD) in Primary Care

contrast administration. Multiple RCTs have shown December 2014 Page 23 of 117 conflicting results as to the efficacy of NAC. Meta-analyses have been performed to address this topic but have been inconclusive. A review of the literature for this update identified one RCT that enrolled cardiac surgery patients receiving IV NAC versus placebo. There was no significant difference between the incidences of AKI in both groups (28% NAC versus 31% placebo). [31] The 2008 CKD CPG commented that the use of NAC (...) or to be Used with Caution in Patients with CKD [89-91] Select Medications* • Most antibiotics (macrolides, clindamycin, and metronidazole are exceptions) and antiviral agents • Multiple anti-cancer therapies (cytotoxic drugs, targeted agents, biologics) • Hypoglycemic agents o Acarbose o Miglitol o Glyburide o Chlorpropamide o Insulin o Metformin o Exenatide o Repaglinide o Alogliptin o Saxagliptin o Sitagliptin o Canagliflozin o Dapagliflozin o Empagliflozin • Cardiovascular agents o Atenolol o Sotalol o

2014 VA/DoD Clinical Practice Guidelines

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