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Clindamycin Topical

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181. Guidelines on Prevention, Diagnosis and Treatment of Infective Endocarditis Full Text available with Trip Pro

of the ESC on a given topic and are regularly updated. Members of this Task Force were selected by the ESC to represent professionals involved with the medical care of patients with this pathology. Selected experts in the field undertook a comprehensive review of the published evidence for management (including diagnosis, treatment, prevention and rehabilitation) of a given condition according to ESC Committee for Practice Guidelines (CPG) policy. A critical evaluation of diagnostic and therapeutic

2015 European Society of Cardiology

182. Diarrhoea - antibiotic associated

Diarrhoea - antibiotic associated Diarrhoea - antibiotic associated - NICE CKS Share Diarrhoea - antibiotic associated: Summary Diarrhoea is a common consequence of treatment with antibiotics, occurring in 2–25% of people taking antibiotics, depending on the antibiotic prescribed. Around 20% to 30% of cases of antibiotic-associated diarrhoea are due to Clostridium difficile . Antibiotics frequently associated with C. difficile infection include clindamycin, cephalosporins (especially third (...) be given on hygiene measures to minimize the spread of C. difficile . Diarrhoea due to C. difficile infection should resolve in 1-2 weeks. The person will remain infectious whilst they still have symptoms and they should stay away from work or school until they have been free from diarrhoea for 48 hours. Have I got the right topic? Have I got the right topic? From age 18 years onwards. This CKS topic covers the management of antibiotic-associated diarrhoea, including Clostridium difficile . This CKS

2019 NICE Clinical Knowledge Summaries

183. Gastroenteritis

should be notified to the Local Authority Proper Officer (in England and Wales, the local Consultant in Communicable Disease Control). Have I got the right topic? Have I got the right topic? From age 1 month onwards. This CKS topic covers the management of gastroenteritis (including presumed infectious gastroenteritis) in adults and children, and briefly covers the prevention of gastroenteritis. This CKS topic covers the management of people returning to the UK with traveller's diarrhoea. Prevention (...) of travellers' diarrhoea and the use of antibiotics for the prophylaxis and empirical treatment of travellers' diarrhoea are covered in the CKS topic on . This CKS topic does not cover the management of gastroenteritis caused by Clostridium difficile . This is covered in the CKS topic on . This CKS topic does not cover the management of gastroenteritis or other causes of acute diarrhoea in neonates. This CKS topic does not cover the epidemiological investigations necessary to identify the source

2019 NICE Clinical Knowledge Summaries

185. Acne vulgaris

Association of Dermatologists — . For people with mild-to-moderate acne: Consider prescribing a single topical treatment such as: A topical retinoid (for example adapalene [if not contraindicated]) alone or in combination with benzoyl peroxide. Retinoids are contraindicated in pregnancy and breastfeeding. A topical antibiotic (for example clindamycin 1%) — antibiotics should always be prescribed in combination with benzoyl peroxide to prevent development of bacterial resistance. Topical benzoyl peroxide (...) -bacterial effects [ ]. Topical monotherapy with antibiotics is not recommended because of the risk of antibiotic resistance [ ; ; ; ; ]. The American Academy of Dermatology [ ] recommend Clindamycin 1% solution or gel as the preferred topical antibiotic for acne. Azelaic acid Azelaic acid is mildly effective as a comedolytic, antibacterial, and anti-inflammatory agent [ ]. It is recommended as second-line treatment in several guidelines [ ; ; ]. Some people may prefer azelaic acid to benzoyl peroxide

2018 NICE Clinical Knowledge Summaries

186. Bacterial vaginosis

, and key randomized controlled trials (RCTs) published since the last revision of this topic. No major changes to recommendations have been made, but the topic has been restructured. Previous changes Previous changes July 2014 — minor update. Update to the text to reflect the fact that there are reports of raised international normalized ratio (INR) levels and increased bleeding in people taking vitamin K antagonists and using topical clindamycin. April 2013 — reviewed. A literature search (...) contraindications and cautions, adverse effects, and possible drug interactions. If the woman prefers topical treatment or cannot tolerate oral metronidazole: Prescribe intravaginal metronidazole gel 0.75% once a day for 5 days (off-label for women aged younger than 18 years) or intravaginal clindamycin cream 2% once a day for 7 days. See the sections on and for prescribing information on these treatments, including contraindications and cautions, adverse effects, and possible drug interactions. Oral

2018 NICE Clinical Knowledge Summaries

187. Dental abscess

updated within prescribing information - metronidazole. February 2017 — reviewed. A literature search was conducted in January 2017 to identify evidence-based guidelines, UK policy, systematic reviews, and key RCTs published since the last revision of the topic. The management section has been restructured. Other changes include removal of: Detailed information on analgesia as this is now covered in the CKS topics on and . Clindamycin as a first-line option for antibiotic treatment in primary care (...) . Neurological signs (for example decreased level of consciousness, headache, eye signs). Dehydration. Clinical judgement should be used regarding admission to hospital or seeking specialist advice for people who: Have signs and symptoms of systemic infection (for example nausea, malaise, pyrexia, or rigors). Are immunocompromised. Are very young or elderly. Experience severe pain despite analgesia prescribed in primary care. Have I got the right topic? Have I got the right topic? From age 12 months onwards

2018 NICE Clinical Knowledge Summaries

188. Guideline for the Treatment of Acne

. Comedonal acne 3 Mild to moderate papulopustular acne Severe papulopustular/ moderate nodular acne Severe nodular/ conglobate acne 13 High strength of recommen- dation - Adapalene + BPO (f.c.) or BPO + Clindamycin (f.c.) 5 Isotretinoin Isotretinoin Medium strength of recommen- dation Topical retinoid 4 Azelaic acid or BPO or Topical Retinoid 4 or Topical Clindamycin + Tretinoin (f.c.) 5,6 or Systemic Antibiotic 5,7,8 + Adapalene 9 Systemic Antibiotic 5,8 + Adapalene 9 or Systemic Antibiotic 5,8 (...) evidence, see Table 12). The fixed dose combinations of clindamycin with BPO showed a trend towards better efficacy against NIL versus clindamycin and comparable efficacy versus BPO (see Table 5). With respect to the safety/ tolerability profile, the combination is comparable to its single components (indirect evidence, see Table 12). Few and only indirect data on patient preference are available. They indicate patient preference for adapalene over other topical retinoids. Additional pathophysiological

2016 European Dermatology Forum

189. Acne clinical guideline Full Text available with Trip Pro

%, and 10% benzoyl peroxide on inflammatory acne vulgaris. Int J Dermatol . 1986 ; 25 : 664–667 | | , x 59 Schutte, H., Cunliffe, W.J., and Forster, R.A. The short-term effects of benzoyl peroxide lotion on the resolution of inflamed acne lesions. Br J Dermatol . 1982 ; 106 : 91–94 | | Topical antibiotics (eg, clindamycin and erythromycin) A I, II x 60 Mills, O. Jr., Thornsberry, C., Cardin, C.W., Smiles, K.A., and Leyden, J.J. Bacterial resistance and therapeutic outcome following three months (...) of topical acne therapy with 2% erythromycin gel versus its vehicle. Acta Derm Venereol . 2002 ; 82 : 260–265 | | | , x 61 Bernstein, J.E. and Shalita, A.R. Topically applied erythromycin in inflammatory acne vulgaris. J Am Acad Dermatol . 1980 ; 2 : 318–321 | | | , x 62 Jones, E.L. and Crumley, A.F. Topical erythromycin vs blank vehicle in a multiclinic acne study. Arch Dermatol . 1981 ; 117 : 551–553 | | , x 63 Shalita, A.R., Smith, E.B., and Bauer, E. Topical erythromycin v clindamycin therapy

2016 American Academy of Dermatology

190. Guidelines for Laparoscopic Ventral Hernia Repair

articles that may have been missed during the original search. Additional relevant articles were obtained and included in the review for grading. To facilitate the review by multiple reviewers, the guideline was divided into the following topics: 1. Laparoscopic vs. Open Repair 2. Preoperative Considerations 3. Operative Technique 4. Postoperative Management: Avoiding and Treating Problems Additional articles pertaining to specific subsections of the above topics were reviewed and graded, providing (...) . Vancomycin or Clindamycin should be given to patients allergic to cephalosporins. (Moderate quality, Strong recommendation) The guidelines recently published jointly by the American Society of Health-System Pharmacists (ASHP), the Infectious Diseases Society of America (IDSA), the Surgical Infection Society (SIS), and the Society for Healthcare Epidemiology of America (SHEA) recommend that a single dose of a first-generation cephalosporin (cefazolin) be administered within 60 minutes prior to incisional

2016 Society of American Gastrointestinal and Endoscopic Surgeons

191. Management of Intra-Abdominal Infection : guidelines by the Surgical Infection Society Full Text available with Trip Pro

Abstract Background: Previous evidence-based guidelines on the management of intra-abdominal infection (IAI) were published by the Surgical Infection Society (SIS) in 1992, 2002, and 2010. At the time the most recent guideline was released, the plan was to update the guideline every five years to ensure the timeliness and appropriateness of the recommendations. Methods: Based on the previous guidelines, the task force outlined a number of topics related to the treatment of patients with IAI (...) and then developed key questions on these various topics. All questions were approached using general and specific literature searches, focusing on articles and other information published since 2008. These publications and additional materials published before 2008 were reviewed by the task force as a whole or by individual subgroups as to relevance to individual questions. Recommendations were developed by a process of iterative consensus, with all task force members voting to accept or reject each

2016 Surgical Infection Society

193. WHO guidelines for the treatment of Chlamydia trachomatis

of key end-users of the STI guidelines will be conducted after the release of the guidelines. The results of the survey will be used to identify challenges and barriers to the uptake of the guidelines, to evaluate their usefulness for improving service delivery, and to identify topics or gaps in treatment that need to be addressed in future editions. 3.3 IMPLEMENTATION OF THE WHO GUIDELINES FOR THE TREATMENT OF C. TRACHOMATIS ADAPTATION, IMPLEMENTATION AND MONITORING These guidelines provide (...) , and Web annex D for details of the evidence reviewed, L Q F O X G L Q JH Y L G H Q F HS UR ? O H VD Q GH Y L G H Q F H W R G H F LVL R Q I U D P HZ R U N V S S 5 ( & 2 0 0 (1 ' $ 7 , 2 1 For all neonates, the WHO STI guideline recommends topical ocular prophylaxis for the prevention of gonococcal and chlamydial ophthalmia neonatorum. Strong recommendation, low quality evidence RECOMMENDATION 7 For ocular prophylaxis, the WHO STI guideline suggests one of the following options for topical

2016 World Health Organisation Guidelines

194. Mirvaso - brimonidine

of Appearance PAW Patient Assessment of Whitening PK Pharmacokinetic PSA Patient Self-Assessment QD Once daily (Latin: quaque die) QOL Quality of life SAE Serious adverse event SD Standard deviation TC Topical corticosteroid TEAE Treatment-emergent adverse event TGA Telangiectasia Grading Assessment UBC United BioSource Corporation Assessment report EMA/CHMP/115246/2014 Page 5/107 1. Background information on the procedure 1.1. Submission of the dossier The applicant Galderma International submitted on 30 (...) . Scientific Advice The applicant did not seek scientific advice at the CHMP. Licensing status The product was not licensed in any country at the time of submission of the application. In 2013, the FDA approved topical application of brimonidine 0.33% (Mirvaso) for the topical treatment of persistent (nontransient) facial erythema of rosacea in adults 18 years of age or older. Assessment report EMA/CHMP/115246/2014 Page 6/107 1.2. Manufacturers Manufacturer of the finished product Laboratoires Galderma Z.I

2014 European Medicines Agency - EPARs

196. Management of Clostridium Difficile Infection

Clinical Practice Guidelines based on the best available evidence. t hese guidelines are inclusive, not pre- scriptive, and are intended for the use of all practitioners, health care workers, and patients who desire information about the management of the conditions addressed by the topics covered in these guidelines. t heir purpose is to pro- vide information on which decisions can be made, rather than dictate a specific form of treatment. it should be recognized that these guidelines should (...) he major risk factor for CDi is recent antibiotic use, with 1 report finding that 96% of symptomatic patients received antibiotics within 14 days of infection, and all af- fected patients were exposed to antibiotics within 3 months of CDi symptoms. 15 a lthough any antibiotic can result in a change in bacterial milieu, certain drugs such as penicil- lins, clindamycin, fluoroquinolones, and third-generation cephalosporins are more commonly associated with its development. 16 o ther risk factors

2015 American Society of Colon and Rectal Surgeons

197. WHO recommendations for prevention and treatment of maternal peripartum infections

should be used in preference to other classes of antibiotics. Conditional recommendation based on very low-quality evidence Treatment of peripartum infections 19. A simple regimen such as ampicillin and once-daily gentamicin is recommended as first-line antibiotics for the treatment of chorioamnionitis. Conditional recommendation based on very low-quality evidence 20. A combination of clindamycin and gentamicin is recommended as first-line antibiotics for the treatment of postpartum endometritis (...) of care for leading causes of maternal death, especially those clustered around the time of childbirth, in the post-MDG era. The guideline is evidence-informed and covers topics related to interventions selected and prioritized by an international, multidisciplinary group of health care professionals, consumer representatives and other stakeholders. Specifically, it presents evidence-based recommendations for preventing and treating genital tract infections during labour, childbirth or puerperium

2015 World Health Organisation Guidelines

198. Peritoneal dialysis catheter-related infection: exit site and tunnel

enterococcus (VRE), if prolonged use of vancomycin is planned. Plum et al in a prospective randomised study, showed the greater efficacy of the intraperitoneal (IP) application of clindamycin as a first-line antibiotic compared with the oral route for the treatment of tunnel infections. [9] The results showed no significant difference in the pericatheter fluid along the catheter at study entry, with 4 mm (median; range: 2-6 mm) in the oral group and 4 mm (range: 2-4 mm) in the IP group. The IP treatment (...) intraperitoneal vancomycin plus oral rifampin or oral trimethoprim/sulfamethoxazole for Gram-positive catheter infections. There was no difference with either treatment on catheter infection cure rate. The second study showed that there is greater efficacy with the intraperitoneal application of clindamycin as a first-line antibiotic compared with the oral route, for the treatment of tunnel infections. The KHA-CARI Guidelines – Caring for Australasians with Renal Impairment

2014 KHA-CARI Guidelines

199. Urological Infections

in this text are graded according to their level of evidence (LE) and Guidelines are given a grade of recommendation (GR), according to a classification system modified from the Oxford Centre for Evidence-Based Medicine Levels of Evidence [22]. The aim of grading recommendations is to provide transparency between the underlying evidence and the recommendation given. In this 2015 EAU Guidelines compilation, all standard information on LE and GR has been taken out of the individual Guidelines topics

2015 European Association of Urology

200. Adult Sinusitis Full Text available with Trip Pro

to confirm diagnosis and guide management, and promote judicious use of systemic and topical therapy, which includes radiography, nasal endoscopy, computed tomography, and testing for allergy and immune function. Emphasis was also placed on identifying multiple chronic conditions that would modify management of rhinosinusitis, including asthma, cystic fibrosis, immunocompromised state, and ciliary dyskinesia. Action statements The update group made strong recommendations that clinicians (1) should (...) and other causes of sinonasal symptoms; (5) should assess the patient with CRS or recurrent ARS for multiple chronic conditions that would modify management, such as asthma, cystic fibrosis, immunocompromised state, and ciliary dyskinesia; (6) should confirm the presence or absence of nasal polyps in a patient with CRS; and (7) should recommend saline nasal irrigation, topical intranasal corticosteroids, or both for symptom relief of CRS. The update group stated as options that clinicians may (1

2015 American Academy of Otolaryngology - Head and Neck Surgery

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